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Identifier: 15679878

GI number: 15679878

Start: 1728238

End: 1728753

Strand: Direct

Name: Not Available

Synonym: MTH1896

Alternate gene names: 15679878

Gene position: 1728238-1728753 (Clockwise)

Preceding gene: 15679874

Following gene: 15679879

Centisome position: 98.68

GC content: 48.26

Gene sequence:

>516_bases
TTGACTTTTAAAGATGATACGATGAAGAGGAAGTATTCACTGGTTGCAGTTGGCGGCACCTTTGACAGGTTTCATAAGGG
CCACAGGAGACTCCTTGATGAGGCATTCCGTGTTGGAGAGACTGTCATGATTGGCGTGACCTCTGATGAATTTGCAGCTG
CAAAGGGAGAGGGTATTGAACCCTGCAGTGTCCGCATGAAGAACCTTGAGGAGTACCTGAGAGATAAGGATGCCGATTAT
CATGTAATGAGACTTGATGATCCCTATGGGACTACAGTAACAGATGAGGCCTTTGAAGCGATAGTTGTGAGCAGGGAGAC
AGAACCCGTTGCCCGTGAGATCAATGCAATAAGGAGGAATAGGGGGTTCAGGGAACTGGACATCATAACAATCGACATGG
TGAATGCTGACGATGGAATACCAATATCCTCCACCAGGATAAGGAGGGGTGAGATAGACCCCATGGGCCACATAATAAAG
AGGATACGCGGGGCCCTTAGAAGGAGAAGGGAGTGA

Upstream 100 bases:

>100_bases
GGCACTTAAACTGCTCCATGGGGCAATACCATGTGAGGTTGAAGGTTCATTAATCTCCGCTGTCTAGCATGATTTATAAA
TTCAGCTGATCTAACTGTTA

Downstream 100 bases:

>100_bases
CCGGTCACGGTGAAGTTTTAGATGGGATGTTACTTTGTGTGGTATGATGACCTGGCTCATATTCAGGTAAAGGAGCAAAT
GGATTCGGTGGTGTTTTACA

Product: phosphopantetheine adenylyltransferase

Products: NA

Alternate protein names: Dephospho-CoA pyrophosphorylase; Pantetheine-phosphate adenylyltransferase; PPAT [H]

Number of amino acids: Translated: 171; Mature: 170

Protein sequence:

>171_residues
MTFKDDTMKRKYSLVAVGGTFDRFHKGHRRLLDEAFRVGETVMIGVTSDEFAAAKGEGIEPCSVRMKNLEEYLRDKDADY
HVMRLDDPYGTTVTDEAFEAIVVSRETEPVAREINAIRRNRGFRELDIITIDMVNADDGIPISSTRIRRGEIDPMGHIIK
RIRGALRRRRE

Sequences:

>Translated_171_residues
MTFKDDTMKRKYSLVAVGGTFDRFHKGHRRLLDEAFRVGETVMIGVTSDEFAAAKGEGIEPCSVRMKNLEEYLRDKDADY
HVMRLDDPYGTTVTDEAFEAIVVSRETEPVAREINAIRRNRGFRELDIITIDMVNADDGIPISSTRIRRGEIDPMGHIIK
RIRGALRRRRE
>Mature_170_residues
TFKDDTMKRKYSLVAVGGTFDRFHKGHRRLLDEAFRVGETVMIGVTSDEFAAAKGEGIEPCSVRMKNLEEYLRDKDADYH
VMRLDDPYGTTVTDEAFEAIVVSRETEPVAREINAIRRNRGFRELDIITIDMVNADDGIPISSTRIRRGEIDPMGHIIKR
IRGALRRRRE

Specific function: Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate [H]

COG id: COG1019

COG function: function code R; Predicted nucleotidyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eukaryotic CoaD family [H]

Homologues:

Organism=Homo sapiens, GI110227605, Length=151, Percent_Identity=33.7748344370861, Blast_Score=71, Evalue=5e-13,
Organism=Homo sapiens, GI110227603, Length=151, Percent_Identity=33.7748344370861, Blast_Score=71, Evalue=5e-13,
Organism=Homo sapiens, GI110227601, Length=151, Percent_Identity=33.7748344370861, Blast_Score=71, Evalue=5e-13,
Organism=Homo sapiens, GI205277394, Length=151, Percent_Identity=33.7748344370861, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI25143409, Length=162, Percent_Identity=33.9506172839506, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6321716, Length=149, Percent_Identity=32.2147651006711, Blast_Score=71, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24658602, Length=166, Percent_Identity=36.144578313253, Blast_Score=89, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004821
- InterPro:   IPR004820
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01467 CTP_transf_2 [H]

EC number: =2.7.7.3 [H]

Molecular weight: Translated: 19631; Mature: 19499

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFKDDTMKRKYSLVAVGGTFDRFHKGHRRLLDEAFRVGETVMIGVTSDEFAAAKGEGIE
CCCCCCHHHHEEEEEEECCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHCCCCCCC
PCSVRMKNLEEYLRDKDADYHVMRLDDPYGTTVTDEAFEAIVVSRETEPVAREINAIRRN
HHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHC
RGFRELDIITIDMVNADDGIPISSTRIRRGEIDPMGHIIKRIRGALRRRRE
CCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TFKDDTMKRKYSLVAVGGTFDRFHKGHRRLLDEAFRVGETVMIGVTSDEFAAAKGEGIE
CCCCCHHHHEEEEEEECCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHCCCCCCC
PCSVRMKNLEEYLRDKDADYHVMRLDDPYGTTVTDEAFEAIVVSRETEPVAREINAIRRN
HHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHC
RGFRELDIITIDMVNADDGIPISSTRIRRGEIDPMGHIIKRIRGALRRRRE
CCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]