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Identifier: 15678988

GI number: 15678988

Start: 884540

End: 886117

Strand: Direct

Name: Not Available

Synonym: MTH970

Alternate gene names: 15678988

Gene position: 884540-886117 (Clockwise)

Preceding gene: 15678985

Following gene: 15678993

Centisome position: 50.51

GC content: 52.85

Gene sequence:

>1578_bases
ATGTCCAGGATGAAAGTGCTTATTGCTGATTCCATCAATGAAAAGGGAATATCAGAACTCGAAGAGGTGGCTGAGGTTGT
GGTCAACACCACCATAACCCCTGAGGAGCTCCTTGATGCCATAAAGGACTTTGATGCCATCGTTGTAAGGAGCAGGACAA
AGGTTACGCGTGAGGTCATAGAGGCGGCGCCCCGCCTCAAGATAATAGCAAGGGCCGGTGTGGGTGTTGACAACGTTGAT
GTTAAGGCTGCCACCGACCGGGGTATAATGGTGATAAACGCCCCTGAGTCCACATCCATAACGGTTGCAGAACACTCAAT
CGGTCTCATGCTCGCACTTGCAAGGAAGATTGCAATCGCAGACAGGTCCGTGAAGGAGGGTAAATGGGAGAAGAACCGGT
TCATGGGTATCGAGCTCAACGGCAAGACCCTGGGTATAATCGGTATGGGTCGCATAGGCTCACAGGTCGTTGTGAGGACA
AAGGCCTTCGGCATGGACATAATGGTCTACGACCCCTACATAAGCAAGGAGGCTGCCGAGGAGATGGGTGTGACCGTCAC
AGACCTTGAAACCCTCCTGAGGGAATCAGATATAGTGACCATACACGTCCCCCTCACACCCGAGACAAGGCACCTCATCT
CAGAGGATGAATTCAAATTGATGAAGGACACGGCCTTCATAGTGAACTGTGCCCGTGGCGGTATAATCGATGAGGACGCC
CTCTACAGGGCCCTTAAGGATGGTGAAATAGCCGGCGCAGCCCTTGACGTCTTTGAGGAGGAGCCTCCTGAGGGCAGCCC
GCTCCTTGAACTTGAAAATGTGGTCCTGACACCACACATAGGAGCCTCCACCTCTGAGGCCCAGAGGGACGCCGCCATCA
TAGTTGCAAATGAGATAAAAACGGTTTTCCAGGGCGGTGCACCGAGGAACGTCCTCAACATGCCGGTGATGGACTCAGAG
ACCTACAAGTCCCTCAAACCATACATTGAACTGGCAGAGAAGATGGGGGCCATCATCGCACAGGCACTCCCGGGTAACAT
AGAGAAACTTGATGTCACATACTGCGGTGAACTGGCAGAGATGCAGTTCGACATCCTCACAAGGACCATGCTCCAGGCCA
TACTCAACCCCATCCTCACAGAACCAGTTAACCTCATAAATGCGCCCTCAATTGCAAAGAAGAGGGGTATAATGGTTACA
GAGGCCCGCCGGTCTGAGTCAGATGGTTACAGGTCAATCATAATCGCCACTGCAGAATCAGACAGGGGCGGGTTCAGTGT
GGAGGCAACACACATCAAGGAGCCTACCATAATCGGGATCAACGGTTACAGGGTCGATGTGAAACCTGAGGGTACCATGA
TAATAGCACGCTACAGGGACCTCCCGGGTACCATCGGCGCCATAGGAACAAAGCTCGGCCAGCACGGTATAAACATTGCA
ACCATGCAGGTCGGCAGGAAGGAGATCGGCGGTGAGGCTGTGATGGTCCTCAAGGTCGATCAGAGTGTCCCGGCAGAGGT
CATCGAGGAGGTTAAGAAGCTGGACAACGTGGATGATGCGGTTGCAATAGAGATCTAA

Upstream 100 bases:

>100_bases
CCGGTACCGGCTGATCCCACCAATAATTATAATATACACTACCTCTATAGATTCTTCTATCATTCTATAAAATCTTCATT
GTGATAAGTGTGGTGAAATT

Downstream 100 bases:

>100_bases
CCCCAGTATCCCTGAGATCCAGCCATTACCTTTTTTTCTTATAAAACGTTTATTCCTCAGAAGATTCCATTTCATGTTTC
CTTTTCTTATAAAACCCTTA

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH

Number of amino acids: Translated: 525; Mature: 524

Protein sequence:

>525_residues
MSRMKVLIADSINEKGISELEEVAEVVVNTTITPEELLDAIKDFDAIVVRSRTKVTREVIEAAPRLKIIARAGVGVDNVD
VKAATDRGIMVINAPESTSITVAEHSIGLMLALARKIAIADRSVKEGKWEKNRFMGIELNGKTLGIIGMGRIGSQVVVRT
KAFGMDIMVYDPYISKEAAEEMGVTVTDLETLLRESDIVTIHVPLTPETRHLISEDEFKLMKDTAFIVNCARGGIIDEDA
LYRALKDGEIAGAALDVFEEEPPEGSPLLELENVVLTPHIGASTSEAQRDAAIIVANEIKTVFQGGAPRNVLNMPVMDSE
TYKSLKPYIELAEKMGAIIAQALPGNIEKLDVTYCGELAEMQFDILTRTMLQAILNPILTEPVNLINAPSIAKKRGIMVT
EARRSESDGYRSIIIATAESDRGGFSVEATHIKEPTIIGINGYRVDVKPEGTMIIARYRDLPGTIGAIGTKLGQHGINIA
TMQVGRKEIGGEAVMVLKVDQSVPAEVIEEVKKLDNVDDAVAIEI

Sequences:

>Translated_525_residues
MSRMKVLIADSINEKGISELEEVAEVVVNTTITPEELLDAIKDFDAIVVRSRTKVTREVIEAAPRLKIIARAGVGVDNVD
VKAATDRGIMVINAPESTSITVAEHSIGLMLALARKIAIADRSVKEGKWEKNRFMGIELNGKTLGIIGMGRIGSQVVVRT
KAFGMDIMVYDPYISKEAAEEMGVTVTDLETLLRESDIVTIHVPLTPETRHLISEDEFKLMKDTAFIVNCARGGIIDEDA
LYRALKDGEIAGAALDVFEEEPPEGSPLLELENVVLTPHIGASTSEAQRDAAIIVANEIKTVFQGGAPRNVLNMPVMDSE
TYKSLKPYIELAEKMGAIIAQALPGNIEKLDVTYCGELAEMQFDILTRTMLQAILNPILTEPVNLINAPSIAKKRGIMVT
EARRSESDGYRSIIIATAESDRGGFSVEATHIKEPTIIGINGYRVDVKPEGTMIIARYRDLPGTIGAIGTKLGQHGINIA
TMQVGRKEIGGEAVMVLKVDQSVPAEVIEEVKKLDNVDDAVAIEI
>Mature_524_residues
SRMKVLIADSINEKGISELEEVAEVVVNTTITPEELLDAIKDFDAIVVRSRTKVTREVIEAAPRLKIIARAGVGVDNVDV
KAATDRGIMVINAPESTSITVAEHSIGLMLALARKIAIADRSVKEGKWEKNRFMGIELNGKTLGIIGMGRIGSQVVVRTK
AFGMDIMVYDPYISKEAAEEMGVTVTDLETLLRESDIVTIHVPLTPETRHLISEDEFKLMKDTAFIVNCARGGIIDEDAL
YRALKDGEIAGAALDVFEEEPPEGSPLLELENVVLTPHIGASTSEAQRDAAIIVANEIKTVFQGGAPRNVLNMPVMDSET
YKSLKPYIELAEKMGAIIAQALPGNIEKLDVTYCGELAEMQFDILTRTMLQAILNPILTEPVNLINAPSIAKKRGIMVTE
ARRSESDGYRSIIIATAESDRGGFSVEATHIKEPTIIGINGYRVDVKPEGTMIIARYRDLPGTIGAIGTKLGQHGINIAT
MQVGRKEIGGEAVMVLKVDQSVPAEVIEEVKKLDNVDDAVAIEI

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain

Homologues:

Organism=Homo sapiens, GI23308577, Length=516, Percent_Identity=36.6279069767442, Blast_Score=313, Evalue=2e-85,
Organism=Homo sapiens, GI4557497, Length=301, Percent_Identity=37.5415282392027, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI61743967, Length=301, Percent_Identity=37.5415282392027, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI145580578, Length=288, Percent_Identity=37.1527777777778, Blast_Score=181, Evalue=2e-45,
Organism=Homo sapiens, GI4557499, Length=288, Percent_Identity=37.1527777777778, Blast_Score=181, Evalue=2e-45,
Organism=Homo sapiens, GI145580575, Length=289, Percent_Identity=37.3702422145329, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI6912396, Length=313, Percent_Identity=32.2683706070287, Blast_Score=157, Evalue=2e-38,
Organism=Escherichia coli, GI1789279, Length=321, Percent_Identity=36.7601246105919, Blast_Score=196, Evalue=3e-51,
Organism=Escherichia coli, GI87082289, Length=273, Percent_Identity=39.1941391941392, Blast_Score=190, Evalue=2e-49,
Organism=Escherichia coli, GI1787645, Length=219, Percent_Identity=38.8127853881278, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI1788660, Length=252, Percent_Identity=29.7619047619048, Blast_Score=86, Evalue=7e-18,
Organism=Escherichia coli, GI87081824, Length=230, Percent_Identity=26.5217391304348, Blast_Score=82, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17532191, Length=311, Percent_Identity=43.0868167202572, Blast_Score=246, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI25147481, Length=307, Percent_Identity=31.5960912052117, Blast_Score=160, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6320925, Length=391, Percent_Identity=37.5959079283887, Blast_Score=220, Evalue=4e-58,
Organism=Saccharomyces cerevisiae, GI6322116, Length=329, Percent_Identity=38.6018237082067, Blast_Score=211, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6324055, Length=328, Percent_Identity=32.6219512195122, Blast_Score=168, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6324964, Length=275, Percent_Identity=31.6363636363636, Blast_Score=129, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6324980, Length=196, Percent_Identity=30.6122448979592, Blast_Score=90, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6325144, Length=183, Percent_Identity=31.6939890710383, Blast_Score=77, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6321253, Length=294, Percent_Identity=25.1700680272109, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI19921140, Length=321, Percent_Identity=41.7445482866044, Blast_Score=248, Evalue=6e-66,
Organism=Drosophila melanogaster, GI24646446, Length=276, Percent_Identity=38.768115942029, Blast_Score=176, Evalue=4e-44,
Organism=Drosophila melanogaster, GI24646448, Length=276, Percent_Identity=38.768115942029, Blast_Score=176, Evalue=4e-44,
Organism=Drosophila melanogaster, GI24646452, Length=276, Percent_Identity=38.768115942029, Blast_Score=176, Evalue=4e-44,
Organism=Drosophila melanogaster, GI24646450, Length=276, Percent_Identity=38.768115942029, Blast_Score=176, Evalue=4e-44,
Organism=Drosophila melanogaster, GI62472511, Length=277, Percent_Identity=38.9891696750903, Blast_Score=175, Evalue=7e-44,
Organism=Drosophila melanogaster, GI28574286, Length=307, Percent_Identity=35.8306188925081, Blast_Score=175, Evalue=7e-44,
Organism=Drosophila melanogaster, GI28574284, Length=306, Percent_Identity=34.640522875817, Blast_Score=166, Evalue=4e-41,
Organism=Drosophila melanogaster, GI45551003, Length=306, Percent_Identity=34.640522875817, Blast_Score=166, Evalue=4e-41,
Organism=Drosophila melanogaster, GI45552429, Length=306, Percent_Identity=34.640522875817, Blast_Score=166, Evalue=5e-41,
Organism=Drosophila melanogaster, GI24585514, Length=306, Percent_Identity=34.640522875817, Blast_Score=166, Evalue=5e-41,
Organism=Drosophila melanogaster, GI28574282, Length=306, Percent_Identity=34.640522875817, Blast_Score=166, Evalue=5e-41,
Organism=Drosophila melanogaster, GI28571528, Length=314, Percent_Identity=33.4394904458599, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24585516, Length=289, Percent_Identity=30.4498269896194, Blast_Score=149, Evalue=7e-36,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): SERA_METTH (O27051)

Other databases:

- EMBL:   AE000666
- PIR:   H69229
- RefSeq:   NP_276105.1
- ProteinModelPortal:   O27051
- SMR:   O27051
- STRING:   O27051
- GeneID:   1471378
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH970
- NMPDR:   fig|187420.1.peg.960
- eggNOG:   arNOG04496
- HOGENOM:   HBG731446
- OMA:   KSFKGME
- PhylomeDB:   O27051
- ProtClustDB:   PRK13581
- BioCyc:   MTHE187420:MTH970-MONOMER
- BRENDA:   1.1.1.95
- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR10996:SF20
- TIGRFAMs:   TIGR01327

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT

EC number: =1.1.1.95

Molecular weight: Translated: 56992; Mature: 56860

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1; PS00670 D_2_HYDROXYACID_DH_2; PS00671 D_2_HYDROXYACID_DH_3

Important sites: ACT_SITE 232-232 ACT_SITE 261-261 ACT_SITE 279-279 BINDING 171-171 BINDING 256-256

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRMKVLIADSINEKGISELEEVAEVVVNTTITPEELLDAIKDFDAIVVRSRTKVTREVI
CCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHEEEEHHHHHHHHHH
EAAPRLKIIARAGVGVDNVDVKAATDRGIMVINAPESTSITVAEHSIGLMLALARKIAIA
HCCCCEEEEEECCCCCCCCEEEEECCCCEEEEECCCCCEEEEEHHHHHHHHHHHHHHHHC
DRSVKEGKWEKNRFMGIELNGKTLGIIGMGRIGSQVVVRTKAFGMDIMVYDPYISKEAAE
CCCCCCCCCCCCCEEEEEECCCEEEEEEECCCCCEEEEEEEECCEEEEEECCCCCHHHHH
EMGVTVTDLETLLRESDIVTIHVPLTPETRHLISEDEFKLMKDTAFIVNCARGGIIDEDA
HHCCCHHHHHHHHCCCCEEEEEEECCCCHHHHCCCCHHHHHHHHEEEEEECCCCCCCHHH
LYRALKDGEIAGAALDVFEEEPPEGSPLLELENVVLTPHIGASTSEAQRDAAIIVANEIK
HHHHHCCCCCCHHHHHHHHCCCCCCCCCEEECCEEEECCCCCCCCCCCCCEEEEEEHHHH
TVFQGGAPRNVLNMPVMDSETYKSLKPYIELAEKMGAIIAQALPGNIEKLDVTYCGELAE
HHHCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHCHHHH
MQFDILTRTMLQAILNPILTEPVNLINAPSIAKKRGIMVTEARRSESDGYRSIIIATAES
HHHHHHHHHHHHHHHHHHHHCCHHHCCCCCHHHHCCEEEEECCCCCCCCCEEEEEEEECC
DRGGFSVEATHIKEPTIIGINGYRVDVKPEGTMIIARYRDLPGTIGAIGTKLGQHGINIA
CCCCEEEEEEECCCCEEEECCCEEEEECCCCCEEEEEECCCCCCHHHHHHHHHHCCCEEE
TMQVGRKEIGGEAVMVLKVDQSVPAEVIEEVKKLDNVDDAVAIEI
EEECCHHHCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCEEEEEC
>Mature Secondary Structure 
SRMKVLIADSINEKGISELEEVAEVVVNTTITPEELLDAIKDFDAIVVRSRTKVTREVI
CCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHEEEEHHHHHHHHHH
EAAPRLKIIARAGVGVDNVDVKAATDRGIMVINAPESTSITVAEHSIGLMLALARKIAIA
HCCCCEEEEEECCCCCCCCEEEEECCCCEEEEECCCCCEEEEEHHHHHHHHHHHHHHHHC
DRSVKEGKWEKNRFMGIELNGKTLGIIGMGRIGSQVVVRTKAFGMDIMVYDPYISKEAAE
CCCCCCCCCCCCCEEEEEECCCEEEEEEECCCCCEEEEEEEECCEEEEEECCCCCHHHHH
EMGVTVTDLETLLRESDIVTIHVPLTPETRHLISEDEFKLMKDTAFIVNCARGGIIDEDA
HHCCCHHHHHHHHCCCCEEEEEEECCCCHHHHCCCCHHHHHHHHEEEEEECCCCCCCHHH
LYRALKDGEIAGAALDVFEEEPPEGSPLLELENVVLTPHIGASTSEAQRDAAIIVANEIK
HHHHHCCCCCCHHHHHHHHCCCCCCCCCEEECCEEEECCCCCCCCCCCCCEEEEEEHHHH
TVFQGGAPRNVLNMPVMDSETYKSLKPYIELAEKMGAIIAQALPGNIEKLDVTYCGELAE
HHHCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHCHHHH
MQFDILTRTMLQAILNPILTEPVNLINAPSIAKKRGIMVTEARRSESDGYRSIIIATAES
HHHHHHHHHHHHHHHHHHHHCCHHHCCCCCHHHHCCEEEEECCCCCCCCCEEEEEEEECC
DRGGFSVEATHIKEPTIIGINGYRVDVKPEGTMIIARYRDLPGTIGAIGTKLGQHGINIA
CCCCEEEEEEECCCCEEEECCCEEEEECCCCCEEEEEECCCCCCHHHHHHHHHHCCCEEE
TMQVGRKEIGGEAVMVLKVDQSVPAEVIEEVKKLDNVDDAVAIEI
EEECCHHHCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463