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Identifier: 15679457

GI number: 15679457

Start: 1321361

End: 1322704

Strand: Direct

Name: Not Available

Synonym: MTH1460

Alternate gene names: 15679457

Gene position: 1321361-1322704 (Clockwise)

Preceding gene: 15679456

Following gene: 15679458

Centisome position: 75.45

GC content: 52.38

Gene sequence:

>1344_bases
ATGAGAGTTGTACTTGCAGGGACAGGGAGTGCGGTTGGTAAGACCACAATAGCAACAGGGATAATGAAGGCGCTCTCAGG
TAGAGGCGTGCAGCCCTTCAAGGTTGGCCCAGACTACATAGACCCATCCTATCATACCATGGCCACCGGCAACACCTCAA
GGAACATTGACTCATTCTTCATGACAGAGGCCCAGATAAGGGAGGCATTCACAAGGGCCATGAAATTATCAGGATCCAGG
ATGGGCATAATAGAGGGTGTAAGGGGATTATATGAGGGTATAAGCCCGATAGGAGATACAGGAAGTACGGCATCAGTTGC
AAAGGCACTCGATGCTCCGGTTGTCCTTATAATAAACTCAAGGAGCCTTGTTAAGAGCGCTGCAGCAATGGTCCTAGGAT
TCAGAAGCCTCGACAGGGAGGTTAAAATAGAGGGCGTCATACTGAACCAGGTCAAGAACAGGAGGCACTACCTCAAGACC
AGAAGGGCCGTGGAGGAACTGACCGGCACAGCGGTTATTGGGGGCATACCCCGCAGCAGTGAACTCGAGGTTGAACAGAG
ACACCTCGGCCTTGTCCCTGCAGTTGAGAGGGATACCATAGCAGCCCAAATCGAGAAGTGGGGCCTTGCAATGGAGGAGT
ACATTGACCTGGAGGCCCTTCAGGATATAATGTCCTCCGCAGGGAAGATAAGGGGTGAAAGGCAACCTCTCTGGCAGAGG
GGAAACAGAAAGAGGGTTAGGATAGGTGTTGCCATCGACGAGGCCTTTAACTTCTACTACCAGGAGAACATTGAGGCCCT
TGAGGACAACGCAGCATCTGTGGTTCCCTTCAGCCCCATACACGACGAGGAGCTTCCAGATGTTGACGCCGTCTACATCG
GTGGGGGATACCCCGAGATCTTTGCAGCGGAACTTGAATCCAACACCTCAATGAGGAAGTCCATCCAGAGGTTCCATGCA
GATGGGAGACCTATCTTCGGGGAATGCGGTGGCCTCATGTACCTCATGAGTTCAATCGATGAACGTGAAATGTGCGGTGT
TTTCCCACACCCCGCTGAAATGACAGGACGCGTCCAGGGATTGAGTTACGTGATAGCCGAGGCAGTGATGGATAACCTGA
TCACAGAGGCCGGTGATAAATTCAGGGGACATGAGTTCCACTACTCAAGGGTCCTGGGGGCTTCAGGCGGAAAATTCGCC
TTCAGGGTCCTCCGGGGGAGGGGGATAGTGGATTCCCTTGATGGTATCACATCAGGCTCATCCCTTGCAAGCTACATCCA
CATACATGCCGCATCCTGCCCACAGTTTGCTGCAAATTTCACAAGGAATGCCTGGGAGTTTTAG

Upstream 100 bases:

>100_bases
CCGCAGGGTATCTTACGGGGCTGATGCATTCCATCAGCTCCGGTCATTTTTCTCTGTTTGTTACAAATAATTTAAATAAA
TTGAGCGCTGACCATCATAC

Downstream 100 bases:

>100_bases
CATGGAGGGATTTCTGCTGATCCAGAAGGGGGGGCCATAAATGAGGTTTGATGTGTTTTCACCATACTCAGTGGTGGCTG
TCATTATAATCTACCTTTCC

Product: cobyrinic acid a,c-diamide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MRVVLAGTGSAVGKTTIATGIMKALSGRGVQPFKVGPDYIDPSYHTMATGNTSRNIDSFFMTEAQIREAFTRAMKLSGSR
MGIIEGVRGLYEGISPIGDTGSTASVAKALDAPVVLIINSRSLVKSAAAMVLGFRSLDREVKIEGVILNQVKNRRHYLKT
RRAVEELTGTAVIGGIPRSSELEVEQRHLGLVPAVERDTIAAQIEKWGLAMEEYIDLEALQDIMSSAGKIRGERQPLWQR
GNRKRVRIGVAIDEAFNFYYQENIEALEDNAASVVPFSPIHDEELPDVDAVYIGGGYPEIFAAELESNTSMRKSIQRFHA
DGRPIFGECGGLMYLMSSIDEREMCGVFPHPAEMTGRVQGLSYVIAEAVMDNLITEAGDKFRGHEFHYSRVLGASGGKFA
FRVLRGRGIVDSLDGITSGSSLASYIHIHAASCPQFAANFTRNAWEF

Sequences:

>Translated_447_residues
MRVVLAGTGSAVGKTTIATGIMKALSGRGVQPFKVGPDYIDPSYHTMATGNTSRNIDSFFMTEAQIREAFTRAMKLSGSR
MGIIEGVRGLYEGISPIGDTGSTASVAKALDAPVVLIINSRSLVKSAAAMVLGFRSLDREVKIEGVILNQVKNRRHYLKT
RRAVEELTGTAVIGGIPRSSELEVEQRHLGLVPAVERDTIAAQIEKWGLAMEEYIDLEALQDIMSSAGKIRGERQPLWQR
GNRKRVRIGVAIDEAFNFYYQENIEALEDNAASVVPFSPIHDEELPDVDAVYIGGGYPEIFAAELESNTSMRKSIQRFHA
DGRPIFGECGGLMYLMSSIDEREMCGVFPHPAEMTGRVQGLSYVIAEAVMDNLITEAGDKFRGHEFHYSRVLGASGGKFA
FRVLRGRGIVDSLDGITSGSSLASYIHIHAASCPQFAANFTRNAWEF
>Mature_447_residues
MRVVLAGTGSAVGKTTIATGIMKALSGRGVQPFKVGPDYIDPSYHTMATGNTSRNIDSFFMTEAQIREAFTRAMKLSGSR
MGIIEGVRGLYEGISPIGDTGSTASVAKALDAPVVLIINSRSLVKSAAAMVLGFRSLDREVKIEGVILNQVKNRRHYLKT
RRAVEELTGTAVIGGIPRSSELEVEQRHLGLVPAVERDTIAAQIEKWGLAMEEYIDLEALQDIMSSAGKIRGERQPLWQR
GNRKRVRIGVAIDEAFNFYYQENIEALEDNAASVVPFSPIHDEELPDVDAVYIGGGYPEIFAAELESNTSMRKSIQRFHA
DGRPIFGECGGLMYLMSSIDEREMCGVFPHPAEMTGRVQGLSYVIAEAVMDNLITEAGDKFRGHEFHYSRVLGASGGKFA
FRVLRGRGIVDSLDGITSGSSLASYIHIHAASCPQFAANFTRNAWEF

Specific function: Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation

COG id: COG1797

COG function: function code H; Cobyrinic acid a,c-diamide synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GATase cobBQ-type domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COBB_METTH (O27509)

Other databases:

- EMBL:   AE000666
- PIR:   E69061
- RefSeq:   NP_276574.1
- ProteinModelPortal:   O27509
- STRING:   O27509
- GeneID:   1471729
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH1460
- NMPDR:   fig|187420.1.peg.1429
- eggNOG:   arNOG04865
- HOGENOM:   HBG634910
- OMA:   MRHLGLV
- ProtClustDB:   PRK01077
- BioCyc:   MTHE187420:MTH1460-MONOMER
- HAMAP:   MF_00027
- InterPro:   IPR002586
- InterPro:   IPR004484
- InterPro:   IPR017929
- InterPro:   IPR011698
- TIGRFAMs:   TIGR00379

Pfam domain/function: PF01656 CbiA; PF07685 GATase_3

EC number: NA

Molecular weight: Translated: 48848; Mature: 48848

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS51274 GATASE_COBBQ

Important sites: ACT_SITE 329-329 ACT_SITE 427-427

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVVLAGTGSAVGKTTIATGIMKALSGRGVQPFKVGPDYIDPSYHTMATGNTSRNIDSFF
CEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCCCCCHHHH
MTEAQIREAFTRAMKLSGSRMGIIEGVRGLYEGISPIGDTGSTASVAKALDAPVVLIINS
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCEEEEECC
RSLVKSAAAMVLGFRSLDREVKIEGVILNQVKNRRHYLKTRRAVEELTGTAVIGGIPRSS
HHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCC
ELEVEQRHLGLVPAVERDTIAAQIEKWGLAMEEYIDLEALQDIMSSAGKIRGERQPLWQR
CCCHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHCHHHHHHHHHHHHHCCCCCCHHHHC
GNRKRVRIGVAIDEAFNFYYQENIEALEDNAASVVPFSPIHDEELPDVDAVYIGGGYPEI
CCCCEEEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCCHHH
FAAELESNTSMRKSIQRFHADGRPIFGECGGLMYLMSSIDEREMCGVFPHPAEMTGRVQG
HHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHCCCCCCCHHHHHHHHH
LSYVIAEAVMDNLITEAGDKFRGHEFHYSRVLGASGGKFAFRVLRGRGIVDSLDGITSGS
HHHHHHHHHHHHHHHHCCCCCCCCCEEHHHHHCCCCCHHHHHHHHCCCCHHHHCCCCCCH
SLASYIHIHAASCPQFAANFTRNAWEF
HHHHHHEEECCCCHHHHHHHCCCCCCC
>Mature Secondary Structure
MRVVLAGTGSAVGKTTIATGIMKALSGRGVQPFKVGPDYIDPSYHTMATGNTSRNIDSFF
CEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCCCCCHHHH
MTEAQIREAFTRAMKLSGSRMGIIEGVRGLYEGISPIGDTGSTASVAKALDAPVVLIINS
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCEEEEECC
RSLVKSAAAMVLGFRSLDREVKIEGVILNQVKNRRHYLKTRRAVEELTGTAVIGGIPRSS
HHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCC
ELEVEQRHLGLVPAVERDTIAAQIEKWGLAMEEYIDLEALQDIMSSAGKIRGERQPLWQR
CCCHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHCHHHHHHHHHHHHHCCCCCCHHHHC
GNRKRVRIGVAIDEAFNFYYQENIEALEDNAASVVPFSPIHDEELPDVDAVYIGGGYPEI
CCCCEEEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCCHHH
FAAELESNTSMRKSIQRFHADGRPIFGECGGLMYLMSSIDEREMCGVFPHPAEMTGRVQG
HHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHCCCCCCCHHHHHHHHH
LSYVIAEAVMDNLITEAGDKFRGHEFHYSRVLGASGGKFAFRVLRGRGIVDSLDGITSGS
HHHHHHHHHHHHHHHHCCCCCCCCCEEHHHHHCCCCCHHHHHHHHCCCCHHHHCCCCCCH
SLASYIHIHAASCPQFAANFTRNAWEF
HHHHHHEEECCCCHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463