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Identifier: 15679084

GI number: 15679084

Start: 976864

End: 977832

Strand: Direct

Name: Not Available

Synonym: MTH1073

Alternate gene names: 15679084

Gene position: 976864-977832 (Clockwise)

Preceding gene: 15679077

Following gene: 15679086

Centisome position: 55.78

GC content: 49.85

Gene sequence:

>969_bases
ATGTTTTATGGGGAGAGAAGTTTAAACATGTCAGTTATCATCCTCCTCTTCCTCTTCACTGTCTCACTGATTGGCGTTAT
AAAGTCGGCCGATATATTCGTGGATCGGATCGTTGATATAGGTAGGGCCCTGGGGATATCCCAGATAATACTGGGGGTGA
CAGTCGCCGCTGCAGGGACCTCCCTTCCTGAATTTGGATCCGCACTGATATCCGTCCTCACAGGAAACCCTGATCTCGGT
GTGGGTGTTGTTATAGGATCAAATATATGGAACATAGCCGGCATCATAGGCATATCAGCCATCCTTTCATGTGCGGTTAC
AACAAACCGGGATGAGATCCGGAGGGATGGTCTTTTCGGGCTTCTGAGCATACTCATCCTCACATTCTTCATGCTCATGG
GACCGGTTGGCCCCCTGACTGGTGTCGTGCTCCTTGCACTCTACGGTGTTTACCTCTGGGTCCTCATAAAAAAACAGAGG
GGCTACTATACCAGCCACCTCATGGATCATGGCGAGGTTGATGCGAAAACCATAATATCCGCCATCCTGGGATTCACTGG
TCTTGTGGTGTTCTGCAGAATACTCGTATACAGTGCCGTTGGGATCGCTGAGATCATGAATGTTCCTGAGATGATAATCG
GTCTTTTTGCCCTCGCAATAGGCACAAGCCTCGCTGAACTGGTCGTTGCTGTTAACTCTGCAATGAAGCGTATGTGCAGC
CTGTCCCTTGGAACCGTCCTGGGGAGCAACATATTCAACATCCTGATAGGCATCGGGGTTCCATCACTCTTTGTTAGGAT
CCCTGTTGAGCCCCTATCCCTCATTCTTGACGCTCCAGTGCTCATGGGGGTGACAGTGGCCGTCATGTACTTCATGTGGA
CTGATATGGAGCTCAGGAGGGTTGAGGGGGTTGCACTGGTGGCATTTTACCTGGCATACGCTGTAATTAGAATAACACTT
ACACGGTAG

Upstream 100 bases:

>100_bases
CCTTGAAACCAGTTCCCTTGAAAGATTCTTCATAAGACCACCATTACACTTAAAGATCTATTTATCACGATCATATATAT
ATGGAGGAGGCCAAAGGATT

Downstream 100 bases:

>100_bases
GTTTAATGCGTTTTTTAAGATGCACTTAGAATAGCACTTACACAGTATATTGACATCAGTTGCACTGAAAAAACTAAAAA
AACCGCTCAATATACCAAAA

Product: cation antiporter

Products: Na (I) [Cytoplasm]; Ca (II) [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 322; Mature: 322

Protein sequence:

>322_residues
MFYGERSLNMSVIILLFLFTVSLIGVIKSADIFVDRIVDIGRALGISQIILGVTVAAAGTSLPEFGSALISVLTGNPDLG
VGVVIGSNIWNIAGIIGISAILSCAVTTNRDEIRRDGLFGLLSILILTFFMLMGPVGPLTGVVLLALYGVYLWVLIKKQR
GYYTSHLMDHGEVDAKTIISAILGFTGLVVFCRILVYSAVGIAEIMNVPEMIIGLFALAIGTSLAELVVAVNSAMKRMCS
LSLGTVLGSNIFNILIGIGVPSLFVRIPVEPLSLILDAPVLMGVTVAVMYFMWTDMELRRVEGVALVAFYLAYAVIRITL
TR

Sequences:

>Translated_322_residues
MFYGERSLNMSVIILLFLFTVSLIGVIKSADIFVDRIVDIGRALGISQIILGVTVAAAGTSLPEFGSALISVLTGNPDLG
VGVVIGSNIWNIAGIIGISAILSCAVTTNRDEIRRDGLFGLLSILILTFFMLMGPVGPLTGVVLLALYGVYLWVLIKKQR
GYYTSHLMDHGEVDAKTIISAILGFTGLVVFCRILVYSAVGIAEIMNVPEMIIGLFALAIGTSLAELVVAVNSAMKRMCS
LSLGTVLGSNIFNILIGIGVPSLFVRIPVEPLSLILDAPVLMGVTVAVMYFMWTDMELRRVEGVALVAFYLAYAVIRITL
TR
>Mature_322_residues
MFYGERSLNMSVIILLFLFTVSLIGVIKSADIFVDRIVDIGRALGISQIILGVTVAAAGTSLPEFGSALISVLTGNPDLG
VGVVIGSNIWNIAGIIGISAILSCAVTTNRDEIRRDGLFGLLSILILTFFMLMGPVGPLTGVVLLALYGVYLWVLIKKQR
GYYTSHLMDHGEVDAKTIISAILGFTGLVVFCRILVYSAVGIAEIMNVPEMIIGLFALAIGTSLAELVVAVNSAMKRMCS
LSLGTVLGSNIFNILIGIGVPSLFVRIPVEPLSLILDAPVLMGVTVAVMYFMWTDMELRRVEGVALVAFYLAYAVIRITL
TR

Specific function: Unknown

COG id: COG0530

COG function: function code P; Ca2+/Na+ antiporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium/potassium/calcium exchanger family [H]

Homologues:

Organism=Escherichia coli, GI1789587, Length=275, Percent_Identity=30.5454545454545, Blast_Score=76, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004481
- InterPro:   IPR004837 [H]

Pfam domain/function: PF01699 Na_Ca_ex [H]

EC number: NA

Molecular weight: Translated: 34479; Mature: 34479

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFYGERSLNMSVIILLFLFTVSLIGVIKSADIFVDRIVDIGRALGISQIILGVTVAAAGT
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SLPEFGSALISVLTGNPDLGVGVVIGSNIWNIAGIIGISAILSCAVTTNRDEIRRDGLFG
CCHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
LLSILILTFFMLMGPVGPLTGVVLLALYGVYLWVLIKKQRGYYTSHLMDHGEVDAKTIIS
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCHHHHHH
AILGFTGLVVFCRILVYSAVGIAEIMNVPEMIIGLFALAIGTSLAELVVAVNSAMKRMCS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSLGTVLGSNIFNILIGIGVPSLFVRIPVEPLSLILDAPVLMGVTVAVMYFMWTDMELRR
HHHHHHHHHHHHHHHHHCCHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
VEGVALVAFYLAYAVIRITLTR
HHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFYGERSLNMSVIILLFLFTVSLIGVIKSADIFVDRIVDIGRALGISQIILGVTVAAAGT
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SLPEFGSALISVLTGNPDLGVGVVIGSNIWNIAGIIGISAILSCAVTTNRDEIRRDGLFG
CCHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
LLSILILTFFMLMGPVGPLTGVVLLALYGVYLWVLIKKQRGYYTSHLMDHGEVDAKTIIS
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCHHHHHH
AILGFTGLVVFCRILVYSAVGIAEIMNVPEMIIGLFALAIGTSLAELVVAVNSAMKRMCS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSLGTVLGSNIFNILIGIGVPSLFVRIPVEPLSLILDAPVLMGVTVAVMYFMWTDMELRR
HHHHHHHHHHHHHHHHHCCHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
VEGVALVAFYLAYAVIRITLTR
HHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; Ca (II) [Cytoplasm] [C]

Specific reaction: Na (I) [Periplasm] + Ca (II) [Cytoplasm] = Na (I) [Cytoplasm] + Ca (II) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]