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The map label for this gene is purE [H]

Identifier: 156937128

GI number: 156937128

Start: 294150

End: 294566

Strand: Direct

Name: purE [H]

Synonym: Igni_0334

Alternate gene names: 156937128

Gene position: 294150-294566 (Clockwise)

Preceding gene: 156937123

Following gene: 156937129

Centisome position: 22.67

GC content: 57.07

Gene sequence:

>417_bases
TTGCAGAAGCCCCTAGTCTCTATAATAATGGGCTCCAAGAGCGACGAGCACGTGGCGAAGAAGGTCATCGAAGTTTTGGA
AGAACACTGCGTACCCTACGAACTCAAGGTGATATCCGCCCACCGGCAGCCAGAGGAGCTGGACAAGTACCTAAAGGAGA
GCAAGGAGTACGTCAAGGTCTACATAACCATAGCGGGCCTCTCCGCTGCGCTCCCCGGCGTGGTGGCCTCCAAGGTAGAA
CAGCCAGTCATAGGGGTGCCCGTGGAAGTCAAGCTAATGGGCTTGGACGCCCTCTTCAGCATAGTCCAAATGCCTCCAGG
GGTGCCGGTGGCGGCGGTAGGCATAGACAACGGCAAGAACGCGGCCTACCTAGCCATAAGGATACTAAAGCTCGCGGGCT
TCCGGCCGTGTAAGTGA

Upstream 100 bases:

>100_bases
TCTCATTCAGAGAAGATATTTAATGAGGGCTTAAAGTTTCGAAGTTGGAAGGTGCGTTGATAACTTAAATAGAAGCCTCG
GAGAGGGCGCGGGAGAGCCC

Downstream 100 bases:

>100_bases
GGGAAGGGCCTCCTTGAACGTAACTAACGTTTTGAGGAAGGCGGCGAAGCTCGCTTACAAATCAAAAGCGTTCGACCTAC
TCGCCTACGTGAAGTCCGCC

Product: phosphoribosylaminoimidazole carboxylase

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 138; Mature: 138

Protein sequence:

>138_residues
MQKPLVSIIMGSKSDEHVAKKVIEVLEEHCVPYELKVISAHRQPEELDKYLKESKEYVKVYITIAGLSAALPGVVASKVE
QPVIGVPVEVKLMGLDALFSIVQMPPGVPVAAVGIDNGKNAAYLAIRILKLAGFRPCK

Sequences:

>Translated_138_residues
MQKPLVSIIMGSKSDEHVAKKVIEVLEEHCVPYELKVISAHRQPEELDKYLKESKEYVKVYITIAGLSAALPGVVASKVE
QPVIGVPVEVKLMGLDALFSIVQMPPGVPVAAVGIDNGKNAAYLAIRILKLAGFRPCK
>Mature_138_residues
MQKPLVSIIMGSKSDEHVAKKVIEVLEEHCVPYELKVISAHRQPEELDKYLKESKEYVKVYITIAGLSAALPGVVASKVE
QPVIGVPVEVKLMGLDALFSIVQMPPGVPVAAVGIDNGKNAAYLAIRILKLAGFRPCK

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=110, Percent_Identity=44.5454545454545, Blast_Score=90, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6324702, Length=131, Percent_Identity=51.9083969465649, Blast_Score=117, Evalue=5e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 14961; Mature: 14961

Theoretical pI: Translated: 8.67; Mature: 8.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKPLVSIIMGSKSDEHVAKKVIEVLEEHCVPYELKVISAHRQPEELDKYLKESKEYVKV
CCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHEEE
YITIAGLSAALPGVVASKVEQPVIGVPVEVKLMGLDALFSIVQMPPGVPVAAVGIDNGKN
EEEEECHHHHHHHHHHHHHCCCCCCCCEEEEEECHHHHHHHHHCCCCCCEEEEECCCCCC
AAYLAIRILKLAGFRPCK
HHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MQKPLVSIIMGSKSDEHVAKKVIEVLEEHCVPYELKVISAHRQPEELDKYLKESKEYVKV
CCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHEEE
YITIAGLSAALPGVVASKVEQPVIGVPVEVKLMGLDALFSIVQMPPGVPVAAVGIDNGKN
EEEEECHHHHHHHHHHHHHCCCCCCCCEEEEEECHHHHHHHHHCCCCCCEEEEECCCCCC
AAYLAIRILKLAGFRPCK
HHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]