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Identifier: 15679133

GI number: 15679133

Start: 1033266

End: 1034807

Strand: Direct

Name: Not Available

Synonym: MTH1122

Alternate gene names: 15679133

Gene position: 1033266-1034807 (Clockwise)

Preceding gene: 15679132

Following gene: 15679134

Centisome position: 59.0

GC content: 54.22

Gene sequence:

>1542_bases
ATGAAATTCAAACTCAAGGGAATAATAAAACTCAGCAAAGAGGTTCCTGGGATAGAGGATGACCTGGAAAAATTCTTCAC
TGAAGCCGAATCAGACATCCTGCGCAGGGGAGTCCCCGAGGGGCAGGAACATGAAGCAGCCCATATAAAATCCTGGAGAC
TTGAAGGCGACACACTCCACATTGAGATGGAGTCAGGGAGACGGGTCAGGGCCCATGATGGTCTTCTAAGGCTCAAGAAA
CCCCTTGGACAGTTACTCGGGCCAAAGTACAGGGTGGGTGTTAGGGGGATATCAGTCACCGATTACACCATGGAAATGAA
GGCCCCGGGTGTATCAGGTATCCCCAGCCTGGCTGAACTGCCCTTCGTGGAGGACGCCGCCATCACAGATGGCACCATAA
TGGTCAGATTCCAGCCCCTGGAGGAATCCGACCTGAGGAAACACGTGTTCGACCGTGTGGTGAAGCACGCCAGGACCCTT
GTTGAATCATCAGATGACCTGACGGTACAGGTCACAAGGGCAACGCCCGGTGAGATAATTGCCAGGAGCAGGAGCAGGGA
TTTTTTCTTTGAGGGTGACCCCACAGAGGAGGCTATGCGCCTTGGATGGGTCAAGAAGTTCCCTGGAAGGGGACAGTGGT
TCTACGGTCCAAAGATAACCGCCCTCCACCGGGCCCTGGAGGAGTTCTTCATTGAAAGGATTGTGAAACCCCTGGGATTT
GTTGAGTGCCTCTTCCCCAAACTCATACCCCTTGACATCATGAACAAGATGAGGTACCTTGAGGGCCTCCCTGAGGGGAT
GTACTACTGCAGCGCCCCGAGCAGGGACCCTGAGACCTTTGAGGAGTTCAAAAATGAGCTCATCATAAACCGGGAGGTTC
CCATGGATCTGCTTAAGAGGGGAATAAAGGATCCCGGTTACGTTATAGCCCCGGCCCAGTGCGAACCCTTCTACCAGTTC
CTCTCACACGAGGTTGTGAGTGCTGAGGACCTCCCAGTAAAGTTCTTTGACAGGAGCGGCTGGACCTACAGGTGGGAGGC
CGGAGGGTCCAAGGGCCTTGACAGGGTCCATGAATTCCAGAGGGTGGAACTCGTATGGCTGGCCGAACCAGGAGAGACAG
AGGAGATACGTGACCGGACAGTTGAACTCTCACATGATGCCGCCGATGAACTGGAACTTGAATGGTACACAGAGGTGGGT
GATGACCCCTTCTACCTGGAGGGCCGGAAGGTTGAGGAGAGGGGTATAGAGTTCCCTGATGTTCCAAAGTATGAGATGAG
GCTCTCACTCCCTGGAAGGGAGAAGGGGGTTGCAGTTGTATCAGCCAATGTCCATGGCACCCACTTCATCGAGGGCTTCT
CAATAAGGGAGGCCCGTAACCTGAACATCTGGACCGGCTGCACCGGCATAGGGCTCTCAAGGTGGATCTATGGTTTCCTG
GCCCAGAAGGGCTTTGAGACCGGGAACTGGCCAGACTTCATAGGAGAACGTGTTGAAGGAGTTGAGAACCCGAGAATCAT
AACCTGGCCGCGCCAGGACTGA

Upstream 100 bases:

>100_bases
TGACCTTATATTCTCTGAGATGGTGGTTGAGAAGATGATGAAACCATGTGATACTGACTGAATTATTGAAATTAGGTGTG
AATAAATAAACGGTGATCGG

Downstream 100 bases:

>100_bases
ATGGTGGTGATGCCTTGAACTGCGACAAACACCCTGAACGTGAGGGTGTGGCCTCATGCATAATATGCGGGAGGATACTC
TGCGAGGAGTGCCGGCTTAA

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 513; Mature: 513

Protein sequence:

>513_residues
MKFKLKGIIKLSKEVPGIEDDLEKFFTEAESDILRRGVPEGQEHEAAHIKSWRLEGDTLHIEMESGRRVRAHDGLLRLKK
PLGQLLGPKYRVGVRGISVTDYTMEMKAPGVSGIPSLAELPFVEDAAITDGTIMVRFQPLEESDLRKHVFDRVVKHARTL
VESSDDLTVQVTRATPGEIIARSRSRDFFFEGDPTEEAMRLGWVKKFPGRGQWFYGPKITALHRALEEFFIERIVKPLGF
VECLFPKLIPLDIMNKMRYLEGLPEGMYYCSAPSRDPETFEEFKNELIINREVPMDLLKRGIKDPGYVIAPAQCEPFYQF
LSHEVVSAEDLPVKFFDRSGWTYRWEAGGSKGLDRVHEFQRVELVWLAEPGETEEIRDRTVELSHDAADELELEWYTEVG
DDPFYLEGRKVEERGIEFPDVPKYEMRLSLPGREKGVAVVSANVHGTHFIEGFSIREARNLNIWTGCTGIGLSRWIYGFL
AQKGFETGNWPDFIGERVEGVENPRIITWPRQD

Sequences:

>Translated_513_residues
MKFKLKGIIKLSKEVPGIEDDLEKFFTEAESDILRRGVPEGQEHEAAHIKSWRLEGDTLHIEMESGRRVRAHDGLLRLKK
PLGQLLGPKYRVGVRGISVTDYTMEMKAPGVSGIPSLAELPFVEDAAITDGTIMVRFQPLEESDLRKHVFDRVVKHARTL
VESSDDLTVQVTRATPGEIIARSRSRDFFFEGDPTEEAMRLGWVKKFPGRGQWFYGPKITALHRALEEFFIERIVKPLGF
VECLFPKLIPLDIMNKMRYLEGLPEGMYYCSAPSRDPETFEEFKNELIINREVPMDLLKRGIKDPGYVIAPAQCEPFYQF
LSHEVVSAEDLPVKFFDRSGWTYRWEAGGSKGLDRVHEFQRVELVWLAEPGETEEIRDRTVELSHDAADELELEWYTEVG
DDPFYLEGRKVEERGIEFPDVPKYEMRLSLPGREKGVAVVSANVHGTHFIEGFSIREARNLNIWTGCTGIGLSRWIYGFL
AQKGFETGNWPDFIGERVEGVENPRIITWPRQD
>Mature_513_residues
MKFKLKGIIKLSKEVPGIEDDLEKFFTEAESDILRRGVPEGQEHEAAHIKSWRLEGDTLHIEMESGRRVRAHDGLLRLKK
PLGQLLGPKYRVGVRGISVTDYTMEMKAPGVSGIPSLAELPFVEDAAITDGTIMVRFQPLEESDLRKHVFDRVVKHARTL
VESSDDLTVQVTRATPGEIIARSRSRDFFFEGDPTEEAMRLGWVKKFPGRGQWFYGPKITALHRALEEFFIERIVKPLGF
VECLFPKLIPLDIMNKMRYLEGLPEGMYYCSAPSRDPETFEEFKNELIINREVPMDLLKRGIKDPGYVIAPAQCEPFYQF
LSHEVVSAEDLPVKFFDRSGWTYRWEAGGSKGLDRVHEFQRVELVWLAEPGETEEIRDRTVELSHDAADELELEWYTEVG
DDPFYLEGRKVEERGIEFPDVPKYEMRLSLPGREKGVAVVSANVHGTHFIEGFSIREARNLNIWTGCTGIGLSRWIYGFL
AQKGFETGNWPDFIGERVEGVENPRIITWPRQD

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-2 seryl-tRNA synthetase subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS2_METTH (O27194)

Other databases:

- EMBL:   AF009823
- EMBL:   AE000666
- PIR:   D69016
- RefSeq:   NP_276250.1
- ProteinModelPortal:   O27194
- SMR:   O27194
- STRING:   O27194
- GeneID:   1471530
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH1122
- NMPDR:   fig|187420.1.peg.1105
- eggNOG:   arNOG04799
- HOGENOM:   HBG542255
- OMA:   PAQCEPF
- ProtClustDB:   PRK00960
- BioCyc:   MTHE187420:MTH1122-MONOMER
- BRENDA:   6.1.1.11
- GO:   GO:0005737
- HAMAP:   MF_01278
- InterPro:   IPR002314
- InterPro:   IPR002317
- InterPro:   IPR004503
- PANTHER:   PTHR11778
- TIGRFAMs:   TIGR00415

Pfam domain/function: PF00587 tRNA-synt_2b

EC number: =6.1.1.11

Molecular weight: Translated: 58809; Mature: 58809

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 312-312 BINDING 344-344 BINDING 474-474

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFKLKGIIKLSKEVPGIEDDLEKFFTEAESDILRRGVPEGQEHEAAHIKSWRLEGDTLH
CCEEECHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHEEEECCCEEE
IEMESGRRVRAHDGLLRLKKPLGQLLGPKYRVGVRGISVTDYTMEMKAPGVSGIPSLAEL
EEECCCCEEEHHCCHHHHHHHHHHHCCCCEEEEEEEEEEEEEEEEECCCCCCCCCCHHHC
PFVEDAAITDGTIMVRFQPLEESDLRKHVFDRVVKHARTLVESSDDLTVQVTRATPGEII
CCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHH
ARSRSRDFFFEGDPTEEAMRLGWVKKFPGRGQWFYGPKITALHRALEEFFIERIVKPLGF
HHCCCCCEEECCCCHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHH
VECLFPKLIPLDIMNKMRYLEGLPEGMYYCSAPSRDPETFEEFKNELIINREVPMDLLKR
HHHHHHHHCCHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHEEECCCCCHHHHHH
GIKDPGYVIAPAQCEPFYQFLSHEVVSAEDLPVKFFDRSGWTYRWEAGGSKGLDRVHEFQ
CCCCCCEEEECCCCCHHHHHHHHHHCCCCCCCEEEEECCCCEEEECCCCCCCHHHHHHHC
RVELVWLAEPGETEEIRDRTVELSHDAADELELEWYTEVGDDPFYLEGRKVEERGIEFPD
EEEEEEEECCCCCHHHHHHEEEECCCCCCCCEEEEEECCCCCCEEECCCCHHHCCCCCCC
VPKYEMRLSLPGREKGVAVVSANVHGTHFIEGFSIREARNLNIWTGCTGIGLSRWIYGFL
CCCEEEEEECCCCCCCEEEEEECCCCEEEEECCEECCCCCCEEEECCCCCHHHHHHHHHH
AQKGFETGNWPDFIGERVEGVENPRIITWPRQD
HHHCCCCCCCHHHHHHHHHCCCCCEEEECCCCC
>Mature Secondary Structure
MKFKLKGIIKLSKEVPGIEDDLEKFFTEAESDILRRGVPEGQEHEAAHIKSWRLEGDTLH
CCEEECHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHEEEECCCEEE
IEMESGRRVRAHDGLLRLKKPLGQLLGPKYRVGVRGISVTDYTMEMKAPGVSGIPSLAEL
EEECCCCEEEHHCCHHHHHHHHHHHCCCCEEEEEEEEEEEEEEEEECCCCCCCCCCHHHC
PFVEDAAITDGTIMVRFQPLEESDLRKHVFDRVVKHARTLVESSDDLTVQVTRATPGEII
CCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHH
ARSRSRDFFFEGDPTEEAMRLGWVKKFPGRGQWFYGPKITALHRALEEFFIERIVKPLGF
HHCCCCCEEECCCCHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHH
VECLFPKLIPLDIMNKMRYLEGLPEGMYYCSAPSRDPETFEEFKNELIINREVPMDLLKR
HHHHHHHHCCHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHEEECCCCCHHHHHH
GIKDPGYVIAPAQCEPFYQFLSHEVVSAEDLPVKFFDRSGWTYRWEAGGSKGLDRVHEFQ
CCCCCCEEEECCCCCHHHHHHHHHHCCCCCCCEEEEECCCCEEEECCCCCCCHHHHHHHC
RVELVWLAEPGETEEIRDRTVELSHDAADELELEWYTEVGDDPFYLEGRKVEERGIEFPD
EEEEEEEECCCCCHHHHHHEEEECCCCCCCCEEEEEECCCCCCEEECCCCHHHCCCCCCC
VPKYEMRLSLPGREKGVAVVSANVHGTHFIEGFSIREARNLNIWTGCTGIGLSRWIYGFL
CCCEEEEEECCCCCCCEEEEEECCCCEEEEECCEECCCCCCEEEECCCCCHHHHHHHHHH
AQKGFETGNWPDFIGERVEGVENPRIITWPRQD
HHHCCCCCCCHHHHHHHHHCCCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9851985; 9371463