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The map label for this gene is mtaP [H]

Identifier: 156937145

GI number: 156937145

Start: 308648

End: 309364

Strand: Direct

Name: mtaP [H]

Synonym: Igni_0351

Alternate gene names: 156937145

Gene position: 308648-309364 (Clockwise)

Preceding gene: 156937144

Following gene: 156937146

Centisome position: 23.79

GC content: 61.51

Gene sequence:

>717_bases
TTGAAGCCCCAACACTTGACCGCCAAGCCGGGAGAGGTGGCCGAGAAGGTAGTCGTGGTCGGCGACCCCGCGAGGGCCAG
GGACGTGGCTAACAAGTTCTTGGAGGATGTCAAACTGGTGAGCGAGAACAGAGAGTTGCTGGTCTTCACCGGCACCTACA
AGGGGAGTAGGGTGAGCGTGGCGGTCCACGGCATAGGTGCACCTTCTGCCGCGATAGTGATTGAGGAGCTCGCCATGCTT
GGGGCTAAGGAAGTGGTTAGGTTGGGGACGGCCGGGAGCATGAAGAAGGAAATAGACGTGAAGGACGCGGTCGTGGTCAC
CGGGGCGGCGCACTACTGCGGGGGCACCTTGGGCGTCTACGCGCCAAACGTGTGCTTGCCCAACTCCCCGGACCCGTGGC
TTACCGTGAAGCTGTACGAGAAGGCTAAAGAGGTCGGGCTGAGGGTCCACTATGGCCCCGTGGTAAGCAACGACGCCTTC
TACGCTGAAAGCCCGGACTTCGTGGAGTTCTGGACTAAGAGGGGGGTGGTGGCGGTGGAGATGGAGTGTGCCACGCTCTT
CGCCTTGGGCTGGATGAGGGGTTTAAGGACCGGGGCCTTAGTAGTAATAGCCGACAGCTTAGTAGACCCCAACAAGAAGG
ACCTCCTCCACCACGAGGAGCTCGCGGACGCCATGGACAAGGCCGCGAGGGCGGTGCTGGAGGCGCTCACCTCTTGA

Upstream 100 bases:

>100_bases
ACTCAAAGGTACAACGTAACGGACGTGAAGCTCCTAGGTTTTCCCGCGTGGGCTGAGCCTACCTTTAACCCCTCCCGTAA
GGCCTTCCCGGGCCTAGGAC

Downstream 100 bases:

>100_bases
ACTTCAAGGTTTACCTCTCGATTAAGAAGCTTTTGAGCGAGGGGTGCTCGGAGCTCCCCGCGGCGTGGGCGGCGGAGCTC
AAGCTCTTGGACTGTTACGA

Product: purine phosphorylase family 1

Products: NA

Alternate protein names: 5'-methylthioadenosine phosphorylase; MTA phosphorylase [H]

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MKPQHLTAKPGEVAEKVVVVGDPARARDVANKFLEDVKLVSENRELLVFTGTYKGSRVSVAVHGIGAPSAAIVIEELAML
GAKEVVRLGTAGSMKKEIDVKDAVVVTGAAHYCGGTLGVYAPNVCLPNSPDPWLTVKLYEKAKEVGLRVHYGPVVSNDAF
YAESPDFVEFWTKRGVVAVEMECATLFALGWMRGLRTGALVVIADSLVDPNKKDLLHHEELADAMDKAARAVLEALTS

Sequences:

>Translated_238_residues
MKPQHLTAKPGEVAEKVVVVGDPARARDVANKFLEDVKLVSENRELLVFTGTYKGSRVSVAVHGIGAPSAAIVIEELAML
GAKEVVRLGTAGSMKKEIDVKDAVVVTGAAHYCGGTLGVYAPNVCLPNSPDPWLTVKLYEKAKEVGLRVHYGPVVSNDAF
YAESPDFVEFWTKRGVVAVEMECATLFALGWMRGLRTGALVVIADSLVDPNKKDLLHHEELADAMDKAARAVLEALTS
>Mature_238_residues
MKPQHLTAKPGEVAEKVVVVGDPARARDVANKFLEDVKLVSENRELLVFTGTYKGSRVSVAVHGIGAPSAAIVIEELAML
GAKEVVRLGTAGSMKKEIDVKDAVVVTGAAHYCGGTLGVYAPNVCLPNSPDPWLTVKLYEKAKEVGLRVHYGPVVSNDAF
YAESPDFVEFWTKRGVVAVEMECATLFALGWMRGLRTGALVVIADSLVDPNKKDLLHHEELADAMDKAARAVLEALTS

Specific function: Endowed with a broad substrate specificity, being able to phosphorolytically cleave inosine, guanosine, and adenosine with a better efficiency than MTA [H]

COG id: COG2820

COG function: function code F; Uridine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/UDP phosphorylase family [H]

Homologues:

Organism=Escherichia coli, GI1790844, Length=210, Percent_Identity=30.4761904761905, Blast_Score=107, Evalue=5e-25,
Organism=Escherichia coli, GI1790265, Length=244, Percent_Identity=31.9672131147541, Blast_Score=107, Evalue=6e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018017
- InterPro:   IPR018016
- InterPro:   IPR000845 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: =2.4.2.28 [H]

Molecular weight: Translated: 25539; Mature: 25539

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPQHLTAKPGEVAEKVVVVGDPARARDVANKFLEDVKLVSENRELLVFTGTYKGSRVSV
CCCCCCCCCCCHHHCEEEEECCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEE
AVHGIGAPSAAIVIEELAMLGAKEVVRLGTAGSMKKEIDVKDAVVVTGAAHYCGGTLGVY
EEEECCCCHHHHHHHHHHHHCHHHHHHHCCCCCCCCCCCCCCEEEEECCHHHHCCCHHHC
APNVCLPNSPDPWLTVKLYEKAKEVGLRVHYGPVVSNDAFYAESPDFVEFWTKRGVVAVE
CCCCCCCCCCCCEEEEEEHHHHHHCCEEEEECCEECCCCCCCCCCHHHHHHHHCCEEEEE
MECATLFALGWMRGLRTGALVVIADSLVDPNKKDLLHHEELADAMDKAARAVLEALTS
HHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKPQHLTAKPGEVAEKVVVVGDPARARDVANKFLEDVKLVSENRELLVFTGTYKGSRVSV
CCCCCCCCCCCHHHCEEEEECCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEE
AVHGIGAPSAAIVIEELAMLGAKEVVRLGTAGSMKKEIDVKDAVVVTGAAHYCGGTLGVY
EEEECCCCHHHHHHHHHHHHCHHHHHHHCCCCCCCCCCCCCCEEEEECCHHHHCCCHHHC
APNVCLPNSPDPWLTVKLYEKAKEVGLRVHYGPVVSNDAFYAESPDFVEFWTKRGVVAVE
CCCCCCCCCCCCEEEEEEHHHHHHCCEEEEECCEECCCCCCCCCCHHHHHHHHCCEEEEE
MECATLFALGWMRGLRTGALVVIADSLVDPNKKDLLHHEELADAMDKAARAVLEALTS
HHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11427726; 7929153 [H]