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Identifier: 15678870

GI number: 15678870

Start: 772376

End: 772900

Strand: Direct

Name: Not Available

Synonym: MTH850

Alternate gene names: 15678870

Gene position: 772376-772900 (Clockwise)

Preceding gene: 15678869

Following gene: 15678871

Centisome position: 44.1

GC content: 48.19

Gene sequence:

>525_bases
GTGAAGGGGAATAGGGGATGTCCCTTCCCCATTCAACGTCAGATAATAAGAGGGATGGATATGAAGAAACCCTTTGAACT
GAGGGTCAAACCAATAAAGAACGGAACAGTTATCGATCATATAACCGCAAACAGATCTCTGAATGTCCTCAACATCCTTG
GGCTCCCTGATGGGCGCAGCAAGGTGACCGTTGCCATGAATATGGATTCCTCCCAGCTTGGATCCAAGGACATAGTTAAA
ATAGAGAACAGGGAACTCAAACCCTCGGAGGTTGACCAGATAGCCCTCATAGCCCCCAGAGCTACAATAAACATTGTGAG
GGATTATAAGATTGTTGAGAAGGCCAAGGTGAGGCTCATGGATGAGGTGAGGGGCATCCTCAGATGTCCCAACCCCAACT
GCATCACAAACAGTGACGAGGGTGTTGAGAACCGTTTCTATGTCATCTCAGAGGAACCCGTTCTCCTACGCTGCTACTAC
TGTGAGCGCCTCATTGAGGCTGATGAGATAGAGTCACAGTTCTAG

Upstream 100 bases:

>100_bases
TCCTCGGAGTCATCATAGGAGTCTTCATCACAAGACCAGTGTATGCAAGATTCATTGAAACCTTCAACGTTGCTGGAAGA
AAATAGGAGGGTCCTCACCA

Downstream 100 bases:

>100_bases
GAGTGATACCATGAAATTTGAATACCCTGAAAGCCAGATCACCCAGAGCCAGTCACAGTTCCAGGAGTGATACCATGAGA
TTGAAGTTAGCTGTCATTCT

Product: aspartate carbamoyltransferase regulatory subunit

Products: phosphate; N-carbamoyl-L-aspartate

Alternate protein names: NA

Number of amino acids: Translated: 174; Mature: 174

Protein sequence:

>174_residues
MKGNRGCPFPIQRQIIRGMDMKKPFELRVKPIKNGTVIDHITANRSLNVLNILGLPDGRSKVTVAMNMDSSQLGSKDIVK
IENRELKPSEVDQIALIAPRATINIVRDYKIVEKAKVRLMDEVRGILRCPNPNCITNSDEGVENRFYVISEEPVLLRCYY
CERLIEADEIESQF

Sequences:

>Translated_174_residues
MKGNRGCPFPIQRQIIRGMDMKKPFELRVKPIKNGTVIDHITANRSLNVLNILGLPDGRSKVTVAMNMDSSQLGSKDIVK
IENRELKPSEVDQIALIAPRATINIVRDYKIVEKAKVRLMDEVRGILRCPNPNCITNSDEGVENRFYVISEEPVLLRCYY
CERLIEADEIESQF
>Mature_174_residues
MKGNRGCPFPIQRQIIRGMDMKKPFELRVKPIKNGTVIDHITANRSLNVLNILGLPDGRSKVTVAMNMDSSQLGSKDIVK
IENRELKPSEVDQIALIAPRATINIVRDYKIVEKAKVRLMDEVRGILRCPNPNCITNSDEGVENRFYVISEEPVLLRCYY
CERLIEADEIESQF

Specific function: Involved in allosteric regulation of aspartate carbamoyltransferase [H]

COG id: COG1781

COG function: function code F; Aspartate carbamoyltransferase, regulatory subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrI family [H]

Homologues:

Organism=Escherichia coli, GI1790692, Length=144, Percent_Identity=38.8888888888889, Blast_Score=110, Evalue=6e-26,

Paralogues:

None

Copy number: 760 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 440 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020545
- InterPro:   IPR002801
- InterPro:   IPR020542
- ProDom:   PD006194 [H]

Pfam domain/function: PF01948 PyrI; PF02748 PyrI_C [H]

EC number: 2.1.3.2

Molecular weight: Translated: 19829; Mature: 19829

Theoretical pI: Translated: 8.48; Mature: 8.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGNRGCPFPIQRQIIRGMDMKKPFELRVKPIKNGTVIDHITANRSLNVLNILGLPDGRS
CCCCCCCCCHHHHHHHCCCCCCCCCEEEEEECCCCEEEEEEECCCCCCEEEEEECCCCCC
KVTVAMNMDSSQLGSKDIVKIENRELKPSEVDQIALIAPRATINIVRDYKIVEKAKVRLM
EEEEEEECCHHHCCCCCEEEECCCCCCCCCCCEEEEECCCCEEEEEHHHHHHHHHHHHHH
DEVRGILRCPNPNCITNSDEGVENRFYVISEEPVLLRCYYCERLIEADEIESQF
HHHHHHEECCCCCCCCCCCCCCCCEEEEEECCCEEEEEHHHHHHHCHHHHCCCC
>Mature Secondary Structure
MKGNRGCPFPIQRQIIRGMDMKKPFELRVKPIKNGTVIDHITANRSLNVLNILGLPDGRS
CCCCCCCCCHHHHHHHCCCCCCCCCEEEEEECCCCEEEEEEECCCCCCEEEEEECCCCCC
KVTVAMNMDSSQLGSKDIVKIENRELKPSEVDQIALIAPRATINIVRDYKIVEKAKVRLM
EEEEEEECCHHHCCCCCEEEECCCCCCCCCCCEEEEECCCCEEEEEHHHHHHHHHHHHHH
DEVRGILRCPNPNCITNSDEGVENRFYVISEEPVLLRCYYCERLIEADEIESQF
HHHHHHEECCCCCCCCCCCCCCCCEEEEEECCCEEEEEHHHHHHHCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: carbamoyl phosphate; L-aspartate

Specific reaction: carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]