Click here to switch to the map view.

The map label for this gene is Not Available

Identifier: 15678688

GI number: 15678688

Start: 588943

End: 590166

Strand: Direct

Name: Not Available

Synonym: MTH661

Alternate gene names: 15678688

Gene position: 588943-590166 (Clockwise)

Preceding gene: 15678682

Following gene: 15678689

Centisome position: 33.63

GC content: 47.3

Gene sequence:

>1224_bases
ATGATGCTAAATTCAGGTGATACAGCATGGATGTTGATCTCAACTGCACTCGTGATACTAATGACGGTGCCAGGGGTTGC
TATGTTCTATTCTGGTTTAACAAAACGTGAGAATGTTCTGAACACCATCTTTCTATCATTTGTTTCCCTTGGCATTGTGA
GTCTGCTCTGGTTTCTGTTTGGATATGGTCTAATATTCGGCGGGGATGTTTCAGGGATCATAGGATCCCATCAGGTGGGC
ATCAGCCTTATTAATTTAGGGTCTGCTTCAAAATATGCTCCAACAATCCCCGAAGGACTCTTTGCAATTTTTCAGATGAC
CTTTGCTGCAATAACAGTTGCCCTGATTTCTGGCGCTGTGGTGGAAAGGATCAAATTCTCGTCATGGATACTGTTCATCC
CCCTCTGGTTTGCACTCGTATATGTACCCGTGGCCCACTGGGTATGGGGCGGAGGATTCCTGCAGAACCTTGGTGTTCAT
GATTTCGCAGGGGGAATTGTGGTGCACATCACCAGTGGCATAGCCGCCCTTGCCCTTGCCCTTGTTACTGGTCCAAGATA
TGACCAGAAACTGATGCCACATCACCTTGGATATTCTGTTATAGGTACCGGTCTTCTCTGGTTTGGCTGGTTTGGATTCA
ACGCCGGTTCAGCCCTCTCTGCCGGATCCCTTGCAGCTAACGCCATGATAGTGACAAACACCTCTGCAGCGGCGGGTATG
ATAGGATGGATCCTCATGGATAGACTTAAAACCGGAAAACCAACACTTCTTGGCGCTCTTTCTGGAGCAGTTGCAGGCCT
GGCATCAATAACACCTGCAGCAGGTTTTGTGGATATAGGTGCCTCCATTGTCACCGGACTTGTGGCAGCTGTTATATGTT
ATCTTGCAGTTTCATGGCTGAAGCCAGCTGCTGGATATGATGATGCGCTTGATGTATTTGGGATTCACGGTGTTTCAGGG
ATCATAGGAACCCTTGGAGTTGGTTTATTTGCAGTTCCAGCCCTAAACCCATCTTTGACCTCAGGAGGTCTTTTAACTGG
AAGCACATCCCTTCTTGTCAGTCAGCTGATTGGTGTTGTCACCGTCACTGTCTACACCTTCGTCGTTACATATATCCTTG
CGATGCTGCTGATGAAATTTAAGGGGCTCCGTGTTGAAAGGGAAGAGGAAATTCAGGGACTTGACATAAATCTCCATGAG
GAAACAGGTTACAGACTGACATGA

Upstream 100 bases:

>100_bases
TCATGATATTTATAATGTTGGTAGATTTTCGGAAGTAGGTTACCGGCATCCTTATATTGGTGATTGCAGATATGTTAGGC
ACATCCAAAAGGAGAGTGAT

Downstream 100 bases:

>100_bases
ACACAGATTTAAACATGGTTCACAGAAGTACTTATAAGAAATCCGGTTAAGGATATTTAAGGTGAAGACCATGAGGAAAA
TCACAGCAATTATCAGAAGG

Product: ammonium transporter

Products: NH3 [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MMLNSGDTAWMLISTALVILMTVPGVAMFYSGLTKRENVLNTIFLSFVSLGIVSLLWFLFGYGLIFGGDVSGIIGSHQVG
ISLINLGSASKYAPTIPEGLFAIFQMTFAAITVALISGAVVERIKFSSWILFIPLWFALVYVPVAHWVWGGGFLQNLGVH
DFAGGIVVHITSGIAALALALVTGPRYDQKLMPHHLGYSVIGTGLLWFGWFGFNAGSALSAGSLAANAMIVTNTSAAAGM
IGWILMDRLKTGKPTLLGALSGAVAGLASITPAAGFVDIGASIVTGLVAAVICYLAVSWLKPAAGYDDALDVFGIHGVSG
IIGTLGVGLFAVPALNPSLTSGGLLTGSTSLLVSQLIGVVTVTVYTFVVTYILAMLLMKFKGLRVEREEEIQGLDINLHE
ETGYRLT

Sequences:

>Translated_407_residues
MMLNSGDTAWMLISTALVILMTVPGVAMFYSGLTKRENVLNTIFLSFVSLGIVSLLWFLFGYGLIFGGDVSGIIGSHQVG
ISLINLGSASKYAPTIPEGLFAIFQMTFAAITVALISGAVVERIKFSSWILFIPLWFALVYVPVAHWVWGGGFLQNLGVH
DFAGGIVVHITSGIAALALALVTGPRYDQKLMPHHLGYSVIGTGLLWFGWFGFNAGSALSAGSLAANAMIVTNTSAAAGM
IGWILMDRLKTGKPTLLGALSGAVAGLASITPAAGFVDIGASIVTGLVAAVICYLAVSWLKPAAGYDDALDVFGIHGVSG
IIGTLGVGLFAVPALNPSLTSGGLLTGSTSLLVSQLIGVVTVTVYTFVVTYILAMLLMKFKGLRVEREEEIQGLDINLHE
ETGYRLT
>Mature_407_residues
MMLNSGDTAWMLISTALVILMTVPGVAMFYSGLTKRENVLNTIFLSFVSLGIVSLLWFLFGYGLIFGGDVSGIIGSHQVG
ISLINLGSASKYAPTIPEGLFAIFQMTFAAITVALISGAVVERIKFSSWILFIPLWFALVYVPVAHWVWGGGFLQNLGVH
DFAGGIVVHITSGIAALALALVTGPRYDQKLMPHHLGYSVIGTGLLWFGWFGFNAGSALSAGSLAANAMIVTNTSAAAGM
IGWILMDRLKTGKPTLLGALSGAVAGLASITPAAGFVDIGASIVTGLVAAVICYLAVSWLKPAAGYDDALDVFGIHGVSG
IIGTLGVGLFAVPALNPSLTSGGLLTGSTSLLVSQLIGVVTVTVYTFVVTYILAMLLMKFKGLRVEREEEIQGLDINLHE
ETGYRLT

Specific function: Involved In The Uptake Of Ammonia (Probable). [C]

COG id: COG0004

COG function: function code P; Ammonia permease

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ammonium transporter (TC 2.A.49) family

Homologues:

Organism=Escherichia coli, GI1786656, Length=405, Percent_Identity=40.9876543209877, Blast_Score=282, Evalue=2e-77,
Organism=Caenorhabditis elegans, GI17550182, Length=436, Percent_Identity=28.2110091743119, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17550180, Length=431, Percent_Identity=27.6102088167053, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI133931100, Length=438, Percent_Identity=25.5707762557078, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI32564042, Length=420, Percent_Identity=28.5714285714286, Blast_Score=99, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6324187, Length=423, Percent_Identity=36.6430260047281, Blast_Score=231, Evalue=1e-61,
Organism=Saccharomyces cerevisiae, GI6325396, Length=416, Percent_Identity=32.6923076923077, Blast_Score=197, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6321559, Length=408, Percent_Identity=31.3725490196078, Blast_Score=186, Evalue=4e-48,
Organism=Drosophila melanogaster, GI161078314, Length=415, Percent_Identity=29.8795180722892, Blast_Score=130, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y661_METTH (O26757)

Other databases:

- EMBL:   AE000666
- PIR:   A69188
- RefSeq:   NP_275803.1
- ProteinModelPortal:   O26757
- SMR:   O26757
- STRING:   O26757
- GeneID:   1470622
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH661
- NMPDR:   fig|187420.1.peg.658
- eggNOG:   arNOG05019
- HOGENOM:   HBG677626
- OMA:   VICYLAV
- PhylomeDB:   O26757
- ProtClustDB:   CLSK2750381
- BioCyc:   MTHE187420:MTH661-MONOMER
- InterPro:   IPR001905
- InterPro:   IPR018047
- InterPro:   IPR002229
- PANTHER:   PTHR11730
- PRINTS:   PR00342
- TIGRFAMs:   TIGR00836

Pfam domain/function: PF00909 Ammonium_transp; SSF111352 RH_like_transpt

EC number: NA

Molecular weight: Translated: 42668; Mature: 42668

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS01219 AMMONIUM_TRANSP

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x100238f4)-; HASH(0xf81ca44)-; HASH(0x10053d98)-; HASH(0x10049f4c)-; HASH(0xff69654)-; HASH(0x10189e6c)-; HASH(0xfdb9e40)-; HASH(0x101ba7a8)-; HASH(0x10103784)-; HASH(0x101e917c)-; HASH(0xf9af464)-; HASH(0xfd50ea0)-;

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMLNSGDTAWMLISTALVILMTVPGVAMFYSGLTKRENVLNTIFLSFVSLGIVSLLWFLF
CCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
GYGLIFGGDVSGIIGSHQVGISLINLGSASKYAPTIPEGLFAIFQMTFAAITVALISGAV
HHHHHCCCCCHHHCCCHHHCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VERIKFSSWILFIPLWFALVYVPVAHWVWGGGFLQNLGVHDFAGGIVVHITSGIAALALA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCHHHCCCEEEEEHHHHHHHHHH
LVTGPRYDQKLMPHHLGYSVIGTGLLWFGWFGFNAGSALSAGSLAANAMIVTNTSAAAGM
HHCCCCCCHHHCHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCEEEEECCCHHHHH
IGWILMDRLKTGKPTLLGALSGAVAGLASITPAAGFVDIGASIVTGLVAAVICYLAVSWL
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KPAAGYDDALDVFGIHGVSGIIGTLGVGLFAVPALNPSLTSGGLLTGSTSLLVSQLIGVV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEECCHHHHHHHHHHHHH
TVTVYTFVVTYILAMLLMKFKGLRVEREEEIQGLDINLHEETGYRLT
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCCEEEECCCCCCCH
>Mature Secondary Structure
MMLNSGDTAWMLISTALVILMTVPGVAMFYSGLTKRENVLNTIFLSFVSLGIVSLLWFLF
CCCCCCCCHHHHHHHHHHHHHHHCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
GYGLIFGGDVSGIIGSHQVGISLINLGSASKYAPTIPEGLFAIFQMTFAAITVALISGAV
HHHHHCCCCCHHHCCCHHHCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VERIKFSSWILFIPLWFALVYVPVAHWVWGGGFLQNLGVHDFAGGIVVHITSGIAALALA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCHHHCCCEEEEEHHHHHHHHHH
LVTGPRYDQKLMPHHLGYSVIGTGLLWFGWFGFNAGSALSAGSLAANAMIVTNTSAAAGM
HHCCCCCCHHHCHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCEEEEECCCHHHHH
IGWILMDRLKTGKPTLLGALSGAVAGLASITPAAGFVDIGASIVTGLVAAVICYLAVSWL
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KPAAGYDDALDVFGIHGVSGIIGTLGVGLFAVPALNPSLTSGGLLTGSTSLLVSQLIGVV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEECCHHHHHHHHHHHHH
TVTVYTFVVTYILAMLLMKFKGLRVEREEEIQGLDINLHEETGYRLT
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCCEEEECCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NH3 [Periplasm] [C]

Specific reaction: NH3 [Periplasm] = NH3 [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9371463