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Identifier: 15678501

GI number: 15678501

Start: 414585

End: 415364

Strand: Direct

Name: Not Available

Synonym: MTH473

Alternate gene names: 15678501

Gene position: 414585-415364 (Clockwise)

Preceding gene: 15678498

Following gene: 15678502

Centisome position: 23.67

GC content: 55.77

Gene sequence:

>780_bases
ATGGATCCTGGAAACCCTGTCTTCAATGCATTCCTTGCAACCATCTTCACCTGGCTCATGACCCTTGCAGGGGCGGCCCT
GGTTTTTCTACCGCTGCAGGGTGATAGAAAACTCCTTGACTCATCCCTTGGATTTGCAGCAGGTATAATGATCGCTGCGA
GCTTCTGGTCACTCCTGGTCCCTGCCATTGAACTTTCACCCACCGGGGTGTATGCCTGGGTTCCTCCGGCTGCCGGGTTC
CTTGCCGGTGGTCTCTTCCTCTCAGCCATGGACAGGATCATACCACACCTTCACCCTGGCTGTGACCCTGAAGGTCTGCC
AACGACCTGGCGGAGGAACAGACTCCTTCTCCTTGCAGTTGTGATACACAACCTTCCTGAGGGGCTGGCCATCGGTGTTG
CCTTCGGTGCAGCTGCCAGTACCGGTGGACTTGCAGCTCCCCTTGCACTGGCACTGGGTATAGGTATACAGAACCTCCCG
GAGGGTGCAGCGGTATCACTGCCCCTCCTTGGTGAGGGACTCTCCAGGTGGAGGAGCTTCATCTATGGACAGTTATCAGG
TGTTATTGAGGTACTTGGAGGGATTGGAGGTGCCCTCATGGTCTACTCCTTTTCAGGGATAATGCCCTATGCCCTTGGCT
TTGCAGCGGGGGCCATGATATTCGTTGTGATAGAGGACCTGATACCGGAGTGCCAGAGCGGAGGTAACACGGATCTTGCC
ACGGTCTCAGCGCTCATGGGCTTTGTTCTCATGATGGTACTTGACCTCGCACTTGCCTGA

Upstream 100 bases:

>100_bases
TTGATGGGAATATTAATGTTTTGTTTGGTTATTAAATCTGTACCGGATTAAAGGGCCTGAACACAAGGAATTATTAAAGA
ATCTGTACATAGAATCTTCA

Downstream 100 bases:

>100_bases
TCCTCATGACACATCATAGTTCAACCGGTGGCCCCTGCCACTGAAAATTTTTTCATGAATACCTGCAGAGCTTGTTTGAA
TGTCCCATTTTATTAGATAT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 259; Mature: 259

Protein sequence:

>259_residues
MDPGNPVFNAFLATIFTWLMTLAGAALVFLPLQGDRKLLDSSLGFAAGIMIAASFWSLLVPAIELSPTGVYAWVPPAAGF
LAGGLFLSAMDRIIPHLHPGCDPEGLPTTWRRNRLLLLAVVIHNLPEGLAIGVAFGAAASTGGLAAPLALALGIGIQNLP
EGAAVSLPLLGEGLSRWRSFIYGQLSGVIEVLGGIGGALMVYSFSGIMPYALGFAAGAMIFVVIEDLIPECQSGGNTDLA
TVSALMGFVLMMVLDLALA

Sequences:

>Translated_259_residues
MDPGNPVFNAFLATIFTWLMTLAGAALVFLPLQGDRKLLDSSLGFAAGIMIAASFWSLLVPAIELSPTGVYAWVPPAAGF
LAGGLFLSAMDRIIPHLHPGCDPEGLPTTWRRNRLLLLAVVIHNLPEGLAIGVAFGAAASTGGLAAPLALALGIGIQNLP
EGAAVSLPLLGEGLSRWRSFIYGQLSGVIEVLGGIGGALMVYSFSGIMPYALGFAAGAMIFVVIEDLIPECQSGGNTDLA
TVSALMGFVLMMVLDLALA
>Mature_259_residues
MDPGNPVFNAFLATIFTWLMTLAGAALVFLPLQGDRKLLDSSLGFAAGIMIAASFWSLLVPAIELSPTGVYAWVPPAAGF
LAGGLFLSAMDRIIPHLHPGCDPEGLPTTWRRNRLLLLAVVIHNLPEGLAIGVAFGAAASTGGLAAPLALALGIGIQNLP
EGAAVSLPLLGEGLSRWRSFIYGQLSGVIEVLGGIGGALMVYSFSGIMPYALGFAAGAMIFVVIEDLIPECQSGGNTDLA
TVSALMGFVLMMVLDLALA

Specific function: Mediates Zinc Uptake. May Also Transport Other Divalent Cations Such As Copper And Cadmium Ions. [C]

COG id: COG0428

COG function: function code P; Predicted divalent heavy-metal cations transporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI229577418, Length=329, Percent_Identity=43.161094224924, Blast_Score=231, Evalue=4e-61,
Organism=Homo sapiens, GI229577422, Length=336, Percent_Identity=40.4761904761905, Blast_Score=192, Evalue=3e-49,
Organism=Escherichia coli, GI1789419, Length=190, Percent_Identity=34.2105263157895, Blast_Score=78, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17507805, Length=315, Percent_Identity=41.2698412698413, Blast_Score=213, Evalue=5e-56,
Organism=Drosophila melanogaster, GI24652846, Length=158, Percent_Identity=49.3670886075949, Blast_Score=146, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003689 [H]

Pfam domain/function: PF02535 Zip [H]

EC number: NA

Molecular weight: Translated: 26748; Mature: 26748

Theoretical pI: Translated: 4.36; Mature: 4.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDPGNPVFNAFLATIFTWLMTLAGAALVFLPLQGDRKLLDSSLGFAAGIMIAASFWSLLV
CCCCCHHHHHHHHHHHHHHHHHHCHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
PAIELSPTGVYAWVPPAAGFLAGGLFLSAMDRIIPHLHPGCDPEGLPTTWRRNRLLLLAV
HHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCHHHHHHH
VIHNLPEGLAIGVAFGAAASTGGLAAPLALALGIGIQNLPEGAAVSLPLLGEGLSRWRSF
HHHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHCCCCCCEEECHHHHHHHHHHHHH
IYGQLSGVIEVLGGIGGALMVYSFSGIMPYALGFAAGAMIFVVIEDLIPECQSGGNTDLA
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
TVSALMGFVLMMVLDLALA
HHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDPGNPVFNAFLATIFTWLMTLAGAALVFLPLQGDRKLLDSSLGFAAGIMIAASFWSLLV
CCCCCHHHHHHHHHHHHHHHHHHCHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
PAIELSPTGVYAWVPPAAGFLAGGLFLSAMDRIIPHLHPGCDPEGLPTTWRRNRLLLLAV
HHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCHHHHHHH
VIHNLPEGLAIGVAFGAAASTGGLAAPLALALGIGIQNLPEGAAVSLPLLGEGLSRWRSF
HHHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHCCCCCCEEECHHHHHHHHHHHHH
IYGQLSGVIEVLGGIGGALMVYSFSGIMPYALGFAAGAMIFVVIEDLIPECQSGGNTDLA
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
TVSALMGFVLMMVLDLALA
HHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7934835 [H]