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Identifier: 15679461

GI number: 15679461

Start: 1325599

End: 1326429

Strand: Direct

Name: Not Available

Synonym: MTH1464

Alternate gene names: 15679461

Gene position: 1325599-1326429 (Clockwise)

Preceding gene: 15679460

Following gene: 15679474

Centisome position: 75.69

GC content: 49.22

Gene sequence:

>831_bases
ATGGTTGTAAAAATTGGGATAATAAGATGCGGTAACATCGGGACCTCACCGGTACTTGACCTGTTACTAGATGAGAGGGC
CGACAGGCCAAACATAGATGTCTGTGTGGTTGGTTCTGGTGCAAAGATGAACCCTGATGAAATTGAGAGGGCAGTACCCA
CCATGCTTGAAATGGACAGGGACTTTGTTATATTTATAAGTCCAAACCCCGGTGCACCGGGCCCTGCAAAGGCAAGGGAA
CTCCTATCAGAGGCTGACGTCCCTGCCATGATAATTGGTGACGCTCCAGGTCTGAGGGTAAAGGATGAAATAGAGGAACA
GGGACTCGGTTACATCATAGTTAAGGCGGACCCAATGATAGGTGCCAGGAGGGAGTTCCTGGACCCAACAGAGATGGCAT
CCTTCAACTCCGACGTTATAAAGGTTCTGGCGTTCACAGGTGCATACAGGGTCGTTCAGAACACAATTGATGCCATGATT
GCCGATGTTGAGGCTGGAAAGGCTCCTGAACTTCCACAGGTTGTTATAGATACCGACGTGGCTGTTGAGGCAGCAGGATA
TGAGAACCCATATGCAAAGGCCAAGGCCATGGCAGCATATGAGATAGCCACCAAGGTTGCAGATATAGACGTTAAGGGCT
GCTTCATGGTGCAGGATCCAGACAAGTACATACCAATAGTTGCATCAGCACATGAAATGCTGGCCGCAGCAGCCAAACTT
GCAGTAGAAGCAAGGGAGATTGAAAAGGCCAACGACACCGTCCTCAGGACACCACACGGTAAAGAGGGCGAAACATTAAG
CAAAACTGATCTTCTGGCCAAACCAGAATAG

Upstream 100 bases:

>100_bases
GCAACCGTGAAAAATATACTACTGATATAAAAGCTTAATCATAATCTTTAAATCATAAAATACTTAATAAGGTGCAAAAT
AATAAGATTCTGGTGATCTA

Downstream 100 bases:

>100_bases
ATCAGTTCTGGTTTTACTTTTTTTCTCCCTTTAATATAATTTTAGAGGTCTCAGCTGAAAAGACATCCACACAAGTTTTG
AAGTTCCACAGCAAAATGAA

Product: F420-dependent methylenetetrahydromethanopterin dehydrogenase

Products: NA

Alternate protein names: MTD; Coenzyme F420-dependent N5,N10-methylenetetrahydromethanopterin dehydrogenase

Number of amino acids: Translated: 276; Mature: 276

Protein sequence:

>276_residues
MVVKIGIIRCGNIGTSPVLDLLLDERADRPNIDVCVVGSGAKMNPDEIERAVPTMLEMDRDFVIFISPNPGAPGPAKARE
LLSEADVPAMIIGDAPGLRVKDEIEEQGLGYIIVKADPMIGARREFLDPTEMASFNSDVIKVLAFTGAYRVVQNTIDAMI
ADVEAGKAPELPQVVIDTDVAVEAAGYENPYAKAKAMAAYEIATKVADIDVKGCFMVQDPDKYIPIVASAHEMLAAAAKL
AVEAREIEKANDTVLRTPHGKEGETLSKTDLLAKPE

Sequences:

>Translated_276_residues
MVVKIGIIRCGNIGTSPVLDLLLDERADRPNIDVCVVGSGAKMNPDEIERAVPTMLEMDRDFVIFISPNPGAPGPAKARE
LLSEADVPAMIIGDAPGLRVKDEIEEQGLGYIIVKADPMIGARREFLDPTEMASFNSDVIKVLAFTGAYRVVQNTIDAMI
ADVEAGKAPELPQVVIDTDVAVEAAGYENPYAKAKAMAAYEIATKVADIDVKGCFMVQDPDKYIPIVASAHEMLAAAAKL
AVEAREIEKANDTVLRTPHGKEGETLSKTDLLAKPE
>Mature_276_residues
MVVKIGIIRCGNIGTSPVLDLLLDERADRPNIDVCVVGSGAKMNPDEIERAVPTMLEMDRDFVIFISPNPGAPGPAKARE
LLSEADVPAMIIGDAPGLRVKDEIEEQGLGYIIVKADPMIGARREFLDPTEMASFNSDVIKVLAFTGAYRVVQNTIDAMI
ADVEAGKAPELPQVVIDTDVAVEAAGYENPYAKAKAMAAYEIATKVADIDVKGCFMVQDPDKYIPIVASAHEMLAAAAKL
AVEAREIEKANDTVLRTPHGKEGETLSKTDLLAKPE

Specific function: Catalyzes the reversible reduction of methenyl- H(4)MPT(+) to methylene-H(4)MPT

COG id: COG1927

COG function: function code C; Coenzyme F420-dependent N(5),N(10)-methenyltetrahydromethanopterin dehydrogenase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MTD family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTD_METTH (Q50501)

Other databases:

- EMBL:   U19362
- EMBL:   AE000666
- PIR:   A69062
- RefSeq:   NP_276578.1
- ProteinModelPortal:   Q50501
- SMR:   Q50501
- STRING:   Q50501
- GeneID:   1471733
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH1464
- NMPDR:   fig|187420.1.peg.1433
- eggNOG:   arNOG04866
- HOGENOM:   HBG538567
- OMA:   IVASAHE
- ProtClustDB:   PRK00994
- BioCyc:   MTHE187420:MTH1464-MONOMER
- BRENDA:   1.5.99.9
- GO:   GO:0015948
- HAMAP:   MF_00058
- InterPro:   IPR002844
- PIRSF:   PIRSF005627
- ProDom:   PD017604

Pfam domain/function: PF01993 MTD; SSF102324 MeTD

EC number: =1.5.99.9

Molecular weight: Translated: 29601; Mature: 29601

Theoretical pI: Translated: 4.33; Mature: 4.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVKIGIIRCGNIGTSPVLDLLLDERADRPNIDVCVVGSGAKMNPDEIERAVPTMLEMDR
CEEEEEEEEECCCCCHHHHHHHHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHCCC
DFVIFISPNPGAPGPAKARELLSEADVPAMIIGDAPGLRVKDEIEEQGLGYIIVKADPMI
CEEEEEECCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHCCCCEEEEECCCCC
GARREFLDPTEMASFNSDVIKVLAFTGAYRVVQNTIDAMIADVEAGKAPELPQVVIDTDV
CCHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCE
AVEAAGYENPYAKAKAMAAYEIATKVADIDVKGCFMVQDPDKYIPIVASAHEMLAAAAKL
EEEECCCCCCHHHHHHHHHHHHHHHHHEECCCEEEEEECCCCCEEEEHHHHHHHHHHHHH
AVEAREIEKANDTVLRTPHGKEGETLSKTDLLAKPE
HHHHHHHHCCCCCEEECCCCCCCCCCCHHCCCCCCC
>Mature Secondary Structure
MVVKIGIIRCGNIGTSPVLDLLLDERADRPNIDVCVVGSGAKMNPDEIERAVPTMLEMDR
CEEEEEEEEECCCCCHHHHHHHHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHCCC
DFVIFISPNPGAPGPAKARELLSEADVPAMIIGDAPGLRVKDEIEEQGLGYIIVKADPMI
CEEEEEECCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHCCCCEEEEECCCCC
GARREFLDPTEMASFNSDVIKVLAFTGAYRVVQNTIDAMIADVEAGKAPELPQVVIDTDV
CCHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCE
AVEAAGYENPYAKAKAMAAYEIATKVADIDVKGCFMVQDPDKYIPIVASAHEMLAAAAKL
EEEECCCCCCHHHHHHHHHHHHHHHHHEECCCEEEEEECCCCCEEEEHHHHHHHHHHHHH
AVEAREIEKANDTVLRTPHGKEGETLSKTDLLAKPE
HHHHHHHHCCCCCEEECCCCCCCCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7730278; 9371463