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Identifier: 15679637

GI number: 15679637

Start: 1507705

End: 1508787

Strand: Direct

Name: Not Available

Synonym: MTH1642

Alternate gene names: 15679637

Gene position: 1507705-1508787 (Clockwise)

Preceding gene: 15679633

Following gene: 15679638

Centisome position: 86.09

GC content: 51.25

Gene sequence:

>1083_bases
ATGATTTTTCAGGGTGAATCCATGAGGATAGTTGAAGAGGATGAGAAGAACGGTGTCATTGAACTCGTACCCGAAACCCT
TGATGATCTCTGGCACCTCTCACACATAATAGAGGAGGGAGACCTCCTATCAGCCAGGACCACGAGGAGGATACAGGATA
CCAGTGGAGAGAAGATAAGAAGTGACAGGGGAGTTAAAAAGACATTTTACCTCGGGATAAGGGTGGAAACTGTCAGCTTC
CACATCTACACCGGTAGACTGAGGGCCACCGGCGTTATAGAGAGAGGTCCTGAGGACCTTGTACCCATGGGCTCCCACCA
CACCCTTGAGGTAAAACTCAACACACCCCTGAGGATCCAGAAGGAGCACTGGAGCAGATGGACACTTAAGAGGCTCAGGA
TGGCTGTAAGGGCATCAAAGAATCTGAAGGCAATCATACTTGTAATGGAGGATGATGTCGCTGAACTGGGCCTCATAAGA
CAGTACGGGGTGGAGTACAGGGGCCCCATAACAGGCCACATTCCTGGTAAGAGAATACAGCAGAGGGACCGGGGTAAACT
GAGGCGGGAATTCTATGAGAGCATCGTGGAGTCACTCCAGAAGTATGGAGACCTTGAGACAATCATAATAGCGGGACCAG
GCTTTTACAAGTCAGATTTCTATGACTACCTCATGGAGAGGTATCCTGAAATCGCAAAGAAGGCGGTACTTGAGAACACC
GGGACCGGGGGGCGCGCCGGCATATCCGAGGTCCTTAGGAAGGGGACGGTTGAAAGGGTATCATCAGAGAAGAGGATAGC
CTCTGAGATAAGGAACGTTAACGAGTTCCTTGAGAAGCTGGCCAGGGACCCTGACTCCGTTGTCTATGGTAAGGTTGAGG
TTATGGATGCCATTAACATGGGGGCCGTTGAGAAGCTCCTGGTACTGGACAGGGTTGTTAGCAGGGAGGACATTGAGGGC
TACCTCGACATGGTTGAGAGCATGGGCGGTTCCGTGGTACTCATAAGCAGTGAACACGAGGGTGGAAAGCAGCTGGAATC
ACTGGGAGGCCTGGCAGGGATTCTAAGATTCAAGATCCAGTGA

Upstream 100 bases:

>100_bases
CCAGATCCATAGTCACCCATCACATTACACTCCGAAGCCTTCCATGAGAATACTCCTAGTTTTATAATAGCATTCTTATA
TATTATCATTAACTCCGCCA

Downstream 100 bases:

>100_bases
CTTCAGGGGGATTCAGAATGTTCAGGAGACTTGAGGATCGATGCAGGGGATGTGGAAACTGCCGCGAACTGAAATGCAGT
GAAAACTGCACTGGCTGCAG

Product: cell division protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 360; Mature: 360

Protein sequence:

>360_residues
MIFQGESMRIVEEDEKNGVIELVPETLDDLWHLSHIIEEGDLLSARTTRRIQDTSGEKIRSDRGVKKTFYLGIRVETVSF
HIYTGRLRATGVIERGPEDLVPMGSHHTLEVKLNTPLRIQKEHWSRWTLKRLRMAVRASKNLKAIILVMEDDVAELGLIR
QYGVEYRGPITGHIPGKRIQQRDRGKLRREFYESIVESLQKYGDLETIIIAGPGFYKSDFYDYLMERYPEIAKKAVLENT
GTGGRAGISEVLRKGTVERVSSEKRIASEIRNVNEFLEKLARDPDSVVYGKVEVMDAINMGAVEKLLVLDRVVSREDIEG
YLDMVESMGGSVVLISSEHEGGKQLESLGGLAGILRFKIQ

Sequences:

>Translated_360_residues
MIFQGESMRIVEEDEKNGVIELVPETLDDLWHLSHIIEEGDLLSARTTRRIQDTSGEKIRSDRGVKKTFYLGIRVETVSF
HIYTGRLRATGVIERGPEDLVPMGSHHTLEVKLNTPLRIQKEHWSRWTLKRLRMAVRASKNLKAIILVMEDDVAELGLIR
QYGVEYRGPITGHIPGKRIQQRDRGKLRREFYESIVESLQKYGDLETIIIAGPGFYKSDFYDYLMERYPEIAKKAVLENT
GTGGRAGISEVLRKGTVERVSSEKRIASEIRNVNEFLEKLARDPDSVVYGKVEVMDAINMGAVEKLLVLDRVVSREDIEG
YLDMVESMGGSVVLISSEHEGGKQLESLGGLAGILRFKIQ
>Mature_360_residues
MIFQGESMRIVEEDEKNGVIELVPETLDDLWHLSHIIEEGDLLSARTTRRIQDTSGEKIRSDRGVKKTFYLGIRVETVSF
HIYTGRLRATGVIERGPEDLVPMGSHHTLEVKLNTPLRIQKEHWSRWTLKRLRMAVRASKNLKAIILVMEDDVAELGLIR
QYGVEYRGPITGHIPGKRIQQRDRGKLRREFYESIVESLQKYGDLETIIIAGPGFYKSDFYDYLMERYPEIAKKAVLENT
GTGGRAGISEVLRKGTVERVSSEKRIASEIRNVNEFLEKLARDPDSVVYGKVEVMDAINMGAVEKLLVLDRVVSREDIEG
YLDMVESMGGSVVLISSEHEGGKQLESLGGLAGILRFKIQ

Specific function: May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has end

COG id: COG1537

COG function: function code R; Predicted RNA-binding proteins

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eukaryotic release factor 1 family. Pelota subfamily [H]

Homologues:

Organism=Homo sapiens, GI31880783, Length=368, Percent_Identity=30.1630434782609, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17554648, Length=368, Percent_Identity=28.804347826087, Blast_Score=137, Evalue=9e-33,
Organism=Saccharomyces cerevisiae, GI6324327, Length=368, Percent_Identity=28.2608695652174, Blast_Score=130, Evalue=3e-31,
Organism=Drosophila melanogaster, GI17136914, Length=365, Percent_Identity=30.1369863013699, Blast_Score=175, Evalue=4e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005140
- InterPro:   IPR005141
- InterPro:   IPR005142
- InterPro:   IPR004405 [H]

Pfam domain/function: PF03463 eRF1_1; PF03464 eRF1_2; PF03465 eRF1_3 [H]

EC number: NA

Molecular weight: Translated: 40815; Mature: 40815

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFQGESMRIVEEDEKNGVIELVPETLDDLWHLSHIIEEGDLLSARTTRRIQDTSGEKIR
CCCCCCCCEEEECCCCCCEEEECHHHHHHHHHHHHHHHCCCEEHHHHHHHHHCCCCCHHH
SDRGVKKTFYLGIRVETVSFHIYTGRLRATGVIERGPEDLVPMGSHHTLEVKLNTPLRIQ
HCCCCCEEEEEEEEEEEEEEEEEECCEEECCCHHCCCCCCCCCCCCEEEEEEECCCEEEE
KEHWSRWTLKRLRMAVRASKNLKAIILVMEDDVAELGLIRQYGVEYRGPITGHIPGKRIQ
HHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCHHHHHHHHHHCCCCCCCCCCCCCCHHHH
QRDRGKLRREFYESIVESLQKYGDLETIIIAGPGFYKSDFYDYLMERYPEIAKKAVLENT
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCC
GTGGRAGISEVLRKGTVERVSSEKRIASEIRNVNEFLEKLARDPDSVVYGKVEVMDAINM
CCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHCH
GAVEKLLVLDRVVSREDIEGYLDMVESMGGSVVLISSEHEGGKQLESLGGLAGILRFKIQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHCCCEEHHEEECC
>Mature Secondary Structure
MIFQGESMRIVEEDEKNGVIELVPETLDDLWHLSHIIEEGDLLSARTTRRIQDTSGEKIR
CCCCCCCCEEEECCCCCCEEEECHHHHHHHHHHHHHHHCCCEEHHHHHHHHHCCCCCHHH
SDRGVKKTFYLGIRVETVSFHIYTGRLRATGVIERGPEDLVPMGSHHTLEVKLNTPLRIQ
HCCCCCEEEEEEEEEEEEEEEEEECCEEECCCHHCCCCCCCCCCCCEEEEEEECCCEEEE
KEHWSRWTLKRLRMAVRASKNLKAIILVMEDDVAELGLIRQYGVEYRGPITGHIPGKRIQ
HHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCHHHHHHHHHHCCCCCCCCCCCCCCHHHH
QRDRGKLRREFYESIVESLQKYGDLETIIIAGPGFYKSDFYDYLMERYPEIAKKAVLENT
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCC
GTGGRAGISEVLRKGTVERVSSEKRIASEIRNVNEFLEKLARDPDSVVYGKVEVMDAINM
CCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHCH
GAVEKLLVLDRVVSREDIEGYLDMVESMGGSVVLISSEHEGGKQLESLGGLAGILRFKIQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHCCCEEHHEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]