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Identifier: 15678594

GI number: 15678594

Start: 509605

End: 510270

Strand: Direct

Name: Not Available

Synonym: MTH566

Alternate gene names: 15678594

Gene position: 509605-510270 (Clockwise)

Preceding gene: 15678593

Following gene: 15678595

Centisome position: 29.1

GC content: 53.3

Gene sequence:

>666_bases
ATGAACACAAAGATCTGTGTCCCTGTATTTGAGAAGACAGCCCCGGAGGTTACTGAGTCAGCCGGGAGGGCCATTGATGC
AGGTGCGGATATCCTTGAAATAAGAATTGATGGCCTCCAGAATCCTGGAGAAGTTAATATCAGGGAACTCATAGAGGATA
TAGGGTTCCCTGTGATTGCAACCAACCGATCACCTGTCGAGGGTGGTCATTTCAGTGGCAGCGAGGATGAAAGAATAAAG
CTGCTGATGGCTGCCGCTGAGGTCGCCGACTTCGTGGATATTGAACTCAGCAGTGCCCGTGAGGACATAGAGCGGGTCAC
AGGTAGTGCCAGGAGAAGCATCGTATCCTACCATAACTTCAGGGAGACGCCCTCACTGGAGGCCCTCCTGAGGATCGTCA
GGATGGCTAAGGAGATGGGTGACATCGCCAAGGTAGCTGTGATGCCAGAGAACCTGGCAGACACCCTGGTGGTACTCCAG
CTCCTCACATTTGAGGAGGACACTGTGGCAATATCCATGGGGGAACTCGGTAAATACACGAGGGTTGCAGCCGCCCTCTT
TGGCTCACCCATCACCTTCGCATCAATGGGGAGGGGGACAGCCCCGGGACAGATGGATGTTGATGTAACCCGGAAAATGA
TTGGAGAACTCATGCCGGAGGATTGA

Upstream 100 bases:

>100_bases
CCCCTCAAAAAATTATTTTATATCAAAAGGGACATAAAGAATCACACTAAAATCTTTAGTTCTCTGAAGACTCCAAAAAA
GTGTGGGAGAAATATTTCAC

Downstream 100 bases:

>100_bases
CCATGAAGAAGGTTCTGATTGCCATTGCAGTGCTTGCCATCATCGCCGTTTCAGGTGCATTTTACTACCTTGATCATGTG
GATTCTGTTGACATAACCAT

Product: 3-dehydroquinate dehydratase

Products: NA

Alternate protein names: 3-dehydroquinase; Type I DHQase

Number of amino acids: Translated: 221; Mature: 221

Protein sequence:

>221_residues
MNTKICVPVFEKTAPEVTESAGRAIDAGADILEIRIDGLQNPGEVNIRELIEDIGFPVIATNRSPVEGGHFSGSEDERIK
LLMAAAEVADFVDIELSSAREDIERVTGSARRSIVSYHNFRETPSLEALLRIVRMAKEMGDIAKVAVMPENLADTLVVLQ
LLTFEEDTVAISMGELGKYTRVAAALFGSPITFASMGRGTAPGQMDVDVTRKMIGELMPED

Sequences:

>Translated_221_residues
MNTKICVPVFEKTAPEVTESAGRAIDAGADILEIRIDGLQNPGEVNIRELIEDIGFPVIATNRSPVEGGHFSGSEDERIK
LLMAAAEVADFVDIELSSAREDIERVTGSARRSIVSYHNFRETPSLEALLRIVRMAKEMGDIAKVAVMPENLADTLVVLQ
LLTFEEDTVAISMGELGKYTRVAAALFGSPITFASMGRGTAPGQMDVDVTRKMIGELMPED
>Mature_221_residues
MNTKICVPVFEKTAPEVTESAGRAIDAGADILEIRIDGLQNPGEVNIRELIEDIGFPVIATNRSPVEGGHFSGSEDERIK
LLMAAAEVADFVDIELSSAREDIERVTGSARRSIVSYHNFRETPSLEALLRIVRMAKEMGDIAKVAVMPENLADTLVVLQ
LLTFEEDTVAISMGELGKYTRVAAALFGSPITFASMGRGTAPGQMDVDVTRKMIGELMPED

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; third step. [C]

COG id: COG0710

COG function: function code E; 3-dehydroquinate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type-I 3-dehydroquinase family

Homologues:

Organism=Escherichia coli, GI1787984, Length=232, Percent_Identity=29.3103448275862, Blast_Score=86, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROD_METTH (O26666)

Other databases:

- EMBL:   AE000666
- PIR:   H69174
- RefSeq:   NP_275709.1
- ProteinModelPortal:   O26666
- SMR:   O26666
- STRING:   O26666
- GeneID:   1470527
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH566
- NMPDR:   fig|187420.1.peg.564
- eggNOG:   arNOG12575
- HOGENOM:   HBG732926
- OMA:   IAKLAVM
- PhylomeDB:   O26666
- ProtClustDB:   CLSK797932
- BioCyc:   MTHE187420:MTH566-MONOMER
- BRENDA:   4.2.1.10
- HAMAP:   MF_00214
- InterPro:   IPR013785
- InterPro:   IPR001381
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR01093

Pfam domain/function: PF01487 DHquinase_I

EC number: =4.2.1.10

Molecular weight: Translated: 23968; Mature: 23968

Theoretical pI: Translated: 4.30; Mature: 4.30

Prosite motif: PS01028 DEHYDROQUINASE_I

Important sites: ACT_SITE 118-118 ACT_SITE 144-144

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTKICVPVFEKTAPEVTESAGRAIDAGADILEIRIDGLQNPGEVNIRELIEDIGFPVIA
CCCCEEEEHHHCCCHHHHHHHCCEECCCCCEEEEEECCCCCCCCCCHHHHHHHCCCCEEE
TNRSPVEGGHFSGSEDERIKLLMAAAEVADFVDIELSSAREDIERVTGSARRSIVSYHNF
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
RETPSLEALLRIVRMAKEMGDIAKVAVMPENLADTLVVLQLLTFEEDTVAISMGELGKYT
CCCCCHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHCCCCCEEEEHHHCCHHH
RVAAALFGSPITFASMGRGTAPGQMDVDVTRKMIGELMPED
HHHHHHHCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNTKICVPVFEKTAPEVTESAGRAIDAGADILEIRIDGLQNPGEVNIRELIEDIGFPVIA
CCCCEEEEHHHCCCHHHHHHHCCEECCCCCEEEEEECCCCCCCCCCHHHHHHHCCCCEEE
TNRSPVEGGHFSGSEDERIKLLMAAAEVADFVDIELSSAREDIERVTGSARRSIVSYHNF
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
RETPSLEALLRIVRMAKEMGDIAKVAVMPENLADTLVVLQLLTFEEDTVAISMGELGKYT
CCCCCHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHCCCCCEEEEHHHCCHHH
RVAAALFGSPITFASMGRGTAPGQMDVDVTRKMIGELMPED
HHHHHHHCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463