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The map label for this gene is glcD [H]

Identifier: 156936797

GI number: 156936797

Start: 2130

End: 3431

Strand: Reverse

Name: glcD [H]

Synonym: Igni_0002

Alternate gene names: 156936797

Gene position: 3431-2130 (Counterclockwise)

Preceding gene: 156936798

Following gene: 156936796

Centisome position: 0.26

GC content: 55.76

Gene sequence:

>1302_bases
ATGGCTTGCCCTCCCCTCGACGTGCTCTGTATAGACGACGAGAGCTTGTTGAGGGCTTACCTTACCGACGCCTCGCCGCT
CCGCGGGAACCTCCCACAAGCCGTCTTGTTCCCCTCGGACGCAGCCGAGGTGGCGAAAGTAATTAGGTGGGCTAACAAGG
AGAAGGTGGCAGTTTACCCCTATGGCGGGGGCTCGAGCCTCGTGGGCTCCCCCTTGCCTTTCGACGGGATAGTCGTAGAC
ACTTCGCTCTTGCTGGACTTGGAGGTTTTTGAGAAGGATAAGTTAGTCCTAGCGGGAGCTGGCTGGAGGCTCTCAGAGCT
GAACCATGTTTTAAGAAGATACGGCCTTTGGTTCCCCGTGGACCCCGGCAGCGTGGAGTGGGCTACGGTAGGCGGCGTAG
TAGCCACCAACGCCGGCGGGATAAGGGCCGTCAAGTACGGTTTGACTTCTGACCACGTGAGGGCGCTCGAGTTCGTTACG
CCCGTCGGAGAGGTCGTGTGGAGCGGGGCGTGGGCTAAGAAGAGCAGCACGTGGTTGAGGGTCCACCAACTCTTGGTGGG
ATCGGAGGGCACTCTAGGCATAGTAACCAAGGCCTTGCTCACGCTCTCGAGGGTTCCCGAGAGGAGGGAAGCTGTCTTGT
TGCTATTTGAAGAGGCAGAGGAGATGGGCGAAGCGGTCTTGGATATCCTAGAGTTAGCGCCATCTGCGCTGGAATTCATG
GATCCCAAGACAGTGAGGGCGGTAAATTCTAGAACTGATATGTCCTTGAAAATGCCGGAGAAATACTTATTGTTAGTTGA
GTTCGACGATGAGCGCTCCTCTGAAAAGACGAAGCTAATCTTGGATAAGTATGAAGGTATCAAGGAAGATCCAGAGACGT
TGTGGAAGTACCGCAAGCTGGCCGGTCCTTCCCTCACGCTCGTGAAGGGTTCTAGATCAGACTGGGACGTCGCGGTTCCG
GTTAGCCTCTTGCCAGAAGCGATAAAGTTCGTTTATGAGAACGCTCGCGACTGGGAGGTGGCCGTCTTCGGACACGCCGG
CGACGGCAACTTGCACGTAAACTTGCTTCACCCTCCGGGAGAGGAGTGGGTTAGAAAGGCTATCGAAAAAGCCAAGGAGA
TCATCTGCGAAATGAGTAAAAGGTACAAGGCCACAGTTAGCGGCGAACACGGGATAGGGCTCCTCAAGCTGGCCTTGCTA
GGCTGCGAGGTCGACGAGCCGGCTTTGGAGCTGTGGAAGGCGATCAAGAAGGCCCTTGATCCCAACCTAATATTAAACCC
TGGCAAGAAGATACCGCTGTAA

Upstream 100 bases:

>100_bases
ACTCCGAATAAGATGGGAATATACATGAATTCCAAGAGAGAAGGATACCTCGAGGAAACGTCTAAGAGTAAGATACTCTA
CCTCGTCTGAGGAAGCGCCC

Downstream 100 bases:

>100_bases
AATATTTAATGGACTCTTCAGACCAGCCGGCGGGCCGCCGTAGCTCAGCCCGGCAGAGCGCCGGCCTCGTACGGCCCTCC
GAGAGAGCCGGTGGTCGCGG

Product: FAD linked oxidase domain-containing protein

Products: 2-oxo acid; H2O2

Alternate protein names: NA

Number of amino acids: Translated: 433; Mature: 432

Protein sequence:

>433_residues
MACPPLDVLCIDDESLLRAYLTDASPLRGNLPQAVLFPSDAAEVAKVIRWANKEKVAVYPYGGGSSLVGSPLPFDGIVVD
TSLLLDLEVFEKDKLVLAGAGWRLSELNHVLRRYGLWFPVDPGSVEWATVGGVVATNAGGIRAVKYGLTSDHVRALEFVT
PVGEVVWSGAWAKKSSTWLRVHQLLVGSEGTLGIVTKALLTLSRVPERREAVLLLFEEAEEMGEAVLDILELAPSALEFM
DPKTVRAVNSRTDMSLKMPEKYLLLVEFDDERSSEKTKLILDKYEGIKEDPETLWKYRKLAGPSLTLVKGSRSDWDVAVP
VSLLPEAIKFVYENARDWEVAVFGHAGDGNLHVNLLHPPGEEWVRKAIEKAKEIICEMSKRYKATVSGEHGIGLLKLALL
GCEVDEPALELWKAIKKALDPNLILNPGKKIPL

Sequences:

>Translated_433_residues
MACPPLDVLCIDDESLLRAYLTDASPLRGNLPQAVLFPSDAAEVAKVIRWANKEKVAVYPYGGGSSLVGSPLPFDGIVVD
TSLLLDLEVFEKDKLVLAGAGWRLSELNHVLRRYGLWFPVDPGSVEWATVGGVVATNAGGIRAVKYGLTSDHVRALEFVT
PVGEVVWSGAWAKKSSTWLRVHQLLVGSEGTLGIVTKALLTLSRVPERREAVLLLFEEAEEMGEAVLDILELAPSALEFM
DPKTVRAVNSRTDMSLKMPEKYLLLVEFDDERSSEKTKLILDKYEGIKEDPETLWKYRKLAGPSLTLVKGSRSDWDVAVP
VSLLPEAIKFVYENARDWEVAVFGHAGDGNLHVNLLHPPGEEWVRKAIEKAKEIICEMSKRYKATVSGEHGIGLLKLALL
GCEVDEPALELWKAIKKALDPNLILNPGKKIPL
>Mature_432_residues
ACPPLDVLCIDDESLLRAYLTDASPLRGNLPQAVLFPSDAAEVAKVIRWANKEKVAVYPYGGGSSLVGSPLPFDGIVVDT
SLLLDLEVFEKDKLVLAGAGWRLSELNHVLRRYGLWFPVDPGSVEWATVGGVVATNAGGIRAVKYGLTSDHVRALEFVTP
VGEVVWSGAWAKKSSTWLRVHQLLVGSEGTLGIVTKALLTLSRVPERREAVLLLFEEAEEMGEAVLDILELAPSALEFMD
PKTVRAVNSRTDMSLKMPEKYLLLVEFDDERSSEKTKLILDKYEGIKEDPETLWKYRKLAGPSLTLVKGSRSDWDVAVPV
SLLPEAIKFVYENARDWEVAVFGHAGDGNLHVNLLHPPGEEWVRKAIEKAKEIICEMSKRYKATVSGEHGIGLLKLALLG
CEVDEPALELWKAIKKALDPNLILNPGKKIPL

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=430, Percent_Identity=32.093023255814, Blast_Score=172, Evalue=7e-43,
Organism=Homo sapiens, GI37595754, Length=453, Percent_Identity=30.6843267108168, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI119964728, Length=428, Percent_Identity=28.5046728971963, Blast_Score=145, Evalue=7e-35,
Organism=Homo sapiens, GI4501993, Length=482, Percent_Identity=24.2738589211618, Blast_Score=98, Evalue=1e-20,
Organism=Escherichia coli, GI1789351, Length=447, Percent_Identity=27.7404921700224, Blast_Score=152, Evalue=5e-38,
Organism=Escherichia coli, GI1787977, Length=499, Percent_Identity=25.250501002004, Blast_Score=102, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI71992373, Length=444, Percent_Identity=31.7567567567568, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI71992381, Length=443, Percent_Identity=31.1512415349887, Blast_Score=187, Evalue=9e-48,
Organism=Caenorhabditis elegans, GI71992392, Length=381, Percent_Identity=32.5459317585302, Blast_Score=168, Evalue=6e-42,
Organism=Caenorhabditis elegans, GI17534361, Length=426, Percent_Identity=28.8732394366197, Blast_Score=155, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI17556096, Length=223, Percent_Identity=29.1479820627803, Blast_Score=92, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6320027, Length=448, Percent_Identity=30.5803571428571, Blast_Score=171, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6320023, Length=433, Percent_Identity=31.4087759815243, Blast_Score=165, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6320764, Length=479, Percent_Identity=27.5574112734864, Blast_Score=153, Evalue=4e-38,
Organism=Drosophila melanogaster, GI18921117, Length=432, Percent_Identity=30.0925925925926, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24639277, Length=432, Percent_Identity=30.0925925925926, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24639275, Length=432, Percent_Identity=30.0925925925926, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24653753, Length=222, Percent_Identity=32.4324324324324, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.3.15

Molecular weight: Translated: 47662; Mature: 47530

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MACPPLDVLCIDDESLLRAYLTDASPLRGNLPQAVLFPSDAAEVAKVIRWANKEKVAVYP
CCCCCCEEEEECCHHHHHHHHCCCCCCCCCCCCEEECCCCHHHHHHHHHHCCCCEEEEEE
YGGGSSLVGSPLPFDGIVVDTSLLLDLEVFEKDKLVLAGAGWRLSELNHVLRRYGLWFPV
CCCCCCCCCCCCCCCCEEECCEEEEEEEEECCCCEEEEECCCCHHHHHHHHHHCCCEEEC
DPGSVEWATVGGVVATNAGGIRAVKYGLTSDHVRALEFVTPVGEVVWSGAWAKKSSTWLR
CCCCEEEEEECCEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
VHQLLVGSEGTLGIVTKALLTLSRVPERREAVLLLFEEAEEMGEAVLDILELAPSALEFM
HHHHHHCCCCCHHHHHHHHHHHHHCCCCHHEEEEEHHHHHHHHHHHHHHHHHCHHHHHHC
DPKTVRAVNSRTDMSLKMPEKYLLLVEFDDERSSEKTKLILDKYEGIKEDPETLWKYRKL
CCHHHHHHCCCCCCEEECCCEEEEEEEECCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHH
AGPSLTLVKGSRSDWDVAVPVSLLPEAIKFVYENARDWEVAVFGHAGDGNLHVNLLHPPG
CCCEEEEEECCCCCCEEECCHHHHHHHHHHHHCCCCCEEEEEEEECCCCEEEEEEECCCC
EEWVRKAIEKAKEIICEMSKRYKATVSGEHGIGLLKLALLGCEVDEPALELWKAIKKALD
HHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCC
PNLILNPGKKIPL
CCEEECCCCCCCC
>Mature Secondary Structure 
ACPPLDVLCIDDESLLRAYLTDASPLRGNLPQAVLFPSDAAEVAKVIRWANKEKVAVYP
CCCCCEEEEECCHHHHHHHHCCCCCCCCCCCCEEECCCCHHHHHHHHHHCCCCEEEEEE
YGGGSSLVGSPLPFDGIVVDTSLLLDLEVFEKDKLVLAGAGWRLSELNHVLRRYGLWFPV
CCCCCCCCCCCCCCCCEEECCEEEEEEEEECCCCEEEEECCCCHHHHHHHHHHCCCEEEC
DPGSVEWATVGGVVATNAGGIRAVKYGLTSDHVRALEFVTPVGEVVWSGAWAKKSSTWLR
CCCCEEEEEECCEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
VHQLLVGSEGTLGIVTKALLTLSRVPERREAVLLLFEEAEEMGEAVLDILELAPSALEFM
HHHHHHCCCCCHHHHHHHHHHHHHCCCCHHEEEEEHHHHHHHHHHHHHHHHHCHHHHHHC
DPKTVRAVNSRTDMSLKMPEKYLLLVEFDDERSSEKTKLILDKYEGIKEDPETLWKYRKL
CCHHHHHHCCCCCCEEECCCEEEEEEEECCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHH
AGPSLTLVKGSRSDWDVAVPVSLLPEAIKFVYENARDWEVAVFGHAGDGNLHVNLLHPPG
CCCEEEEEECCCCCCEEECCHHHHHHHHHHHHCCCCCEEEEEEEECCCCEEEEEEECCCC
EEWVRKAIEKAKEIICEMSKRYKATVSGEHGIGLLKLALLGCEVDEPALELWKAIKKALD
HHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCC
PNLILNPGKKIPL
CCEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-2-hydroxy acid; O2

Specific reaction: (S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]