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Identifier: 15679347

GI number: 15679347

Start: 1213978

End: 1214676

Strand: Direct

Name: Not Available

Synonym: MTH1348

Alternate gene names: 15679347

Gene position: 1213978-1214676 (Clockwise)

Preceding gene: 15679345

Following gene: 15679349

Centisome position: 69.32

GC content: 53.51

Gene sequence:

>699_bases
ATGCATGGAAAACTCATCGGTGTGGGTGTGGGTCCCGGGGACAGTGAACTTCTGACCCTCAGGGCTGTGAATGTACTCAG
ATCTGTTCCAGTTATATGCGCACCCCGTTCATCATCTGAGAGGGAGAGCATAGCCCTCTCAATCGTTGAAGATATCCTCA
CTGAACGCAGGGACGGCTGCAGAATACTTGACCCTGTGTTTCCAATGACTGATGACCGGGATGAACTTGAAAGTCACTGG
GATTCTGCGGCCAGAATGGTTGCAGCTGAACTTGAGGATGGACGGGATGTTGCCTTCATAACACTGGGTGATCCATCCAT
CTACAGTACCTTCAGTTACCTCCAGCAGCGCATTGAGGATATGGGCTTTAAGACAGAGATGGTGCCAGGAGTCACCTCCT
TCACGGCATGTGCAGCCACCGCTGGCAGAACCCTCGTTGAGGGTGATGAGATCCTCCTTGTGGTGCCCCGGGTTGATGAT
CGGTTTGAGAGGGTGCTCAGGGATGTGGATGCCTGTGTGATCATGAAGACGTCACGCCATGGCAGGAGGGCCATGGAGGT
TGTGGAGTCTGATCCCCGCGGAAAGGATGTTGTATCTGTGGCAAACTGCAGCATGGATGACGAGGTCGTTGAAAGGGGAT
TTGCCTCCGGTGGAGGGTATCTTGCAACAACCCTTGTGAGGTTCAGGGAGCAATCCTGA

Upstream 100 bases:

>100_bases
GTGCCACAGAAAAATAATGATAATAAAGGCGGGTCTGGATATTTCCAGAGAAGGATGACCAGACCATCATCATGTCTACA
GAGTTATTAAAGGTGTTCTA

Downstream 100 bases:

>100_bases
AGCAACACCTCTATATATAAACCAAAAAAAATCAGCTTTCAGGAACAATCCTGAAGGAGCACCTTCCATCACCACGGGCA
TAACATTCCGTCTCCTCCAC

Product: precorrin-2 methyltransferase

Products: NA

Alternate protein names: S-adenosyl-L-methionine--cobalt-precorrin-2 methyltransferase [H]

Number of amino acids: Translated: 232; Mature: 232

Protein sequence:

>232_residues
MHGKLIGVGVGPGDSELLTLRAVNVLRSVPVICAPRSSSERESIALSIVEDILTERRDGCRILDPVFPMTDDRDELESHW
DSAARMVAAELEDGRDVAFITLGDPSIYSTFSYLQQRIEDMGFKTEMVPGVTSFTACAATAGRTLVEGDEILLVVPRVDD
RFERVLRDVDACVIMKTSRHGRRAMEVVESDPRGKDVVSVANCSMDDEVVERGFASGGGYLATTLVRFREQS

Sequences:

>Translated_232_residues
MHGKLIGVGVGPGDSELLTLRAVNVLRSVPVICAPRSSSERESIALSIVEDILTERRDGCRILDPVFPMTDDRDELESHW
DSAARMVAAELEDGRDVAFITLGDPSIYSTFSYLQQRIEDMGFKTEMVPGVTSFTACAATAGRTLVEGDEILLVVPRVDD
RFERVLRDVDACVIMKTSRHGRRAMEVVESDPRGKDVVSVANCSMDDEVVERGFASGGGYLATTLVRFREQS
>Mature_232_residues
MHGKLIGVGVGPGDSELLTLRAVNVLRSVPVICAPRSSSERESIALSIVEDILTERRDGCRILDPVFPMTDDRDELESHW
DSAARMVAAELEDGRDVAFITLGDPSIYSTFSYLQQRIEDMGFKTEMVPGVTSFTACAATAGRTLVEGDEILLVVPRVDD
RFERVLRDVDACVIMKTSRHGRRAMEVVESDPRGKDVVSVANCSMDDEVVERGFASGGGYLATTLVRFREQS

Specific function: Methylates cobalt-precorrin-2 at the C-20 position to produce cobalt-precorrin-3A in the anaerobic cobalamin biosynthesis pathway [H]

COG id: COG2243

COG function: function code H; Precorrin-2 methylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR012382
- InterPro:   IPR006364
- InterPro:   IPR003043 [H]

Pfam domain/function: PF00590 TP_methylase [H]

EC number: =2.1.1.151 [H]

Molecular weight: Translated: 25472; Mature: 25472

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHGKLIGVGVGPGDSELLTLRAVNVLRSVPVICAPRSSSERESIALSIVEDILTERRDGC
CCCCEEEEECCCCCCHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCC
RILDPVFPMTDDRDELESHWDSAARMVAAELEDGRDVAFITLGDPSIYSTFSYLQQRIED
EEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHH
MGFKTEMVPGVTSFTACAATAGRTLVEGDEILLVVPRVDDRFERVLRDVDACVIMKTSRH
CCCCCCCCCCCHHHHHHHHHCCCEEECCCEEEEEECCCCHHHHHHHHHCCCEEEEECCCC
GRRAMEVVESDPRGKDVVSVANCSMDDEVVERGFASGGGYLATTLVRFREQS
HHHHHHHHHCCCCCCCEEEECCCCCCHHHHHCCCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MHGKLIGVGVGPGDSELLTLRAVNVLRSVPVICAPRSSSERESIALSIVEDILTERRDGC
CCCCEEEEECCCCCCHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCC
RILDPVFPMTDDRDELESHWDSAARMVAAELEDGRDVAFITLGDPSIYSTFSYLQQRIED
EEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHH
MGFKTEMVPGVTSFTACAATAGRTLVEGDEILLVVPRVDDRFERVLRDVDACVIMKTSRH
CCCCCCCCCCCHHHHHHHHHCCCEEECCCEEEEEECCCCHHHHHHHHHCCCEEEEECCCC
GRRAMEVVESDPRGKDVVSVANCSMDDEVVERGFASGGGYLATTLVRFREQS
HHHHHHHHHCCCCCCCEEEECCCCCCHHHHHCCCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]