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Identifier: 15678618

GI number: 15678618

Start: 530108

End: 531106

Strand: Direct

Name: Not Available

Synonym: MTH590

Alternate gene names: 15678618

Gene position: 530108-531106 (Clockwise)

Preceding gene: 15678617

Following gene: 15678626

Centisome position: 30.27

GC content: 48.25

Gene sequence:

>999_bases
GTGCCAGATTATGTTTATGGTGATTCTATGGTTCTAAAACTTACCCTTGAATATTCATCTGTGCTGCTCGTGTCACTGAT
ATGCTGCATAATAGCCTTCACATCCACCTACACGGTGATGCCACGCCTCATAAATAAGCTGAAGGAGGCCAATGTGGTCG
GTAATGACATACACAAAATCTCAAAGCCCATAGTGGCTGAGATGGGTGGTATCGGGATACTCTTCGGCTTCACCATAGGG
ATGTTCATAGGTATGTACTGCTTCCCTGAACTCCAGTACGAGCTCATGGTGACCCTCCTTGTCATACTCCTGGTCGGCAT
TGTTGGAATGGTGGACGACCTTGTGAGGCTCTCGTCACGTGAAAAACTCTTCCTGCTCTTCCTTGCGGGTCTTCCAATAA
TCTGGGTTGCCCCTCCGAAGGTCGGGATACTCTACATGATCATGATGCCGGTAGCCGTTTCAATAGCTTCAAACCTGACC
AACATGCTGGCGGGACTGAATGGTATCGAATCAGGGCTCGGGTCAATTGCAATGACGGCCCTCACAGCCTCATGTATAAT
AATGGGCAAGTATGATGTCTCAATAATAACCATGGCCATGCTGGGGGCCCTCCTGGCATTCCTCATGTACAACAGGTACC
CATCAAGGGTGTTCCCTGGTGATGTTGGAACACTGATAATAGGTGCCTGCATAGCATCGGTTGCATTCATAGGCAGGGTC
AAGATAATAGCCCTCATAGTCCTGCTACCGAATATCATAGATGGGATTCTGAAATTCTACAGTGCCGGTGTCGTTGAGAG
GCACAAACACAGGCCCACAGAAATTGCAGAGGATGGTAAACTCATAGCACCCCCTGAGGGCTTCAACTCACTTATAAGGT
GGATACTGAGAAGGCCAATGACCGAGAAGAAGGTTGTCATGATAGTGTGGTCCATAGGAATGTTCTTCGGGTTCCTTGGA
GTCCTCCTGGCATTTATACTCCCACTTGATCCCTTCTAA

Upstream 100 bases:

>100_bases
AAGATGGATTACCCCGGTTATGATCCTCCAAAGAACGGCTGATGAAACCAAAAATGTATAAACCAGAGGGTGTTAATGAA
AAGTATAACCTTTAAATTCT

Downstream 100 bases:

>100_bases
CACCAGAGCCCCTAAAAACTGTATAATGTGTTCAGAAGTTCAAGGGTAACTGACTCCAGTTCCTTTTCATCGAGTTTCTG
GAGTATCTCAACTGCGGCCC

Product: N-acetylglucosamine-1-phosphate transferase

Products: UMP; N-acetyl-D-glucosaminyl-diphosphodolichol

Alternate protein names: NA

Number of amino acids: Translated: 332; Mature: 331

Protein sequence:

>332_residues
MPDYVYGDSMVLKLTLEYSSVLLVSLICCIIAFTSTYTVMPRLINKLKEANVVGNDIHKISKPIVAEMGGIGILFGFTIG
MFIGMYCFPELQYELMVTLLVILLVGIVGMVDDLVRLSSREKLFLLFLAGLPIIWVAPPKVGILYMIMMPVAVSIASNLT
NMLAGLNGIESGLGSIAMTALTASCIIMGKYDVSIITMAMLGALLAFLMYNRYPSRVFPGDVGTLIIGACIASVAFIGRV
KIIALIVLLPNIIDGILKFYSAGVVERHKHRPTEIAEDGKLIAPPEGFNSLIRWILRRPMTEKKVVMIVWSIGMFFGFLG
VLLAFILPLDPF

Sequences:

>Translated_332_residues
MPDYVYGDSMVLKLTLEYSSVLLVSLICCIIAFTSTYTVMPRLINKLKEANVVGNDIHKISKPIVAEMGGIGILFGFTIG
MFIGMYCFPELQYELMVTLLVILLVGIVGMVDDLVRLSSREKLFLLFLAGLPIIWVAPPKVGILYMIMMPVAVSIASNLT
NMLAGLNGIESGLGSIAMTALTASCIIMGKYDVSIITMAMLGALLAFLMYNRYPSRVFPGDVGTLIIGACIASVAFIGRV
KIIALIVLLPNIIDGILKFYSAGVVERHKHRPTEIAEDGKLIAPPEGFNSLIRWILRRPMTEKKVVMIVWSIGMFFGFLG
VLLAFILPLDPF
>Mature_331_residues
PDYVYGDSMVLKLTLEYSSVLLVSLICCIIAFTSTYTVMPRLINKLKEANVVGNDIHKISKPIVAEMGGIGILFGFTIGM
FIGMYCFPELQYELMVTLLVILLVGIVGMVDDLVRLSSREKLFLLFLAGLPIIWVAPPKVGILYMIMMPVAVSIASNLTN
MLAGLNGIESGLGSIAMTALTASCIIMGKYDVSIITMAMLGALLAFLMYNRYPSRVFPGDVGTLIIGACIASVAFIGRVK
IIALIVLLPNIIDGILKFYSAGVVERHKHRPTEIAEDGKLIAPPEGFNSLIRWILRRPMTEKKVVMIVWSIGMFFGFLGV
LLAFILPLDPF

Specific function: First Step Of The Lipid Cycle Reactions In The Biosynthesis Of The Cell Wall Peptidoglycan. [C]

COG id: COG0472

COG function: function code M; UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 4 family [H]

Homologues:

Organism=Homo sapiens, GI42794009, Length=279, Percent_Identity=26.8817204301075, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI19921214, Length=273, Percent_Identity=27.8388278388278, Blast_Score=82, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000715 [H]

Pfam domain/function: PF00953 Glycos_transf_4 [H]

EC number: 2.7.8.15

Molecular weight: Translated: 36337; Mature: 36206

Theoretical pI: Translated: 8.44; Mature: 8.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
6.0 %Met     (Translated Protein)
7.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
5.7 %Met     (Mature Protein)
7.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDYVYGDSMVLKLTLEYSSVLLVSLICCIIAFTSTYTVMPRLINKLKEANVVGNDIHKI
CCCCEECCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
SKPIVAEMGGIGILFGFTIGMFIGMYCFPELQYELMVTLLVILLVGIVGMVDDLVRLSSR
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
EKLFLLFLAGLPIIWVAPPKVGILYMIMMPVAVSIASNLTNMLAGLNGIESGLGSIAMTA
CHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
LTASCIIMGKYDVSIITMAMLGALLAFLMYNRYPSRVFPGDVGTLIIGACIASVAFIGRV
HHHHHHEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
KIIALIVLLPNIIDGILKFYSAGVVERHKHRPTEIAEDGKLIAPPEGFNSLIRWILRRPM
HHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCHHCCCCEECCCCCHHHHHHHHHHCCC
TEKKVVMIVWSIGMFFGFLGVLLAFILPLDPF
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
PDYVYGDSMVLKLTLEYSSVLLVSLICCIIAFTSTYTVMPRLINKLKEANVVGNDIHKI
CCCEECCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
SKPIVAEMGGIGILFGFTIGMFIGMYCFPELQYELMVTLLVILLVGIVGMVDDLVRLSSR
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
EKLFLLFLAGLPIIWVAPPKVGILYMIMMPVAVSIASNLTNMLAGLNGIESGLGSIAMTA
CHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
LTASCIIMGKYDVSIITMAMLGALLAFLMYNRYPSRVFPGDVGTLIIGACIASVAFIGRV
HHHHHHEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
KIIALIVLLPNIIDGILKFYSAGVVERHKHRPTEIAEDGKLIAPPEGFNSLIRWILRRPM
HHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCHHCCCCEECCCCCHHHHHHHHHHCCC
TEKKVVMIVWSIGMFFGFLGVLLAFILPLDPF
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-glucosamine; dolichyl phosphate

Specific reaction: UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UMP + N-acetyl-D-glucosaminyl-diphosphodolichol

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]