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Identifier: 15679442

GI number: 15679442

Start: 1305591

End: 1306964

Strand: Direct

Name: Not Available

Synonym: MTH1445

Alternate gene names: 15679442

Gene position: 1305591-1306964 (Clockwise)

Preceding gene: 15679437

Following gene: 15679443

Centisome position: 74.55

GC content: 50.58

Gene sequence:

>1374_bases
GTGCTAAGATTATATAAAACAATAGGGAGATTTAACCTTATCAATTTCCAGGAGGATTATCCGATGAAAATACTTGTTGT
GGGAACAGGAGCAAGGGAACATGCCATATGCAGTGCACTGGCAGATGAAGCAACCATATACTCTGTGATGGGTAACAGAA
ACCCGGGTATATCAAGGCTCGCAGGGAATTCACTGTTGCTCCTGAAGTTGACACCGAAGGTGGTCAGGTTCGCATCAGAG
AAGGGAGTTGACATGGCATTCATAGGGCCGGAGGCCCACCTTGAGGCTGGACTGGTGGACGCCCTTGAGGAGGCAGGTAT
ACCCTCGGTGGGACCCACCAGGGATGCAGCCCGCATCGAAACAGATAAATCATTCATGCGCAAACTCTTTGAGGATTACA
GAATACCGGGGTCAATAACCTACCGGGTCTTCAGTGACCCTGAGGAGCTACGTGAATTCATGGAAGACTTTGACAGTGAG
GCAGTTGTAAAGCCAGTCGGCCTCACAGGAGGAAAGGGCGTCAAGATAGTTGGAGAACACCTCAGGGATAACATGGAGGC
CCTCAAATACGCAACAGAGGTCATTGAGAAAAGGATAGGCGGTCATCCCAGTGTGGTGATAGAGGAGCGGGTTGTTGGAG
AGGAATTCACTGTACAGGCCTTCTCCGACGGTGAACACATAGTGCCAATGCCAGCAGTCCAGGACCACCCCCACGCCTAT
GAGGGCGACCAGGGCCCCATAACAGGAGGGATGGGATCATATTCTGACTCAGACGGGCTTCTTCCATTCCTGACACAGAA
GGACTATGAAGACGCCGTGGAAATAATGCAGAGGACGGTTGATGCCATAAGGAAGGAGACAGGGCCCTACAGGGGCATAC
TTTATGGTCAGTTCATGCTCTCTGCAGATGGTCCGAAACTCATAGAGTACAATGCACGATTCGGTGACCCTGAGGCAATG
AACGTGCTCCCATTACTTGAATCCAGCATGCTGGAAATATGTGAGGGTATAGTGGATGGAAACCTTAAATCAGCAAGTTT
CATGAACCTTGCAACGGTCTGCAAGTATCTGGTACCTGAGGGCTACCCTGAATCAGGTGTTGCCGGCGCCGAGATAAAGG
TTGACGAGAAGAAGATAGAGGATATGGGCGTCATAACCTATTATGCGGCTGTGAACCAGGAGGATGATCACATATACACA
TCATCATCCCGTGCACTTGCACTCGTGGCCCCTGCAGATGACATATACTCTGCAGAGGAGCTCTGTGAGGAAGCAACGGC
CCATGTGAAGGGAAGGCTCTACCACAGGAGGGATATAGGTACCAGGGAACTCGTTGAGAAGAGGATTAAACATATGGAGG
ACCTGCGGTCCTGA

Upstream 100 bases:

>100_bases
TCTGATTATTGCCTGGCCACCTTTCATTGGAAACACCTTGAACGGAATCTGTCATTATTATTAATGACATATTTCCTATA
AAATATATACTTTCAAATAA

Downstream 100 bases:

>100_bases
GGGAGTTGGGCAGATGAAGCACCTTCTATCTGTATGTGACATGGATAACGTGGTGGACCTCCTTGACCTCGCAGATGACT
ACAAGGAGGGGAAGATCAGG

Product: phosphoribosylamine--glycine ligase

Products: NA

Alternate protein names: GARS; Glycinamide ribonucleotide synthetase; Phosphoribosylglycinamide synthetase [H]

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MLRLYKTIGRFNLINFQEDYPMKILVVGTGAREHAICSALADEATIYSVMGNRNPGISRLAGNSLLLLKLTPKVVRFASE
KGVDMAFIGPEAHLEAGLVDALEEAGIPSVGPTRDAARIETDKSFMRKLFEDYRIPGSITYRVFSDPEELREFMEDFDSE
AVVKPVGLTGGKGVKIVGEHLRDNMEALKYATEVIEKRIGGHPSVVIEERVVGEEFTVQAFSDGEHIVPMPAVQDHPHAY
EGDQGPITGGMGSYSDSDGLLPFLTQKDYEDAVEIMQRTVDAIRKETGPYRGILYGQFMLSADGPKLIEYNARFGDPEAM
NVLPLLESSMLEICEGIVDGNLKSASFMNLATVCKYLVPEGYPESGVAGAEIKVDEKKIEDMGVITYYAAVNQEDDHIYT
SSSRALALVAPADDIYSAEELCEEATAHVKGRLYHRRDIGTRELVEKRIKHMEDLRS

Sequences:

>Translated_457_residues
MLRLYKTIGRFNLINFQEDYPMKILVVGTGAREHAICSALADEATIYSVMGNRNPGISRLAGNSLLLLKLTPKVVRFASE
KGVDMAFIGPEAHLEAGLVDALEEAGIPSVGPTRDAARIETDKSFMRKLFEDYRIPGSITYRVFSDPEELREFMEDFDSE
AVVKPVGLTGGKGVKIVGEHLRDNMEALKYATEVIEKRIGGHPSVVIEERVVGEEFTVQAFSDGEHIVPMPAVQDHPHAY
EGDQGPITGGMGSYSDSDGLLPFLTQKDYEDAVEIMQRTVDAIRKETGPYRGILYGQFMLSADGPKLIEYNARFGDPEAM
NVLPLLESSMLEICEGIVDGNLKSASFMNLATVCKYLVPEGYPESGVAGAEIKVDEKKIEDMGVITYYAAVNQEDDHIYT
SSSRALALVAPADDIYSAEELCEEATAHVKGRLYHRRDIGTRELVEKRIKHMEDLRS
>Mature_457_residues
MLRLYKTIGRFNLINFQEDYPMKILVVGTGAREHAICSALADEATIYSVMGNRNPGISRLAGNSLLLLKLTPKVVRFASE
KGVDMAFIGPEAHLEAGLVDALEEAGIPSVGPTRDAARIETDKSFMRKLFEDYRIPGSITYRVFSDPEELREFMEDFDSE
AVVKPVGLTGGKGVKIVGEHLRDNMEALKYATEVIEKRIGGHPSVVIEERVVGEEFTVQAFSDGEHIVPMPAVQDHPHAY
EGDQGPITGGMGSYSDSDGLLPFLTQKDYEDAVEIMQRTVDAIRKETGPYRGILYGQFMLSADGPKLIEYNARFGDPEAM
NVLPLLESSMLEICEGIVDGNLKSASFMNLATVCKYLVPEGYPESGVAGAEIKVDEKKIEDMGVITYYAAVNQEDDHIYT
SSSRALALVAPADDIYSAEELCEEATAHVKGRLYHRRDIGTRELVEKRIKHMEDLRS

Specific function: De novo purine biosynthesis; second step. [C]

COG id: COG0151

COG function: function code F; Phosphoribosylamine-glycine ligase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Homo sapiens, GI28416899, Length=437, Percent_Identity=34.324942791762, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI4503915, Length=437, Percent_Identity=34.324942791762, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI209869995, Length=437, Percent_Identity=34.324942791762, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI209869993, Length=437, Percent_Identity=34.324942791762, Blast_Score=244, Evalue=1e-64,
Organism=Escherichia coli, GI1790438, Length=431, Percent_Identity=29.9303944315545, Blast_Score=182, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17567511, Length=436, Percent_Identity=31.4220183486239, Blast_Score=168, Evalue=5e-42,
Organism=Saccharomyces cerevisiae, GI6321203, Length=446, Percent_Identity=29.8206278026906, Blast_Score=184, Evalue=3e-47,
Organism=Drosophila melanogaster, GI24582400, Length=364, Percent_Identity=34.8901098901099, Blast_Score=185, Evalue=6e-47,
Organism=Drosophila melanogaster, GI62471619, Length=364, Percent_Identity=33.5164835164835, Blast_Score=185, Evalue=7e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR020561
- InterPro:   IPR000115
- InterPro:   IPR020560
- InterPro:   IPR020559
- InterPro:   IPR020562
- InterPro:   IPR011054 [H]

Pfam domain/function: PF01071 GARS_A; PF02843 GARS_C; PF02844 GARS_N [H]

EC number: =6.3.4.13 [H]

Molecular weight: Translated: 50497; Mature: 50497

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: PS50975 ATP_GRASP ; PS00184 GARS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRLYKTIGRFNLINFQEDYPMKILVVGTGAREHAICSALADEATIYSVMGNRNPGISRL
CCHHHHHHCCEEEEEECCCCCEEEEEEECCCHHHHHHHHHHHHHHEEEECCCCCCCHHHH
AGNSLLLLKLTPKVVRFASEKGVDMAFIGPEAHLEAGLVDALEEAGIPSVGPTRDAARIE
CCCCEEEEEECHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHH
TDKSFMRKLFEDYRIPGSITYRVFSDPEELREFMEDFDSEAVVKPVGLTGGKGVKIVGEH
HHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHH
LRDNMEALKYATEVIEKRIGGHPSVVIEERVVGEEFTVQAFSDGEHIVPMPAVQDHPHAY
HHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHCCCEEEEEEECCCCEEECCCCCCCCCCCC
EGDQGPITGGMGSYSDSDGLLPFLTQKDYEDAVEIMQRTVDAIRKETGPYRGILYGQFML
CCCCCCCCCCCCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEE
SADGPKLIEYNARFGDPEAMNVLPLLESSMLEICEGIVDGNLKSASFMNLATVCKYLVPE
ECCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCC
GYPESGVAGAEIKVDEKKIEDMGVITYYAAVNQEDDHIYTSSSRALALVAPADDIYSAEE
CCCCCCCCCCEEEECHHHHHHCCEEEEEEECCCCCCEEEECCCCEEEEEECCHHHHHHHH
LCEEATAHVKGRLYHRRDIGTRELVEKRIKHMEDLRS
HHHHHHHHHHHHEEEHHCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLRLYKTIGRFNLINFQEDYPMKILVVGTGAREHAICSALADEATIYSVMGNRNPGISRL
CCHHHHHHCCEEEEEECCCCCEEEEEEECCCHHHHHHHHHHHHHHEEEECCCCCCCHHHH
AGNSLLLLKLTPKVVRFASEKGVDMAFIGPEAHLEAGLVDALEEAGIPSVGPTRDAARIE
CCCCEEEEEECHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHH
TDKSFMRKLFEDYRIPGSITYRVFSDPEELREFMEDFDSEAVVKPVGLTGGKGVKIVGEH
HHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHH
LRDNMEALKYATEVIEKRIGGHPSVVIEERVVGEEFTVQAFSDGEHIVPMPAVQDHPHAY
HHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHCCCEEEEEEECCCCEEECCCCCCCCCCCC
EGDQGPITGGMGSYSDSDGLLPFLTQKDYEDAVEIMQRTVDAIRKETGPYRGILYGQFML
CCCCCCCCCCCCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEE
SADGPKLIEYNARFGDPEAMNVLPLLESSMLEICEGIVDGNLKSASFMNLATVCKYLVPE
ECCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCC
GYPESGVAGAEIKVDEKKIEDMGVITYYAAVNQEDDHIYTSSSRALALVAPADDIYSAEE
CCCCCCCCCCEEEECHHHHHHCCEEEEEEECCCCCCEEEECCCCEEEEEECCHHHHHHHH
LCEEATAHVKGRLYHRRDIGTRELVEKRIKHMEDLRS
HHHHHHHHHHHHEEEHHCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]