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Identifier: 15679844

GI number: 15679844

Start: 1692885

End: 1694465

Strand: Direct

Name: Not Available

Synonym: MTH1856

Alternate gene names: 15679844

Gene position: 1692885-1694465 (Clockwise)

Preceding gene: 15679841

Following gene: 15679845

Centisome position: 96.66

GC content: 51.36

Gene sequence:

>1581_bases
ATGGATCTTTTAGTACTCGGTATCGTCGTTCTCATCTACTTCCTTCTTGTGGGCTACGTTGGATACGTGGCATGGAGAAG
GACGGAGACCTCAGAGGACTACATGGTGGCCGGTAGAAGGACCCACCCCTACATCATGGCCATGAGCTATGGAGCCACCT
TCATAAGTACGGCGGCCATCGTCGGCTTCGGTGGAATGGCAGGTGTCTTCGGGATGGGTATACTCTGGCTCGTGTTTCTC
AACATACTTGTAGGTATATTCATTGCATTCGTGTTTTTTGGTAAGCGCACAATGAAGATGGGCCACAACATGTCGGCCCT
CACATTCCCGGAATTCCTGGGGAGGAGATTTAACAGCAGATTCCTTCAGTACTTTGGTGGGGCCATAATCTTTCTTGGAA
TGCCCCTGTATGCATCCGTTGTCCTGATAGGTGCTGCAAGGTTCATTGAAACAACCCTTGGCCTGGACTTCAGCATCGCC
CTGATACTGATGGCTGTCATAGTGGCTGTTTATGTTGTTCTTGGAGGTATAAGGGGTGTTATGTACACCGACGCCCTTCA
GGGCACCATAATGTTCCTTGGAATGATATTCCTTGTTGTATCGACCTACTACCTTCTTGGCGGAGTTGTGGACGCTCATC
AGGCACTCACAAACATTTCACACCTCATACCCGCCAAGGCCAGGGCAATAGGGGCAACTGGCTGGACCAGCATGCCTTTA
TATGGTAGCCCCTACTGGTGGACGCTCCTCTCAACAATAATCCTTGGTGTTGGTGTGGGTGTCCTTGCACAGCCCCAGCT
CATAGTGAGGTTCATGACCGTGAAATCCAACAGGGAGCTCAACAGAGGTGTTCTAATAGGTGCACTCTTCATATTCGTGA
TGACCTGGAGCGCCTACGTCGTTGGGGCACTTTCGAATGTCTACTTCTTCAGGAAGATGGGCATGATAGCGGTGCAGGCT
GCTGGTGGAAACGCAGATAAGATAATACCTTTCTTCATAAAGTCTGCCATGCCCGAGTGGTTCTCGTACATCTTCATGCT
GACGCTGCTCTCAGCAGCCATGTCAACACTCAGTGCCCAGTTCCATGTCCAGGGGACTGCCATAGGTAGGGACGTCTATG
AGACAGTAAGAAGGAGGAAGGGTGATAGATCCGTCCTCATCACAAGGGGAGGCATAATAATAGCGGTACTTATAGCGGTG
GTCCTCGGCTACCTGCTACCAGGAAGCATAGTTGCACAGGGAACAGCCCTTTTCTTCGGGATATGTGCAGCATCCTTCCT
TTCGGTCTATGTTGCAGCCATATTCTGGAAGAGGGCCACAAGGCAGGGTGCGATAGCCGGGATGGTTTCAGGAGCCATTG
TAAGTCTGTTCTGGCTACTTTTCGAATACAAGAAGACTGCGGAGGCCCTTGGAATCGCCAAGGCACTCTTCGGGGGCCCG
GTTATAGCATCGATGCCATGGCCGGTGGTGGACCCGATACTGGTGGGTGTGCCGGTCTCAGCCATCTTCATGGTGGCTGT
CAGCCTTCTTACGGAACCACCCTCTGATGAGCACATCCAGAAATGTTTTAACGGAGTTTAG

Upstream 100 bases:

>100_bases
TCCTTCGATGAGCTTTCTTGTTTTTTCTGTCTCTAAAGACTTATATGTTAACTGTCATTATCATTAATTATAATTTGATG
GATTTAAAGGAGGATGTTGA

Downstream 100 bases:

>100_bases
TGGAGGTCAAGCATGGTACTTGGAATACCTGACCCATGGGTATGGGGCGCATATATCCTCTGCATCCTGATAACAGTCTT
CTGCGTTATCTACGGCCTGG

Product: sodium/proline symporter (proline permease)

Products: NA

Alternate protein names: Pantothenate permease [H]

Number of amino acids: Translated: 526; Mature: 526

Protein sequence:

>526_residues
MDLLVLGIVVLIYFLLVGYVGYVAWRRTETSEDYMVAGRRTHPYIMAMSYGATFISTAAIVGFGGMAGVFGMGILWLVFL
NILVGIFIAFVFFGKRTMKMGHNMSALTFPEFLGRRFNSRFLQYFGGAIIFLGMPLYASVVLIGAARFIETTLGLDFSIA
LILMAVIVAVYVVLGGIRGVMYTDALQGTIMFLGMIFLVVSTYYLLGGVVDAHQALTNISHLIPAKARAIGATGWTSMPL
YGSPYWWTLLSTIILGVGVGVLAQPQLIVRFMTVKSNRELNRGVLIGALFIFVMTWSAYVVGALSNVYFFRKMGMIAVQA
AGGNADKIIPFFIKSAMPEWFSYIFMLTLLSAAMSTLSAQFHVQGTAIGRDVYETVRRRKGDRSVLITRGGIIIAVLIAV
VLGYLLPGSIVAQGTALFFGICAASFLSVYVAAIFWKRATRQGAIAGMVSGAIVSLFWLLFEYKKTAEALGIAKALFGGP
VIASMPWPVVDPILVGVPVSAIFMVAVSLLTEPPSDEHIQKCFNGV

Sequences:

>Translated_526_residues
MDLLVLGIVVLIYFLLVGYVGYVAWRRTETSEDYMVAGRRTHPYIMAMSYGATFISTAAIVGFGGMAGVFGMGILWLVFL
NILVGIFIAFVFFGKRTMKMGHNMSALTFPEFLGRRFNSRFLQYFGGAIIFLGMPLYASVVLIGAARFIETTLGLDFSIA
LILMAVIVAVYVVLGGIRGVMYTDALQGTIMFLGMIFLVVSTYYLLGGVVDAHQALTNISHLIPAKARAIGATGWTSMPL
YGSPYWWTLLSTIILGVGVGVLAQPQLIVRFMTVKSNRELNRGVLIGALFIFVMTWSAYVVGALSNVYFFRKMGMIAVQA
AGGNADKIIPFFIKSAMPEWFSYIFMLTLLSAAMSTLSAQFHVQGTAIGRDVYETVRRRKGDRSVLITRGGIIIAVLIAV
VLGYLLPGSIVAQGTALFFGICAASFLSVYVAAIFWKRATRQGAIAGMVSGAIVSLFWLLFEYKKTAEALGIAKALFGGP
VIASMPWPVVDPILVGVPVSAIFMVAVSLLTEPPSDEHIQKCFNGV
>Mature_526_residues
MDLLVLGIVVLIYFLLVGYVGYVAWRRTETSEDYMVAGRRTHPYIMAMSYGATFISTAAIVGFGGMAGVFGMGILWLVFL
NILVGIFIAFVFFGKRTMKMGHNMSALTFPEFLGRRFNSRFLQYFGGAIIFLGMPLYASVVLIGAARFIETTLGLDFSIA
LILMAVIVAVYVVLGGIRGVMYTDALQGTIMFLGMIFLVVSTYYLLGGVVDAHQALTNISHLIPAKARAIGATGWTSMPL
YGSPYWWTLLSTIILGVGVGVLAQPQLIVRFMTVKSNRELNRGVLIGALFIFVMTWSAYVVGALSNVYFFRKMGMIAVQA
AGGNADKIIPFFIKSAMPEWFSYIFMLTLLSAAMSTLSAQFHVQGTAIGRDVYETVRRRKGDRSVLITRGGIIIAVLIAV
VLGYLLPGSIVAQGTALFFGICAASFLSVYVAAIFWKRATRQGAIAGMVSGAIVSLFWLLFEYKKTAEALGIAKALFGGP
VIASMPWPVVDPILVGVPVSAIFMVAVSLLTEPPSDEHIQKCFNGV

Specific function: Catalyzes the sodium-dependent uptake of extracellular pantothenate [H]

COG id: COG0591

COG function: function code ER; Na+/proline symporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=537, Percent_Identity=25.8845437616387, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI14140236, Length=551, Percent_Identity=25.0453720508167, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI110835708, Length=557, Percent_Identity=24.7755834829443, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI109659836, Length=449, Percent_Identity=24.2761692650334, Blast_Score=99, Evalue=9e-21,
Organism=Homo sapiens, GI4507031, Length=568, Percent_Identity=25.3521126760563, Blast_Score=93, Evalue=8e-19,
Organism=Homo sapiens, GI4507033, Length=560, Percent_Identity=25.1785714285714, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI109659839, Length=469, Percent_Identity=24.5202558635394, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI206597487, Length=448, Percent_Identity=25.6696428571429, Blast_Score=83, Evalue=7e-16,
Organism=Homo sapiens, GI206597483, Length=448, Percent_Identity=25.6696428571429, Blast_Score=83, Evalue=7e-16,
Organism=Homo sapiens, GI17941285, Length=558, Percent_Identity=23.4767025089606, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI4507035, Length=421, Percent_Identity=20.4275534441805, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI256985183, Length=452, Percent_Identity=22.1238938053097, Blast_Score=74, Evalue=5e-13,
Organism=Homo sapiens, GI157671931, Length=476, Percent_Identity=21.218487394958, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI167466278, Length=440, Percent_Identity=22.5, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1787251, Length=453, Percent_Identity=25.60706401766, Blast_Score=142, Evalue=5e-35,
Organism=Escherichia coli, GI87082237, Length=447, Percent_Identity=24.8322147651007, Blast_Score=141, Evalue=9e-35,
Organism=Escherichia coli, GI1790503, Length=492, Percent_Identity=22.3577235772358, Blast_Score=76, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI32566512, Length=415, Percent_Identity=23.855421686747, Blast_Score=78, Evalue=9e-15,
Organism=Drosophila melanogaster, GI221459584, Length=380, Percent_Identity=21.8421052631579, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI28573698, Length=466, Percent_Identity=21.6738197424893, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24651739, Length=464, Percent_Identity=21.551724137931, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011849
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 57107; Mature: 57107

Theoretical pI: Translated: 10.06; Mature: 10.06

Prosite motif: PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLLVLGIVVLIYFLLVGYVGYVAWRRTETSEDYMVAGRRTHPYIMAMSYGATFISTAAI
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCEEEEEECCHHHHHHHHH
VGFGGMAGVFGMGILWLVFLNILVGIFIAFVFFGKRTMKMGHNMSALTFPEFLGRRFNSR
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
FLQYFGGAIIFLGMPLYASVVLIGAARFIETTLGLDFSIALILMAVIVAVYVVLGGIRGV
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
MYTDALQGTIMFLGMIFLVVSTYYLLGGVVDAHQALTNISHLIPAKARAIGATGWTSMPL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCC
YGSPYWWTLLSTIILGVGVGVLAQPQLIVRFMTVKSNRELNRGVLIGALFIFVMTWSAYV
CCCCHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
VGALSNVYFFRKMGMIAVQAAGGNADKIIPFFIKSAMPEWFSYIFMLTLLSAAMSTLSAQ
HHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FHVQGTAIGRDVYETVRRRKGDRSVLITRGGIIIAVLIAVVLGYLLPGSIVAQGTALFFG
HEEECHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
ICAASFLSVYVAAIFWKRATRQGAIAGMVSGAIVSLFWLLFEYKKTAEALGIAKALFGGP
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
VIASMPWPVVDPILVGVPVSAIFMVAVSLLTEPPSDEHIQKCFNGV
EEECCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHCCC
>Mature Secondary Structure
MDLLVLGIVVLIYFLLVGYVGYVAWRRTETSEDYMVAGRRTHPYIMAMSYGATFISTAAI
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCEEEEEECCHHHHHHHHH
VGFGGMAGVFGMGILWLVFLNILVGIFIAFVFFGKRTMKMGHNMSALTFPEFLGRRFNSR
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
FLQYFGGAIIFLGMPLYASVVLIGAARFIETTLGLDFSIALILMAVIVAVYVVLGGIRGV
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
MYTDALQGTIMFLGMIFLVVSTYYLLGGVVDAHQALTNISHLIPAKARAIGATGWTSMPL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCC
YGSPYWWTLLSTIILGVGVGVLAQPQLIVRFMTVKSNRELNRGVLIGALFIFVMTWSAYV
CCCCHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
VGALSNVYFFRKMGMIAVQAAGGNADKIIPFFIKSAMPEWFSYIFMLTLLSAAMSTLSAQ
HHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FHVQGTAIGRDVYETVRRRKGDRSVLITRGGIIIAVLIAVVLGYLLPGSIVAQGTALFFG
HEEECHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
ICAASFLSVYVAAIFWKRATRQGAIAGMVSGAIVSLFWLLFEYKKTAEALGIAKALFGGP
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
VIASMPWPVVDPILVGVPVSAIFMVAVSLLTEPPSDEHIQKCFNGV
EEECCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]