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Identifier: 15679820

GI number: 15679820

Start: 1672185

End: 1673024

Strand: Direct

Name: Not Available

Synonym: MTH1832

Alternate gene names: 15679820

Gene position: 1672185-1673024 (Clockwise)

Preceding gene: 15679814

Following gene: 15679821

Centisome position: 95.48

GC content: 50.83

Gene sequence:

>840_bases
ATGATGGATATTATCAGGGAGATGATCAGGGCCGATGTGGGATTTGAGGATATAACAACCGAGGCACTCATTGACAGGGG
AACCAGGGTTGTGGCGGATATCGTTTCCAGGGAAGAGGGAGTTGTTGCAGGTGTTGAGGTTGCCGAGATGATGGCCCGGG
AGTTCTCCATATCCATCATCAGATGGAAGGATGATGGTGACCCCTTAAGCGGCGGTGAACGGGTCTTAACCCTTGAGGGG
GATGCCATGGATATCCTTATGGTTGAGAGGACCATGCTGAACCTCATGATGAAGATGAGCGGTATAGCAACCCTGACAAG
GAGCATGCTTCAGAGGGCGAGGGCGGTAAATGAGGGCATAAGGATAGCGGCCACAAGGAAAACCACTCCAGGTCTTCAGT
GGTTTGAGAAACAGGCTGTTAGGATCGGTGGTGGCGACACCCACCGCTTCAGGCTTGATGACTGTGCAATGATCAAGGAC
AATCACATCGCCATTGTGGGCAACATTGAGGATGCGGTGAGGCGTGTGAGGGATCATGTGAGTTTCACAAAGAAGGTTGA
GGTTGAGGTTGAGAGTCCTGATGATGCAGTCCGGGCGGCTGAGGCCGGAGCTGATATAGTACTCCTTGATAACATGTCAC
CTGAGACAATCCGAAATACCCTGGAGGAACTTGAAAGGCGCGGGCTCCGGGATAATGTCATAGTGGAGGCATCAGGGGGC
ATCAAACCGGATAATATTGAACTTTATGCTTCTACCGGCGTTGAAGTGATATCCATGGGTTTCATAACAGCTTCAGCTCA
TCCAGTTGACCTCAGCCTTGAAATAAGGGGACTAAAATGA

Upstream 100 bases:

>100_bases
TCCATCATATCACTCTTTCATAAATGCTCTTCTTTTGCAGATCTCCCTTCTGGACATAAGATTTATAATTCTTCCATTTA
TATTAATTTAGGGGATCTTT

Downstream 100 bases:

>100_bases
GTTTTAATTCTGGTGATTGGAACCCTCAATCTACTTAATGGGATACCTTCCACTTAACATTATAATTGATGGTTTCTTCA
ATTATATGGAATACATTTAT

Product: quinolinate phosphoribosyltransferase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase

Number of amino acids: Translated: 279; Mature: 279

Protein sequence:

>279_residues
MMDIIREMIRADVGFEDITTEALIDRGTRVVADIVSREEGVVAGVEVAEMMAREFSISIIRWKDDGDPLSGGERVLTLEG
DAMDILMVERTMLNLMMKMSGIATLTRSMLQRARAVNEGIRIAATRKTTPGLQWFEKQAVRIGGGDTHRFRLDDCAMIKD
NHIAIVGNIEDAVRRVRDHVSFTKKVEVEVESPDDAVRAAEAGADIVLLDNMSPETIRNTLEELERRGLRDNVIVEASGG
IKPDNIELYASTGVEVISMGFITASAHPVDLSLEIRGLK

Sequences:

>Translated_279_residues
MMDIIREMIRADVGFEDITTEALIDRGTRVVADIVSREEGVVAGVEVAEMMAREFSISIIRWKDDGDPLSGGERVLTLEG
DAMDILMVERTMLNLMMKMSGIATLTRSMLQRARAVNEGIRIAATRKTTPGLQWFEKQAVRIGGGDTHRFRLDDCAMIKD
NHIAIVGNIEDAVRRVRDHVSFTKKVEVEVESPDDAVRAAEAGADIVLLDNMSPETIRNTLEELERRGLRDNVIVEASGG
IKPDNIELYASTGVEVISMGFITASAHPVDLSLEIRGLK
>Mature_279_residues
MMDIIREMIRADVGFEDITTEALIDRGTRVVADIVSREEGVVAGVEVAEMMAREFSISIIRWKDDGDPLSGGERVLTLEG
DAMDILMVERTMLNLMMKMSGIATLTRSMLQRARAVNEGIRIAATRKTTPGLQWFEKQAVRIGGGDTHRFRLDDCAMIKD
NHIAIVGNIEDAVRRVRDHVSFTKKVEVEVESPDDAVRAAEAGADIVLLDNMSPETIRNTLEELERRGLRDNVIVEASGG
IKPDNIELYASTGVEVISMGFITASAHPVDLSLEIRGLK

Specific function: Involved in the catabolism of quinolinic acid (QA)

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family

Homologues:

Organism=Homo sapiens, GI45269149, Length=275, Percent_Identity=35.2727272727273, Blast_Score=160, Evalue=8e-40,
Organism=Escherichia coli, GI1786299, Length=276, Percent_Identity=32.9710144927536, Blast_Score=125, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6321162, Length=273, Percent_Identity=34.0659340659341, Blast_Score=157, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NADC_METTH (O27860)

Other databases:

- EMBL:   AE000666
- PIR:   A69112
- RefSeq:   NP_276938.1
- ProteinModelPortal:   O27860
- SMR:   O27860
- STRING:   O27860
- GeneID:   1470917
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH1832
- NMPDR:   fig|187420.1.peg.1793
- eggNOG:   arNOG04747
- HOGENOM:   HBG751540
- OMA:   IATIEGP
- PhylomeDB:   O27860
- ProtClustDB:   CLSK342536
- BioCyc:   MTHE187420:MTH1832-MONOMER
- BRENDA:   2.4.2.19
- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR00078

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N; SSF51690 Q_phspho_trans

EC number: =2.4.2.19

Molecular weight: Translated: 30807; Mature: 30807

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: NA

Important sites: BINDING 90-90 BINDING 149-149 BINDING 159-159 BINDING 189-189 BINDING 210-210

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMDIIREMIRADVGFEDITTEALIDRGTRVVADIVSREEGVVAGVEVAEMMAREFSISII
CHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHCCCCCCEEHHHHHHHHHHHHEEEEE
RWKDDGDPLSGGERVLTLEGDAMDILMVERTMLNLMMKMSGIATLTRSMLQRARAVNEGI
EECCCCCCCCCCCEEEEEECCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
RIAATRKTTPGLQWFEKQAVRIGGGDTHRFRLDDCAMIKDNHIAIVGNIEDAVRRVRDHV
EEEEECCCCCCHHHHHHHHEEECCCCCEEEEECCEEEEECCCEEEEECHHHHHHHHHHHC
SFTKKVEVEVESPDDAVRAAEAGADIVLLDNMSPETIRNTLEELERRGLRDNVIVEASGG
CEEEEEEEEECCCCHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCEEEEECCC
IKPDNIELYASTGVEVISMGFITASAHPVDLSLEIRGLK
CCCCCEEEEECCCCEEEEEEEEEECCCCEEEEEEEECCC
>Mature Secondary Structure
MMDIIREMIRADVGFEDITTEALIDRGTRVVADIVSREEGVVAGVEVAEMMAREFSISII
CHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHCCCCCCEEHHHHHHHHHHHHEEEEE
RWKDDGDPLSGGERVLTLEGDAMDILMVERTMLNLMMKMSGIATLTRSMLQRARAVNEGI
EECCCCCCCCCCCEEEEEECCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
RIAATRKTTPGLQWFEKQAVRIGGGDTHRFRLDDCAMIKDNHIAIVGNIEDAVRRVRDHV
EEEEECCCCCCHHHHHHHHEEECCCCCEEEEECCEEEEECCCEEEEECHHHHHHHHHHHC
SFTKKVEVEVESPDDAVRAAEAGADIVLLDNMSPETIRNTLEELERRGLRDNVIVEASGG
CEEEEEEEEECCCCHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCEEEEECCC
IKPDNIELYASTGVEVISMGFITASAHPVDLSLEIRGLK
CCCCCEEEEECCCCEEEEEEEEEECCCCEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463