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Identifier: 15678611

GI number: 15678611

Start: 521315

End: 521869

Strand: Direct

Name: Not Available

Synonym: MTH583

Alternate gene names: 15678611

Gene position: 521315-521869 (Clockwise)

Preceding gene: 15678610

Following gene: 15678612

Centisome position: 29.77

GC content: 52.07

Gene sequence:

>555_bases
ATGAAGGTCAGAGCATTCCTTGCAGTTGACCTCGATGAGGGACTGCGGGACCATGTATCCAGGATACAGGATACCCTCAA
ATCTGCGGATGCCCAGGTCAAATTCGTTGAACCAGAGAACCTGCACTTCACCCTCAAGTTCTTCGGTGATGTTGGTGAGG
GTAAGCTCAGGAGGATAGAGAATGTGGTGAGGGACACCCTCCGAGGCTATGAGCCCTTTGAAATCAGCATAAGGGGGGCT
GGTGTCTTCCCGAACCCCAGATACATACGTGTGGTCTGGCTAGGAGTTGAAAACCCTGAAACCTTCTCAGATCTTCAGAG
GAGCCTTGACATGGAATTCGTGAAGATGGGGTTCCGTCCTGAGAGGGACTACGTACCCCACCTCACAGTAGGGAGGGTTA
AGGGACCGAGGAACAGGGATAAACTCGCTGAGCTCATAGGGGAACTTCAGAACGTTGAGGTCGGATCAATGAGGGTCAGT
GAGGTGTCCCTCAAGAGGAGTGAACTCACACCTGCAGGGCCAATCTACACTGATATGGAGGTCTTCAGACTTTGA

Upstream 100 bases:

>100_bases
TCTTCAGCAGGGTGGATCTGTACATCCTCAACACCATCGAAACACCCAGGGAGAGCCTTGAAAGGCTCAGAAGCCTTGAA
CATAGTGGGGAGGTTAAGCA

Downstream 100 bases:

>100_bases
GGTTCTGATCCGACCCCATGAGTGGCAGAAAATTTTTTGATTCATGGCCCCCTATATGGATAGCTGGTGCACTCTCACTC
CGGTTCCTATCCTGGATTAG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 184; Mature: 184

Protein sequence:

>184_residues
MKVRAFLAVDLDEGLRDHVSRIQDTLKSADAQVKFVEPENLHFTLKFFGDVGEGKLRRIENVVRDTLRGYEPFEISIRGA
GVFPNPRYIRVVWLGVENPETFSDLQRSLDMEFVKMGFRPERDYVPHLTVGRVKGPRNRDKLAELIGELQNVEVGSMRVS
EVSLKRSELTPAGPIYTDMEVFRL

Sequences:

>Translated_184_residues
MKVRAFLAVDLDEGLRDHVSRIQDTLKSADAQVKFVEPENLHFTLKFFGDVGEGKLRRIENVVRDTLRGYEPFEISIRGA
GVFPNPRYIRVVWLGVENPETFSDLQRSLDMEFVKMGFRPERDYVPHLTVGRVKGPRNRDKLAELIGELQNVEVGSMRVS
EVSLKRSELTPAGPIYTDMEVFRL
>Mature_184_residues
MKVRAFLAVDLDEGLRDHVSRIQDTLKSADAQVKFVEPENLHFTLKFFGDVGEGKLRRIENVVRDTLRGYEPFEISIRGA
GVFPNPRYIRVVWLGVENPETFSDLQRSLDMEFVKMGFRPERDYVPHLTVGRVKGPRNRDKLAELIGELQNVEVGSMRVS
EVSLKRSELTPAGPIYTDMEVFRL

Specific function: Specifically Ligates tRNA Half-Molecules Containing Nucleoside Base Modifications And Shows A Preference Among Different tRNA Species. Acts In The Absence Of ATP To Form A 2'-5' Phosphodiester Linkage. [C]

COG id: COG1514

COG function: function code J; 2'-5' RNA ligase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPF0097 family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y583_METTH (O26683)

Other databases:

- EMBL:   AE000666
- PIR:   C69177
- RefSeq:   NP_275726.1
- ProteinModelPortal:   O26683
- SMR:   O26683
- STRING:   O26683
- GeneID:   1470544
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH583
- NMPDR:   fig|187420.1.peg.581
- eggNOG:   arNOG10084
- HOGENOM:   HBG699408
- OMA:   RCFLAIE
- ProtClustDB:   CLSK2750348
- BioCyc:   MTHE187420:MTH583-MONOMER
- GO:   GO:0005622
- InterPro:   IPR004175
- InterPro:   IPR014051
- InterPro:   IPR009097
- TIGRFAMs:   TIGR02258

Pfam domain/function: PF02834 2_5_RNA_ligase; SSF55144 Cyc_nuc_Pdiester

EC number: 6.5.1.- [C]

Molecular weight: Translated: 21108; Mature: 21108

Theoretical pI: Translated: 6.82; Mature: 6.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVRAFLAVDLDEGLRDHVSRIQDTLKSADAQVKFVEPENLHFTLKFFGDVGEGKLRRIE
CCEEEEEEEEHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEEEECCCCCHHHHHHH
NVVRDTLRGYEPFEISIRGAGVFPNPRYIRVVWLGVENPETFSDLQRSLDMEFVKMGFRP
HHHHHHHCCCCCEEEEEEECCCCCCCCEEEEEEEECCCCHHHHHHHHHHCHHHHHCCCCC
ERDYVPHLTVGRVKGPRNRDKLAELIGELQNVEVGSMRVSEVSLKRSELTPAGPIYTDME
CCCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCEEEHHHHHHHHCCCCCCCCCCCHH
VFRL
HHCC
>Mature Secondary Structure
MKVRAFLAVDLDEGLRDHVSRIQDTLKSADAQVKFVEPENLHFTLKFFGDVGEGKLRRIE
CCEEEEEEEEHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEEEEECCCCCHHHHHHH
NVVRDTLRGYEPFEISIRGAGVFPNPRYIRVVWLGVENPETFSDLQRSLDMEFVKMGFRP
HHHHHHHCCCCCEEEEEEECCCCCCCCEEEEEEEECCCCHHHHHHHHHHCHHHHHCCCCC
ERDYVPHLTVGRVKGPRNRDKLAELIGELQNVEVGSMRVSEVSLKRSELTPAGPIYTDME
CCCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCEEEHHHHHHHHCCCCCCCCCCCHH
VFRL
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463