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Identifier: 15678774

GI number: 15678774

Start: 676606

End: 677730

Strand: Direct

Name: Not Available

Synonym: MTH748

Alternate gene names: 15678774

Gene position: 676606-677730 (Clockwise)

Preceding gene: 15678773

Following gene: 15678775

Centisome position: 38.63

GC content: 53.78

Gene sequence:

>1125_bases
TTGATACTGTGTGGTGATTCGGTGGCCGGGAACAGTACCGGTGAAATGTTCAGAGTAACGACCTTCGGATCCAGCCATGG
TCCTGCAGTGGGTGCCGTTATCGACGGCTGCCCCGCAGGTCTCGAGCTGAGTGAGGATGACATACAGCAGGAACTTAACA
GGAGAAGACCTGGAACCGGCGCCCTGACCACTCCACGGGCTGAATCCGACAGGGTCGAGATACTCTCAGGTATATTCAGG
GGAAGAACAGATGGCACTCCAATAGCTGGAATCGTCAGAAACCTGGACGCCGACTCAAAAAGTTACAGCAACATTAAGAA
TACACCAAGGCCGGGGCACGGCGACTACACCTGGAGGGCGAGGTTCAGGAACTACGACTACCGTGGCGGTGGCCGTGGAA
GTGGAAGGGTTACCATTGGGCACGTAATCGGTGGGGCCGTTGCAAAGAAACTCATCGGTAATTATGGTTTGACCGTAACA
GGCCACGTTGTACAGGTGGGTGATGTTAAGGCAGACACTGTAAGCCTTAAAAGGATAGGCGAGTATGCTGAGAGCAATCC
TGTTCGCTGTGCAGATCCCAGGGCGGCCAGACAGATGGAGAAGGTTATACTTGATGCCCGCAGCAGGGGAGACTCCGTTG
GCGGGGTTGTTGAGGTTGTTGTCCTGGGTGCGCCCCCTGGACTCGGCGATCCGGTATTCAGTAAACTCGATGCAGATATG
GCCAGGGCCCTCATGGGTATCGGGTCTGTGAAGGGTGTTGAGATCGGGATGGGATTCGAGGTTGCAGAACACCGTGCAAG
TGAGATAAACGATGAGTTCTACCTGGATGATGATGGTAAGGTGAGGACAACAACAAACACCTCTGGAGGCATACTTGGAG
GAATATCAAGCGGCATGCCAATAACTGCAAGGATAGCAGTAAAGCCCACACCATCCATATCAGTCCCCCAGAAGACCGTT
GACCTTGAAAGGATGGAGGAAACAACCATTGAGGTCCGTGGAAGACATGATCCCTGCATCTGCCCCAGGGTTGTGCCTGT
TGCAGAGGCTGCGGTTGCAATCGTCCTTGCCGACCATATGATAAGGGCCGGCTTCATCCACCCCACATACATTGGAAACG
AATGA

Upstream 100 bases:

>100_bases
GTTGCAGAATTTGAAGGTACAGGAACCGTATACATGCAGAGCCGGAGCATTGATAGCTTCGTTGGATGGTTAACACCCAT
GCTCCCCTCAAGGAGTTAGA

Downstream 100 bases:

>100_bases
AAGAATCCCTATCTGACCAGAGAGATGACAGCAGAACTGCTCGAATTCCTTGAGGAGCTGAGCCGCGCCCTCATAGCCTC
AGGGAATTCTGTTACAGATA

Product: chorismate synthase

Products: NA

Alternate protein names: 5-enolpyruvylshikimate-3-phosphate phospholyase

Number of amino acids: Translated: 374; Mature: 374

Protein sequence:

>374_residues
MILCGDSVAGNSTGEMFRVTTFGSSHGPAVGAVIDGCPAGLELSEDDIQQELNRRRPGTGALTTPRAESDRVEILSGIFR
GRTDGTPIAGIVRNLDADSKSYSNIKNTPRPGHGDYTWRARFRNYDYRGGGRGSGRVTIGHVIGGAVAKKLIGNYGLTVT
GHVVQVGDVKADTVSLKRIGEYAESNPVRCADPRAARQMEKVILDARSRGDSVGGVVEVVVLGAPPGLGDPVFSKLDADM
ARALMGIGSVKGVEIGMGFEVAEHRASEINDEFYLDDDGKVRTTTNTSGGILGGISSGMPITARIAVKPTPSISVPQKTV
DLERMEETTIEVRGRHDPCICPRVVPVAEAAVAIVLADHMIRAGFIHPTYIGNE

Sequences:

>Translated_374_residues
MILCGDSVAGNSTGEMFRVTTFGSSHGPAVGAVIDGCPAGLELSEDDIQQELNRRRPGTGALTTPRAESDRVEILSGIFR
GRTDGTPIAGIVRNLDADSKSYSNIKNTPRPGHGDYTWRARFRNYDYRGGGRGSGRVTIGHVIGGAVAKKLIGNYGLTVT
GHVVQVGDVKADTVSLKRIGEYAESNPVRCADPRAARQMEKVILDARSRGDSVGGVVEVVVLGAPPGLGDPVFSKLDADM
ARALMGIGSVKGVEIGMGFEVAEHRASEINDEFYLDDDGKVRTTTNTSGGILGGISSGMPITARIAVKPTPSISVPQKTV
DLERMEETTIEVRGRHDPCICPRVVPVAEAAVAIVLADHMIRAGFIHPTYIGNE
>Mature_374_residues
MILCGDSVAGNSTGEMFRVTTFGSSHGPAVGAVIDGCPAGLELSEDDIQQELNRRRPGTGALTTPRAESDRVEILSGIFR
GRTDGTPIAGIVRNLDADSKSYSNIKNTPRPGHGDYTWRARFRNYDYRGGGRGSGRVTIGHVIGGAVAKKLIGNYGLTVT
GHVVQVGDVKADTVSLKRIGEYAESNPVRCADPRAARQMEKVILDARSRGDSVGGVVEVVVLGAPPGLGDPVFSKLDADM
ARALMGIGSVKGVEIGMGFEVAEHRASEINDEFYLDDDGKVRTTTNTSGGILGGISSGMPITARIAVKPTPSISVPQKTV
DLERMEETTIEVRGRHDPCICPRVVPVAEAAVAIVLADHMIRAGFIHPTYIGNE

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; seventh step. [C]

COG id: COG0082

COG function: function code E; Chorismate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chorismate synthase family

Homologues:

Organism=Escherichia coli, GI1788669, Length=356, Percent_Identity=48.0337078651685, Blast_Score=303, Evalue=2e-83,
Organism=Saccharomyces cerevisiae, GI6321290, Length=363, Percent_Identity=41.8732782369146, Blast_Score=279, Evalue=6e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROC_METTH (O26843)

Other databases:

- EMBL:   AE000666
- PIR:   A69200
- RefSeq:   NP_275891.1
- ProteinModelPortal:   O26843
- SMR:   O26843
- STRING:   O26843
- GeneID:   1471156
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH748
- NMPDR:   fig|187420.1.peg.746
- eggNOG:   arNOG04618
- HOGENOM:   HBG292336
- OMA:   SRFTTQR
- PhylomeDB:   O26843
- ProtClustDB:   PRK05382
- BioCyc:   MTHE187420:MTH748-MONOMER
- BRENDA:   4.2.3.5
- HAMAP:   MF_00300_A
- InterPro:   IPR000453
- InterPro:   IPR020541
- PANTHER:   PTHR21085
- PIRSF:   PIRSF001456
- TIGRFAMs:   TIGR00033

Pfam domain/function: PF01264 Chorismate_synt; SSF103263 Chorismate_synth

EC number: =4.2.3.5

Molecular weight: Translated: 39589; Mature: 39589

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS00787 CHORISMATE_SYNTHASE_1; PS00788 CHORISMATE_SYNTHASE_2; PS00789 CHORISMATE_SYNTHASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILCGDSVAGNSTGEMFRVTTFGSSHGPAVGAVIDGCPAGLELSEDDIQQELNRRRPGTG
CEECCCCCCCCCCCCEEEEEECCCCCCCEEEHEECCCCCCCCCCHHHHHHHHHHCCCCCC
ALTTPRAESDRVEILSGIFRGRTDGTPIAGIVRNLDADSKSYSNIKNTPRPGHGDYTWRA
CCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCHHHHCCCCCCCCCCCCEEEE
RFRNYDYRGGGRGSGRVTIGHVIGGAVAKKLIGNYGLTVTGHVVQVGDVKADTVSLKRIG
EECCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCHHHHHHHHH
EYAESNPVRCADPRAARQMEKVILDARSRGDSVGGVVEVVVLGAPPGLGDPVFSKLDADM
HHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHH
ARALMGIGSVKGVEIGMGFEVAEHRASEINDEFYLDDDGKVRTTTNTSGGILGGISSGMP
HHHHHHCCCCCEEEEECCHHHHHHHHHHCCCCEEECCCCCEEEECCCCCCEEECCCCCCC
ITARIAVKPTPSISVPQKTVDLERMEETTIEVRGRHDPCICPRVVPVAEAAVAIVLADHM
EEEEEEECCCCCCCCCHHHHHHHHHHCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHH
IRAGFIHPTYIGNE
HHHCCCCCEECCCC
>Mature Secondary Structure
MILCGDSVAGNSTGEMFRVTTFGSSHGPAVGAVIDGCPAGLELSEDDIQQELNRRRPGTG
CEECCCCCCCCCCCCEEEEEECCCCCCCEEEHEECCCCCCCCCCHHHHHHHHHHCCCCCC
ALTTPRAESDRVEILSGIFRGRTDGTPIAGIVRNLDADSKSYSNIKNTPRPGHGDYTWRA
CCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCHHHHCCCCCCCCCCCCEEEE
RFRNYDYRGGGRGSGRVTIGHVIGGAVAKKLIGNYGLTVTGHVVQVGDVKADTVSLKRIG
EECCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCHHHHHHHHH
EYAESNPVRCADPRAARQMEKVILDARSRGDSVGGVVEVVVLGAPPGLGDPVFSKLDADM
HHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHH
ARALMGIGSVKGVEIGMGFEVAEHRASEINDEFYLDDDGKVRTTTNTSGGILGGISSGMP
HHHHHHCCCCCEEEEECCHHHHHHHHHHCCCCEEECCCCCEEEECCCCCCEEECCCCCCC
ITARIAVKPTPSISVPQKTVDLERMEETTIEVRGRHDPCICPRVVPVAEAAVAIVLADHM
EEEEEEECCCCCCCCCHHHHHHHHHHCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHH
IRAGFIHPTYIGNE
HHHCCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463