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Identifier: 15678487

GI number: 15678487

Start: 399277

End: 400764

Strand: Direct

Name: Not Available

Synonym: MTH459

Alternate gene names: 15678487

Gene position: 399277-400764 (Clockwise)

Preceding gene: 15678486

Following gene: 15678489

Centisome position: 22.8

GC content: 49.73

Gene sequence:

>1488_bases
ATGAAGGGGGTCAGGGGAAACCTCCATGTCATGGTCCACAGGGGTGATCTTCCAGATTCAGGTCAGATGATCCTGAGCTT
CAATGACATAACAAAACTCAGGGAGTCCCAGAGGAAACTGAGGGATGAAGTCCGTGTTAGAAGGGTCCTCAGTGAAATCT
ACCCACAAGCGGTCTCAACTGATAATCTGGGGGAATTCACAGAGTACATACTCGATGCTACATGCAAAGTTACAGGCGCG
GATGGAGGAATCATAAGACTGAGAAATGTGGAGACAATCACCATCACAGAAAAGCTGGAACCCCCTGAAGAGGTTCCAGA
CCTTGAGGGACTCTCAGAAGATGGTAAAATGATCCGCATAACCTCCTCCTCTGCAGATATGAGCTCAGAGTTCATACTCA
GGGGCACCAGCTTCAGCAAAGCGGATCTCAGGGCTGTCAGGCACATCTCACAGTACTATATGCTGGCTGTAAAGCAGATC
AGCTACAGGAGGAGGATGAATGAGCACTGGAACCACCTCAGGCTCATAAATATCATACTCAAGCTGGCTGATACAGAAGA
CCCTGAATTATTCCTCAGGGGAGTCCTTGATTTCATAATCAGATGCCCTGAATTCAATGGGGGATCAGCATACCTTGACC
CAGATTTAAAGGTTGAGAGGGGATTGATACCTCCAGACAGCATTCCAGATACAGAAGGTGTCCTGGTGGATGGAGAAATC
ATTGAGATACCCCTGAGTGTGGATGGGGCTGTAAGGGGTGTCTTAAGGCTCCAGGCAGCATACAGTGACGTTAAAGAAAA
AACTGAGTTCCTGGAGGTACTTGGAGGGGAAATATCCGATGGTCTGCAGCGGATAACCATGCGAAATCAGCTCAGGGAAT
CCCTCCGTGAGAAGGAGGTCCTGCTGAGGGAGATACACCACCGGGTCAAGAACAACCTCCAGATAGTGGCAAGTCTGCTG
TCCCTCCAGACAGCATATACAGACAACCAGGAGACCCTCAATGTCCTCAGGGATAGCCAGATGAGGGTCAGGGCCATGGC
AGTTGCCCATGAGAAGATATACAGGTCAAGCAGCCTGTCCATGATAAACGTTGGAGACTACCTCAGGGCAATCGCAGAGG
AGATGACCACCCTGCAGTCCACCGGTGGGCTCCTTGTGGATCTCGATGTCCACTACGATGATATAATGGCCGAGATGGAC
AGGTGCATCCCCCTGGGCCTGATAACCAATGAGATAATCTCCAATTCAATCAAACACGCCTTCACAGGGGACAGGGGCAG
GATAGTGATCTCACTCAAGAGGGAGGACGATCTTGGTATCCTTGAAATATCAGATAACGGCAGGGGGCTCCCTGAGGACT
TCAACATTGATGAACTGGAATCACTCGGAATGCAGCTTGTATCAAACCTTGTGATGCAGATTGGGGGTGAACTGGAATAT
GGAAACAGGGATGGTGCATTCTTCAGGGTCACGTTCCCACTTGAATGA

Upstream 100 bases:

>100_bases
CTTCGGTGTTGATGAGGGCTTCAATTTAAGGGACCTGCTGGACTAGGATGAACTTCAGAAACTTGAGAAACTCCGGGAAT
CCCAGAGGGCGCTGATAAGG

Downstream 100 bases:

>100_bases
ACTATTCCACCCTTCCAGCGCCCCTGAGCATCAGGGACCTTTCTATCCTGGCTATGAAGTACTTCATCCTCAGGATCTTA
TCCGGGCTTGTGGATATACC

Product: sensory transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 495; Mature: 495

Protein sequence:

>495_residues
MKGVRGNLHVMVHRGDLPDSGQMILSFNDITKLRESQRKLRDEVRVRRVLSEIYPQAVSTDNLGEFTEYILDATCKVTGA
DGGIIRLRNVETITITEKLEPPEEVPDLEGLSEDGKMIRITSSSADMSSEFILRGTSFSKADLRAVRHISQYYMLAVKQI
SYRRRMNEHWNHLRLINIILKLADTEDPELFLRGVLDFIIRCPEFNGGSAYLDPDLKVERGLIPPDSIPDTEGVLVDGEI
IEIPLSVDGAVRGVLRLQAAYSDVKEKTEFLEVLGGEISDGLQRITMRNQLRESLREKEVLLREIHHRVKNNLQIVASLL
SLQTAYTDNQETLNVLRDSQMRVRAMAVAHEKIYRSSSLSMINVGDYLRAIAEEMTTLQSTGGLLVDLDVHYDDIMAEMD
RCIPLGLITNEIISNSIKHAFTGDRGRIVISLKREDDLGILEISDNGRGLPEDFNIDELESLGMQLVSNLVMQIGGELEY
GNRDGAFFRVTFPLE

Sequences:

>Translated_495_residues
MKGVRGNLHVMVHRGDLPDSGQMILSFNDITKLRESQRKLRDEVRVRRVLSEIYPQAVSTDNLGEFTEYILDATCKVTGA
DGGIIRLRNVETITITEKLEPPEEVPDLEGLSEDGKMIRITSSSADMSSEFILRGTSFSKADLRAVRHISQYYMLAVKQI
SYRRRMNEHWNHLRLINIILKLADTEDPELFLRGVLDFIIRCPEFNGGSAYLDPDLKVERGLIPPDSIPDTEGVLVDGEI
IEIPLSVDGAVRGVLRLQAAYSDVKEKTEFLEVLGGEISDGLQRITMRNQLRESLREKEVLLREIHHRVKNNLQIVASLL
SLQTAYTDNQETLNVLRDSQMRVRAMAVAHEKIYRSSSLSMINVGDYLRAIAEEMTTLQSTGGLLVDLDVHYDDIMAEMD
RCIPLGLITNEIISNSIKHAFTGDRGRIVISLKREDDLGILEISDNGRGLPEDFNIDELESLGMQLVSNLVMQIGGELEY
GNRDGAFFRVTFPLE
>Mature_495_residues
MKGVRGNLHVMVHRGDLPDSGQMILSFNDITKLRESQRKLRDEVRVRRVLSEIYPQAVSTDNLGEFTEYILDATCKVTGA
DGGIIRLRNVETITITEKLEPPEEVPDLEGLSEDGKMIRITSSSADMSSEFILRGTSFSKADLRAVRHISQYYMLAVKQI
SYRRRMNEHWNHLRLINIILKLADTEDPELFLRGVLDFIIRCPEFNGGSAYLDPDLKVERGLIPPDSIPDTEGVLVDGEI
IEIPLSVDGAVRGVLRLQAAYSDVKEKTEFLEVLGGEISDGLQRITMRNQLRESLREKEVLLREIHHRVKNNLQIVASLL
SLQTAYTDNQETLNVLRDSQMRVRAMAVAHEKIYRSSSLSMINVGDYLRAIAEEMTTLQSTGGLLVDLDVHYDDIMAEMD
RCIPLGLITNEIISNSIKHAFTGDRGRIVISLKREDDLGILEISDNGRGLPEDFNIDELESLGMQLVSNLVMQIGGELEY
GNRDGAFFRVTFPLE

Specific function: Member of the two-component regulatory system pdtaR/pdtaS. Autophosphorylates, probably on a histidine residue, and transfers its phosphate group to pdtaR [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR022066
- InterPro:   IPR011495
- InterPro:   IPR005467 [H]

Pfam domain/function: PF12282 H_kinase_N; PF02518 HATPase_c; PF07568 HisKA_2 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 55814; Mature: 55814

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGVRGNLHVMVHRGDLPDSGQMILSFNDITKLRESQRKLRDEVRVRRVLSEIYPQAVST
CCCCCCCEEEEEEECCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCC
DNLGEFTEYILDATCKVTGADGGIIRLRNVETITITEKLEPPEEVPDLEGLSEDGKMIRI
CCHHHHHHHHHHCCEEEECCCCCEEEEECCEEEEEEECCCCHHCCCCCCCCCCCCCEEEE
TSSSADMSSEFILRGTSFSKADLRAVRHISQYYMLAVKQISYRRRMNEHWNHLRLINIIL
ECCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLADTEDPELFLRGVLDFIIRCPEFNGGSAYLDPDLKVERGLIPPDSIPDTEGVLVDGEI
HHCCCCCHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCEEECCEE
IEIPLSVDGAVRGVLRLQAAYSDVKEKTEFLEVLGGEISDGLQRITMRNQLRESLREKEV
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
LLREIHHRVKNNLQIVASLLSLQTAYTDNQETLNVLRDSQMRVRAMAVAHEKIYRSSSLS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCC
MINVGDYLRAIAEEMTTLQSTGGLLVDLDVHYDDIMAEMDRCIPLGLITNEIISNSIKHA
EEEHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
FTGDRGRIVISLKREDDLGILEISDNGRGLPEDFNIDELESLGMQLVSNLVMQIGGELEY
HCCCCCEEEEEEECCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEC
GNRDGAFFRVTFPLE
CCCCCEEEEEEECCC
>Mature Secondary Structure
MKGVRGNLHVMVHRGDLPDSGQMILSFNDITKLRESQRKLRDEVRVRRVLSEIYPQAVST
CCCCCCCEEEEEEECCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCC
DNLGEFTEYILDATCKVTGADGGIIRLRNVETITITEKLEPPEEVPDLEGLSEDGKMIRI
CCHHHHHHHHHHCCEEEECCCCCEEEEECCEEEEEEECCCCHHCCCCCCCCCCCCCEEEE
TSSSADMSSEFILRGTSFSKADLRAVRHISQYYMLAVKQISYRRRMNEHWNHLRLINIIL
ECCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLADTEDPELFLRGVLDFIIRCPEFNGGSAYLDPDLKVERGLIPPDSIPDTEGVLVDGEI
HHCCCCCHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCEEECCEE
IEIPLSVDGAVRGVLRLQAAYSDVKEKTEFLEVLGGEISDGLQRITMRNQLRESLREKEV
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
LLREIHHRVKNNLQIVASLLSLQTAYTDNQETLNVLRDSQMRVRAMAVAHEKIYRSSSLS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCC
MINVGDYLRAIAEEMTTLQSTGGLLVDLDVHYDDIMAEMDRCIPLGLITNEIISNSIKHA
EEEHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
FTGDRGRIVISLKREDDLGILEISDNGRGLPEDFNIDELESLGMQLVSNLVMQIGGELEY
HCCCCCEEEEEEECCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEC
GNRDGAFFRVTFPLE
CCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]