| Definition | Methanothermobacter thermautotrophicus str. Delta H chromosome, complete genome. |
|---|---|
| Accession | NC_000916 |
| Length | 1,751,377 |
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Identifier: 15679071
GI number: 15679071
Start: 966311
End: 967552
Strand: Direct
Name: Not Available
Synonym: MTH1058
Alternate gene names: 15679071
Gene position: 966311-967552 (Clockwise)
Preceding gene: 15679070
Following gene: 15679072
Centisome position: 55.17
GC content: 50.24
Gene sequence:
>1242_bases ATGGCTAAAGAAAAAGAACACATGAACCTGGCGTTTATTGGACACGTAGACCACGGAAAATCCACACTAGTGGGACACCT GCTCCTGCAGGCCGGAGCAATCGCCGAGCAGCAGTTAGCTGAAGGTGAGGACAAGTTCAGGTTTGTCATGGACAGGCTCT CCGAGGAAAGGGAAAGGGGAGTTACAATCGACCTTGCACACGCCAAATTCGAAACAGACAAGTACGAGTTCACAATCGTG GACTGCCCTGGACACCGTGACTTCGTTAAAAACATGATCACAGGTGCGTCCCAGGCAGACGCAGCAGTCCTTGTTGTCGC AGTTGACGACGGTGTAATGCCTCAGACCAAGGAACACGTGTTCCTATCAAGGACACTTGGTATAAACCAGCTCATAGTCG CAATCAACAAGATGGACCTCGTCAACTACGACGAAGAGAAATTCAACGCCCTCAAGGATGAGGTTGCAGCCCTCATCAAA ACCGTGGGTTACAAGCCAAGCGACGTTGAATTCATCCCACTCTCCGCCTTTGAAGGGGACAACATAACATCAAAGAGCGA AAACACCCCATGGTACAAGGGTAAAACACTCGTTGAAGCCCTCGACGACCTTGAAGCACCTGAAAAACCTGTGGACCTTC CACTGAGGATACCTATACAGGACGTCTACTCCATCACAGGTGTCGGTACAGTTCCAGTGGGACGTGTCGAGACCGGTGTC CTCAAGAAGGGTGAAAACGTCATATTCGAACCAGCAGGTGTAAGTGGAGAGGTTAAATCAATCGAAATGCACCACGAAAT GATCGAACAGGCAGAACCCGGTGACAACATAGGTTTCAACGTCAGGGGTGTCGGTAAAAACGACATCAGAAGGGGAGACG TTGCAGGACACCTTGACAACCCACCAAAGGTTGCCAAGGAGTTCACAGCACAGATCGTTGTTCTCCAGCACCCTGGTGTC ATAACAGTGGGTTACACACCTGTATTCCACTGCCACACAGCACAGGTTGCCTGTACCTTCCTTGAACTGGTGCAGAAAAT GAACCCTGCCACAGGTCAGGTGGAAGAGGAAAACCCTGACTTCCTGAAAACAGGTAACGCTGCTGTTGTGAAGGTCAAAC CAACCAAGCCACTGGTCATCGAGAAGATAAAGGACATCCCACACATGGGAAGATTCGCCATAAGGGACATGGGACAGACA GTGGCTGCTGGAATGTGCATAGACCTCGTACCAGCAAAATAA
Upstream 100 bases:
>100_bases ATATAATTAAAAAGAATATAGGAAATTACCTTAGACAAACAGCATGCCCATTTGCTGGATCTAAAAAATCAGGCTAAACC ATCATATATGGAGGTATATT
Downstream 100 bases:
>100_bases ACCCACCTCTTCCCTTTTTTACAGGAGGATTTAAATGCACAAAGCAAGGATTAAACTGACAGGGACAGACCCTGAAAAAC TGGCATACGTCTGTGACCAG
Product: elongation factor 1-alpha
Products: GDP; phosphate
Alternate protein names: EF-1-alpha; Elongation factor Tu; EF-Tu
Number of amino acids: Translated: 413; Mature: 412
Protein sequence:
>413_residues MAKEKEHMNLAFIGHVDHGKSTLVGHLLLQAGAIAEQQLAEGEDKFRFVMDRLSEERERGVTIDLAHAKFETDKYEFTIV DCPGHRDFVKNMITGASQADAAVLVVAVDDGVMPQTKEHVFLSRTLGINQLIVAINKMDLVNYDEEKFNALKDEVAALIK TVGYKPSDVEFIPLSAFEGDNITSKSENTPWYKGKTLVEALDDLEAPEKPVDLPLRIPIQDVYSITGVGTVPVGRVETGV LKKGENVIFEPAGVSGEVKSIEMHHEMIEQAEPGDNIGFNVRGVGKNDIRRGDVAGHLDNPPKVAKEFTAQIVVLQHPGV ITVGYTPVFHCHTAQVACTFLELVQKMNPATGQVEEENPDFLKTGNAAVVKVKPTKPLVIEKIKDIPHMGRFAIRDMGQT VAAGMCIDLVPAK
Sequences:
>Translated_413_residues MAKEKEHMNLAFIGHVDHGKSTLVGHLLLQAGAIAEQQLAEGEDKFRFVMDRLSEERERGVTIDLAHAKFETDKYEFTIV DCPGHRDFVKNMITGASQADAAVLVVAVDDGVMPQTKEHVFLSRTLGINQLIVAINKMDLVNYDEEKFNALKDEVAALIK TVGYKPSDVEFIPLSAFEGDNITSKSENTPWYKGKTLVEALDDLEAPEKPVDLPLRIPIQDVYSITGVGTVPVGRVETGV LKKGENVIFEPAGVSGEVKSIEMHHEMIEQAEPGDNIGFNVRGVGKNDIRRGDVAGHLDNPPKVAKEFTAQIVVLQHPGV ITVGYTPVFHCHTAQVACTFLELVQKMNPATGQVEEENPDFLKTGNAAVVKVKPTKPLVIEKIKDIPHMGRFAIRDMGQT VAAGMCIDLVPAK >Mature_412_residues AKEKEHMNLAFIGHVDHGKSTLVGHLLLQAGAIAEQQLAEGEDKFRFVMDRLSEERERGVTIDLAHAKFETDKYEFTIVD CPGHRDFVKNMITGASQADAAVLVVAVDDGVMPQTKEHVFLSRTLGINQLIVAINKMDLVNYDEEKFNALKDEVAALIKT VGYKPSDVEFIPLSAFEGDNITSKSENTPWYKGKTLVEALDDLEAPEKPVDLPLRIPIQDVYSITGVGTVPVGRVETGVL KKGENVIFEPAGVSGEVKSIEMHHEMIEQAEPGDNIGFNVRGVGKNDIRRGDVAGHLDNPPKVAKEFTAQIVVLQHPGVI TVGYTPVFHCHTAQVACTFLELVQKMNPATGQVEEENPDFLKTGNAAVVKVKPTKPLVIEKIKDIPHMGRFAIRDMGQTV AAGMCIDLVPAK
Specific function: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
COG id: COG5256
COG function: function code J; Translation elongation factor EF-1alpha (GTPase)
Gene ontology:
Cell location: Cytoplasm
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the GTP-binding elongation factor family. EF-Tu/EF-1A subfamily
Homologues:
Organism=Homo sapiens, GI4503471, Length=437, Percent_Identity=50.3432494279176, Blast_Score=448, Evalue=1e-126, Organism=Homo sapiens, GI4503475, Length=437, Percent_Identity=49.1990846681922, Blast_Score=447, Evalue=1e-125, Organism=Homo sapiens, GI223555963, Length=425, Percent_Identity=36.4705882352941, Blast_Score=295, Evalue=7e-80, Organism=Homo sapiens, GI5729864, Length=425, Percent_Identity=36.4705882352941, Blast_Score=294, Evalue=8e-80, Organism=Homo sapiens, GI194018522, Length=432, Percent_Identity=35.8796296296296, Blast_Score=282, Evalue=4e-76, Organism=Homo sapiens, GI194018520, Length=432, Percent_Identity=35.8796296296296, Blast_Score=282, Evalue=4e-76, Organism=Homo sapiens, GI194097354, Length=432, Percent_Identity=35.8796296296296, Blast_Score=282, Evalue=5e-76, Organism=Homo sapiens, GI46094014, Length=432, Percent_Identity=35.4166666666667, Blast_Score=280, Evalue=2e-75, Organism=Homo sapiens, GI34147630, Length=423, Percent_Identity=32.6241134751773, Blast_Score=202, Evalue=7e-52, Organism=Homo sapiens, GI54607086, Length=324, Percent_Identity=26.5432098765432, Blast_Score=99, Evalue=1e-20, Organism=Homo sapiens, GI82546879, Length=445, Percent_Identity=24.4943820224719, Blast_Score=92, Evalue=7e-19, Organism=Homo sapiens, GI157426893, Length=180, Percent_Identity=35, Blast_Score=86, Evalue=8e-17, Organism=Homo sapiens, GI53729339, Length=240, Percent_Identity=30, Blast_Score=77, Evalue=3e-14, Organism=Homo sapiens, GI53729337, Length=240, Percent_Identity=30, Blast_Score=77, Evalue=3e-14, Organism=Homo sapiens, GI169162126, Length=138, Percent_Identity=35.5072463768116, Blast_Score=75, Evalue=1e-13, Organism=Homo sapiens, GI169162824, Length=138, Percent_Identity=35.5072463768116, Blast_Score=75, Evalue=1e-13, Organism=Homo sapiens, GI239752724, Length=138, Percent_Identity=35.5072463768116, Blast_Score=75, Evalue=2e-13, Organism=Homo sapiens, GI18390331, Length=108, Percent_Identity=36.1111111111111, Blast_Score=67, Evalue=2e-11, Organism=Homo sapiens, GI94966754, Length=135, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=2e-11, Organism=Escherichia coli, GI1789108, Length=427, Percent_Identity=34.4262295081967, Blast_Score=196, Evalue=2e-51, Organism=Escherichia coli, GI1790412, Length=421, Percent_Identity=33.9667458432304, Blast_Score=189, Evalue=4e-49, Organism=Escherichia coli, GI1789737, Length=421, Percent_Identity=33.9667458432304, Blast_Score=189, Evalue=4e-49, Organism=Escherichia coli, GI2367247, Length=334, Percent_Identity=31.1377245508982, Blast_Score=122, Evalue=3e-29, Organism=Escherichia coli, GI48994988, Length=245, Percent_Identity=31.4285714285714, Blast_Score=96, Evalue=4e-21, Organism=Escherichia coli, GI1788922, Length=248, Percent_Identity=27.0161290322581, Blast_Score=75, Evalue=1e-14, Organism=Caenorhabditis elegans, GI17552884, Length=437, Percent_Identity=51.0297482837529, Blast_Score=448, Evalue=1e-126, Organism=Caenorhabditis elegans, GI17569207, Length=437, Percent_Identity=51.0297482837529, Blast_Score=448, Evalue=1e-126, Organism=Caenorhabditis elegans, GI32566303, Length=430, Percent_Identity=48.6046511627907, Blast_Score=413, Evalue=1e-116, Organism=Caenorhabditis elegans, GI32566629, Length=429, Percent_Identity=33.1002331002331, Blast_Score=255, Evalue=3e-68, Organism=Caenorhabditis elegans, GI115532067, Length=428, Percent_Identity=34.5794392523364, Blast_Score=241, Evalue=7e-64, Organism=Caenorhabditis elegans, GI115532065, Length=428, Percent_Identity=34.5794392523364, Blast_Score=240, Evalue=1e-63, Organism=Caenorhabditis elegans, GI17556456, Length=421, Percent_Identity=33.0166270783848, Blast_Score=192, Evalue=2e-49, Organism=Caenorhabditis elegans, GI25141371, Length=341, Percent_Identity=35.4838709677419, Blast_Score=181, Evalue=6e-46, Organism=Caenorhabditis elegans, GI32566301, Length=149, Percent_Identity=51.6778523489933, Blast_Score=152, Evalue=2e-37, Organism=Caenorhabditis elegans, GI17557151, Length=239, Percent_Identity=30.9623430962343, Blast_Score=94, Evalue=2e-19, Organism=Caenorhabditis elegans, GI17506081, Length=281, Percent_Identity=24.9110320284698, Blast_Score=84, Evalue=1e-16, Organism=Caenorhabditis elegans, GI17565438, Length=421, Percent_Identity=22.3277909738717, Blast_Score=78, Evalue=1e-14, Organism=Caenorhabditis elegans, GI71994658, Length=237, Percent_Identity=31.6455696202532, Blast_Score=75, Evalue=5e-14, Organism=Caenorhabditis elegans, GI17509919, Length=367, Percent_Identity=23.7057220708447, Blast_Score=73, Evalue=3e-13, Organism=Caenorhabditis elegans, GI17533571, Length=133, Percent_Identity=33.0827067669173, Blast_Score=66, Evalue=3e-11, Organism=Caenorhabditis elegans, GI17556745, Length=108, Percent_Identity=37.962962962963, Blast_Score=65, Evalue=6e-11, Organism=Saccharomyces cerevisiae, GI6325337, Length=435, Percent_Identity=51.4942528735632, Blast_Score=463, Evalue=1e-131, Organism=Saccharomyces cerevisiae, GI6319594, Length=435, Percent_Identity=51.4942528735632, Blast_Score=463, Evalue=1e-131, Organism=Saccharomyces cerevisiae, GI6320377, Length=429, Percent_Identity=33.5664335664336, Blast_Score=243, Evalue=6e-65, Organism=Saccharomyces cerevisiae, GI6324761, Length=439, Percent_Identity=32.3462414578588, Blast_Score=202, Evalue=8e-53, Organism=Saccharomyces cerevisiae, GI6322937, Length=451, Percent_Identity=29.7117516629712, Blast_Score=179, Evalue=9e-46, Organism=Saccharomyces cerevisiae, GI6323320, Length=261, Percent_Identity=28.735632183908, Blast_Score=82, Evalue=2e-16, Organism=Saccharomyces cerevisiae, GI6324550, Length=247, Percent_Identity=27.5303643724696, Blast_Score=74, Evalue=6e-14, Organism=Saccharomyces cerevisiae, GI6324707, Length=148, Percent_Identity=35.8108108108108, Blast_Score=69, Evalue=2e-12, Organism=Saccharomyces cerevisiae, GI6320593, Length=148, Percent_Identity=35.8108108108108, Blast_Score=69, Evalue=2e-12, Organism=Saccharomyces cerevisiae, GI6323098, Length=170, Percent_Identity=32.3529411764706, Blast_Score=68, Evalue=3e-12, Organism=Drosophila melanogaster, GI24652838, Length=437, Percent_Identity=51.487414187643, Blast_Score=461, Evalue=1e-130, Organism=Drosophila melanogaster, GI17137572, Length=437, Percent_Identity=51.487414187643, Blast_Score=461, Evalue=1e-130, Organism=Drosophila melanogaster, GI45553807, Length=437, Percent_Identity=50.1144164759725, Blast_Score=447, Evalue=1e-126, Organism=Drosophila melanogaster, GI45553816, Length=437, Percent_Identity=50.1144164759725, Blast_Score=447, Evalue=1e-126, Organism=Drosophila melanogaster, GI24651721, Length=437, Percent_Identity=50.1144164759725, Blast_Score=447, Evalue=1e-126, Organism=Drosophila melanogaster, GI17864154, Length=437, Percent_Identity=50.1144164759725, Blast_Score=447, Evalue=1e-126, Organism=Drosophila melanogaster, GI45550900, Length=424, Percent_Identity=34.1981132075472, Blast_Score=275, Evalue=6e-74, Organism=Drosophila melanogaster, GI17137380, Length=429, Percent_Identity=34.2657342657343, Blast_Score=274, Evalue=1e-73, Organism=Drosophila melanogaster, GI281363316, Length=417, Percent_Identity=33.3333333333333, Blast_Score=219, Evalue=3e-57, Organism=Drosophila melanogaster, GI17864358, Length=417, Percent_Identity=33.3333333333333, Blast_Score=219, Evalue=3e-57, Organism=Drosophila melanogaster, GI19921738, Length=420, Percent_Identity=28.3333333333333, Blast_Score=168, Evalue=7e-42, Organism=Drosophila melanogaster, GI19922690, Length=316, Percent_Identity=29.1139240506329, Blast_Score=102, Evalue=5e-22, Organism=Drosophila melanogaster, GI19922512, Length=448, Percent_Identity=22.9910714285714, Blast_Score=95, Evalue=8e-20, Organism=Drosophila melanogaster, GI24654852, Length=448, Percent_Identity=22.9910714285714, Blast_Score=95, Evalue=8e-20, Organism=Drosophila melanogaster, GI78706572, Length=152, Percent_Identity=35.5263157894737, Blast_Score=72, Evalue=1e-12, Organism=Drosophila melanogaster, GI24582462, Length=108, Percent_Identity=36.1111111111111, Blast_Score=69, Evalue=5e-12, Organism=Drosophila melanogaster, GI28572034, Length=171, Percent_Identity=34.5029239766082, Blast_Score=69, Evalue=7e-12,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): EF1A_METTH (O27132)
Other databases:
- EMBL: AE000666 - PIR: F69007 - RefSeq: NP_276188.1 - ProteinModelPortal: O27132 - SMR: O27132 - MINT: MINT-6551005 - STRING: O27132 - GeneID: 1471466 - GenomeReviews: AE000666_GR - KEGG: mth:MTH1058 - NMPDR: fig|187420.1.peg.1043 - eggNOG: arNOG04484 - HOGENOM: HBG307581 - OMA: AFIGHVD - PhylomeDB: O27132 - ProtClustDB: PRK12317 - BioCyc: MTHE187420:MTH1058-MONOMER - GO: GO:0005737 - HAMAP: MF_00118_A - InterPro: IPR000795 - InterPro: IPR005225 - InterPro: IPR009001 - InterPro: IPR004539 - InterPro: IPR004161 - InterPro: IPR004160 - InterPro: IPR009000 - PRINTS: PR00315 - TIGRFAMs: TIGR00483 - TIGRFAMs: TIGR00231
Pfam domain/function: PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2; PF03143 GTP_EFTU_D3; SSF50465 Elong_init_C; SSF50447 Translat_factor
EC number: 3.6.5.3
Molecular weight: Translated: 45216; Mature: 45085
Theoretical pI: Translated: 5.22; Mature: 5.22
Prosite motif: PS00301 EFACTOR_GTP
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.0 %Cys (Translated Protein) 2.9 %Met (Translated Protein) 3.9 %Cys+Met (Translated Protein) 1.0 %Cys (Mature Protein) 2.7 %Met (Mature Protein) 3.6 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MAKEKEHMNLAFIGHVDHGKSTLVGHLLLQAGAIAEQQLAEGEDKFRFVMDRLSEERERG CCCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHHHCC VTIDLAHAKFETDKYEFTIVDCPGHRDFVKNMITGASQADAAVLVVAVDDGVMPQTKEHV CEEEEECCEECCCCEEEEEEECCCCHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCE FLSRTLGINQLIVAINKMDLVNYDEEKFNALKDEVAALIKTVGYKPSDVEFIPLSAFEGD EEEHHCCCCCEEEEEEHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCC NITSKSENTPWYKGKTLVEALDDLEAPEKPVDLPLRIPIQDVYSITGVGTVPVGRVETGV CCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCEEECCHHHHHHHCCCCCCCCCCCCHHH LKKGENVIFEPAGVSGEVKSIEMHHEMIEQAEPGDNIGFNVRGVGKNDIRRGDVAGHLDN HCCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCC PPKVAKEFTAQIVVLQHPGVITVGYTPVFHCHTAQVACTFLELVQKMNPATGQVEEENPD CHHHHHHHCEEEEEEECCCEEEECCCCEEEECHHHHHHHHHHHHHHCCCCCCCCCCCCCC FLKTGNAAVVKVKPTKPLVIEKIKDIPHMGRFAIRDMGQTVAAGMCIDLVPAK EEECCCEEEEEECCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHCEEEEEECCC >Mature Secondary Structure AKEKEHMNLAFIGHVDHGKSTLVGHLLLQAGAIAEQQLAEGEDKFRFVMDRLSEERERG CCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHHHCC VTIDLAHAKFETDKYEFTIVDCPGHRDFVKNMITGASQADAAVLVVAVDDGVMPQTKEHV CEEEEECCEECCCCEEEEEEECCCCHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCE FLSRTLGINQLIVAINKMDLVNYDEEKFNALKDEVAALIKTVGYKPSDVEFIPLSAFEGD EEEHHCCCCCEEEEEEHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCC NITSKSENTPWYKGKTLVEALDDLEAPEKPVDLPLRIPIQDVYSITGVGTVPVGRVETGV CCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCEEECCHHHHHHHCCCCCCCCCCCCHHH LKKGENVIFEPAGVSGEVKSIEMHHEMIEQAEPGDNIGFNVRGVGKNDIRRGDVAGHLDN HCCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCC PPKVAKEFTAQIVVLQHPGVITVGYTPVFHCHTAQVACTFLELVQKMNPATGQVEEENPD CHHHHHHHCEEEEEEECCCEEEECCCCEEEECHHHHHHHHHHHHHHCCCCCCCCCCCCCC FLKTGNAAVVKVKPTKPLVIEKIKDIPHMGRFAIRDMGQTVAAGMCIDLVPAK EEECCCEEEEEECCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHCEEEEEECCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: GTP; H2O
Specific reaction: GTP + H2O = GDP + phosphate
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 9371463