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Identifier: 15679702

GI number: 15679702

Start: 1563797

End: 1566139

Strand: Direct

Name: Not Available

Synonym: MTH1708

Alternate gene names: 15679702

Gene position: 1563797-1566139 (Clockwise)

Preceding gene: 15679697

Following gene: 15679703

Centisome position: 89.29

GC content: 52.8

Gene sequence:

>2343_bases
GTGATAGATGTGGCGCCTGAATCAAAAAAAGCCAAAGACCTTAAAGGGGATTTCTGGGATGCCAAGAACATCCAGATATC
CATAGGAGAAATAATAACTGAGGAAAAGCCTCCTGAGGAAGAGGTTAAGGGCCCTAAACCCCGTCCCCACGTGACTGACC
TGAGATCATGGGACATGAAACTGCTTGAAAGGTACGAACCATTCTACGCACCATTCTGTGACATGTGCTGTCTCTGCACC
TACGGTAAATGTGAACTTCTCGGGAAGAAGGGAGCATGTGGTATAGACGCAGCCACACAGCAGGCAAGGACGGTGCTGCT
GGCATGTCTGATAGGGACAGCCGCCCATGCAGGACACGCAAGGCACCTGGTGGACCACCTCATAGAGAGGCTTGGAGAGG
ATTATAAGATAGACCTAGGCAGCAACGTGGATATAGAGGCACCAATAACACGGACGGTGATGGGTAAGAGACCCGCCACA
CTCGGGGACCTGAGGGAGGTGATGGACTACGCTGAGGAACAGATGTCCCACCTCCTTTCAGCCTGTCACACGGGACAGGA
GGGGGACAGCAAGGACTTTGAATCAAAGGCATTCCACGCTGGCCTCATGGATGACCTTACAAGGGAAGTTGCAGACCTGG
CCCAGATAGTGGCCCTGGACCTTCCAAAGGGTGACGAGGACGCACCCCTGGTTGAACTTGGATTCGGGACCATAGATACA
GAGAAACCGGTTGTTCTCTGCATAGGCCACAACGTGCTGCCAGGCGCAGACATAGTTGACTACCTTGATGAGAATGAAAT
GGAGGACCAGGTTGAGGTCTGCGGAATCTGCTGTGCAGCAATAGACGTGACCAGGTACAATGAGGCAGCAAAGGTTGTAG
GTCCACTATCAAAACAGCTCCGCTTCATAAGAAGTGGCGTTGCAGATGTGATAGTGGTTGACGAACAGTGCGTCAGGACA
GATGTACTGGAGGAGGCCCTCAAGAACAGGTCAGCGGTCATCGCCACAACAGATAAGATGTGCCTTGGACTCCCTGACAT
GACCGATGAGGACCCTGATAAAATCGTGAATGACCTGATAAACGGTAACATAGAGGGCGCCCTGATACTGGACCCTGAAA
AGGTGGGTGAGGTGGCTGTTAAGACTGCGATGAAACTTGCACCCATCAGGAAATCCCTCAAAAAGCTGCCAGATATTGAT
GAGATAATCGAGCTGGCATCAGAGTGCACAGACTGTGGCTGGTGCCAGAGGGTCTGCCCCAACAGCCTCCCGGTCATGGA
CGCCGTGAAGAAGGCAGCGGATGGTGACCTCAGCAAACTTGAGGAGATGGCCATTGAGGAGCTCTGCTACACCTGTGGAC
GCTGCGAACAGGAATGTGAAAGGAACATACCCATAGTATCCATGGTTACAAAGGCAGGTGAGAGGCGGGTCAAGGACGAA
AAATACAGGATAAGGGCTGGAAGGGGACCGGCCCAGGACGTTGAGATAAGGAGGGTCGGAGCACCAATCGTCCTGGGGGA
TATACCCGGAGTGGTGGCATTTGTGGGCTGCTCAAACTACCCTGAGGGTGGAAAGGACGTCGCACTGATGGCAAAGGAGT
TCCTTGAGAGGAACTACATCGTGGTAACAACAGGCTGCGGAGCAATGTCCATAGGCGAATACAGGGACGAGGACGGTCAG
ACGCTCTATGAAAAATATGGTGGACAGTTCGATGCAAAGGGACTCGTCAACATGGGGTCATGCGTCTCAAATGCACACGT
ATCAGGAGCAGCCATAAAGATAGCCAACATATTCGCACAGAAACCCCTTGAAGGTAACTTTGAGGAGATAGCAGACTACA
TACTGAACCGTGTGGGTGCCTGTGGGGTTGCCTGGGGTGCCTACTCCCAGAAGGCGGCTGCCATAGCAACCGGTGTGAAC
AGATGGGGAATACCCGTCGTCCTGGGTCCGCACGGATCAAAGTATCGCAGGCTCTTCCTTGGAAGGGCAGATGATGAGGA
GAAGTGGAAGCTGAAGGACCTCAGAACAGGTGAGGTTATCGATGGGGAGCCAGCACCCGAGCACCTCCTCTACGCAGCAG
AGAACCGGGAGGAGGCAACGGTCATGATAGCCAAGCTATGCATAAGGCCAACAGACACACCCAAGGGCCGTCAGATGAAA
CTCAGCAACTACATAGACCTTCACAGGAAATATCTTGGCACCATCCCGGACGATATAGACAGGTTCATAAGGACCGAGAA
GGACATCCCGATAGTCTACAAGAGGGATGTCATGAAGATCCTTGAGGAGAAAAACTGGAAACCCAGGGAGCTTCCAAAGG
AACCCTCACTCCTGGAGAGGTGA

Upstream 100 bases:

>100_bases
GTGTTCAGCGACAATGCACAAAGTTTATATATAGATTCCATAAAATTAAAAACATCATTATAAATCATTAATAATTGTCA
ATCGGGATTTAGTAATACTG

Downstream 100 bases:

>100_bases
TAGTCTTGAATGACAGAATAATACCATGGCAGCCCACTGTTATAGCCGGGCCAAAACAGGCAATGCTCGTAACACCCGAA
ACTGCGACCATGATGATAAA

Product: acetyl-CoA decarbonylase/synthase complex subunit alpha

Products: NA

Alternate protein names: ACDS complex subunit alpha; ACDS complex carbon monoxide dehydrogenase; ACDS CODH

Number of amino acids: Translated: 780; Mature: 780

Protein sequence:

>780_residues
MIDVAPESKKAKDLKGDFWDAKNIQISIGEIITEEKPPEEEVKGPKPRPHVTDLRSWDMKLLERYEPFYAPFCDMCCLCT
YGKCELLGKKGACGIDAATQQARTVLLACLIGTAAHAGHARHLVDHLIERLGEDYKIDLGSNVDIEAPITRTVMGKRPAT
LGDLREVMDYAEEQMSHLLSACHTGQEGDSKDFESKAFHAGLMDDLTREVADLAQIVALDLPKGDEDAPLVELGFGTIDT
EKPVVLCIGHNVLPGADIVDYLDENEMEDQVEVCGICCAAIDVTRYNEAAKVVGPLSKQLRFIRSGVADVIVVDEQCVRT
DVLEEALKNRSAVIATTDKMCLGLPDMTDEDPDKIVNDLINGNIEGALILDPEKVGEVAVKTAMKLAPIRKSLKKLPDID
EIIELASECTDCGWCQRVCPNSLPVMDAVKKAADGDLSKLEEMAIEELCYTCGRCEQECERNIPIVSMVTKAGERRVKDE
KYRIRAGRGPAQDVEIRRVGAPIVLGDIPGVVAFVGCSNYPEGGKDVALMAKEFLERNYIVVTTGCGAMSIGEYRDEDGQ
TLYEKYGGQFDAKGLVNMGSCVSNAHVSGAAIKIANIFAQKPLEGNFEEIADYILNRVGACGVAWGAYSQKAAAIATGVN
RWGIPVVLGPHGSKYRRLFLGRADDEEKWKLKDLRTGEVIDGEPAPEHLLYAAENREEATVMIAKLCIRPTDTPKGRQMK
LSNYIDLHRKYLGTIPDDIDRFIRTEKDIPIVYKRDVMKILEEKNWKPRELPKEPSLLER

Sequences:

>Translated_780_residues
MIDVAPESKKAKDLKGDFWDAKNIQISIGEIITEEKPPEEEVKGPKPRPHVTDLRSWDMKLLERYEPFYAPFCDMCCLCT
YGKCELLGKKGACGIDAATQQARTVLLACLIGTAAHAGHARHLVDHLIERLGEDYKIDLGSNVDIEAPITRTVMGKRPAT
LGDLREVMDYAEEQMSHLLSACHTGQEGDSKDFESKAFHAGLMDDLTREVADLAQIVALDLPKGDEDAPLVELGFGTIDT
EKPVVLCIGHNVLPGADIVDYLDENEMEDQVEVCGICCAAIDVTRYNEAAKVVGPLSKQLRFIRSGVADVIVVDEQCVRT
DVLEEALKNRSAVIATTDKMCLGLPDMTDEDPDKIVNDLINGNIEGALILDPEKVGEVAVKTAMKLAPIRKSLKKLPDID
EIIELASECTDCGWCQRVCPNSLPVMDAVKKAADGDLSKLEEMAIEELCYTCGRCEQECERNIPIVSMVTKAGERRVKDE
KYRIRAGRGPAQDVEIRRVGAPIVLGDIPGVVAFVGCSNYPEGGKDVALMAKEFLERNYIVVTTGCGAMSIGEYRDEDGQ
TLYEKYGGQFDAKGLVNMGSCVSNAHVSGAAIKIANIFAQKPLEGNFEEIADYILNRVGACGVAWGAYSQKAAAIATGVN
RWGIPVVLGPHGSKYRRLFLGRADDEEKWKLKDLRTGEVIDGEPAPEHLLYAAENREEATVMIAKLCIRPTDTPKGRQMK
LSNYIDLHRKYLGTIPDDIDRFIRTEKDIPIVYKRDVMKILEEKNWKPRELPKEPSLLER
>Mature_780_residues
MIDVAPESKKAKDLKGDFWDAKNIQISIGEIITEEKPPEEEVKGPKPRPHVTDLRSWDMKLLERYEPFYAPFCDMCCLCT
YGKCELLGKKGACGIDAATQQARTVLLACLIGTAAHAGHARHLVDHLIERLGEDYKIDLGSNVDIEAPITRTVMGKRPAT
LGDLREVMDYAEEQMSHLLSACHTGQEGDSKDFESKAFHAGLMDDLTREVADLAQIVALDLPKGDEDAPLVELGFGTIDT
EKPVVLCIGHNVLPGADIVDYLDENEMEDQVEVCGICCAAIDVTRYNEAAKVVGPLSKQLRFIRSGVADVIVVDEQCVRT
DVLEEALKNRSAVIATTDKMCLGLPDMTDEDPDKIVNDLINGNIEGALILDPEKVGEVAVKTAMKLAPIRKSLKKLPDID
EIIELASECTDCGWCQRVCPNSLPVMDAVKKAADGDLSKLEEMAIEELCYTCGRCEQECERNIPIVSMVTKAGERRVKDE
KYRIRAGRGPAQDVEIRRVGAPIVLGDIPGVVAFVGCSNYPEGGKDVALMAKEFLERNYIVVTTGCGAMSIGEYRDEDGQ
TLYEKYGGQFDAKGLVNMGSCVSNAHVSGAAIKIANIFAQKPLEGNFEEIADYILNRVGACGVAWGAYSQKAAAIATGVN
RWGIPVVLGPHGSKYRRLFLGRADDEEKWKLKDLRTGEVIDGEPAPEHLLYAAENREEATVMIAKLCIRPTDTPKGRQMK
LSNYIDLHRKYLGTIPDDIDRFIRTEKDIPIVYKRDVMKILEEKNWKPRELPKEPSLLER

Specific function: Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2)

COG id: COG1152

COG function: function code C; CO dehydrogenase/acetyl-CoA synthase alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ACDA_METTH (O27743)

Other databases:

- EMBL:   AE000666
- PIR:   E69095
- RefSeq:   NP_276820.1
- ProteinModelPortal:   O27743
- SMR:   O27743
- STRING:   O27743
- GeneID:   1470793
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH1708
- NMPDR:   fig|187420.1.peg.1675
- eggNOG:   arNOG04918
- HOGENOM:   HBG539676
- OMA:   ICCTAID
- ProtClustDB:   PRK00941
- BioCyc:   MTHE187420:MTH1708-MONOMER
- BRENDA:   1.2.99.2
- GO:   GO:0005737
- HAMAP:   MF_01137
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR004460
- InterPro:   IPR016101
- InterPro:   IPR012285
- InterPro:   IPR004137
- InterPro:   IPR011254
- InterPro:   IPR016099
- Gene3D:   G3DSA:1.20.1270.30
- Gene3D:   G3DSA:1.10.1060.10
- Gene3D:   G3DSA:3.40.50.2030
- TIGRFAMs:   TIGR00314

Pfam domain/function: PF03063 Prismane; SSF56821 Prismane_like

EC number: =1.2.99.2

Molecular weight: Translated: 86069; Mature: 86069

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS00198 4FE4S_FER_1; PS51379 4FE4S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
3.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDVAPESKKAKDLKGDFWDAKNIQISIGEIITEEKPPEEEVKGPKPRPHVTDLRSWDMK
CCCCCCCCCHHHHCCCCCCCCCCCEEEHHHHHCCCCCCHHHCCCCCCCCCCCHHHHHHHH
LLERYEPFYAPFCDMCCLCTYGKCELLGKKGACGIDAATQQARTVLLACLIGTAAHAGHA
HHHHCCCHHCCHHHHHHHCCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHH
RHLVDHLIERLGEDYKIDLGSNVDIEAPITRTVMGKRPATLGDLREVMDYAEEQMSHLLS
HHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
ACHTGQEGDSKDFESKAFHAGLMDDLTREVADLAQIVALDLPKGDEDAPLVELGFGTIDT
HHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCC
EKPVVLCIGHNVLPGADIVDYLDENEMEDQVEVCGICCAAIDVTRYNEAAKVVGPLSKQL
CCCEEEEECCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RFIRSGVADVIVVDEQCVRTDVLEEALKNRSAVIATTDKMCLGLPDMTDEDPDKIVNDLI
HHHHCCCCEEEEECHHHHHHHHHHHHHHCCCEEEEECCHHHCCCCCCCCCCHHHHHHHHH
NGNIEGALILDPEKVGEVAVKTAMKLAPIRKSLKKLPDIDEIIELASECTDCGWCQRVCP
CCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHCC
NSLPVMDAVKKAADGDLSKLEEMAIEELCYTCGRCEQECERNIPIVSMVTKAGERRVKDE
CCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHCCCC
KYRIRAGRGPAQDVEIRRVGAPIVLGDIPGVVAFVGCSNYPEGGKDVALMAKEFLERNYI
CEEEECCCCCCCCCEEEECCCCEEEECCCCHHEEECCCCCCCCCCHHHHHHHHHHHCCCE
VVTTGCGAMSIGEYRDEDGQTLYEKYGGQFDAKGLVNMGSCVSNAHVSGAAIKIANIFAQ
EEEECCCCCCCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHC
KPLEGNFEEIADYILNRVGACGVAWGAYSQKAAAIATGVNRWGIPVVLGPHGSKYRRLFL
CCCCCCHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHCCCCCCCEEEECCCCCCCHHEEE
GRADDEEKWKLKDLRTGEVIDGEPAPEHLLYAAENREEATVMIAKLCIRPTDTPKGRQMK
CCCCCCCHHHHHCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCCCCCCCCEE
LSNYIDLHRKYLGTIPDDIDRFIRTEKDIPIVYKRDVMKILEEKNWKPRELPKEPSLLER
HHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEEEHHHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MIDVAPESKKAKDLKGDFWDAKNIQISIGEIITEEKPPEEEVKGPKPRPHVTDLRSWDMK
CCCCCCCCCHHHHCCCCCCCCCCCEEEHHHHHCCCCCCHHHCCCCCCCCCCCHHHHHHHH
LLERYEPFYAPFCDMCCLCTYGKCELLGKKGACGIDAATQQARTVLLACLIGTAAHAGHA
HHHHCCCHHCCHHHHHHHCCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHH
RHLVDHLIERLGEDYKIDLGSNVDIEAPITRTVMGKRPATLGDLREVMDYAEEQMSHLLS
HHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
ACHTGQEGDSKDFESKAFHAGLMDDLTREVADLAQIVALDLPKGDEDAPLVELGFGTIDT
HHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCC
EKPVVLCIGHNVLPGADIVDYLDENEMEDQVEVCGICCAAIDVTRYNEAAKVVGPLSKQL
CCCEEEEECCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RFIRSGVADVIVVDEQCVRTDVLEEALKNRSAVIATTDKMCLGLPDMTDEDPDKIVNDLI
HHHHCCCCEEEEECHHHHHHHHHHHHHHCCCEEEEECCHHHCCCCCCCCCCHHHHHHHHH
NGNIEGALILDPEKVGEVAVKTAMKLAPIRKSLKKLPDIDEIIELASECTDCGWCQRVCP
CCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHCC
NSLPVMDAVKKAADGDLSKLEEMAIEELCYTCGRCEQECERNIPIVSMVTKAGERRVKDE
CCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHCCCC
KYRIRAGRGPAQDVEIRRVGAPIVLGDIPGVVAFVGCSNYPEGGKDVALMAKEFLERNYI
CEEEECCCCCCCCCEEEECCCCEEEECCCCHHEEECCCCCCCCCCHHHHHHHHHHHCCCE
VVTTGCGAMSIGEYRDEDGQTLYEKYGGQFDAKGLVNMGSCVSNAHVSGAAIKIANIFAQ
EEEECCCCCCCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHC
KPLEGNFEEIADYILNRVGACGVAWGAYSQKAAAIATGVNRWGIPVVLGPHGSKYRRLFL
CCCCCCHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHCCCCCCCEEEECCCCCCCHHEEE
GRADDEEKWKLKDLRTGEVIDGEPAPEHLLYAAENREEATVMIAKLCIRPTDTPKGRQMK
CCCCCCCHHHHHCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCCCCCCCCEE
LSNYIDLHRKYLGTIPDDIDRFIRTEKDIPIVYKRDVMKILEEKNWKPRELPKEPSLLER
HHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEEEHHHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463