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Identifier: 15679533

GI number: 15679533

Start: 1399902

End: 1401251

Strand: Direct

Name: Not Available

Synonym: MTH1537

Alternate gene names: 15679533

Gene position: 1399902-1401251 (Clockwise)

Preceding gene: 15679531

Following gene: 15679534

Centisome position: 79.93

GC content: 51.93

Gene sequence:

>1350_bases
ATGGCCATTCATCCAGTTGAATTCAGGTACGGGACACCTGAAATGAGGGTTATCTGGGAGGCTGAAAATAAGCTCCAGAA
GATGCTTGACGTTGAGGCGGCCCTTGCACAGGCAGAGGGCGAACTTGGAATCATACCTGCTGAAGCGGCCTCTGAGATAG
TCAGGAAGGCCAGCACAGAATTTGTAACCCTTGAAAGGGTTAATGAGATTGAGAGGGACACAAAGCATGATATTGCATCC
CTTGTAAAGGCCCTTGCAGAGCAGTGTGAGGGTGACGCAGGGGAATATGTGCACTTCGGTGCAACATCCAATGACATTGT
TGACACATCCAATTCCCTGCTTCTCAGGGACTCAATCTCGGTTCTCAGGGATAAACTCACCAGGGTACTTGAGGTTCTCC
TTGCTCTGGCGGATGAAAACAGGGACAGGGTCTGCATCGGAAGGACCCATGGACAGCACGCCCTCCCAACCACCTATGGC
ATGAAATTCGCCATCTGGGCAGATGAGATCCACCGGCAGCTGGAGCGCCTTGATGCGTGCAGTGAAAGGCTCTGTGTCGG
GATGATGACAGGAGCCGTCGGAACCACAGCGGCCCTGGGGGAGGAGGGCCTGGAGGTCCATGAGAGGGTCTCAGAGATAC
TGGGACTCAGACCGGTCCTGATATCCAACCAGGTCGTCCAGAGGGATAACCATGCAGAGTTCATAATGGTCCTTGCCAAC
ATAGCCACAACCCTTGATAAGATAGCCCTCGAGATCAGGAACCTTCAGAGGACAGAGATAATGGAGGTTGGAGAGAAATT
TGACCCTGAGAAACAGGTGGGCAGCAGTACCATGCCTCATAAGATGAACCCAATAACTGCAGAGAGGATATGTGGTATTG
CGCGTGTTATAAGGTCCTATGTTGTCGCGGCCCTGGAGAACAACCCATTATGGCATGAGAGGGACCTCACAAATTCATCA
TCCGAACGCATAATCCTTCCTGAGGCATGCATCCTCACGGACTACATACTTAAACTGACACTGGATGTCCTCTGCAACCT
CGTCTTCTACCCTGAGAATATTAAGAGGAACCTTGAATTCACAGGAGGCCTGATAATGGCGGAGAGGCTCATGGCTGAGC
TAACAAGGAGGGGCATGGGTCGGCAGACAGCATATGCAGCTGTGCGCCAGTGTGCCATTGAGGCCAGCAGGACAGGAAGA
AGCCTAAGGGATGTGGTCCTTGAGAGGTCCGAGATCATGGATTACCTTACAGTGGAGGACCTTGAGGAGATAATGAACCC
TGAGACCTACATCGGATCAGCCAGGAGGATGGTTGAGAGGGTCCTTGAGGAATCACAAAAATGGCTCTGA

Upstream 100 bases:

>100_bases
GGGACCGAAACTCACACCGGAACAGGTAGTTGTGATGAGCATAATACTGGCAGTGTTCTGCCTTGTACTCAGATTTTCGG
GATGATCAAGGAGTGTTAAG

Downstream 100 bases:

>100_bases
TCGGTCTGGAAGACGCATATTCTTCTTAATACCTCAAAAAAATCTTCTCATAAATTTTTTATATGTCCTGTCACCATAAA
TCATTATGGTGATAAGATGG

Product: adenylosuccinate lyase

Products: NA

Alternate protein names: ASL; Adenylosuccinase; ASase

Number of amino acids: Translated: 449; Mature: 448

Protein sequence:

>449_residues
MAIHPVEFRYGTPEMRVIWEAENKLQKMLDVEAALAQAEGELGIIPAEAASEIVRKASTEFVTLERVNEIERDTKHDIAS
LVKALAEQCEGDAGEYVHFGATSNDIVDTSNSLLLRDSISVLRDKLTRVLEVLLALADENRDRVCIGRTHGQHALPTTYG
MKFAIWADEIHRQLERLDACSERLCVGMMTGAVGTTAALGEEGLEVHERVSEILGLRPVLISNQVVQRDNHAEFIMVLAN
IATTLDKIALEIRNLQRTEIMEVGEKFDPEKQVGSSTMPHKMNPITAERICGIARVIRSYVVAALENNPLWHERDLTNSS
SERIILPEACILTDYILKLTLDVLCNLVFYPENIKRNLEFTGGLIMAERLMAELTRRGMGRQTAYAAVRQCAIEASRTGR
SLRDVVLERSEIMDYLTVEDLEEIMNPETYIGSARRMVERVLEESQKWL

Sequences:

>Translated_449_residues
MAIHPVEFRYGTPEMRVIWEAENKLQKMLDVEAALAQAEGELGIIPAEAASEIVRKASTEFVTLERVNEIERDTKHDIAS
LVKALAEQCEGDAGEYVHFGATSNDIVDTSNSLLLRDSISVLRDKLTRVLEVLLALADENRDRVCIGRTHGQHALPTTYG
MKFAIWADEIHRQLERLDACSERLCVGMMTGAVGTTAALGEEGLEVHERVSEILGLRPVLISNQVVQRDNHAEFIMVLAN
IATTLDKIALEIRNLQRTEIMEVGEKFDPEKQVGSSTMPHKMNPITAERICGIARVIRSYVVAALENNPLWHERDLTNSS
SERIILPEACILTDYILKLTLDVLCNLVFYPENIKRNLEFTGGLIMAERLMAELTRRGMGRQTAYAAVRQCAIEASRTGR
SLRDVVLERSEIMDYLTVEDLEEIMNPETYIGSARRMVERVLEESQKWL
>Mature_448_residues
AIHPVEFRYGTPEMRVIWEAENKLQKMLDVEAALAQAEGELGIIPAEAASEIVRKASTEFVTLERVNEIERDTKHDIASL
VKALAEQCEGDAGEYVHFGATSNDIVDTSNSLLLRDSISVLRDKLTRVLEVLLALADENRDRVCIGRTHGQHALPTTYGM
KFAIWADEIHRQLERLDACSERLCVGMMTGAVGTTAALGEEGLEVHERVSEILGLRPVLISNQVVQRDNHAEFIMVLANI
ATTLDKIALEIRNLQRTEIMEVGEKFDPEKQVGSSTMPHKMNPITAERICGIARVIRSYVVAALENNPLWHERDLTNSSS
ERIILPEACILTDYILKLTLDVLCNLVFYPENIKRNLEFTGGLIMAERLMAELTRRGMGRQTAYAAVRQCAIEASRTGRS
LRDVVLERSEIMDYLTVEDLEEIMNPETYIGSARRMVERVLEESQKWL

Specific function: De novo purine biosynthesis; eighth step. [C]

COG id: COG0015

COG function: function code F; Adenylosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI4557269, Length=454, Percent_Identity=29.295154185022, Blast_Score=178, Evalue=8e-45,
Organism=Homo sapiens, GI183227688, Length=388, Percent_Identity=30.6701030927835, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI19743875, Length=346, Percent_Identity=24.8554913294798, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI1787376, Length=472, Percent_Identity=27.1186440677966, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1790398, Length=376, Percent_Identity=24.468085106383, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17508577, Length=378, Percent_Identity=28.042328042328, Blast_Score=142, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI32564234, Length=324, Percent_Identity=29.320987654321, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17553882, Length=348, Percent_Identity=26.1494252873563, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI32565146, Length=341, Percent_Identity=26.3929618768328, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323391, Length=456, Percent_Identity=27.4122807017544, Blast_Score=171, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24647570, Length=454, Percent_Identity=28.6343612334802, Blast_Score=165, Evalue=7e-41,
Organism=Drosophila melanogaster, GI24640177, Length=348, Percent_Identity=26.1494252873563, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24640179, Length=348, Percent_Identity=26.1494252873563, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24662684, Length=347, Percent_Identity=25.3602305475504, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI78710009, Length=202, Percent_Identity=31.1881188118812, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24583245, Length=348, Percent_Identity=24.4252873563218, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PUR8_METTH (O27580)

Other databases:

- EMBL:   AE000666
- PIR:   A69072
- RefSeq:   NP_276650.1
- ProteinModelPortal:   O27580
- SMR:   O27580
- STRING:   O27580
- GeneID:   1471806
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH1537
- NMPDR:   fig|187420.1.peg.1505
- eggNOG:   arNOG04272
- HOGENOM:   HBG499008
- OMA:   HAVPTTY
- PhylomeDB:   O27580
- ProtClustDB:   PRK08540
- BioCyc:   MTHE187420:MTH1537-MONOMER
- BRENDA:   4.3.2.2
- InterPro:   IPR019468
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- InterPro:   IPR004769
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00928

Pfam domain/function: PF10397 ADSL_C; PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.2

Molecular weight: Translated: 50502; Mature: 50371

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: ACT_SITE 76-76 ACT_SITE 150-150

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIHPVEFRYGTPEMRVIWEAENKLQKMLDVEAALAQAEGELGIIPAEAASEIVRKASTE
CCCCCEEEECCCCCEEEEECHHHHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHHHHCCC
FVTLERVNEIERDTKHDIASLVKALAEQCEGDAGEYVHFGATSNDIVDTSNSLLLRDSIS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCEEHHHHHH
VLRDKLTRVLEVLLALADENRDRVCIGRTHGQHALPTTYGMKFAIWADEIHRQLERLDAC
HHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHCCEEEEEHHHHHHHHHHHHHH
SERLCVGMMTGAVGTTAALGEEGLEVHERVSEILGLRPVLISNQVVQRDNHAEFIMVLAN
HHHHHHHHHHCCCHHHHHHCHHHHHHHHHHHHHHCCCCHHHCCHHHHCCCCHHHHHHHHH
IATTLDKIALEIRNLQRTEIMEVGEKFDPEKQVGSSTMPHKMNPITAERICGIARVIRSY
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHH
VVAALENNPLWHERDLTNSSSERIILPEACILTDYILKLTLDVLCNLVFYPENIKRNLEF
HHHHHCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHH
TGGLIMAERLMAELTRRGMGRQTAYAAVRQCAIEASRTGRSLRDVVLERSEIMDYLTVED
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
LEEIMNPETYIGSARRMVERVLEESQKWL
HHHHHCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AIHPVEFRYGTPEMRVIWEAENKLQKMLDVEAALAQAEGELGIIPAEAASEIVRKASTE
CCCCEEEECCCCCEEEEECHHHHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHHHHCCC
FVTLERVNEIERDTKHDIASLVKALAEQCEGDAGEYVHFGATSNDIVDTSNSLLLRDSIS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCEEHHHHHH
VLRDKLTRVLEVLLALADENRDRVCIGRTHGQHALPTTYGMKFAIWADEIHRQLERLDAC
HHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHCCEEEEEHHHHHHHHHHHHHH
SERLCVGMMTGAVGTTAALGEEGLEVHERVSEILGLRPVLISNQVVQRDNHAEFIMVLAN
HHHHHHHHHHCCCHHHHHHCHHHHHHHHHHHHHHCCCCHHHCCHHHHCCCCHHHHHHHHH
IATTLDKIALEIRNLQRTEIMEVGEKFDPEKQVGSSTMPHKMNPITAERICGIARVIRSY
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHH
VVAALENNPLWHERDLTNSSSERIILPEACILTDYILKLTLDVLCNLVFYPENIKRNLEF
HHHHHCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHH
TGGLIMAERLMAELTRRGMGRQTAYAAVRQCAIEASRTGRSLRDVVLERSEIMDYLTVED
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
LEEIMNPETYIGSARRMVERVLEESQKWL
HHHHHCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463