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Identifier: 15679118

GI number: 15679118

Start: 1020208

End: 1021914

Strand: Direct

Name: Not Available

Synonym: MTH1107

Alternate gene names: 15679118

Gene position: 1020208-1021914 (Clockwise)

Preceding gene: 15679116

Following gene: 15679122

Centisome position: 58.25

GC content: 54.48

Gene sequence:

>1707_bases
ATGAAAGGGATAAAGGTCGTTGAAACAGCATTCAGGGATGCGCACCAGTCACTTCTTGCAACACGCCTCCGTACCCGTGA
CATGACACCCATCGCAGAGGAAATGGACCGGGTGGGTTTCTTCTCACTGGAGGCATGGGGCGGTGCAACCTTCGATACCT
GCATACGCTACCTGAATGAGGATCCATGGGAGAGGCTACGGGAACTTAAGGAACACGTGAAAAGGACGCCGATACAGATG
CTCCTCAGGGGCCAGAACCTTGTGGGGTACAAGCACTACCCCGATGACATAGTGAGGAAGTTCATTGAGAAGTCCTATGA
AAACGGCGTTGATGTCTTCAGGATATTCGACGCCCTCAATGACATAAGGAACATGGAGTACGCCATAAAGGTCGCCAGGG
AACAGGAAGCCCATGTGCAGGGAGTCATCTGCTACACCATCAGCCCTTATCACACCCTTGAGAGTTATGTGGACTTTGCA
AGGGAACTGGAGGCCCTTGAATGTGACTCCGTTGCAATAAAGGACATGGCAGGCCTAATATCTCCACATGATGCCTACGA
ACTCGTGAGGGCCCTCAAGGAAGAGACCGACCTCATGGTGAACCTTCACTGCCACTGCACAAGTGGAATGACACCCATGA
GCTACTATGCCGCCTGTGAGGCCGGCGTTGATATACTTGATACCGCCATATCACCCCTATCCTGGGGTGCCTCCCAGCCA
CCCACAGAGAGCATTGTGGCTGCACTCCGGGACACACCCTACGACACGGGCCTTGACCTTGAGATCCTGAAGAACATCAA
GAAGTACTTCGAGGAGATCCGGAAGAAGTACAGCAGCATCCTCGACCCCATAGCCGAGCAGATCGACACAGACGTCCTCA
TATACCAGATACCCGGGGGTATGCTGTCAAACCTTGTTGCGCAGCTCAAGGAGCAGAACGCCCTGGACCGCTATGAGGAG
GTCCTCGAGGAGATGCCCCGGGTGAGGAAGGATATGGGTTACCCTCCCCTTGTAACCCCAACCAGTCAGATAGTCGGTAT
ACAGGCCGTTATGAACGTCCTGAGCGGTGAGAGGTACAGCATGGTCACCAATGAGGTGAAGGACTACTTCCGGGGACTCT
ACGGCAGACCCCCTGCCCCATTAAATGAGGAGGTCGCAAGGAAGGTCATCGGAGATGAGAAACCCATCGACTGCAGACCA
GCGGACATCCTCAAACCCCAGTATGATGAGTGCAGGAGGAAGGGTGAGGAGATGGGCATAATAGAGAAGGAGGAGGACAT
ACTGACCCTCGCCCTCTACCCTGCCATTGCACCTAAATTCCTGAGGGGTGAAATCGAGGAGGAGCCCCTGGAGCCCCCGG
CAGAGGAGATGGCCCCGACAGGTGAGGTGCCAACCGTCTTCCACGTGGAGGTCGATGGTGACGAGTTCGAGGTCAAGGTG
GTCCCCACAGGCTACATGACCATCGAGGAAGCTGAACCCGAACCGGTGGATGTTGAGGGTGCAGTTAAGTCCACCATGCA
GGGCATGGTTGTGAAGCTCAAGGTCAGTGAGGGCGACCAGGTGAATGCCGGGGACGTTGTCGCGGTTGTTGAAGCCATGA
AGATGGAGAACGATATCCAGACACCCCACGGTGGTGTTGTTGAGAAGATATACACCGCTGAGGGTGAAAAGGTTGAGACC
GGCGACATAATCATGGTCATAAAATAA

Upstream 100 bases:

>100_bases
TGTAGTACAGAGTTCTGATGAATTAATACATCTGCTGTGTATTTAAGGAAGTTCCTACTATGTATATAAAGAATCTAATT
GATCTCATGAGAGGGTCACG

Downstream 100 bases:

>100_bases
AAACCTTCTTTTATATTCTGCCTCTAGTCCGGGACCGTTAAATATATGATTCAGGCCTCAACCATTCCTCTGAAAGAAGC
CTGTTTTCATTATTTTTTTC

Product: pyruvate carboxylase subunit B

Products: NA

Alternate protein names: Pyruvic carboxylase B

Number of amino acids: Translated: 568; Mature: 568

Protein sequence:

>568_residues
MKGIKVVETAFRDAHQSLLATRLRTRDMTPIAEEMDRVGFFSLEAWGGATFDTCIRYLNEDPWERLRELKEHVKRTPIQM
LLRGQNLVGYKHYPDDIVRKFIEKSYENGVDVFRIFDALNDIRNMEYAIKVAREQEAHVQGVICYTISPYHTLESYVDFA
RELEALECDSVAIKDMAGLISPHDAYELVRALKEETDLMVNLHCHCTSGMTPMSYYAACEAGVDILDTAISPLSWGASQP
PTESIVAALRDTPYDTGLDLEILKNIKKYFEEIRKKYSSILDPIAEQIDTDVLIYQIPGGMLSNLVAQLKEQNALDRYEE
VLEEMPRVRKDMGYPPLVTPTSQIVGIQAVMNVLSGERYSMVTNEVKDYFRGLYGRPPAPLNEEVARKVIGDEKPIDCRP
ADILKPQYDECRRKGEEMGIIEKEEDILTLALYPAIAPKFLRGEIEEEPLEPPAEEMAPTGEVPTVFHVEVDGDEFEVKV
VPTGYMTIEEAEPEPVDVEGAVKSTMQGMVVKLKVSEGDQVNAGDVVAVVEAMKMENDIQTPHGGVVEKIYTAEGEKVET
GDIIMVIK

Sequences:

>Translated_568_residues
MKGIKVVETAFRDAHQSLLATRLRTRDMTPIAEEMDRVGFFSLEAWGGATFDTCIRYLNEDPWERLRELKEHVKRTPIQM
LLRGQNLVGYKHYPDDIVRKFIEKSYENGVDVFRIFDALNDIRNMEYAIKVAREQEAHVQGVICYTISPYHTLESYVDFA
RELEALECDSVAIKDMAGLISPHDAYELVRALKEETDLMVNLHCHCTSGMTPMSYYAACEAGVDILDTAISPLSWGASQP
PTESIVAALRDTPYDTGLDLEILKNIKKYFEEIRKKYSSILDPIAEQIDTDVLIYQIPGGMLSNLVAQLKEQNALDRYEE
VLEEMPRVRKDMGYPPLVTPTSQIVGIQAVMNVLSGERYSMVTNEVKDYFRGLYGRPPAPLNEEVARKVIGDEKPIDCRP
ADILKPQYDECRRKGEEMGIIEKEEDILTLALYPAIAPKFLRGEIEEEPLEPPAEEMAPTGEVPTVFHVEVDGDEFEVKV
VPTGYMTIEEAEPEPVDVEGAVKSTMQGMVVKLKVSEGDQVNAGDVVAVVEAMKMENDIQTPHGGVVEKIYTAEGEKVET
GDIIMVIK
>Mature_568_residues
MKGIKVVETAFRDAHQSLLATRLRTRDMTPIAEEMDRVGFFSLEAWGGATFDTCIRYLNEDPWERLRELKEHVKRTPIQM
LLRGQNLVGYKHYPDDIVRKFIEKSYENGVDVFRIFDALNDIRNMEYAIKVAREQEAHVQGVICYTISPYHTLESYVDFA
RELEALECDSVAIKDMAGLISPHDAYELVRALKEETDLMVNLHCHCTSGMTPMSYYAACEAGVDILDTAISPLSWGASQP
PTESIVAALRDTPYDTGLDLEILKNIKKYFEEIRKKYSSILDPIAEQIDTDVLIYQIPGGMLSNLVAQLKEQNALDRYEE
VLEEMPRVRKDMGYPPLVTPTSQIVGIQAVMNVLSGERYSMVTNEVKDYFRGLYGRPPAPLNEEVARKVIGDEKPIDCRP
ADILKPQYDECRRKGEEMGIIEKEEDILTLALYPAIAPKFLRGEIEEEPLEPPAEEMAPTGEVPTVFHVEVDGDEFEVKV
VPTGYMTIEEAEPEPVDVEGAVKSTMQGMVVKLKVSEGDQVNAGDVVAVVEAMKMENDIQTPHGGVVEKIYTAEGEKVET
GDIIMVIK

Specific function: Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second

COG id: COG5016

COG function: function code C; Pyruvate/oxaloacetate carboxyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain

Homologues:

Organism=Homo sapiens, GI106049528, Length=621, Percent_Identity=33.0112721417069, Blast_Score=290, Evalue=3e-78,
Organism=Homo sapiens, GI106049295, Length=621, Percent_Identity=33.0112721417069, Blast_Score=290, Evalue=3e-78,
Organism=Homo sapiens, GI106049292, Length=621, Percent_Identity=33.0112721417069, Blast_Score=290, Evalue=3e-78,
Organism=Caenorhabditis elegans, GI17562816, Length=614, Percent_Identity=32.4104234527687, Blast_Score=298, Evalue=7e-81,
Organism=Saccharomyces cerevisiae, GI6319695, Length=623, Percent_Identity=31.7817014446228, Blast_Score=295, Evalue=2e-80,
Organism=Saccharomyces cerevisiae, GI6321376, Length=621, Percent_Identity=31.4009661835749, Blast_Score=291, Evalue=2e-79,
Organism=Drosophila melanogaster, GI281363050, Length=620, Percent_Identity=33.0645161290323, Blast_Score=301, Evalue=7e-82,
Organism=Drosophila melanogaster, GI24652224, Length=620, Percent_Identity=33.0645161290323, Blast_Score=301, Evalue=7e-82,
Organism=Drosophila melanogaster, GI24652222, Length=620, Percent_Identity=33.0645161290323, Blast_Score=301, Evalue=7e-82,
Organism=Drosophila melanogaster, GI24652220, Length=620, Percent_Identity=33.0645161290323, Blast_Score=301, Evalue=7e-82,
Organism=Drosophila melanogaster, GI24652218, Length=620, Percent_Identity=33.0645161290323, Blast_Score=301, Evalue=7e-82,
Organism=Drosophila melanogaster, GI24652212, Length=620, Percent_Identity=32.9032258064516, Blast_Score=301, Evalue=7e-82,
Organism=Drosophila melanogaster, GI24652210, Length=620, Percent_Identity=32.9032258064516, Blast_Score=301, Evalue=7e-82,
Organism=Drosophila melanogaster, GI24652214, Length=620, Percent_Identity=32.9032258064516, Blast_Score=301, Evalue=7e-82,
Organism=Drosophila melanogaster, GI19921944, Length=620, Percent_Identity=32.9032258064516, Blast_Score=301, Evalue=7e-82,
Organism=Drosophila melanogaster, GI24652216, Length=620, Percent_Identity=32.9032258064516, Blast_Score=301, Evalue=7e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYCB_METTH (O27179)

Other databases:

- EMBL:   AE000666
- EMBL:   AF039105
- PIR:   C69014
- RefSeq:   NP_276235.1
- ProteinModelPortal:   O27179
- SMR:   O27179
- STRING:   O27179
- GeneID:   1471515
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH1107
- NMPDR:   fig|187420.1.peg.1090
- eggNOG:   arNOG04796
- HOGENOM:   HBG717218
- OMA:   RDNNILD
- PhylomeDB:   O27179
- ProtClustDB:   PRK09282
- BioCyc:   MetaCyc:MONOMER-14538
- BioCyc:   MTHE187420:MTH1107-MONOMER
- BRENDA:   6.4.1.1
- GO:   GO:0006094
- InterPro:   IPR013785
- InterPro:   IPR000089
- InterPro:   IPR003379
- InterPro:   IPR005776
- InterPro:   IPR000891
- InterPro:   IPR011053
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR01108

Pfam domain/function: PF00364 Biotin_lipoyl; PF00682 HMGL-like; PF02436 PYC_OADA; SSF51230 Hybrid_motif

EC number: =6.4.1.1

Molecular weight: Translated: 63956; Mature: 63956

Theoretical pI: Translated: 4.38; Mature: 4.38

Prosite motif: PS00188 BIOTIN; PS50968 BIOTINYL_LIPOYL; PS50991 PYR_CT

Important sites: BINDING 83-83 BINDING 339-339

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGIKVVETAFRDAHQSLLATRLRTRDMTPIAEEMDRVGFFSLEAWGGATFDTCIRYLNE
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCEEEEECCCCCCHHHHHHHHCC
DPWERLRELKEHVKRTPIQMLLRGQNLVGYKHYPDDIVRKFIEKSYENGVDVFRIFDALN
CHHHHHHHHHHHHHHCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHH
DIRNMEYAIKVAREQEAHVQGVICYTISPYHTLESYVDFARELEALECDSVAIKDMAGLI
HHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHC
SPHDAYELVRALKEETDLMVNLHCHCTSGMTPMSYYAACEAGVDILDTAISPLSWGASQP
CCHHHHHHHHHHHHCCCEEEEEEEEECCCCCHHHHHHHHHHCHHHHHHHCCCCCCCCCCC
PTESIVAALRDTPYDTGLDLEILKNIKKYFEEIRKKYSSILDPIAEQIDTDVLIYQIPGG
CHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCH
MLSNLVAQLKEQNALDRYEEVLEEMPRVRKDMGYPPLVTPTSQIVGIQAVMNVLSGERYS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCHHH
MVTNEVKDYFRGLYGRPPAPLNEEVARKVIGDEKPIDCRPADILKPQYDECRRKGEEMGI
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCHHCCCCCHHHHHHCCCCCCC
IEKEEDILTLALYPAIAPKFLRGEIEEEPLEPPAEEMAPTGEVPTVFHVEVDGDEFEVKV
EECCCCEEEEEHHHHHCHHHHHCCCCCCCCCCCHHHCCCCCCCCEEEEEEECCCEEEEEE
VPTGYMTIEEAEPEPVDVEGAVKSTMQGMVVKLKVSEGDQVNAGDVVAVVEAMKMENDIQ
EECCCEEEECCCCCCCCCHHHHHHHHCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCC
TPHGGVVEKIYTAEGEKVETGDIIMVIK
CCCCCHHHHHHCCCCCEEECCCEEEEEC
>Mature Secondary Structure
MKGIKVVETAFRDAHQSLLATRLRTRDMTPIAEEMDRVGFFSLEAWGGATFDTCIRYLNE
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCEEEEECCCCCCHHHHHHHHCC
DPWERLRELKEHVKRTPIQMLLRGQNLVGYKHYPDDIVRKFIEKSYENGVDVFRIFDALN
CHHHHHHHHHHHHHHCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHH
DIRNMEYAIKVAREQEAHVQGVICYTISPYHTLESYVDFARELEALECDSVAIKDMAGLI
HHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHC
SPHDAYELVRALKEETDLMVNLHCHCTSGMTPMSYYAACEAGVDILDTAISPLSWGASQP
CCHHHHHHHHHHHHCCCEEEEEEEEECCCCCHHHHHHHHHHCHHHHHHHCCCCCCCCCCC
PTESIVAALRDTPYDTGLDLEILKNIKKYFEEIRKKYSSILDPIAEQIDTDVLIYQIPGG
CHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCH
MLSNLVAQLKEQNALDRYEEVLEEMPRVRKDMGYPPLVTPTSQIVGIQAVMNVLSGERYS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCHHH
MVTNEVKDYFRGLYGRPPAPLNEEVARKVIGDEKPIDCRPADILKPQYDECRRKGEEMGI
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCHHCCCCCHHHHHHCCCCCCC
IEKEEDILTLALYPAIAPKFLRGEIEEEPLEPPAEEMAPTGEVPTVFHVEVDGDEFEVKV
EECCCCEEEEEHHHHHCHHHHHCCCCCCCCCCCHHHCCCCCCCCEEEEEEECCCEEEEEE
VPTGYMTIEEAEPEPVDVEGAVKSTMQGMVVKLKVSEGDQVNAGDVVAVVEAMKMENDIQ
EECCCEEEECCCCCCCCCHHHHHHHHCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCC
TPHGGVVEKIYTAEGEKVETGDIIMVIK
CCCCCHHHHHHCCCCCEEECCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463; 9478969