BacMap

Definition	Methanothermobacter thermautotrophicus str. Delta H chromosome, complete genome.
Accession	NC_000916
Length	1,751,377

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The map label for this gene is Not Available

Identifier: 15679338

GI number: 15679338

Start: 1204839

End: 1205264

Strand: Direct

Name: Not Available

Synonym: MTH1338

Alternate gene names: 15679338

Gene position: 1204839-1205264 (Clockwise)

Preceding gene: 15679336

Following gene: 15679345

Centisome position: 68.79

GC content: 52.82

Gene sequence:

>426_bases
ATGAAAAGTGCTGTCATTGAAACCGTTAAGGGAGATATAGAGCTGATCCTCTTTGAGGAGGACGCCCCAAACACGGTTGC
GAATTTTGAAAAACTTTCAAACAGTGGATTCTATGATGGACTCACCTTCCACAGGGTCATACCTGACTTCGTGATCCAGG
GAGGGTGTCCGGTGGGTGATGGGACAGGCGGCCCCGGTTACACAATAAAGTGCGAGATAAACCCGAACAGGCACGTTAAG
GGGGCCCTGTCCATGGCACATGCAGGGAGAGATACCGGGGGCAGCCAGTTCTTCATAACACTATCTCCCCAGCCCCACCT
CGATGGCGTCCACACCGTCTTCGGAAAGGTTGTGAGGGGTATGGATGTTGTTGAATCCATAGAGAGGGGAGACCGGATGC
TCAGGGTCAGGGTCTACGACGAATGA

Upstream 100 bases:

>100_bases
TTATTTCCTCTGAATCCATGATATCACCAAAAATTTATATGGGGACCTGTATTAATGTTGAACCTAAACTGATAATAAAT
ATTTATGTTGAGGTGGTTAA

Downstream 100 bases:

>100_bases
ACCGTTCCCTGATATCACTCCAGGGGTATCTCACCCCTCCAGAACCTTCTGAGGACCCCGGCATAGTGCCCCGCAATTTC
CTCAGCTATTCTCAGGTGTG

Product: peptidyl-prolyl cis-trans isomerase B

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 141; Mature: 141

Protein sequence:

>141_residues
MKSAVIETVKGDIELILFEEDAPNTVANFEKLSNSGFYDGLTFHRVIPDFVIQGGCPVGDGTGGPGYTIKCEINPNRHVK
GALSMAHAGRDTGGSQFFITLSPQPHLDGVHTVFGKVVRGMDVVESIERGDRMLRVRVYDE

Sequences:

>Translated_141_residues
MKSAVIETVKGDIELILFEEDAPNTVANFEKLSNSGFYDGLTFHRVIPDFVIQGGCPVGDGTGGPGYTIKCEINPNRHVK
GALSMAHAGRDTGGSQFFITLSPQPHLDGVHTVFGKVVRGMDVVESIERGDRMLRVRVYDE
>Mature_141_residues
MKSAVIETVKGDIELILFEEDAPNTVANFEKLSNSGFYDGLTFHRVIPDFVIQGGCPVGDGTGGPGYTIKCEINPNRHVK
GALSMAHAGRDTGGSQFFITLSPQPHLDGVHTVFGKVVRGMDVVESIERGDRMLRVRVYDE

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI7706339, Length=127, Percent_Identity=47.244094488189, Blast_Score=114, Evalue=2e-26,
Organism=Homo sapiens, GI24308049, Length=130, Percent_Identity=50, Blast_Score=112, Evalue=7e-26,
Organism=Homo sapiens, GI19557636, Length=132, Percent_Identity=42.4242424242424, Blast_Score=101, Evalue=2e-22,
Organism=Homo sapiens, GI4505991, Length=128, Percent_Identity=51.5625, Blast_Score=99, Evalue=1e-21,
Organism=Homo sapiens, GI4758950, Length=122, Percent_Identity=50, Blast_Score=95, Evalue=2e-20,
Organism=Homo sapiens, GI64276486, Length=120, Percent_Identity=41.6666666666667, Blast_Score=93, Evalue=7e-20,
Organism=Homo sapiens, GI6631100, Length=134, Percent_Identity=44.7761194029851, Blast_Score=92, Evalue=2e-19,
Organism=Homo sapiens, GI4826932, Length=152, Percent_Identity=41.4473684210526, Blast_Score=89, Evalue=1e-18,
Organism=Homo sapiens, GI10863927, Length=128, Percent_Identity=46.875, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI150418007, Length=127, Percent_Identity=48.0314960629921, Blast_Score=87, Evalue=3e-18,
Organism=Homo sapiens, GI42560244, Length=134, Percent_Identity=41.7910447761194, Blast_Score=87, Evalue=6e-18,
Organism=Homo sapiens, GI20911035, Length=138, Percent_Identity=38.4057971014493, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI22547212, Length=128, Percent_Identity=46.875, Blast_Score=85, Evalue=2e-17,
Organism=Homo sapiens, GI7657473, Length=128, Percent_Identity=46.875, Blast_Score=85, Evalue=2e-17,
Organism=Homo sapiens, GI22547215, Length=128, Percent_Identity=46.875, Blast_Score=85, Evalue=3e-17,
Organism=Homo sapiens, GI310127646, Length=127, Percent_Identity=42.5196850393701, Blast_Score=84, Evalue=5e-17,
Organism=Homo sapiens, GI310114371, Length=127, Percent_Identity=42.5196850393701, Blast_Score=84, Evalue=5e-17,
Organism=Homo sapiens, GI310119221, Length=127, Percent_Identity=42.5196850393701, Blast_Score=84, Evalue=5e-17,
Organism=Homo sapiens, GI5454154, Length=134, Percent_Identity=43.2835820895522, Blast_Score=83, Evalue=1e-16,
Organism=Homo sapiens, GI45439316, Length=127, Percent_Identity=41.7322834645669, Blast_Score=82, Evalue=1e-16,
Organism=Homo sapiens, GI303305009, Length=126, Percent_Identity=42.0634920634921, Blast_Score=81, Evalue=3e-16,
Organism=Homo sapiens, GI5174637, Length=126, Percent_Identity=42.0634920634921, Blast_Score=81, Evalue=3e-16,
Organism=Homo sapiens, GI5031987, Length=126, Percent_Identity=46.8253968253968, Blast_Score=80, Evalue=5e-16,
Organism=Homo sapiens, GI310129267, Length=131, Percent_Identity=41.2213740458015, Blast_Score=79, Evalue=9e-16,
Organism=Homo sapiens, GI310120620, Length=131, Percent_Identity=41.2213740458015, Blast_Score=79, Evalue=9e-16,
Organism=Homo sapiens, GI310110104, Length=131, Percent_Identity=41.2213740458015, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI256017253, Length=126, Percent_Identity=42.8571428571429, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI221139811, Length=126, Percent_Identity=42.8571428571429, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI256017251, Length=126, Percent_Identity=42.8571428571429, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI178057341, Length=126, Percent_Identity=42.0634920634921, Blast_Score=77, Evalue=7e-15,
Organism=Homo sapiens, GI169164185, Length=126, Percent_Identity=41.2698412698413, Blast_Score=76, Evalue=8e-15,
Organism=Homo sapiens, GI169163623, Length=126, Percent_Identity=41.2698412698413, Blast_Score=76, Evalue=8e-15,
Organism=Homo sapiens, GI209417936, Length=126, Percent_Identity=42.0634920634921, Blast_Score=76, Evalue=8e-15,
Organism=Homo sapiens, GI30102944, Length=126, Percent_Identity=42.0634920634921, Blast_Score=76, Evalue=8e-15,
Organism=Homo sapiens, GI219842199, Length=126, Percent_Identity=42.0634920634921, Blast_Score=76, Evalue=8e-15,
Organism=Homo sapiens, GI169163387, Length=126, Percent_Identity=41.2698412698413, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI310132444, Length=131, Percent_Identity=38.1679389312977, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI310113152, Length=131, Percent_Identity=38.1679389312977, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI169214050, Length=126, Percent_Identity=38.8888888888889, Blast_Score=66, Evalue=7e-12,
Organism=Homo sapiens, GI310127745, Length=118, Percent_Identity=38.135593220339, Blast_Score=66, Evalue=8e-12,
Organism=Homo sapiens, GI310119290, Length=118, Percent_Identity=38.135593220339, Blast_Score=66, Evalue=8e-12,
Organism=Homo sapiens, GI310114540, Length=118, Percent_Identity=38.135593220339, Blast_Score=66, Evalue=8e-12,
Organism=Homo sapiens, GI239751853, Length=126, Percent_Identity=38.8888888888889, Blast_Score=66, Evalue=9e-12,
Organism=Homo sapiens, GI113428306, Length=126, Percent_Identity=38.8888888888889, Blast_Score=66, Evalue=9e-12,
Organism=Homo sapiens, GI27735045, Length=128, Percent_Identity=32.8125, Blast_Score=63, Evalue=9e-11,
Organism=Escherichia coli, GI1789763, Length=133, Percent_Identity=42.8571428571429, Blast_Score=89, Evalue=1e-19,
Organism=Escherichia coli, GI1786736, Length=132, Percent_Identity=36.3636363636364, Blast_Score=65, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17539496, Length=132, Percent_Identity=47.7272727272727, Blast_Score=118, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17506311, Length=134, Percent_Identity=50, Blast_Score=109, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI71980590, Length=131, Percent_Identity=42.7480916030534, Blast_Score=100, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71980594, Length=131, Percent_Identity=42.7480916030534, Blast_Score=100, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17506307, Length=131, Percent_Identity=47.3282442748092, Blast_Score=99, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI71997782, Length=141, Percent_Identity=41.1347517730496, Blast_Score=97, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17552780, Length=128, Percent_Identity=49.21875, Blast_Score=95, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17532641, Length=124, Percent_Identity=39.5161290322581, Blast_Score=94, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17551284, Length=132, Percent_Identity=44.6969696969697, Blast_Score=86, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17551282, Length=132, Percent_Identity=44.6969696969697, Blast_Score=86, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17559074, Length=135, Percent_Identity=42.2222222222222, Blast_Score=86, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17552782, Length=133, Percent_Identity=41.3533834586466, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17552784, Length=141, Percent_Identity=40.4255319148936, Blast_Score=84, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17565860, Length=141, Percent_Identity=40.4255319148936, Blast_Score=84, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17566266, Length=135, Percent_Identity=41.4814814814815, Blast_Score=84, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17539498, Length=127, Percent_Identity=44.0944881889764, Blast_Score=83, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17532643, Length=132, Percent_Identity=43.1818181818182, Blast_Score=82, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI32563659, Length=138, Percent_Identity=33.3333333333333, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323562, Length=133, Percent_Identity=48.1203007518797, Blast_Score=100, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6321848, Length=134, Percent_Identity=47.0149253731343, Blast_Score=95, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6320359, Length=128, Percent_Identity=46.875, Blast_Score=93, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6320510, Length=128, Percent_Identity=48.4375, Blast_Score=89, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6323246, Length=137, Percent_Identity=43.7956204379562, Blast_Score=80, Evalue=8e-17,
Organism=Drosophila melanogaster, GI17986117, Length=128, Percent_Identity=50, Blast_Score=118, Evalue=1e-27,
Organism=Drosophila melanogaster, GI19922376, Length=128, Percent_Identity=43.75, Blast_Score=107, Evalue=2e-24,
Organism=Drosophila melanogaster, GI20130249, Length=135, Percent_Identity=46.6666666666667, Blast_Score=100, Evalue=5e-22,
Organism=Drosophila melanogaster, GI19922912, Length=131, Percent_Identity=48.8549618320611, Blast_Score=97, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24650807, Length=134, Percent_Identity=42.5373134328358, Blast_Score=94, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21357249, Length=118, Percent_Identity=39.8305084745763, Blast_Score=92, Evalue=9e-20,
Organism=Drosophila melanogaster, GI17647301, Length=127, Percent_Identity=41.7322834645669, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI45549139, Length=126, Percent_Identity=44.4444444444444, Blast_Score=82, Evalue=9e-17,
Organism=Drosophila melanogaster, GI17136360, Length=131, Percent_Identity=43.5114503816794, Blast_Score=82, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24652460, Length=132, Percent_Identity=35.6060606060606, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24664125, Length=126, Percent_Identity=43.6507936507937, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21357783, Length=126, Percent_Identity=43.6507936507937, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24586038, Length=138, Percent_Identity=41.304347826087, Blast_Score=80, Evalue=5e-16,
Organism=Drosophila melanogaster, GI21355677, Length=138, Percent_Identity=36.9565217391304, Blast_Score=73, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 15351; Mature: 15351

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSAVIETVKGDIELILFEEDAPNTVANFEKLSNSGFYDGLTFHRVIPDFVIQGGCPVGD
CCCHHHEECCCCEEEEEECCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHEECCCCCCC
GTGGPGYTIKCEINPNRHVKGALSMAHAGRDTGGSQFFITLSPQPHLDGVHTVFGKVVRG
CCCCCCEEEEEEECCCCCCHHHHHHHHCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHH
MDVVESIERGDRMLRVRVYDE
HHHHHHHHCCCEEEEEEEECC
>Mature Secondary Structure
MKSAVIETVKGDIELILFEEDAPNTVANFEKLSNSGFYDGLTFHRVIPDFVIQGGCPVGD
CCCHHHEECCCCEEEEEECCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHEECCCCCCC
GTGGPGYTIKCEINPNRHVKGALSMAHAGRDTGGSQFFITLSPQPHLDGVHTVFGKVVRG
CCCCCCEEEEEEECCCCCCHHHHHHHHCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHH
MDVVESIERGDRMLRVRVYDE
HHHHHHHHCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA