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Identifier: 15679892

GI number: 15679892

Start: 1743405

End: 1744082

Strand: Direct

Name: Not Available

Synonym: MTH1910

Alternate gene names: 15679892

Gene position: 1743405-1744082 (Clockwise)

Preceding gene: 15679890

Following gene: 15679893

Centisome position: 99.54

GC content: 54.57

Gene sequence:

>678_bases
ATGTTTTTCATGGAGATTAAACTTGAAACACCACTTTCTGAGGAGGTAACTGAACTCCGTGTGGGTGACGTGGTCTACAT
AAATGGGAGGATATTCACAGCCCGTGACAGGGCCCATAAGAGGATCCTTGAGAGGGGAGCTCCCTTTGATATTGAGGGTT
CTGTGATATTCCATGCGGGACCGATAATAAGGTTCAACGAGGAGCCTAACACCACAGCTGAATCCATCAGGGACCCCCAG
GCAGAACTTGTTGTTGTGGGACCCACAACCAGCGGCAGGATGAACCCCTTCCAGCCGGAGGTCCTGGGGCTTGGCGTGAG
GGCAGTTATAGGTAAGGGGGGGATGGATGATCGAACAGGATCCGCCCTTAGAAGGTACGGGGCAGTTTACCTTGCCGCTG
TCGGGGGCTGCGCAGCCCTCTATGGCTCAGCCGTGAAGGGCATAAGGGCAGTTCACTGGCTTGACCTGGGGGTGCCTGAG
GCGATCTGGGAGCTCGAGGTGGAGGAATTCGGACCCCTCATAGTTGCCATGGACTCCACCGGGCGCAGCTCTATAATACA
GAGGAGGCCAGCCATGACCTTGAGGTCCAGAAACTCCTCGATTAGTAGCGGAATCATGTCCCAGCCCCTGATTCTCATAG
GTATCTCATGTGGAAGAGGCAGGTGGATTGATGTTTGA

Upstream 100 bases:

>100_bases
AGTGCCAAAAATCTGATCCATCTTGTAATATTCGATGGCACGAACTCGTGATTCGGTGTCCTTGTGCATGGTGCACAGCC
TTATCTACTGAGGGCAGGAG

Downstream 100 bases:

>100_bases
CTTCAGCCTCTCAGAGGACATTGAACTTTCCGGTCTGGTGGACACCCATGTGCACACGGCCCCGGATGTGAAGGAGAGGA
TAATGAACGACCTGGAACTT

Product: fumarate hydratase, class I related protein

Products: NA

Alternate protein names: Fumarase [H]

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MFFMEIKLETPLSEEVTELRVGDVVYINGRIFTARDRAHKRILERGAPFDIEGSVIFHAGPIIRFNEEPNTTAESIRDPQ
AELVVVGPTTSGRMNPFQPEVLGLGVRAVIGKGGMDDRTGSALRRYGAVYLAAVGGCAALYGSAVKGIRAVHWLDLGVPE
AIWELEVEEFGPLIVAMDSTGRSSIIQRRPAMTLRSRNSSISSGIMSQPLILIGISCGRGRWIDV

Sequences:

>Translated_225_residues
MFFMEIKLETPLSEEVTELRVGDVVYINGRIFTARDRAHKRILERGAPFDIEGSVIFHAGPIIRFNEEPNTTAESIRDPQ
AELVVVGPTTSGRMNPFQPEVLGLGVRAVIGKGGMDDRTGSALRRYGAVYLAAVGGCAALYGSAVKGIRAVHWLDLGVPE
AIWELEVEEFGPLIVAMDSTGRSSIIQRRPAMTLRSRNSSISSGIMSQPLILIGISCGRGRWIDV
>Mature_225_residues
MFFMEIKLETPLSEEVTELRVGDVVYINGRIFTARDRAHKRILERGAPFDIEGSVIFHAGPIIRFNEEPNTTAESIRDPQ
AELVVVGPTTSGRMNPFQPEVLGLGVRAVIGKGGMDDRTGSALRRYGAVYLAAVGGCAALYGSAVKGIRAVHWLDLGVPE
AIWELEVEEFGPLIVAMDSTGRSSIIQRRPAMTLRSRNSSISSGIMSQPLILIGISCGRGRWIDV

Specific function: Unknown

COG id: COG1838

COG function: function code C; Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I fumarase family [H]

Homologues:

Organism=Escherichia coli, GI1789443, Length=196, Percent_Identity=40.3061224489796, Blast_Score=150, Evalue=6e-38,
Organism=Escherichia coli, GI1787897, Length=192, Percent_Identity=29.6875, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1790564, Length=194, Percent_Identity=27.319587628866, Blast_Score=69, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004647 [H]

Pfam domain/function: PF05683 Fumerase_C [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 24509; Mature: 24509

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFFMEIKLETPLSEEVTELRVGDVVYINGRIFTARDRAHKRILERGAPFDIEGSVIFHAG
CEEEEEEECCCCHHHHHHEECCCEEEECCEEEECHHHHHHHHHHCCCCCCCCCCEEEECC
PIIRFNEEPNTTAESIRDPQAELVVVGPTTSGRMNPFQPEVLGLGVRAVIGKGGMDDRTG
CEEEECCCCCCHHHHHCCCCCCEEEECCCCCCCCCCCCCHHHCCCCEEEECCCCCCCCHH
SALRRYGAVYLAAVGGCAALYGSAVKGIRAVHWLDLGVPEAIWELEVEEFGPLIVAMDST
HHHHHHHHEEEEHHHHHHHHHHHHHHHHHEEEEEECCCCHHHHEEEHHHCCCEEEEECCC
GRSSIIQRRPAMTLRSRNSSISSGIMSQPLILIGISCGRGRWIDV
CCHHHHHHCCCHHHHCCCCCHHCCHHHCCEEEEEEECCCCEEECC
>Mature Secondary Structure
MFFMEIKLETPLSEEVTELRVGDVVYINGRIFTARDRAHKRILERGAPFDIEGSVIFHAG
CEEEEEEECCCCHHHHHHEECCCEEEECCEEEECHHHHHHHHHHCCCCCCCCCCEEEECC
PIIRFNEEPNTTAESIRDPQAELVVVGPTTSGRMNPFQPEVLGLGVRAVIGKGGMDDRTG
CEEEECCCCCCHHHHHCCCCCCEEEECCCCCCCCCCCCCHHHCCCCEEEECCCCCCCCHH
SALRRYGAVYLAAVGGCAALYGSAVKGIRAVHWLDLGVPEAIWELEVEEFGPLIVAMDST
HHHHHHHHEEEEHHHHHHHHHHHHHHHHHEEEEEECCCCHHHHEEEHHHCCCEEEEECCC
GRSSIIQRRPAMTLRSRNSSISSGIMSQPLILIGISCGRGRWIDV
CCHHHHHHCCCHHHHCCCCCHHCCHHHCCEEEEEEECCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]