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The map label for this gene is yitJ [H]

Identifier: 156937290

GI number: 156937290

Start: 442922

End: 443911

Strand: Direct

Name: yitJ [H]

Synonym: Igni_0496

Alternate gene names: 156937290

Gene position: 442922-443911 (Clockwise)

Preceding gene: 156937289

Following gene: 156937291

Centisome position: 34.14

GC content: 60.81

Gene sequence:

>990_bases
GTGCGAGTGATCTGCCCTAAGAAGATGCTCAACGGCCCTTGCGGAGGCGTGAGGGGAGAGCTCTGCGAGGTCGACGACTT
CAAGTGCCCCTTCGTCGAGGCGTTTAGGAACTTAAGGAGCTCCGAGTACCTAAAGCCCTTGTTGGACCCCGGGTTCAAGG
TGGGCTGCGAAGTCGTAGAGGTGGAGCCCTCCCCGTACGTCAAGAAGCTCGAGGACTTCGCGGTCTCGGCGGAGGTCGAA
CCTTGGGGGCCGGAGGAGCTGGAGAGGGCCTCGAAGTGGAGGGTGGACGCGCTGAACGTCACCGACAACCCCCTGGGCTT
GCCCCACTTGGACTCGGTCTGGGCATCGGCCGCGCTGGCCTCCAAGGGAAAGGAGGTCATAGCCCAGCTGACTTGTAGGG
GGAGGACGAGGGAGGCGCTCGCTTCCTCCTTGCTCGCGCTTGATGCCTCTGGGGTCAACAACGTTTTAGCCTTGACGGGC
GACTGGGCCCCCAACGCGGCCTTCGACCTAGACGCGGTGAGGCTCGTCTGCTTGGTACAAGCCTTGAGGAAAGGGGTCGA
CTGGGAGGGGAGAAAGACTAGGAGGGTAAGGCTTTCGGTGGGGGTGGCCTCCAACCCGTACTTCAGTTACGAAGAGAAGA
GGCTCTTGAGGAAGGCCCACGCCGGGGCCCAGTTCGCCCAGACACAACCGGTGTTCAAGAAGGAACTGTTGTACAAGATA
AAGAAATACCCCCTCCCCACCGTGCCCAGCCTCTTGCTCACCACCTCTAGGAAAGTGGTGAGGGCATTAATGGAGAGGGG
AGTGGACGCGAAGGAGTTCTACGAGGAGCTGGTGAAGGCTAAGAGGGAAGGCAAGGCTGACGAGCTCGTGCTCAAGAAAT
CCCTAGAGATGTACGAGGAGGCCTACTCGTCGGAGCTCCCCGGGGTACACTTGATGGCCCCCGGCAGGCCGGACTTGCTC
GAGCGCTTCCTAGAGCTTTTGAGGCTTTAG

Upstream 100 bases:

>100_bases
CCTTGTTGGACAGAGAGGAGGGCAGCGTAGAGGAGATAGAAAAGAGGGGCGTGGAGTTCATCAGGTTGTTGACTCTTAAC
CAAGTGTTGAGGGGGTTGAG

Downstream 100 bases:

>100_bases
TCCGATGGGCCCTCGGGTAGGCGTTTTGGAGTGGCGCCCGAGACACTACATCAAGGTAACCGACTACGCCTCTAAGTCGG
TTATTAAGGTGCTTCCCGCC

Product: methylenetetrahydrofolate reductase

Products: NA

Alternate protein names: Homocysteine S-methyltransferase; S-methylmethionine:homocysteine methyltransferase; 5,10-methylenetetrahydrofolate reductase [H]

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MRVICPKKMLNGPCGGVRGELCEVDDFKCPFVEAFRNLRSSEYLKPLLDPGFKVGCEVVEVEPSPYVKKLEDFAVSAEVE
PWGPEELERASKWRVDALNVTDNPLGLPHLDSVWASAALASKGKEVIAQLTCRGRTREALASSLLALDASGVNNVLALTG
DWAPNAAFDLDAVRLVCLVQALRKGVDWEGRKTRRVRLSVGVASNPYFSYEEKRLLRKAHAGAQFAQTQPVFKKELLYKI
KKYPLPTVPSLLLTTSRKVVRALMERGVDAKEFYEELVKAKREGKADELVLKKSLEMYEEAYSSELPGVHLMAPGRPDLL
ERFLELLRL

Sequences:

>Translated_329_residues
MRVICPKKMLNGPCGGVRGELCEVDDFKCPFVEAFRNLRSSEYLKPLLDPGFKVGCEVVEVEPSPYVKKLEDFAVSAEVE
PWGPEELERASKWRVDALNVTDNPLGLPHLDSVWASAALASKGKEVIAQLTCRGRTREALASSLLALDASGVNNVLALTG
DWAPNAAFDLDAVRLVCLVQALRKGVDWEGRKTRRVRLSVGVASNPYFSYEEKRLLRKAHAGAQFAQTQPVFKKELLYKI
KKYPLPTVPSLLLTTSRKVVRALMERGVDAKEFYEELVKAKREGKADELVLKKSLEMYEEAYSSELPGVHLMAPGRPDLL
ERFLELLRL
>Mature_329_residues
MRVICPKKMLNGPCGGVRGELCEVDDFKCPFVEAFRNLRSSEYLKPLLDPGFKVGCEVVEVEPSPYVKKLEDFAVSAEVE
PWGPEELERASKWRVDALNVTDNPLGLPHLDSVWASAALASKGKEVIAQLTCRGRTREALASSLLALDASGVNNVLALTG
DWAPNAAFDLDAVRLVCLVQALRKGVDWEGRKTRRVRLSVGVASNPYFSYEEKRLLRKAHAGAQFAQTQPVFKKELLYKI
KKYPLPTVPSLLLTTSRKVVRALMERGVDAKEFYEELVKAKREGKADELVLKKSLEMYEEAYSSELPGVHLMAPGRPDLL
ERFLELLRL

Specific function: Unknown

COG id: COG0685

COG function: function code E; 5,10-methylenetetrahydrofolate reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Hcy-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003171
- InterPro:   IPR003726 [H]

Pfam domain/function: PF02219 MTHFR; PF02574 S-methyl_trans [H]

EC number: =2.1.1.10; =1.5.1.20 [H]

Molecular weight: Translated: 36758; Mature: 36758

Theoretical pI: Translated: 8.45; Mature: 8.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVICPKKMLNGPCGGVRGELCEVDDFKCPFVEAFRNLRSSEYLKPLLDPGFKVGCEVVE
CCCCCCHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHCCEEEE
VEPSPYVKKLEDFAVSAEVEPWGPEELERASKWRVDALNVTDNPLGLPHLDSVWASAALA
ECCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCEEEECCCCCCCCCCCHHHHHHHHHHH
SKGKEVIAQLTCRGRTREALASSLLALDASGVNNVLALTGDWAPNAAFDLDAVRLVCLVQ
HHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHH
ALRKGVDWEGRKTRRVRLSVGVASNPYFSYEEKRLLRKAHAGAQFAQTQPVFKKELLYKI
HHHCCCCCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHH
KKYPLPTVPSLLLTTSRKVVRALMERGVDAKEFYEELVKAKREGKADELVLKKSLEMYEE
HHCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
AYSSELPGVHLMAPGRPDLLERFLELLRL
HHHCCCCCEEEECCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MRVICPKKMLNGPCGGVRGELCEVDDFKCPFVEAFRNLRSSEYLKPLLDPGFKVGCEVVE
CCCCCCHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHCCEEEE
VEPSPYVKKLEDFAVSAEVEPWGPEELERASKWRVDALNVTDNPLGLPHLDSVWASAALA
ECCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCEEEECCCCCCCCCCCHHHHHHHHHHH
SKGKEVIAQLTCRGRTREALASSLLALDASGVNNVLALTGDWAPNAAFDLDAVRLVCLVQ
HHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHH
ALRKGVDWEGRKTRRVRLSVGVASNPYFSYEEKRLLRKAHAGAQFAQTQPVFKKELLYKI
HHHCCCCCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHH
KKYPLPTVPSLLLTTSRKVVRALMERGVDAKEFYEELVKAKREGKADELVLKKSLEMYEE
HHCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
AYSSELPGVHLMAPGRPDLLERFLELLRL
HHHCCCCCEEEECCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9353932; 9384377 [H]