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Identifier: 15679298

GI number: 15679298

Start: 1175279

End: 1176178

Strand: Direct

Name: Not Available

Synonym: MTH1296

Alternate gene names: 15679298

Gene position: 1175279-1176178 (Clockwise)

Preceding gene: 15679295

Following gene: 15679303

Centisome position: 67.11

GC content: 51.56

Gene sequence:

>900_bases
GTGATAAAGATGATCGAATCATACTTGAAGGCGGGTAAAATTGTATCAAAGGTCAGAAGGGAAGCCGCGGGGATAATAAG
GGATGGCTTGCCCATAATAGAACTCGTAAATTACGTGGAGGATCGTATAATTGAGGAGGGTGGTAGGCCAGCTTTTCCAT
GTAACGTATCTGTGAATGAGGTAACGGCCCACTACACCTCCCCGCCAGGCGATGATAGTGTAATAGGTGATGGTGACCTT
GTTAAGCTGGACCTGGGCGCCCATGTGGATGGATTCATAGCCGACACCGCCATCACGGTGCCTGTGGGGGATGTTGATGA
TAAATGCCACCAGATGATGGACGCTGCAAGGGAGGCCCTTGAGAATGCCATTTCAACCATAAGGGCAGGTGTTGAGGTTG
GAGAAATTGGACGGGTAATCGAGGAAACCATTCACTCCCATGGCATGAACCCTGTTTCCAATCTGACCGGGCACAGCATG
GAGCGCTGGATACTGCACTCAGGACTATCAATACCCAATATAAATGAAAGGAACACTCATCAGCTGGAGGAGGGGGACGT
CCTGGCGATTGAACCCTTTGCCACGGATGGTGTGGGCCTTGTGACTGATATGCCTCAGACCTACATATTCCGGTTCCTCA
GGGAGAGGCCCCTCCGGCTTGTACATGCCAGGAGGGTCCTGGGTAAGATACGGGAGGAGTATCACGCCCTCCCCTTTGCA
CAGCGGTGGCTTGAAGAGTACTTCGATGCAAAGAGACTGAATGCCTCCATGAGAATGCTGATACAGTCAAGGGCCATATA
CCCCTACCATGTGCTGAGGGAAAAGAGCGGTGCAATGGTCGCCCAGTGGGAACATACAGTCATTGTTGAGGAGGACGGCT
GCACGGTTATAACAGAATAG

Upstream 100 bases:

>100_bases
CTGAGGTACCGTTGCCGTGGTCGCCATATACTGCCCCCTTGCATAGTATTATCTACTGTATATATAACTCCTTATTTAAA
TAAATAGCAGAACAGGATCA

Downstream 100 bases:

>100_bases
TTAACTTGAGGATGCAGTTGAATGGACTGAATGTTCTGAAAAATAGAAAATTTAGGGATGGGATCAGTATGGTGTTGGTA
ATCCCATCTCTTTCCTTGCA

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MIKMIESYLKAGKIVSKVRREAAGIIRDGLPIIELVNYVEDRIIEEGGRPAFPCNVSVNEVTAHYTSPPGDDSVIGDGDL
VKLDLGAHVDGFIADTAITVPVGDVDDKCHQMMDAAREALENAISTIRAGVEVGEIGRVIEETIHSHGMNPVSNLTGHSM
ERWILHSGLSIPNINERNTHQLEEGDVLAIEPFATDGVGLVTDMPQTYIFRFLRERPLRLVHARRVLGKIREEYHALPFA
QRWLEEYFDAKRLNASMRMLIQSRAIYPYHVLREKSGAMVAQWEHTVIVEEDGCTVITE

Sequences:

>Translated_299_residues
MIKMIESYLKAGKIVSKVRREAAGIIRDGLPIIELVNYVEDRIIEEGGRPAFPCNVSVNEVTAHYTSPPGDDSVIGDGDL
VKLDLGAHVDGFIADTAITVPVGDVDDKCHQMMDAAREALENAISTIRAGVEVGEIGRVIEETIHSHGMNPVSNLTGHSM
ERWILHSGLSIPNINERNTHQLEEGDVLAIEPFATDGVGLVTDMPQTYIFRFLRERPLRLVHARRVLGKIREEYHALPFA
QRWLEEYFDAKRLNASMRMLIQSRAIYPYHVLREKSGAMVAQWEHTVIVEEDGCTVITE
>Mature_299_residues
MIKMIESYLKAGKIVSKVRREAAGIIRDGLPIIELVNYVEDRIIEEGGRPAFPCNVSVNEVTAHYTSPPGDDSVIGDGDL
VKLDLGAHVDGFIADTAITVPVGDVDDKCHQMMDAAREALENAISTIRAGVEVGEIGRVIEETIHSHGMNPVSNLTGHSM
ERWILHSGLSIPNINERNTHQLEEGDVLAIEPFATDGVGLVTDMPQTYIFRFLRERPLRLVHARRVLGKIREEYHALPFA
QRWLEEYFDAKRLNASMRMLIQSRAIYPYHVLREKSGAMVAQWEHTVIVEEDGCTVITE

Specific function: Removes the amino-terminal methionine from nascent proteins

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family

Homologues:

Organism=Homo sapiens, GI5803092, Length=300, Percent_Identity=30.3333333333333, Blast_Score=143, Evalue=1e-34,
Organism=Homo sapiens, GI124494254, Length=263, Percent_Identity=27.3764258555133, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI164420681, Length=210, Percent_Identity=27.6190476190476, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI40385867, Length=151, Percent_Identity=30.4635761589404, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1786364, Length=204, Percent_Identity=26.9607843137255, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17544396, Length=304, Percent_Identity=31.5789473684211, Blast_Score=149, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17542840, Length=316, Percent_Identity=28.4810126582279, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71996291, Length=213, Percent_Identity=30.0469483568075, Blast_Score=78, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6319380, Length=315, Percent_Identity=26.984126984127, Blast_Score=117, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6323273, Length=205, Percent_Identity=28.2926829268293, Blast_Score=66, Evalue=7e-12,
Organism=Drosophila melanogaster, GI17137568, Length=298, Percent_Identity=29.8657718120805, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24658585, Length=320, Percent_Identity=25.9375, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI21355531, Length=213, Percent_Identity=29.1079812206573, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24583427, Length=207, Percent_Identity=24.6376811594203, Blast_Score=78, Evalue=8e-15,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): AMPM_METTH (O27355)

Other databases:

- EMBL:   AE000666
- PIR:   C69039
- RefSeq:   NP_276415.1
- ProteinModelPortal:   O27355
- SMR:   O27355
- STRING:   O27355
- MEROPS:   M24.002
- GeneID:   1471013
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH1296
- NMPDR:   fig|187420.1.peg.1270
- eggNOG:   arNOG05112
- HOGENOM:   HBG318153
- OMA:   IEPFATN
- PhylomeDB:   O27355
- ProtClustDB:   PRK08671
- BioCyc:   MTHE187420:MTH1296-MONOMER
- BRENDA:   3.4.11.18
- GO:   GO:0006508
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002468
- InterPro:   IPR018349
- InterPro:   IPR011991
- Gene3D:   G3DSA:3.90.230.10
- Gene3D:   G3DSA:1.10.10.10
- PANTHER:   PTHR10804
- PRINTS:   PR00599
- TIGRFAMs:   TIGR00501

Pfam domain/function: PF00557 Peptidase_M24; SSF55920 Peptidase_M24_cat_core

EC number: =3.4.11.18

Molecular weight: Translated: 33432; Mature: 33432

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS01202 MAP_2

Important sites: BINDING 64-64 BINDING 166-166

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKMIESYLKAGKIVSKVRREAAGIIRDGLPIIELVNYVEDRIIEEGGRPAFPCNVSVNE
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHH
VTAHYTSPPGDDSVIGDGDLVKLDLGAHVDGFIADTAITVPVGDVDDKCHQMMDAAREAL
EEEEECCCCCCCCEECCCCEEEEECCCCCCCEEECCEEEEECCCCCHHHHHHHHHHHHHH
ENAISTIRAGVEVGEIGRVIEETIHSHGMNPVSNLTGHSMERWILHSGLSIPNINERNTH
HHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHCCCCCCCCCCCCCC
QLEEGDVLAIEPFATDGVGLVTDMPQTYIFRFLRERPLRLVHARRVLGKIREEYHALPFA
CCCCCCEEEECCCCCCCCCHHHCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCHHH
QRWLEEYFDAKRLNASMRMLIQSRAIYPYHVLREKSGAMVAQWEHTVIVEEDGCTVITE
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCEEEEECEEEEEECCCCEEECC
>Mature Secondary Structure
MIKMIESYLKAGKIVSKVRREAAGIIRDGLPIIELVNYVEDRIIEEGGRPAFPCNVSVNE
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHH
VTAHYTSPPGDDSVIGDGDLVKLDLGAHVDGFIADTAITVPVGDVDDKCHQMMDAAREAL
EEEEECCCCCCCCEECCCCEEEEECCCCCCCEEECCEEEEECCCCCHHHHHHHHHHHHHH
ENAISTIRAGVEVGEIGRVIEETIHSHGMNPVSNLTGHSMERWILHSGLSIPNINERNTH
HHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHCCCCCCCCCCCCCC
QLEEGDVLAIEPFATDGVGLVTDMPQTYIFRFLRERPLRLVHARRVLGKIREEYHALPFA
CCCCCCEEEECCCCCCCCCHHHCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCHHH
QRWLEEYFDAKRLNASMRMLIQSRAIYPYHVLREKSGAMVAQWEHTVIVEEDGCTVITE
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCEEEEECEEEEEECCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463