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Identifier: 15678917

GI number: 15678917

Start: 814854

End: 815615

Strand: Direct

Name: Not Available

Synonym: MTH897

Alternate gene names: 15678917

Gene position: 814854-815615 (Clockwise)

Preceding gene: 15678916

Following gene: 15678918

Centisome position: 46.53

GC content: 51.71

Gene sequence:

>762_bases
GTGATGGAGATGAGAATAACATTCCTGGGTGGTGGCCGGGTAGTCAGAATAATCCTCGGGGGCCTCCAGAGGGCAGGTAA
ACTACCCCGGGAGGTGATGGTGTGCGACCCCGATGAGGATTCCCTCAGAAGCCTTGAAGATGAATTCGGGGTTAAAACAT
CAGCTGACTGCAGCAGCATGGAAGGAGATGTGATATTCCTTGCACTGCATCCACCTGTCCTGAAGGATGTTCTGAACAAA
ATGGAGTCCCCTTCCCCTGAATCACTGATAGTGTCCCTGGCGCCCAGGATCAGAATAGAGGAGATACAGCAGGCACTGGA
CCACCCAAAGGTCGCGAGGGTCATACCCAACGCCCTCTCTCTTGTTAACAGGGGCTACAATCCCTTCAGCGCGGCAGATG
AACTCACCGGGACTGACCTGGAAATACTTCAATCACTATTTGAACCTCTCGGAAAGTTTCCAGAGGTATCTGAGGACAAA
CTTGAAGCATACGCCGTTATAACTGCGATGGGTCCGACTTATCTATGGTTCCAGCTGGCTGAACTGGAAAAACTGGCTGT
TGAGTTCGGCATGTCCCCTGATGAGGCTGCAACCGCTGTGCATTCCATGGCATCAGGCGCAGTGGAGGCCCTGTATTCAC
ACCCAAACAGGGATATGGTTATGGACCTCATAGCTGTGAAGCCCCTGGAGGATGCAGAGGATGATATAAGGGCCATCTAC
AGGAAAAGTCTTATGAGAATATACCAAAGCCTGACGGAGTGA

Upstream 100 bases:

>100_bases
AGAAGTCAGGGCTGAGGTACGTAAACTGCAAGGGCTGCGGTAAACTATTCAAAACCGACAGGGACACCGAGTACTGCATG
GACTGTGAAAAAAAGATGAA

Downstream 100 bases:

>100_bases
CAGCACCCTAAGGAGGTATGATATGTACAGAAAAATATTGCTTGCAACGGATGGATCCGAATGTTCAATGCAGGCTGCAG
GATACGCCATTGAAACTGCA

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 253; Mature: 253

Protein sequence:

>253_residues
MMEMRITFLGGGRVVRIILGGLQRAGKLPREVMVCDPDEDSLRSLEDEFGVKTSADCSSMEGDVIFLALHPPVLKDVLNK
MESPSPESLIVSLAPRIRIEEIQQALDHPKVARVIPNALSLVNRGYNPFSAADELTGTDLEILQSLFEPLGKFPEVSEDK
LEAYAVITAMGPTYLWFQLAELEKLAVEFGMSPDEAATAVHSMASGAVEALYSHPNRDMVMDLIAVKPLEDAEDDIRAIY
RKSLMRIYQSLTE

Sequences:

>Translated_253_residues
MMEMRITFLGGGRVVRIILGGLQRAGKLPREVMVCDPDEDSLRSLEDEFGVKTSADCSSMEGDVIFLALHPPVLKDVLNK
MESPSPESLIVSLAPRIRIEEIQQALDHPKVARVIPNALSLVNRGYNPFSAADELTGTDLEILQSLFEPLGKFPEVSEDK
LEAYAVITAMGPTYLWFQLAELEKLAVEFGMSPDEAATAVHSMASGAVEALYSHPNRDMVMDLIAVKPLEDAEDDIRAIY
RKSLMRIYQSLTE
>Mature_253_residues
MMEMRITFLGGGRVVRIILGGLQRAGKLPREVMVCDPDEDSLRSLEDEFGVKTSADCSSMEGDVIFLALHPPVLKDVLNK
MESPSPESLIVSLAPRIRIEEIQQALDHPKVARVIPNALSLVNRGYNPFSAADELTGTDLEILQSLFEPLGKFPEVSEDK
LEAYAVITAMGPTYLWFQLAELEKLAVEFGMSPDEAATAVHSMASGAVEALYSHPNRDMVMDLIAVKPLEDAEDDIRAIY
RKSLMRIYQSLTE

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786585, Length=230, Percent_Identity=30, Blast_Score=92, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17569021, Length=201, Percent_Identity=27.363184079602, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI21358587, Length=198, Percent_Identity=28.7878787878788, Blast_Score=81, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 27980; Mature: 27980

Theoretical pI: Translated: 4.36; Mature: 4.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMEMRITFLGGGRVVRIILGGLQRAGKLPREVMVCDPDEDSLRSLEDEFGVKTSADCSSM
CCEEEEEEECCCHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCC
EGDVIFLALHPPVLKDVLNKMESPSPESLIVSLAPRIRIEEIQQALDHPKVARVIPNALS
CCCEEEEEECCHHHHHHHHHHCCCCCHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHH
LVNRGYNPFSAADELTGTDLEILQSLFEPLGKFPEVSEDKLEAYAVITAMGPTYLWFQLA
HHHCCCCCCCCHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHH
ELEKLAVEFGMSPDEAATAVHSMASGAVEALYSHPNRDMVMDLIAVKPLEDAEDDIRAIY
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHH
RKSLMRIYQSLTE
HHHHHHHHHHHCC
>Mature Secondary Structure
MMEMRITFLGGGRVVRIILGGLQRAGKLPREVMVCDPDEDSLRSLEDEFGVKTSADCSSM
CCEEEEEEECCCHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCC
EGDVIFLALHPPVLKDVLNKMESPSPESLIVSLAPRIRIEEIQQALDHPKVARVIPNALS
CCCEEEEEECCHHHHHHHHHHCCCCCHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHH
LVNRGYNPFSAADELTGTDLEILQSLFEPLGKFPEVSEDKLEAYAVITAMGPTYLWFQLA
HHHCCCCCCCCHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHH
ELEKLAVEFGMSPDEAATAVHSMASGAVEALYSHPNRDMVMDLIAVKPLEDAEDDIRAIY
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHH
RKSLMRIYQSLTE
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6296787; 9278503 [H]