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Identifier: 15679801

GI number: 15679801

Start: 1655484

End: 1656470

Strand: Direct

Name: Not Available

Synonym: MTH1813

Alternate gene names: 15679801

Gene position: 1655484-1656470 (Clockwise)

Preceding gene: 15679797

Following gene: 15679802

Centisome position: 94.52

GC content: 48.73

Gene sequence:

>987_bases
ATGATCGAATCAAAATATACTAACAAGGGATCTGATTTTAGTGAAACAGAACTTGAAGAGCAGGAAATAATGGATGCCTA
CTCAGAGGCTGTTATGGGTGCAGCCGATAGAGTGAGCCCCTCCGTTGTAAGGGTAACAACGGTGGCCCGATCAAAAAACA
GGACCGTGGGTGGAGGTTCAGGTCTCATATACACTGAATACGGGCATATAATCACAAACAGTCATGTTGTCCACGGATCA
GAGAGAATTGAAGTAACACTGAACACAGGGGAAGAGTACCGGGCAACTGTTGTTGGTGATGACCCCCACACAGACATCTC
GGTCCTGAAAATCGAACCTCAGCATGAACTCAGAACACCTGAATTTGCAGACTCCAGCAGGGTGAGGGTGGGACAGCTTG
CCCTGGCAATAGGCAACCCCTTCGGGTTCCAGTTCACAGTAACAGCAGGAGTTGTGAGTGCAACCGGCAGATCCCTGCGG
ACCATGACAGGGAGGCTCGTGGATGGGGTTATACAGACAGATGCAGCACTAAACCCTGGAAAATCAGGCGGACCACTGGT
TGATTTTCGCGGAAGGGTCCTGGGGATAAACACGGCCCTTATAAGACCTGCTCAGGGGCTTTGCTTTGCAATACCATCAA
ATACAGTCAGGGAAGTCGCAGATAAACTTATAGAGGATGGTAAAATAAGAAGGGCCCACCTGGGAGTGGCCTGCCAGAAC
ATGGTGCTGAAGCCAGAAACAGTTGAGAAACTGAAACTGAATTCGGATAGGGGAGTTATGGTTGCATCACTCTCAGATGG
TCCGGCAGGAGATGCTGGAGTCATGCGTGGTGATATCATAATAGCCCTCGACGGCGAAGCAGTTGAAACAGTCGATGACC
TTCACAGAATCCTCAATGAGGAAAGGATCGGTATGGAATGTGATCTGGATGTCATAAGGGGGTCTGAGATCTTTAAAATC
TCTGTGAAACCATCAGAACTGGAATAA

Upstream 100 bases:

>100_bases
TAAGGACTTTTAATAACTTAATTTAACTAAAAATTCAGTAACCTGAAAAAAGTTCCAGAACATTTAAAATAAACTTAAAA
ACCAATTAAAAGTTAGAAAA

Downstream 100 bases:

>100_bases
GCCCATCTAAAGTTTTATTAAGAGGGGGTGCCAGACTAATTCTGGAGACCCCATTGGCAGTGGTTTGAATGAATACAACT
GAAAAGCTGGATAAAATCGA

Product: serine protease HtrA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MIESKYTNKGSDFSETELEEQEIMDAYSEAVMGAADRVSPSVVRVTTVARSKNRTVGGGSGLIYTEYGHIITNSHVVHGS
ERIEVTLNTGEEYRATVVGDDPHTDISVLKIEPQHELRTPEFADSSRVRVGQLALAIGNPFGFQFTVTAGVVSATGRSLR
TMTGRLVDGVIQTDAALNPGKSGGPLVDFRGRVLGINTALIRPAQGLCFAIPSNTVREVADKLIEDGKIRRAHLGVACQN
MVLKPETVEKLKLNSDRGVMVASLSDGPAGDAGVMRGDIIIALDGEAVETVDDLHRILNEERIGMECDLDVIRGSEIFKI
SVKPSELE

Sequences:

>Translated_328_residues
MIESKYTNKGSDFSETELEEQEIMDAYSEAVMGAADRVSPSVVRVTTVARSKNRTVGGGSGLIYTEYGHIITNSHVVHGS
ERIEVTLNTGEEYRATVVGDDPHTDISVLKIEPQHELRTPEFADSSRVRVGQLALAIGNPFGFQFTVTAGVVSATGRSLR
TMTGRLVDGVIQTDAALNPGKSGGPLVDFRGRVLGINTALIRPAQGLCFAIPSNTVREVADKLIEDGKIRRAHLGVACQN
MVLKPETVEKLKLNSDRGVMVASLSDGPAGDAGVMRGDIIIALDGEAVETVDDLHRILNEERIGMECDLDVIRGSEIFKI
SVKPSELE
>Mature_328_residues
MIESKYTNKGSDFSETELEEQEIMDAYSEAVMGAADRVSPSVVRVTTVARSKNRTVGGGSGLIYTEYGHIITNSHVVHGS
ERIEVTLNTGEEYRATVVGDDPHTDISVLKIEPQHELRTPEFADSSRVRVGQLALAIGNPFGFQFTVTAGVVSATGRSLR
TMTGRLVDGVIQTDAALNPGKSGGPLVDFRGRVLGINTALIRPAQGLCFAIPSNTVREVADKLIEDGKIRRAHLGVACQN
MVLKPETVEKLKLNSDRGVMVASLSDGPAGDAGVMRGDIIIALDGEAVETVDDLHRILNEERIGMECDLDVIRGSEIFKI
SVKPSELE

Specific function: Protease With A Shared Specificity With Degp. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI22129776, Length=312, Percent_Identity=34.6153846153846, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI24308541, Length=315, Percent_Identity=33.968253968254, Blast_Score=145, Evalue=4e-35,
Organism=Homo sapiens, GI4506141, Length=313, Percent_Identity=32.9073482428115, Blast_Score=145, Evalue=5e-35,
Organism=Homo sapiens, GI7019477, Length=312, Percent_Identity=32.6923076923077, Blast_Score=131, Evalue=1e-30,
Organism=Escherichia coli, GI1789629, Length=271, Percent_Identity=36.90036900369, Blast_Score=177, Evalue=6e-46,
Organism=Escherichia coli, GI1786356, Length=260, Percent_Identity=37.6923076923077, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI1789630, Length=282, Percent_Identity=36.1702127659575, Blast_Score=152, Evalue=4e-38,
Organism=Drosophila melanogaster, GI24646839, Length=293, Percent_Identity=29.3515358361775, Blast_Score=115, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 35299; Mature: 35299

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIESKYTNKGSDFSETELEEQEIMDAYSEAVMGAADRVSPSVVRVTTVARSKNRTVGGGS
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHCCCCCEEEEEEEECCCCCCCCCCC
GLIYTEYGHIITNSHVVHGSERIEVTLNTGEEYRATVVGDDPHTDISVLKIEPQHELRTP
CEEEEECCCEEECCEEEECCCEEEEEEECCCCEEEEEECCCCCCCEEEEEECCHHHCCCC
EFADSSRVRVGQLALAIGNPFGFQFTVTAGVVSATGRSLRTMTGRLVDGVIQTDAALNPG
CCCCCCCEEEEEEEEEECCCCCEEEEEEECEEHHCCCHHHHHHHHHHHHHHHCCCCCCCC
KSGGPLVDFRGRVLGINTALIRPAQGLCFAIPSNTVREVADKLIEDGKIRRAHLGVACQN
CCCCCEEEECCEEEEEEHHEECCCCCEEEECCCHHHHHHHHHHHCCCCEEEEECCHHHHC
MVLKPETVEKLKLNSDRGVMVASLSDGPAGDAGVMRGDIIIALDGEAVETVDDLHRILNE
EEECCCHHHHEEECCCCCEEEEEECCCCCCCCCEEECCEEEEECCCHHHHHHHHHHHHCC
ERIGMECDLDVIRGSEIFKISVKPSELE
CCCCCEECEEEECCCEEEEEEECCCCCC
>Mature Secondary Structure
MIESKYTNKGSDFSETELEEQEIMDAYSEAVMGAADRVSPSVVRVTTVARSKNRTVGGGS
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHCCCCCEEEEEEEECCCCCCCCCCC
GLIYTEYGHIITNSHVVHGSERIEVTLNTGEEYRATVVGDDPHTDISVLKIEPQHELRTP
CEEEEECCCEEECCEEEECCCEEEEEEECCCCEEEEEECCCCCCCEEEEEECCHHHCCCC
EFADSSRVRVGQLALAIGNPFGFQFTVTAGVVSATGRSLRTMTGRLVDGVIQTDAALNPG
CCCCCCCEEEEEEEEEECCCCCEEEEEEECEEHHCCCHHHHHHHHHHHHHHHCCCCCCCC
KSGGPLVDFRGRVLGINTALIRPAQGLCFAIPSNTVREVADKLIEDGKIRRAHLGVACQN
CCCCCEEEECCEEEEEEHHEECCCCCEEEECCCHHHHHHHHHHHCCCCEEEEECCHHHHC
MVLKPETVEKLKLNSDRGVMVASLSDGPAGDAGVMRGDIIIALDGEAVETVDDLHRILNE
EEECCCHHHHEEECCCCCEEEEEECCCCCCCCCEEECCEEEEECCCHHHHHHHHHHHHCC
ERIGMECDLDVIRGSEIFKISVKPSELE
CCCCCEECEEEECCCEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7861951 [H]