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Identifier: 15679002

GI number: 15679002

Start: 896898

End: 897923

Strand: Direct

Name: Not Available

Synonym: MTH984

Alternate gene names: 15679002

Gene position: 896898-897923 (Clockwise)

Preceding gene: 15679001

Following gene: 15679003

Centisome position: 51.21

GC content: 54.58

Gene sequence:

>1026_bases
GTGACCGACAGGGGGTTAATGAAGACTGGATTCGTTGAGGATGTCAGCTCCTCCCTTGAGGAGGAGGGCCTCGAATATGT
CATCTTTGATGATGTGACGCCCAACCCCCGTGACCATGAGGTCATGGAGGGTGCTGAGGTCTTCGATGCCGAGGAATGCA
ACATGATAGTTGCCCTGGGTGGTGGAAGCCCCATTGACTGTGCAAAGGCCATGGGTGCTGTTGTATCCAACAGGATGCAC
GTACTTGACTTTGAGGGTGTTGATATGATCCCGACCCCCTCGGTTCCCATAATATGCATCCCCACAACTGCAGGGACAGG
AGCGGACGTCTCCCAGTTTGCAATCATCCTCGACACCCGGAGGATGGTGAAGATAGCCATCATAAGCAAGGCCATGATAC
CCGACGCATCACTCATAGACCCTGAGACCACCGTCACCATGGACCGGGAACTGACAGCTTCAACAGGTATGGATGCCCTT
GCCCATTCCATCGAAGCCTATGTATCCAATGCAAGCTTCCATCTGACTGACCTCAACGCCCTGGACGCCATCAGAATCAT
AAGCAGGTGCCTCCCATCTGCCGTTGATGAACCCGAGAACATGGAGTACCGTGAGGGTATGATGCTTGCAAGCCTCGAGG
CTGGCCTTGCATTCTCAAATGCCAGTCTGGGACTTGTCCATGCAATGGCCCACAGCCTTGGAGGCAAACTTGACATGGCC
CACGGTGAGGCCAATGCACTGCTACTTGAACACGTGATAGAATTCAACTACCCTGGAGCCACTGAACGGTACCATGAAAT
CGCACGGGCAATGGGCCTCAGGGGCTCGGGGCCCGCCGAGCTCATTGATTACATCCGGGAATTCAGGTCCAGCATAGGGA
TCGACATGACCCTGGAGGATCTCGGCGTCGGGGAGGACGACATACCTGAACTTGCAGAGGCCTCAATGAAGGACCCCTGC
ATTGTAACAAACCCTGTACGGCCCTCAATTGAAGATGTTGAGGCCATATTCAGGAGGGCCCTCTGA

Upstream 100 bases:

>100_bases
AACTTAGAAAATTCGTTACAAGTGAATTCGTATTTGGTGACAGGGCAAGATTCCTTGCTGGCAGATACGCCCTGAACCTC
GGAGCCGACAGGTCCTCCTT

Downstream 100 bases:

>100_bases
GGTGCTGGTGAAATGTCTGATAGAGACTGGGAAACCCTCCGGGAAAAGATAATCGGATTCGGTGAGAAATCCGTAAGGAA
GAGCTACTACCCGAGACTTC

Product: 1,3-propanediol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 340

Protein sequence:

>341_residues
MTDRGLMKTGFVEDVSSSLEEEGLEYVIFDDVTPNPRDHEVMEGAEVFDAEECNMIVALGGGSPIDCAKAMGAVVSNRMH
VLDFEGVDMIPTPSVPIICIPTTAGTGADVSQFAIILDTRRMVKIAIISKAMIPDASLIDPETTVTMDRELTASTGMDAL
AHSIEAYVSNASFHLTDLNALDAIRIISRCLPSAVDEPENMEYREGMMLASLEAGLAFSNASLGLVHAMAHSLGGKLDMA
HGEANALLLEHVIEFNYPGATERYHEIARAMGLRGSGPAELIDYIREFRSSIGIDMTLEDLGVGEDDIPELAEASMKDPC
IVTNPVRPSIEDVEAIFRRAL

Sequences:

>Translated_341_residues
MTDRGLMKTGFVEDVSSSLEEEGLEYVIFDDVTPNPRDHEVMEGAEVFDAEECNMIVALGGGSPIDCAKAMGAVVSNRMH
VLDFEGVDMIPTPSVPIICIPTTAGTGADVSQFAIILDTRRMVKIAIISKAMIPDASLIDPETTVTMDRELTASTGMDAL
AHSIEAYVSNASFHLTDLNALDAIRIISRCLPSAVDEPENMEYREGMMLASLEAGLAFSNASLGLVHAMAHSLGGKLDMA
HGEANALLLEHVIEFNYPGATERYHEIARAMGLRGSGPAELIDYIREFRSSIGIDMTLEDLGVGEDDIPELAEASMKDPC
IVTNPVRPSIEDVEAIFRRAL
>Mature_340_residues
TDRGLMKTGFVEDVSSSLEEEGLEYVIFDDVTPNPRDHEVMEGAEVFDAEECNMIVALGGGSPIDCAKAMGAVVSNRMHV
LDFEGVDMIPTPSVPIICIPTTAGTGADVSQFAIILDTRRMVKIAIISKAMIPDASLIDPETTVTMDRELTASTGMDALA
HSIEAYVSNASFHLTDLNALDAIRIISRCLPSAVDEPENMEYREGMMLASLEAGLAFSNASLGLVHAMAHSLGGKLDMAH
GEANALLLEHVIEFNYPGATERYHEIARAMGLRGSGPAELIDYIREFRSSIGIDMTLEDLGVGEDDIPELAEASMKDPCI
VTNPVRPSIEDVEAIFRRAL

Specific function: Unknown

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=388, Percent_Identity=29.3814432989691, Blast_Score=136, Evalue=3e-32,
Organism=Escherichia coli, GI48994951, Length=347, Percent_Identity=42.9394812680115, Blast_Score=275, Evalue=3e-75,
Organism=Escherichia coli, GI1789163, Length=350, Percent_Identity=37.4285714285714, Blast_Score=224, Evalue=8e-60,
Organism=Escherichia coli, GI87082107, Length=340, Percent_Identity=34.4117647058824, Blast_Score=199, Evalue=2e-52,
Organism=Escherichia coli, GI1787493, Length=378, Percent_Identity=31.2169312169312, Blast_Score=186, Evalue=3e-48,
Organism=Escherichia coli, GI1789386, Length=321, Percent_Identity=26.4797507788162, Blast_Score=86, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17537053, Length=387, Percent_Identity=24.8062015503876, Blast_Score=115, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6321181, Length=342, Percent_Identity=39.4736842105263, Blast_Score=235, Evalue=9e-63,
Organism=Drosophila melanogaster, GI24657991, Length=386, Percent_Identity=26.6839378238342, Blast_Score=123, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 36775; Mature: 36644

Theoretical pI: Translated: 4.11; Mature: 4.11

Prosite motif: PS00060 ADH_IRON_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDRGLMKTGFVEDVSSSLEEEGLEYVIFDDVTPNPRDHEVMEGAEVFDAEECNMIVALG
CCCCCCCHHCCHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHCCHHHCCCCCCCEEEEEC
GGSPIDCAKAMGAVVSNRMHVLDFEGVDMIPTPSVPIICIPTTAGTGADVSQFAIILDTR
CCCCHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCEEEEECCCCCCCCHHHEEEEECCH
RMVKIAIISKAMIPDASLIDPETTVTMDRELTASTGMDALAHSIEAYVSNASFHLTDLNA
HHHHHHHHHHHHCCCCCCCCCCCEEEECCCHHHHCCHHHHHHHHHHHHCCCEEEEECCHH
LDAIRIISRCLPSAVDEPENMEYREGMMLASLEAGLAFSNASLGLVHAMAHSLGGKLDMA
HHHHHHHHHHHHHHCCCCCCCHHHHCEEEEEHHHCCEECCCCHHHHHHHHHHHCCCEEEC
HGEANALLLEHVIEFNYPGATERYHEIARAMGLRGSGPAELIDYIREFRSSIGIDMTLED
CCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEHHH
LGVGEDDIPELAEASMKDPCIVTNPVRPSIEDVEAIFRRAL
CCCCCCCHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
TDRGLMKTGFVEDVSSSLEEEGLEYVIFDDVTPNPRDHEVMEGAEVFDAEECNMIVALG
CCCCCCHHCCHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHCCHHHCCCCCCCEEEEEC
GGSPIDCAKAMGAVVSNRMHVLDFEGVDMIPTPSVPIICIPTTAGTGADVSQFAIILDTR
CCCCHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCEEEEECCCCCCCCHHHEEEEECCH
RMVKIAIISKAMIPDASLIDPETTVTMDRELTASTGMDALAHSIEAYVSNASFHLTDLNA
HHHHHHHHHHHHCCCCCCCCCCCEEEECCCHHHHCCHHHHHHHHHHHHCCCEEEEECCHH
LDAIRIISRCLPSAVDEPENMEYREGMMLASLEAGLAFSNASLGLVHAMAHSLGGKLDMA
HHHHHHHHHHHHHHCCCCCCCHHHHCEEEEEHHHCCEECCCCHHHHHHHHHHHCCCEEEC
HGEANALLLEHVIEFNYPGATERYHEIARAMGLRGSGPAELIDYIREFRSSIGIDMTLED
CCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEHHH
LGVGEDDIPELAEASMKDPCIVTNPVRPSIEDVEAIFRRAL
CCCCCCCHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8041620; 9278503; 7768815 [H]