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Identifier: 15679897

GI number: 15679897

Start: 1747208

End: 1748221

Strand: Direct

Name: Not Available

Synonym: MTH1915

Alternate gene names: 15679897

Gene position: 1747208-1748221 (Clockwise)

Preceding gene: 15679896

Following gene: 15679900

Centisome position: 99.76

GC content: 54.73

Gene sequence:

>1014_bases
GTGATAGTTATCGATGGATCAGAGGGTGAGGGTGGAGGAGCTGTTGTGAGGGTCTCCACAGCACTCGCGGCGGTGACCTC
CAGGAGTGTAAGGGTATACAATATCAGGGCCAGGAGGTCGAGGAGTGGATTATCACACCAGCACCTCACAGCAGTGAGGG
CCGTTGCCAGGATAAGCAACGGGACACTGAGGGGTGATGAGCTCGGGTCAATGGAACTTGAATTCTCCCCCGGCAGGGTG
ACGGGCGGGACATTTAACTTCGATGTTAAAACGGCCGGAAGCACGGGTCTGGTCCTGCAGGCCATCATGGTCGCTGCTGC
AGCCTCCGAAGGTGAAATTGATGTAACGGTCTCAGGGGGAACCGATGTCCTGTGGGCACCAACCTGTGACTACCTGAGGG
AGGTAACGATCCCGGTCCTGGAGATGATGGGGTACAGTGCCAGGATTGAAATCATCAGGAGGGGTTATTACCCTGAGGGC
GGGGGCAGGGTTCATGCAATCATTGAACCATCTGAACTCAGACCCATCACCCTTGAGGAGTCAGAGATCCATGCTGTGAG
GGGCATATCCCATTCCAGGAACCTTCCGGTTCACGTGGCAGAGAGACAGGCTGAATCAGCCATGAAGATCCTCAGGGGGG
CAGGTCTCGATGTTGATATAATGGTCGAGGATGCATCAGGTCCGGTGGGGAGAGGTTCAGGCATAACACTATGGGCTGAG
GGTAATACACGGCTCGGAGCAGTATCCCTTGGAAAACCGGGTAAGAGGGCTGAGAAAGTCGGTTCAGAGGCTGCAAGGGA
ACTTTTAGGCTTCATAGAATCGGGGAGCCCCCTCGATAGATACATGGGCGACCAGATAATCCCCTACATGGCTCTCACTG
GAGATTCGAGGGTTAGAACCTGTGAGCTCACACTCCACGCCGAGACCAACATAATCCTTTCAGAAAAAATAACCGGTAGA
AGGTTCCGGGTTGAGGGTGAACGTGGAGGCCCGGCAACCATAGAGGTCCTTTAA

Upstream 100 bases:

>100_bases
CATCAATGATGATGAGAAAATGCGCAGACTGATTCTTGGATGATCAGGCTCTGACCAGAACACAATGAGCTGCTTTTAAG
TGTGACAGGGAGGTATCCGA

Downstream 100 bases:

>100_bases
TTTTTTTATCTGACAGTAAAAACAAATTTAAGGAACAGACCCTCAAAGGGTCAGATTATCTGTGTATACACTCCCCTGAG
ATGACCTTGCGCAGTGTGCC

Product: RNA 3'-terminal-phosphate cyclase

Products: NA

Alternate protein names: RNA cyclase; RNA-3'-phosphate cyclase

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MIVIDGSEGEGGGAVVRVSTALAAVTSRSVRVYNIRARRSRSGLSHQHLTAVRAVARISNGTLRGDELGSMELEFSPGRV
TGGTFNFDVKTAGSTGLVLQAIMVAAAASEGEIDVTVSGGTDVLWAPTCDYLREVTIPVLEMMGYSARIEIIRRGYYPEG
GGRVHAIIEPSELRPITLEESEIHAVRGISHSRNLPVHVAERQAESAMKILRGAGLDVDIMVEDASGPVGRGSGITLWAE
GNTRLGAVSLGKPGKRAEKVGSEAARELLGFIESGSPLDRYMGDQIIPYMALTGDSRVRTCELTLHAETNIILSEKITGR
RFRVEGERGGPATIEVL

Sequences:

>Translated_337_residues
MIVIDGSEGEGGGAVVRVSTALAAVTSRSVRVYNIRARRSRSGLSHQHLTAVRAVARISNGTLRGDELGSMELEFSPGRV
TGGTFNFDVKTAGSTGLVLQAIMVAAAASEGEIDVTVSGGTDVLWAPTCDYLREVTIPVLEMMGYSARIEIIRRGYYPEG
GGRVHAIIEPSELRPITLEESEIHAVRGISHSRNLPVHVAERQAESAMKILRGAGLDVDIMVEDASGPVGRGSGITLWAE
GNTRLGAVSLGKPGKRAEKVGSEAARELLGFIESGSPLDRYMGDQIIPYMALTGDSRVRTCELTLHAETNIILSEKITGR
RFRVEGERGGPATIEVL
>Mature_337_residues
MIVIDGSEGEGGGAVVRVSTALAAVTSRSVRVYNIRARRSRSGLSHQHLTAVRAVARISNGTLRGDELGSMELEFSPGRV
TGGTFNFDVKTAGSTGLVLQAIMVAAAASEGEIDVTVSGGTDVLWAPTCDYLREVTIPVLEMMGYSARIEIIRRGYYPEG
GGRVHAIIEPSELRPITLEESEIHAVRGISHSRNLPVHVAERQAESAMKILRGAGLDVDIMVEDASGPVGRGSGITLWAE
GNTRLGAVSLGKPGKRAEKVGSEAARELLGFIESGSPLDRYMGDQIIPYMALTGDSRVRTCELTLHAETNIILSEKITGR
RFRVEGERGGPATIEVL

Specific function: Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps:(A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA- N3'PP5'A;

COG id: COG0430

COG function: function code A; RNA 3'-terminal phosphate cyclase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily

Homologues:

Organism=Homo sapiens, GI4506589, Length=339, Percent_Identity=38.9380530973451, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI195927044, Length=352, Percent_Identity=37.7840909090909, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI157426877, Length=285, Percent_Identity=27.719298245614, Blast_Score=69, Evalue=8e-12,
Organism=Escherichia coli, GI48994937, Length=325, Percent_Identity=34.1538461538462, Blast_Score=170, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI32564710, Length=285, Percent_Identity=24.5614035087719, Blast_Score=71, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6324564, Length=292, Percent_Identity=22.6027397260274, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI18543269, Length=340, Percent_Identity=33.5294117647059, Blast_Score=167, Evalue=8e-42,
Organism=Drosophila melanogaster, GI18860065, Length=239, Percent_Identity=23.8493723849372, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RTCA_METTH (O27937)

Other databases:

- EMBL:   AE000666
- PIR:   G69122
- RefSeq:   NP_277015.1
- ProteinModelPortal:   O27937
- SMR:   O27937
- STRING:   O27937
- GeneID:   1471000
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH1915
- NMPDR:   fig|187420.1.peg.1870
- eggNOG:   arNOG04553
- HOGENOM:   HBG683539
- OMA:   EIDGSYG
- PhylomeDB:   O27937
- ProtClustDB:   PRK04204
- BioCyc:   MTHE187420:MTH1915-MONOMER
- BRENDA:   6.5.1.4
- GO:   GO:0005737
- GO:   GO:0005654
- HAMAP:   MF_00200
- InterPro:   IPR000228
- InterPro:   IPR020719
- InterPro:   IPR013796
- InterPro:   IPR020723
- InterPro:   IPR017770
- InterPro:   IPR013792
- Gene3D:   G3DSA:3.65.10.20
- PANTHER:   PTHR11096
- TIGRFAMs:   TIGR03399

Pfam domain/function: PF01137 RTC; PF05189 RTC_insert; SSF55205 RNA3'_cycl/enolpyr_transf_A/B

EC number: =6.5.1.4

Molecular weight: Translated: 35932; Mature: 35932

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS01287 RTC

Important sites: ACT_SITE 306-306 BINDING 100-100

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVIDGSEGEGGGAVVRVSTALAAVTSRSVRVYNIRARRSRSGLSHQHLTAVRAVARISN
CEEEECCCCCCCCEEEEEEHHHHHHHCCCEEEEEEEEHHCCCCCCHHHHHHHHHHHHHCC
GTLRGDELGSMELEFSPGRVTGGTFNFDVKTAGSTGLVLQAIMVAAAASEGEIDVTVSGG
CCCCCCCCCCEEEEECCCEEECCEEEEEEEECCCCHHHHHHHHHHHCCCCCCEEEEEECC
TDVLWAPTCDYLREVTIPVLEMMGYSARIEIIRRGYYPEGGGRVHAIIEPSELRPITLEE
CEEEECCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCEEEEEECCCCCCEEEECC
SEIHAVRGISHSRNLPVHVAERQAESAMKILRGAGLDVDIMVEDASGPVGRGSGITLWAE
CHHHEEECCCCCCCCCEEEHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCEEEEEC
GNTRLGAVSLGKPGKRAEKVGSEAARELLGFIESGSPLDRYMGDQIIPYMALTGDSRVRT
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCEEEEECCCCCEEE
CELTLHAETNIILSEKITGRRFRVEGERGGPATIEVL
EEEEEEECCCEEEECCCCCCEEEEECCCCCCEEEEEC
>Mature Secondary Structure
MIVIDGSEGEGGGAVVRVSTALAAVTSRSVRVYNIRARRSRSGLSHQHLTAVRAVARISN
CEEEECCCCCCCCEEEEEEHHHHHHHCCCEEEEEEEEHHCCCCCCHHHHHHHHHHHHHCC
GTLRGDELGSMELEFSPGRVTGGTFNFDVKTAGSTGLVLQAIMVAAAASEGEIDVTVSGG
CCCCCCCCCCEEEEECCCEEECCEEEEEEEECCCCHHHHHHHHHHHCCCCCCEEEEEECC
TDVLWAPTCDYLREVTIPVLEMMGYSARIEIIRRGYYPEGGGRVHAIIEPSELRPITLEE
CEEEECCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCEEEEEECCCCCCEEEECC
SEIHAVRGISHSRNLPVHVAERQAESAMKILRGAGLDVDIMVEDASGPVGRGSGITLWAE
CHHHEEECCCCCCCCCEEEHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCEEEEEC
GNTRLGAVSLGKPGKRAEKVGSEAARELLGFIESGSPLDRYMGDQIIPYMALTGDSRVRT
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCEEEEECCCCCEEE
CELTLHAETNIILSEKITGRRFRVEGERGGPATIEVL
EEEEEEECCCEEEECCCCCCEEEEECCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463