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Identifier: 15679411

GI number: 15679411

Start: 1278180

End: 1279328

Strand: Direct

Name: Not Available

Synonym: MTH1412

Alternate gene names: 15679411

Gene position: 1278180-1279328 (Clockwise)

Preceding gene: 15679409

Following gene: 15679418

Centisome position: 72.98

GC content: 47.43

Gene sequence:

>1149_bases
ATGAACATTTTTGATGAGATAGGGGACAAAGAATCTGTTTTTAAGGATAAGAAATATCTTGATCACAGGTTCCTTCCTGA
CAGATTACCTCACAGGGAGGAGCAGATACGATCAATAGCCAAGTACTGGGTCGAGGCCCTCAATGGAGTGACACCTCCAG
ACATTACAATCTATGGTAAAACAGGTACAGGGAAAACTGCCGTTGCAAAATTTGCCATGAAACAGCTGAAGGAGGCATCA
AAGGACTGTGACGTGAATATAAGGACTGAATACATCCGCTGCACAGATTACACAACAGAGTACCAGGTCATAGCAAGATT
ATGCCAGCAGCTCGGTCGTGATGTCCCCTACCGTGGCTGGACAAAGGCTGAAATCGTGAACACCTTCAGGAACATGTTCA
AGAAAAACGCCTTTGGCCAGGACATGATACTCATGGTCGTACTTGATGAAATAGACATACTCCTCAGAAATGATGGAGAT
GGACTCCTGTACACCCTCACAAGGACAGATAATGTCTCCATTTTATCCATAAGTAACTACGTGGAATTCAAGAAATTCAT
AAAACCCCGGGTCAGGAGCAGCCTCAGGGACAGGGAGATAGTTTTCCCACCCTATGGGGCCCAGCAGCTTGTTGATATCC
TTGAGGAGAGGTCAAAGATGTCCTTCAAGGAGGGTGCCCTTGATGATGATGTCATACCCCTATGCGCAGCTCTGGCAGCC
AAGGAGGAGGGTGATGCAAGGTACGCCCTGGACCTCCTCAGGACAGCAGGTGAAATTGCCGATGAAAGGGACTCAGATAA
AGTCCTGGGGGACTTTGTGAGGGAGGCCAAGGACTACATAGAACACAACAAGATCACAGACATAATACTGACACTACCGA
GCCAGCAGCAGAGGGTGCTTGAGGCCATACTCTACCTCACAAAGAGGAAGGAGGAAATAACCTCCGGAAGGCTTTATGAG
GTCTACAAGGAAATAGCAAAGGGGGACTCTGTTTCCTACAGGAGGATATTTGACTTCATAAACGAGCTTGAAATGCTCGG
CCTCATATCCACAAATACTGTTTCACGGGGAAGGGGAAAGGGACGTACAAATATCATAGACCTGCAGTGCGAAACCTCCC
TCCTGGAGGACTCACTCTGGGGTGTTTAA

Upstream 100 bases:

>100_bases
AAGGTCATCCTGATATTGAATTTCACTGTATCCAGATTTTAGGGCCTTTACTGAAATTTGATGCAGCAGTTTTCTCTAAA
AATTTAGTTGAAGTGGTACT

Downstream 100 bases:

>100_bases
AGCTTTTTTCTAGAGCCATCCCGCTCAAACTATCTTCTGGTTTTCAGATCCTCTCCTCTCACTTATCAGCAGCCTCAGGA
GGGCCATCCGGACCGGCACA

Product: Cdc6 related protein

Products: NA

Alternate protein names: CDC6 homolog 1

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MNIFDEIGDKESVFKDKKYLDHRFLPDRLPHREEQIRSIAKYWVEALNGVTPPDITIYGKTGTGKTAVAKFAMKQLKEAS
KDCDVNIRTEYIRCTDYTTEYQVIARLCQQLGRDVPYRGWTKAEIVNTFRNMFKKNAFGQDMILMVVLDEIDILLRNDGD
GLLYTLTRTDNVSILSISNYVEFKKFIKPRVRSSLRDREIVFPPYGAQQLVDILEERSKMSFKEGALDDDVIPLCAALAA
KEEGDARYALDLLRTAGEIADERDSDKVLGDFVREAKDYIEHNKITDIILTLPSQQQRVLEAILYLTKRKEEITSGRLYE
VYKEIAKGDSVSYRRIFDFINELEMLGLISTNTVSRGRGKGRTNIIDLQCETSLLEDSLWGV

Sequences:

>Translated_382_residues
MNIFDEIGDKESVFKDKKYLDHRFLPDRLPHREEQIRSIAKYWVEALNGVTPPDITIYGKTGTGKTAVAKFAMKQLKEAS
KDCDVNIRTEYIRCTDYTTEYQVIARLCQQLGRDVPYRGWTKAEIVNTFRNMFKKNAFGQDMILMVVLDEIDILLRNDGD
GLLYTLTRTDNVSILSISNYVEFKKFIKPRVRSSLRDREIVFPPYGAQQLVDILEERSKMSFKEGALDDDVIPLCAALAA
KEEGDARYALDLLRTAGEIADERDSDKVLGDFVREAKDYIEHNKITDIILTLPSQQQRVLEAILYLTKRKEEITSGRLYE
VYKEIAKGDSVSYRRIFDFINELEMLGLISTNTVSRGRGKGRTNIIDLQCETSLLEDSLWGV
>Mature_382_residues
MNIFDEIGDKESVFKDKKYLDHRFLPDRLPHREEQIRSIAKYWVEALNGVTPPDITIYGKTGTGKTAVAKFAMKQLKEAS
KDCDVNIRTEYIRCTDYTTEYQVIARLCQQLGRDVPYRGWTKAEIVNTFRNMFKKNAFGQDMILMVVLDEIDILLRNDGD
GLLYTLTRTDNVSILSISNYVEFKKFIKPRVRSSLRDREIVFPPYGAQQLVDILEERSKMSFKEGALDDDVIPLCAALAA
KEEGDARYALDLLRTAGEIADERDSDKVLGDFVREAKDYIEHNKITDIILTLPSQQQRVLEAILYLTKRKEEITSGRLYE
VYKEIAKGDSVSYRRIFDFINELEMLGLISTNTVSRGRGKGRTNIIDLQCETSLLEDSLWGV

Specific function: Might be involved in the initiation of DNA replication

COG id: COG1474

COG function: function code LO; Cdc6-related protein, AAA superfamily ATPase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CDC6/cdc18 family

Homologues:

Organism=Homo sapiens, GI4502703, Length=354, Percent_Identity=25.7062146892655, Blast_Score=102, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17555708, Length=309, Percent_Identity=26.537216828479, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17506005, Length=233, Percent_Identity=28.3261802575107, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI21355681, Length=343, Percent_Identity=27.1137026239067, Blast_Score=89, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CDC61_METTH (O27463)

Other databases:

- EMBL:   AE000666
- PIR:   B69055
- RefSeq:   NP_276528.1
- ProteinModelPortal:   O27463
- SMR:   O27463
- STRING:   O27463
- PhosSite:   O27463
- GeneID:   1471129
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH1412
- NMPDR:   fig|187420.1.peg.1383
- eggNOG:   arNOG04006
- HOGENOM:   HBG553472
- OMA:   IPMTGWP
- ProtClustDB:   CLSK798166
- BioCyc:   MTHE187420:MTH1412-MONOMER
- HAMAP:   MF_01407
- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR015163
- InterPro:   IPR014277
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PANTHER:   PTHR10763:SF8
- SMART:   SM00382
- TIGRFAMs:   TIGR02928

Pfam domain/function: PF00004 AAA; PF09079 Cdc6_C

EC number: NA

Molecular weight: Translated: 43876; Mature: 43876

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIFDEIGDKESVFKDKKYLDHRFLPDRLPHREEQIRSIAKYWVEALNGVTPPDITIYGK
CCCHHHCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEC
TGTGKTAVAKFAMKQLKEASKDCDVNIRTEYIRCTDYTTEYQVIARLCQQLGRDVPYRGW
CCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCC
TKAEIVNTFRNMFKKNAFGQDMILMVVLDEIDILLRNDGDGLLYTLTRTDNVSILSISNY
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHEEEEECCCCEEEEEEECCCEEEEEHHHH
VEFKKFIKPRVRSSLRDREIVFPPYGAQQLVDILEERSKMSFKEGALDDDVIPLCAALAA
HHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHCCHHCCCCCCHHHHHHHHHHH
KEEGDARYALDLLRTAGEIADERDSDKVLGDFVREAKDYIEHNKITDIILTLPSQQQRVL
CCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHH
EAILYLTKRKEEITSGRLYEVYKEIAKGDSVSYRRIFDFINELEMLGLISTNTVSRGRGK
HHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
GRTNIIDLQCETSLLEDSLWGV
CCCCEEEEEEHHHHHHHHHCCC
>Mature Secondary Structure
MNIFDEIGDKESVFKDKKYLDHRFLPDRLPHREEQIRSIAKYWVEALNGVTPPDITIYGK
CCCHHHCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEC
TGTGKTAVAKFAMKQLKEASKDCDVNIRTEYIRCTDYTTEYQVIARLCQQLGRDVPYRGW
CCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCC
TKAEIVNTFRNMFKKNAFGQDMILMVVLDEIDILLRNDGDGLLYTLTRTDNVSILSISNY
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHEEEEECCCCEEEEEEECCCEEEEEHHHH
VEFKKFIKPRVRSSLRDREIVFPPYGAQQLVDILEERSKMSFKEGALDDDVIPLCAALAA
HHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHCCHHCCCCCCHHHHHHHHHHH
KEEGDARYALDLLRTAGEIADERDSDKVLGDFVREAKDYIEHNKITDIILTLPSQQQRVL
CCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHH
EAILYLTKRKEEITSGRLYEVYKEIAKGDSVSYRRIFDFINELEMLGLISTNTVSRGRGK
HHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
GRTNIIDLQCETSLLEDSLWGV
CCCCEEEEEEHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463; 11514535