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Identifier: 15679354

GI number: 15679354

Start: 1220029

End: 1220421

Strand: Direct

Name: Not Available

Synonym: MTH1355

Alternate gene names: 15679354

Gene position: 1220029-1220421 (Clockwise)

Preceding gene: 15679351

Following gene: 15679355

Centisome position: 69.66

GC content: 51.65

Gene sequence:

>393_bases
ATGAAGAGTAAGGTTCTATTCATATGCAGGAACAACTCCGGGAGGTCCCAGATGGCTGAGGGGATACTCAGGGCCATGTA
CGGTGCCCACTATGAGGTCCACAGTGCCGGCAGTGACCCGAAGGATATCAGCCCCCTCACCATACAGGTCATGGAGGAGA
TTGGTGTGGACATGACTGGCCACAGACCAAAGAGTCTCAGGGAATTTGAGGGCGAAAAATTTGACATCGTTGCAAGCCTC
TGCGATGAGGCATGCCCTGTATTCCTGGGTGGTGAGAGGTACCTTCATGCTGAATTCCCTGACCCGAGGGGTGCAGATAT
TGACACCCTCAGAAGGATCCGTGATGAAATCTCTGACTGGATAAAGAAGGAGTTCAACCCTGAAAAACTGTGA

Upstream 100 bases:

>100_bases
CGGTTATAGGTCTCTTCTTCATTTTATAAATAATTCAGATATATTTATAAATTTGGATACATCAATAGATCTGTGTGGTA
GTTATAAGGGAGCATCAAAC

Downstream 100 bases:

>100_bases
TTTACTAAAGGAGAGTGATTTAATGATTAAGGTTGCCATCGTAACAGACGGGCCCTACGGTGAAAGGGCCTATGAGAACA
TAGCCCGTGAATTCGAGACC

Product: arsenate reductase

Products: NA

Alternate protein names: Arsenate reductase 2; Arsenical pump modifier 2; Low molecular weight protein-tyrosine-phosphatase 2 [H]

Number of amino acids: Translated: 130; Mature: 130

Protein sequence:

>130_residues
MKSKVLFICRNNSGRSQMAEGILRAMYGAHYEVHSAGSDPKDISPLTIQVMEEIGVDMTGHRPKSLREFEGEKFDIVASL
CDEACPVFLGGERYLHAEFPDPRGADIDTLRRIRDEISDWIKKEFNPEKL

Sequences:

>Translated_130_residues
MKSKVLFICRNNSGRSQMAEGILRAMYGAHYEVHSAGSDPKDISPLTIQVMEEIGVDMTGHRPKSLREFEGEKFDIVASL
CDEACPVFLGGERYLHAEFPDPRGADIDTLRRIRDEISDWIKKEFNPEKL
>Mature_130_residues
MKSKVLFICRNNSGRSQMAEGILRAMYGAHYEVHSAGSDPKDISPLTIQVMEEIGVDMTGHRPKSLREFEGEKFDIVASL
CDEACPVFLGGERYLHAEFPDPRGADIDTLRRIRDEISDWIKKEFNPEKL

Specific function: Reduces arsenate [As(V)] to arsenite [As(III)] and dephosphorylates tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Could switch between different functions in different circumstances [H]

COG id: COG0394

COG function: function code T; Protein-tyrosine-phosphatase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the low molecular weight phosphotyrosine protein phosphatase superfamily. ArsC family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014064
- InterPro:   IPR017867 [H]

Pfam domain/function: PF01451 LMWPc [H]

EC number: =3.1.3.48 [H]

Molecular weight: Translated: 14757; Mature: 14757

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSKVLFICRNNSGRSQMAEGILRAMYGAHYEVHSAGSDPKDISPLTIQVMEEIGVDMTG
CCCCEEEEEECCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHHCCCCCC
HRPKSLREFEGEKFDIVASLCDEACPVFLGGERYLHAEFPDPRGADIDTLRRIRDEISDW
CCCCHHHHHCCCHHHHHHHHHHHCCCEEECCCEEEECCCCCCCCCCHHHHHHHHHHHHHH
IKKEFNPEKL
HHHCCCCCCC
>Mature Secondary Structure
MKSKVLFICRNNSGRSQMAEGILRAMYGAHYEVHSAGSDPKDISPLTIQVMEEIGVDMTG
CCCCEEEEEECCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHHCCCCCC
HRPKSLREFEGEKFDIVASLCDEACPVFLGGERYLHAEFPDPRGADIDTLRRIRDEISDW
CCCCHHHHHCCCHHHHHHHHHHHCCCEEECCCEEEECCCCCCCCCCHHHHHHHHHHHHHH
IKKEFNPEKL
HHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA