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Identifier: 15678863

GI number: 15678863

Start: 766116

End: 766982

Strand: Direct

Name: Not Available

Synonym: MTH843

Alternate gene names: 15678863

Gene position: 766116-766982 (Clockwise)

Preceding gene: 15678861

Following gene: 15678864

Centisome position: 43.74

GC content: 48.44

Gene sequence:

>867_bases
TTGCACACCACCTTCACCTTCCATTTATATCCATGGATACTTAAATATCTTAAAGGAGGGGAAGGAAATTTTAAATATCT
TCATCAGGAAAACCCCAAACAGGAGATTACTGACAGCAGTGATAAAATGAGCTTTTGGAAGGACAGAATGCTTATAATAC
CGGCCGTGGATATAAAGGATGGAAAATGTGTTCAGCTTGTTCAGGGAAAACCCGGTACGGAGCAGGTCGTGCTTGATGAT
CCTGCCGGAGTTGCTGGAAGGTGGGAATCCCTGGGGGCTGAAACAATCCATGTTGTGGACCTTGATGGGGCCCTTGGTCT
TGAGAAGAATACAGGTATACTGAAGGAGATCACAGAGAGAGTTTCAGTGCCCCTCCAGATAGGTGGAGGTATAAGGAGTA
GAGAATATGCAGGGAAACTCCTTGATATGGGCTTTGAGAGGGTTATACTGGGCACCATGGCCATAGAAAATCCGGCCATC
GTTGAGGAACTTGCAGGTGAATACGGATCGGAACGCATAATGGTCTCACTTGATAGCAGGGACTCACGGGTTGTTATAAG
GGGATGGACAGAGAAGGTCCCCTTCACAGCAGAGGAGATGGCCAGGAAATTCCAGGAGAGGGGAGCTGGTAGCATACTCT
TTACCAACGTGGACTTCGAGGGTCTTCTCTCAGGATTTGACCTGAAACCCGTGAGTGAACTTGTGGAGGCAGTTGAGATA
CCTGTAATCTACTCCGGGGGTGTTAGCAGCCTAAATGACCTGAGGATGCTGCAGGGGACCGGTGTAATGGGGGTCGTTAT
AGGATCAGCCATCTACAGGGGCCTCATAGACCTCACCGAGGCCCTCAAATATCAGGACCTTAAATGA

Upstream 100 bases:

>100_bases
TCCTTAATAGGCTCTCTGGGACCGATTCCAGTTCTTTCACTCATTATCTCATCGTCTGTGGTTCTCCGGTATTCCTCAAT
GATGGCCCCGATATTCTCCA

Downstream 100 bases:

>100_bases
ACACCTTCAGCAGGATGATAAAATGAAGACAGTTATGGCAACAGGCACCTTTGACATAATACACCCCGGACATGGGTTCT
TCCTTGAGGAGGCCAGGAAA

Product: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase [H]

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MHTTFTFHLYPWILKYLKGGEGNFKYLHQENPKQEITDSSDKMSFWKDRMLIIPAVDIKDGKCVQLVQGKPGTEQVVLDD
PAGVAGRWESLGAETIHVVDLDGALGLEKNTGILKEITERVSVPLQIGGGIRSREYAGKLLDMGFERVILGTMAIENPAI
VEELAGEYGSERIMVSLDSRDSRVVIRGWTEKVPFTAEEMARKFQERGAGSILFTNVDFEGLLSGFDLKPVSELVEAVEI
PVIYSGGVSSLNDLRMLQGTGVMGVVIGSAIYRGLIDLTEALKYQDLK

Sequences:

>Translated_288_residues
MHTTFTFHLYPWILKYLKGGEGNFKYLHQENPKQEITDSSDKMSFWKDRMLIIPAVDIKDGKCVQLVQGKPGTEQVVLDD
PAGVAGRWESLGAETIHVVDLDGALGLEKNTGILKEITERVSVPLQIGGGIRSREYAGKLLDMGFERVILGTMAIENPAI
VEELAGEYGSERIMVSLDSRDSRVVIRGWTEKVPFTAEEMARKFQERGAGSILFTNVDFEGLLSGFDLKPVSELVEAVEI
PVIYSGGVSSLNDLRMLQGTGVMGVVIGSAIYRGLIDLTEALKYQDLK
>Mature_288_residues
MHTTFTFHLYPWILKYLKGGEGNFKYLHQENPKQEITDSSDKMSFWKDRMLIIPAVDIKDGKCVQLVQGKPGTEQVVLDD
PAGVAGRWESLGAETIHVVDLDGALGLEKNTGILKEITERVSVPLQIGGGIRSREYAGKLLDMGFERVILGTMAIENPAI
VEELAGEYGSERIMVSLDSRDSRVVIRGWTEKVPFTAEEMARKFQERGAGSILFTNVDFEGLLSGFDLKPVSELVEAVEI
PVIYSGGVSSLNDLRMLQGTGVMGVVIGSAIYRGLIDLTEALKYQDLK

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family [H]

Homologues:

Organism=Escherichia coli, GI87082028, Length=239, Percent_Identity=30.9623430962343, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1788336, Length=251, Percent_Identity=25.0996015936255, Blast_Score=93, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00977 His_biosynth [H]

EC number: =5.3.1.16 [H]

Molecular weight: Translated: 31769; Mature: 31769

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHTTFTFHLYPWILKYLKGGEGNFKYLHQENPKQEITDSSDKMSFWKDRMLIIPAVDIKD
CCCEEEEEHHHHHHHHHHCCCCCEEEECCCCCHHHHCCCCCHHHHHHCCEEEEEEEECCC
GKCVQLVQGKPGTEQVVLDDPAGVAGRWESLGAETIHVVDLDGALGLEKNTGILKEITER
CCEEEEECCCCCCCEEEEECCCCCCCCHHHCCCCEEEEEEECCCCCCCCCCCHHHHHHHH
VSVPLQIGGGIRSREYAGKLLDMGFERVILGTMAIENPAIVEELAGEYGSERIMVSLDSR
HCCCEEECCCCCCHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEEECCC
DSRVVIRGWTEKVPFTAEEMARKFQERGAGSILFTNVDFEGLLSGFDLKPVSELVEAVEI
CCEEEEEECCCCCCCCHHHHHHHHHHCCCCEEEEECCCHHHHHCCCCCCHHHHHHHHHHC
PVIYSGGVSSLNDLRMLQGTGVMGVVIGSAIYRGLIDLTEALKYQDLK
CEEEECCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MHTTFTFHLYPWILKYLKGGEGNFKYLHQENPKQEITDSSDKMSFWKDRMLIIPAVDIKD
CCCEEEEEHHHHHHHHHHCCCCCEEEECCCCCHHHHCCCCCHHHHHHCCEEEEEEEECCC
GKCVQLVQGKPGTEQVVLDDPAGVAGRWESLGAETIHVVDLDGALGLEKNTGILKEITER
CCEEEEECCCCCCCEEEEECCCCCCCCHHHCCCCEEEEEEECCCCCCCCCCCHHHHHHHH
VSVPLQIGGGIRSREYAGKLLDMGFERVILGTMAIENPAIVEELAGEYGSERIMVSLDSR
HCCCEEECCCCCCHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEEECCC
DSRVVIRGWTEKVPFTAEEMARKFQERGAGSILFTNVDFEGLLSGFDLKPVSELVEAVEI
CCEEEEEECCCCCCCCHHHHHHHHHHCCCCEEEEECCCHHHHHCCCCCCHHHHHHHHHHC
PVIYSGGVSSLNDLRMLQGTGVMGVVIGSAIYRGLIDLTEALKYQDLK
CEEEECCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]