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The map label for this gene is pepQ [H]

Identifier: 156936895

GI number: 156936895

Start: 93710

End: 94735

Strand: Reverse

Name: pepQ [H]

Synonym: Igni_0100

Alternate gene names: 156936895

Gene position: 94735-93710 (Counterclockwise)

Preceding gene: 156936896

Following gene: 156936894

Centisome position: 7.3

GC content: 60.92

Gene sequence:

>1026_bases
GTGGCCTCCTCGAAAAGGAGTTACTCCCGCAAGAGGGAGCTGTTTTTAGATTGCACCCTCATCCTCCACCCTTCTAACGT
GCGCTGGCTGACCGGCTTCGACGCGGGCATAGTCCTAATGGGGAAGGACGAAGACTACTTGATCGTCCCGGAGCTGGAGT
ATGAAAGGGCCCTAGAGGTCGTGGACTGGCTAAACGTGGTGAAGGGGCCGAGAGGGGCCCTGTGGAAGAAGGCCCTCGAG
CTGTGCAATGGACCCTTCTTCGCCGACCTCTCCTACCTCAACTTCAGAACTGCAATAACCTTGATGACTGAACTCGGCGC
AGGGGACGCGTCCAAGACCGTCAGGAGGGCTAGGATGAGTAAGGACGAGGAGGAACTATCGAGAATAAAGAAGGCTCTGG
AAATAGCGGAGAGGGCCTTCCTAGAGACTTGGAAGGAGTTAGAAGAGGGCACAACCGAGCTGGCCGCCGCGGGCGCCTTG
GAGGCCCACATGAGGGAGTTCGGGGCGCAAGAGTTCGCGTTCCCCACGATAGTGGCCTTCGGGCCCAACTCCTCCAAGCC
CCACGCTGTCCCCGGCGAGGCCCAGCTCAGCTTCGGGAGCGTGGCGCTCTTCGACTTCGGGGCCGTTTACGGAGGGTTCC
GGAGCGACATAACGAGAACCTACGTACCGGACAAGGAGCCCTACGCCTCTTGGTACCACGCGGTGCTGGAAGCGGTTAAC
GCCGCGCTTAAGGCCTTGAAGCCCGGGGCGAGGGGCAAGGACGTCGACGCGGCCGCGCGAGAGGTGCTGGCGGAGTACGG
CTTCGAGAAGGCCTTCGTCCACGGCTTGGGCCACGGGGTGGGGGCGGACATACACGAGCCTCCGTTCCTCTCGCCCTCCT
CGGAGGACGTAGTGTCCAAGGGGGCAGTGGTCACCGTGGAGCCGGGGGTATACTTCAAGGGTCAAGGCGGGGTCAGGGTG
GAACAGCTCGTTTACGTGGATTATAATCCTATAGTGCTGAATTCCACACCGGTGATGTGGTGGTAA

Upstream 100 bases:

>100_bases
ACTGAAGGAGGCTCAGCTGATAGCGCAGAAGAGGCTCGAGGAGAGCTTGGCGGTCGCCTCCGAGGAAGGTTCTAAAGCTT
AAGTTCCTTCACCCGCTCGG

Downstream 100 bases:

>100_bases
GGGCCGAGGGCCCCGCGCGCGAAGTGTTAGAGCTGGTCAAACGCTGCTTGTCGGAGCTCGAGAGCATAGACGAAAGCTTA
CAAAAGGAGGACATAGACCT

Product: peptidase M24

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 341; Mature: 340

Protein sequence:

>341_residues
MASSKRSYSRKRELFLDCTLILHPSNVRWLTGFDAGIVLMGKDEDYLIVPELEYERALEVVDWLNVVKGPRGALWKKALE
LCNGPFFADLSYLNFRTAITLMTELGAGDASKTVRRARMSKDEEELSRIKKALEIAERAFLETWKELEEGTTELAAAGAL
EAHMREFGAQEFAFPTIVAFGPNSSKPHAVPGEAQLSFGSVALFDFGAVYGGFRSDITRTYVPDKEPYASWYHAVLEAVN
AALKALKPGARGKDVDAAAREVLAEYGFEKAFVHGLGHGVGADIHEPPFLSPSSEDVVSKGAVVTVEPGVYFKGQGGVRV
EQLVYVDYNPIVLNSTPVMWW

Sequences:

>Translated_341_residues
MASSKRSYSRKRELFLDCTLILHPSNVRWLTGFDAGIVLMGKDEDYLIVPELEYERALEVVDWLNVVKGPRGALWKKALE
LCNGPFFADLSYLNFRTAITLMTELGAGDASKTVRRARMSKDEEELSRIKKALEIAERAFLETWKELEEGTTELAAAGAL
EAHMREFGAQEFAFPTIVAFGPNSSKPHAVPGEAQLSFGSVALFDFGAVYGGFRSDITRTYVPDKEPYASWYHAVLEAVN
AALKALKPGARGKDVDAAAREVLAEYGFEKAFVHGLGHGVGADIHEPPFLSPSSEDVVSKGAVVTVEPGVYFKGQGGVRV
EQLVYVDYNPIVLNSTPVMWW
>Mature_340_residues
ASSKRSYSRKRELFLDCTLILHPSNVRWLTGFDAGIVLMGKDEDYLIVPELEYERALEVVDWLNVVKGPRGALWKKALEL
CNGPFFADLSYLNFRTAITLMTELGAGDASKTVRRARMSKDEEELSRIKKALEIAERAFLETWKELEEGTTELAAAGALE
AHMREFGAQEFAFPTIVAFGPNSSKPHAVPGEAQLSFGSVALFDFGAVYGGFRSDITRTYVPDKEPYASWYHAVLEAVNA
ALKALKPGARGKDVDAAAREVLAEYGFEKAFVHGLGHGVGADIHEPPFLSPSSEDVVSKGAVVTVEPGVYFKGQGGVRVE
QLVYVDYNPIVLNSTPVMWW

Specific function: Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Archaeal-type prolidase subfamily [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=355, Percent_Identity=26.1971830985915, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI264681563, Length=215, Percent_Identity=31.6279069767442, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI260593665, Length=287, Percent_Identity=26.8292682926829, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI149589008, Length=287, Percent_Identity=26.8292682926829, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI264681565, Length=212, Percent_Identity=28.3018867924528, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI260593663, Length=235, Percent_Identity=28.0851063829787, Blast_Score=66, Evalue=6e-11,
Organism=Homo sapiens, GI93141226, Length=194, Percent_Identity=27.8350515463918, Blast_Score=65, Evalue=7e-11,
Organism=Escherichia coli, GI1788728, Length=241, Percent_Identity=37.344398340249, Blast_Score=154, Evalue=6e-39,
Organism=Escherichia coli, GI1789275, Length=225, Percent_Identity=26.2222222222222, Blast_Score=87, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17509539, Length=272, Percent_Identity=28.6764705882353, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17508215, Length=282, Percent_Identity=25.886524822695, Blast_Score=78, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6321118, Length=231, Percent_Identity=26.8398268398268, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI19920384, Length=251, Percent_Identity=28.2868525896414, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21357079, Length=241, Percent_Identity=27.8008298755187, Blast_Score=71, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 37572; Mature: 37441

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASSKRSYSRKRELFLDCTLILHPSNVRWLTGFDAGIVLMGKDEDYLIVPELEYERALEV
CCCCCHHHHHHHHEEEEEEEEEECCCCEEEEECCCCEEEEECCCCEEEECCCCHHHHHHH
VDWLNVVKGPRGALWKKALELCNGPFFADLSYLNFRTAITLMTELGAGDASKTVRRARMS
HHHHHHHCCCCHHHHHHHHHHHCCCCEECHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCC
KDEEELSRIKKALEIAERAFLETWKELEEGTTELAAAGALEAHMREFGAQEFAFPTIVAF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCEEEEE
GPNSSKPHAVPGEAQLSFGSVALFDFGAVYGGFRSDITRTYVPDKEPYASWYHAVLEAVN
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHCCHHCCCCCCCHHHHHHHHHHHHHH
AALKALKPGARGKDVDAAAREVLAEYGFEKAFVHGLGHGVGADIHEPPFLSPSSEDVVSK
HHHHHHCCCCCCCCHHHHHHHHHHHHCHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHC
GAVVTVEPGVYFKGQGGVRVEQLVYVDYNPIVLNSTPVMWW
CCEEEECCCEEEECCCCCEEEEEEEEECCCEEECCCCCCCC
>Mature Secondary Structure 
ASSKRSYSRKRELFLDCTLILHPSNVRWLTGFDAGIVLMGKDEDYLIVPELEYERALEV
CCCCHHHHHHHHEEEEEEEEEECCCCEEEEECCCCEEEEECCCCEEEECCCCHHHHHHH
VDWLNVVKGPRGALWKKALELCNGPFFADLSYLNFRTAITLMTELGAGDASKTVRRARMS
HHHHHHHCCCCHHHHHHHHHHHCCCCEECHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCC
KDEEELSRIKKALEIAERAFLETWKELEEGTTELAAAGALEAHMREFGAQEFAFPTIVAF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCEEEEE
GPNSSKPHAVPGEAQLSFGSVALFDFGAVYGGFRSDITRTYVPDKEPYASWYHAVLEAVN
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHCCHHCCCCCCCHHHHHHHHHHHHHH
AALKALKPGARGKDVDAAAREVLAEYGFEKAFVHGLGHGVGADIHEPPFLSPSSEDVVSK
HHHHHHCCCCCCCCHHHHHHHHHHHHCHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHC
GAVVTVEPGVYFKGQGGVRVEQLVYVDYNPIVLNSTPVMWW
CCEEEECCCEEEECCCCCEEEEEEEEECCCEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9733678; 11223522; 11210522 [H]