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Identifier: 15679535

GI number: 15679535

Start: 1402497

End: 1404827

Strand: Direct

Name: Not Available

Synonym: MTH1539

Alternate gene names: 15679535

Gene position: 1402497-1404827 (Clockwise)

Preceding gene: 15679534

Following gene: 15679542

Centisome position: 80.08

GC content: 54.27

Gene sequence:

>2331_bases
TTGTATGGTGATCCTGTGATTGATGATTCACGTCTTCTGGCTGCAATGCCAACAAAGGCAGAAACATGTGTACTGAAAAA
TAATGGTGTACGGGAAAAATTCAGCCATGAAAAGCTCGTAAAATCCCTCCTGAACCTGGGGGCCAGTTTATGGACCTCCG
AGAATGTGGCCTCAGAGGTTGCAAGGTCTGTCTACAATGGAATAACCACCAAGGAGATAAAGATCCTGGTCTACGACTCC
CTCAGAAAGGTGGATGAGGAACTGGCAGATCGTTACCTTGCAGCCAACAGACTCAGGGTGAGGACATCAAGGGATAAGAT
AGAGACCTTTGACCAGAAGAAGATAGAGGACAACCTCATAAGGGAGACTGGCGCCTCAGAGGATGTTGCAAGGGAAATCG
CCACCGAGGTCTGGAGGGAGCTCAAGAAACTGAACGTGGAATACCTCACAGCCCCCATGATAAGGGAGGTTGTTAACACA
AAGCTCATAGAGCACGGCCTTGAGACCCTCAGGAAGAGGTACACACGTCTCGGGATCCCGGTCTACAACATCACAAACCT
CATAGAGAACGGCTCCAGGGACAACGCCAACATGATCCACAACCCTGAAACCGTCCACAAGTACGTGGCTGATGAGGCCC
TCAAACAGTACACACTCCTCCACATACTCCCCTCCAGGCTCGCAGACGCCCACATGTCAGGTGACATACACATCCATGAC
CTCGAATTCTTCGCTGCACGGCCACTTAACTGCCTGCAGCACGATCTCCGGCTATTCATAAGGCACGGGCTCCGGGTTGA
CGGTACAGGGGACCACACATCAGTTGCAGGACCACCAAAGCACCTGGAGACCCTCATGAACCATGCAGGGGAGATAATGC
TGGCATCCCAGCAGAACATGTCCGGCGGCCAGGCCATGAGCCTCTGGAACGTCTTCGTGGCACCCTTCGCCTCAGGGCTG
TCCTATGAGAAGATCAAACAGGCGGTCCAGATGTTCATATTCAACCTCAACATGGCCTACGCTGCAAGGGGAAGTCAGGT
ACCATTCACAAGCATAAACCTGGAGTTCGGGGTCCCGGAGTTCCTTGAGGACGAACCAGCCTATGGGCCCCGCGGGGAGT
ATGCTGGTGTATACGGTGACTTCGCTGAGGAGGCAAGGCTCCTCACAAGGGCCTTCACCGAGGTCCTCCTCGAGGGTGAT
GCCGATGGGAAGCCCCACCTCTTCCCCAACACCATATACTCCCTCCGGAGGGAGACCTTCAGGGGGGAATTCGATGAGGA
ACTGAGCCTGGTCCATGAACTGGCATCCAAGTACGGGACAGCCTACTTCATAAACATGCTGGCGGATTACAGGGGCAAGA
TGGCAAACTACATGGGCTGCCGTACGAGCCTTGCAGATAACTGGACAGGTGACTGGGAGAAGGACTGCCTCAGGACAGGA
AACCTTGCCTACATAACCCTCAACCTCCCCAGGATAGCCTACCAGTCACGGGATGATGATGAACTATTCGAGTACCTTGA
TGAGTACATTGACATGGCGGTTGAGGTGCTCAGGATAAGGAGGAGCCAGGCTCAGAGATGCCTGGACGACTACCACCTGC
TCCCATTCCTCTCCCAGGAGATAGACGGTGAGAGGTACTACCGTATAGAGAATGCGACAATGAGCTTCGGATTCACGGGA
CTCAATGAGATGCTCGAGTACCACCTTGGGGCAGGTATACAGAGCCCTGAAGCCAACAGGTTCGGCCTGAGGGTCATAGA
GCACATAAATGAACGTGCAGCTGAACTCAAAAAGGAGACAGGATGGCGGTGGAGTGTCCTCCAGACACCTGCAGAGTCCA
CAGCCCACAGATTCGCAATGCTGGACCATGAGCATTACCCTGAGGAGGCTGTGCTCCAGGGCACCGAGGGGGCATACTAC
TACACCAACTCCAGCCACACACCCGTGAATGCAGAGGTGGACCTTGTTGAGAAGATAAGGATCGAGGAGAAGTACCACCC
GCTGACACCCGGCGGGCACATATTCAATGCATGGCTGGGTGAGGCGAAACCTGACCCAGCAGCCCTTGAGGGTCTCACCA
GGAGGATCTGCAGGAGGAGTGACATAGGATTCTGGGCGTACAGCAATGCCCTGAGCTTCTGCCTGAGGTGCAAGACCCTC
ATGAGGGGTCTGCAGGATTCCTGTGCACGCTGCGGCGAGAGGGATGAGGTTGAGTGGTATGACAGGATCACAGGTTACGT
ACAGCAGGTGGGCCGTGCCAAGTCCTCAAGCGGTGGCTGGAACAGGGGTAAACAGCAGGAACTTCTTGATAGACGAAGAA
TAGACCTCTGA

Upstream 100 bases:

>100_bases
AAAGGTGTTATTAATCAGCCGATGATTTTTAAGGGGGGCGCGGCACCTTTAATATGGGTGGTGAACATAAAATTACTCAG
ACATTAGATTCTATAAGGAG

Downstream 100 bases:

>100_bases
GTTTAATATGGTCAGCCACTAACTGAATCTCTCTTATTTTTGCCGGTATGCCGATAGCTAATTTCTCAGTTGAATGACAG
AGAACAAACCAGTGCCTCAA

Product: anaerobic ribonucleoside-triphosphate reductase

Products: ribonucleoside triphosphate; thioredoxin

Alternate protein names: NA

Number of amino acids: Translated: 776; Mature: 776

Protein sequence:

>776_residues
MYGDPVIDDSRLLAAMPTKAETCVLKNNGVREKFSHEKLVKSLLNLGASLWTSENVASEVARSVYNGITTKEIKILVYDS
LRKVDEELADRYLAANRLRVRTSRDKIETFDQKKIEDNLIRETGASEDVAREIATEVWRELKKLNVEYLTAPMIREVVNT
KLIEHGLETLRKRYTRLGIPVYNITNLIENGSRDNANMIHNPETVHKYVADEALKQYTLLHILPSRLADAHMSGDIHIHD
LEFFAARPLNCLQHDLRLFIRHGLRVDGTGDHTSVAGPPKHLETLMNHAGEIMLASQQNMSGGQAMSLWNVFVAPFASGL
SYEKIKQAVQMFIFNLNMAYAARGSQVPFTSINLEFGVPEFLEDEPAYGPRGEYAGVYGDFAEEARLLTRAFTEVLLEGD
ADGKPHLFPNTIYSLRRETFRGEFDEELSLVHELASKYGTAYFINMLADYRGKMANYMGCRTSLADNWTGDWEKDCLRTG
NLAYITLNLPRIAYQSRDDDELFEYLDEYIDMAVEVLRIRRSQAQRCLDDYHLLPFLSQEIDGERYYRIENATMSFGFTG
LNEMLEYHLGAGIQSPEANRFGLRVIEHINERAAELKKETGWRWSVLQTPAESTAHRFAMLDHEHYPEEAVLQGTEGAYY
YTNSSHTPVNAEVDLVEKIRIEEKYHPLTPGGHIFNAWLGEAKPDPAALEGLTRRICRRSDIGFWAYSNALSFCLRCKTL
MRGLQDSCARCGERDEVEWYDRITGYVQQVGRAKSSSGGWNRGKQQELLDRRRIDL

Sequences:

>Translated_776_residues
MYGDPVIDDSRLLAAMPTKAETCVLKNNGVREKFSHEKLVKSLLNLGASLWTSENVASEVARSVYNGITTKEIKILVYDS
LRKVDEELADRYLAANRLRVRTSRDKIETFDQKKIEDNLIRETGASEDVAREIATEVWRELKKLNVEYLTAPMIREVVNT
KLIEHGLETLRKRYTRLGIPVYNITNLIENGSRDNANMIHNPETVHKYVADEALKQYTLLHILPSRLADAHMSGDIHIHD
LEFFAARPLNCLQHDLRLFIRHGLRVDGTGDHTSVAGPPKHLETLMNHAGEIMLASQQNMSGGQAMSLWNVFVAPFASGL
SYEKIKQAVQMFIFNLNMAYAARGSQVPFTSINLEFGVPEFLEDEPAYGPRGEYAGVYGDFAEEARLLTRAFTEVLLEGD
ADGKPHLFPNTIYSLRRETFRGEFDEELSLVHELASKYGTAYFINMLADYRGKMANYMGCRTSLADNWTGDWEKDCLRTG
NLAYITLNLPRIAYQSRDDDELFEYLDEYIDMAVEVLRIRRSQAQRCLDDYHLLPFLSQEIDGERYYRIENATMSFGFTG
LNEMLEYHLGAGIQSPEANRFGLRVIEHINERAAELKKETGWRWSVLQTPAESTAHRFAMLDHEHYPEEAVLQGTEGAYY
YTNSSHTPVNAEVDLVEKIRIEEKYHPLTPGGHIFNAWLGEAKPDPAALEGLTRRICRRSDIGFWAYSNALSFCLRCKTL
MRGLQDSCARCGERDEVEWYDRITGYVQQVGRAKSSSGGWNRGKQQELLDRRRIDL
>Mature_776_residues
MYGDPVIDDSRLLAAMPTKAETCVLKNNGVREKFSHEKLVKSLLNLGASLWTSENVASEVARSVYNGITTKEIKILVYDS
LRKVDEELADRYLAANRLRVRTSRDKIETFDQKKIEDNLIRETGASEDVAREIATEVWRELKKLNVEYLTAPMIREVVNT
KLIEHGLETLRKRYTRLGIPVYNITNLIENGSRDNANMIHNPETVHKYVADEALKQYTLLHILPSRLADAHMSGDIHIHD
LEFFAARPLNCLQHDLRLFIRHGLRVDGTGDHTSVAGPPKHLETLMNHAGEIMLASQQNMSGGQAMSLWNVFVAPFASGL
SYEKIKQAVQMFIFNLNMAYAARGSQVPFTSINLEFGVPEFLEDEPAYGPRGEYAGVYGDFAEEARLLTRAFTEVLLEGD
ADGKPHLFPNTIYSLRRETFRGEFDEELSLVHELASKYGTAYFINMLADYRGKMANYMGCRTSLADNWTGDWEKDCLRTG
NLAYITLNLPRIAYQSRDDDELFEYLDEYIDMAVEVLRIRRSQAQRCLDDYHLLPFLSQEIDGERYYRIENATMSFGFTG
LNEMLEYHLGAGIQSPEANRFGLRVIEHINERAAELKKETGWRWSVLQTPAESTAHRFAMLDHEHYPEEAVLQGTEGAYY
YTNSSHTPVNAEVDLVEKIRIEEKYHPLTPGGHIFNAWLGEAKPDPAALEGLTRRICRRSDIGFWAYSNALSFCLRCKTL
MRGLQDSCARCGERDEVEWYDRITGYVQQVGRAKSSSGGWNRGKQQELLDRRRIDL

Specific function: Unknown

COG id: COG1328

COG function: function code F; Oxygen-sensitive ribonucleoside-triphosphate reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 DOD-type homing endonuclease domains [H]

Homologues:

Organism=Escherichia coli, GI1790686, Length=648, Percent_Identity=24.537037037037, Blast_Score=147, Evalue=3e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR003586
- InterPro:   IPR003587
- InterPro:   IPR007869
- InterPro:   IPR006142
- InterPro:   IPR004042
- InterPro:   IPR006141
- InterPro:   IPR012833 [H]

Pfam domain/function: PF03477 ATP-cone; PF05204 Hom_end [H]

EC number: 1.17.4.2

Molecular weight: Translated: 88596; Mature: 88596

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS51161 ATP_CONE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYGDPVIDDSRLLAAMPTKAETCVLKNNGVREKFSHEKLVKSLLNLGASLWTSENVASEV
CCCCCCCCCCCHHEECCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCHHHHCCHHHHHHH
ARSVYNGITTKEIKILVYDSLRKVDEELADRYLAANRLRVRTSRDKIETFDQKKIEDNLI
HHHHHCCCCHHHEEEEEHHHHHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHHH
RETGASEDVAREIATEVWRELKKLNVEYLTAPMIREVVNTKLIEHGLETLRKRYTRLGIP
HHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
VYNITNLIENGSRDNANMIHNPETVHKYVADEALKQYTLLHILPSRLADAHMSGDIHIHD
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
LEFFAARPLNCLQHDLRLFIRHGLRVDGTGDHTSVAGPPKHLETLMNHAGEIMLASQQNM
HHHHHHCCHHHHHHHHHHHHHCCCEECCCCCCCCCCCCHHHHHHHHHCCCCEEEECCCCC
SGGQAMSLWNVFVAPFASGLSYEKIKQAVQMFIFNLNMAYAARGSQVPFTSINLEFGVPE
CCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHCCCCCCCEEEEEEECCCHH
FLEDEPAYGPRGEYAGVYGDFAEEARLLTRAFTEVLLEGDADGKPHLFPNTIYSLRRETF
HHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
RGEFDEELSLVHELASKYGTAYFINMLADYRGKMANYMGCRTSLADNWTGDWEKDCLRTG
CCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCC
NLAYITLNLPRIAYQSRDDDELFEYLDEYIDMAVEVLRIRRSQAQRCLDDYHLLPFLSQE
CEEEEEEECCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IDGERYYRIENATMSFGFTGLNEMLEYHLGAGIQSPEANRFGLRVIEHINERAAELKKET
CCCCEEEEEECCEEECCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
GWRWSVLQTPAESTAHRFAMLDHEHYPEEAVLQGTEGAYYYTNSSHTPVNAEVDLVEKIR
CCEEEEECCCHHHHHHHHHHHCCCCCCCHHHHCCCCCCEEEECCCCCCCCCHHHHHHHHH
IEEKYHPLTPGGHIFNAWLGEAKPDPAALEGLTRRICRRSDIGFWAYSNALSFCLRCKTL
HHHHCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
MRGLQDSCARCGERDEVEWYDRITGYVQQVGRAKSSSGGWNRGKQQELLDRRRIDL
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCC
>Mature Secondary Structure
MYGDPVIDDSRLLAAMPTKAETCVLKNNGVREKFSHEKLVKSLLNLGASLWTSENVASEV
CCCCCCCCCCCHHEECCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCHHHHCCHHHHHHH
ARSVYNGITTKEIKILVYDSLRKVDEELADRYLAANRLRVRTSRDKIETFDQKKIEDNLI
HHHHHCCCCHHHEEEEEHHHHHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHHH
RETGASEDVAREIATEVWRELKKLNVEYLTAPMIREVVNTKLIEHGLETLRKRYTRLGIP
HHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
VYNITNLIENGSRDNANMIHNPETVHKYVADEALKQYTLLHILPSRLADAHMSGDIHIHD
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
LEFFAARPLNCLQHDLRLFIRHGLRVDGTGDHTSVAGPPKHLETLMNHAGEIMLASQQNM
HHHHHHCCHHHHHHHHHHHHHCCCEECCCCCCCCCCCCHHHHHHHHHCCCCEEEECCCCC
SGGQAMSLWNVFVAPFASGLSYEKIKQAVQMFIFNLNMAYAARGSQVPFTSINLEFGVPE
CCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHCCCCCCCEEEEEEECCCHH
FLEDEPAYGPRGEYAGVYGDFAEEARLLTRAFTEVLLEGDADGKPHLFPNTIYSLRRETF
HHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
RGEFDEELSLVHELASKYGTAYFINMLADYRGKMANYMGCRTSLADNWTGDWEKDCLRTG
CCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCC
NLAYITLNLPRIAYQSRDDDELFEYLDEYIDMAVEVLRIRRSQAQRCLDDYHLLPFLSQE
CEEEEEEECCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IDGERYYRIENATMSFGFTGLNEMLEYHLGAGIQSPEANRFGLRVIEHINERAAELKKET
CCCCEEEEEECCEEECCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
GWRWSVLQTPAESTAHRFAMLDHEHYPEEAVLQGTEGAYYYTNSSHTPVNAEVDLVEKIR
CCEEEEECCCHHHHHHHHHHHCCCCCCCHHHHCCCCCCEEEECCCCCCCCCHHHHHHHHH
IEEKYHPLTPGGHIFNAWLGEAKPDPAALEGLTRRICRRSDIGFWAYSNALSFCLRCKTL
HHHHCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
MRGLQDSCARCGERDEVEWYDRITGYVQQVGRAKSSSGGWNRGKQQELLDRRRIDL
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Ca2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2'-deoxyribonucleoside triphosphate; thioredoxin disulfide; H2O

Specific reaction: 2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]