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Identifier: 15678479

GI number: 15678479

Start: 388797

End: 390572

Strand: Direct

Name: Not Available

Synonym: MTH451

Alternate gene names: NA

Gene position: 388797-390572 (Clockwise)

Preceding gene: 15678478

Following gene: 15678480

Centisome position: 22.2

GC content: 52.42

Gene sequence:

>1776_bases
TTGGATAATCATTACTTCCCATTCACAGCCATCGTTGGACAGGAACTCCTCAAGAAGGCCCTCATCCTCAACGCCATAAA
CCCATCAATAGGCGGCGTCCTGATCAGGGGCGATAAGGGGACAGGTAAATCAACTGCAGTGAGATCACTGAGGGATGTAC
TCCCTGATAGGAAAATGGTGGAGGGCTGCAGGTTCGGATGCGACCCTGATGGAGCAGAAATATGCATGGAGTGCCGCAGA
AAACTTGAGGAACAGGGTAGCCTGCCATCAAGACAGGTCAGGATGGAGGTGGTCGACCTCCCTGTATCCGCAACCGAGGA
TATGGTTGTGGGTTCACTGGACATAAAGAGGGCCCTCAGGGATGGAATAAAGGCCCTTGAGCCAGGCATACTTGCACGTG
CCAACGGCAACATCCTCTACATCGATGAGGTCAACCTCCTTGATGACTACATAGTGAACGTCCTCCTCGATGCAGCAGCC
ATGGGCGTGAATATCATTGAAAGGGAGGGCATATCCATCCAGCATCCATCAAGGTTCATACTTGCAGGTACAATGAACCC
TGAGGAGGGTGATCTCAGACCCCAGATACTTGACAGATTCGGCCTCAGTGTTGATGTGGAGGCAATAAAGGACCCTGATG
AAAGAATTGAAGTCATAAAGCGTGCAATGAAGTTCCAGGAGGATCCAGAGTCCTTCCACTCAAGGTTCCGGAGGAAACAG
GAGGAGCTCAGGGAGAAAATCATCAGGGCACGGAGTTTACTTGAGATGGTCGAGTTGGATGATGAGACCCTGGGCCTCAT
AGTTGAGATAGCAGCAGCCCTTGGCATCAGGACCCACAGGGCCGATATCATAACTGCAAGGACCGCGAGGGCACTGGCGG
CATTCAACGGCAGGAGGAGGGTCACAGGGGATGATGTGATGGAGGCTGCGCTCCTTGCCATGAAGCACAGACTTAGACAG
CTACCATTCCAGAGGCAACAGGAACTCAGCCAGGAGATTATAGAGGACATCATGAATGGCGAATTCGAGGATGACTCAGA
GATTGACAGGGAACGGAGGCTGAGGCGTGACCTGAAGATCCCTGACCTGAAGGGATCCCTCCAGGGTCAGAGCAGTTCAA
CGGTAACCGGGAGGAGGGGTAAGTATGTCCGCGCCCGGGAGAACCCTGAACCATCCAGCGTGGCCGTTGATGCAACCCTG
AGGAAGGCTGCTTCAGCTGGAACCGGAACCATAGAACCCGAACACCTCATGGAGAAGGTTCGGATCGGGAAATCCAGGGC
ACTCTACATAATCGTCCTTGACACCTCGTCATCAATGAGACTTGAGAGGAAGATAAAATTTGCAAAGACGGTCTCATGGC
TGCTCCTGAGGGACTCCTATGAAAAGAGGAACAGGATAGCCCTCATAGCCTTCAGGGGATATGAGGCAAACCTGGTGGTT
GAGCCCACATCGAATCTTGAGACCGTTGAGGAGGCCCTTGAGGGTCTCAGGTCAGGCGGGAGGACACCCCTCACACCGGC
ACTCAGACTGGCAGCTGAGGTTGCATCATCATCCAGCGATGAGGCATGCACAGCCGTTGTAATATCAGACGGCCGCTGCA
ACGTATTCATCAACTCCAACCTCGAGGAGGACATGAATATGCTTGAAACTGAACTGAGGAACCTGAACCTTTTATTCGTT
AATGCAGAACCCGAGAAGAGGAGCCTGGGTATACTTGAGGACATGGCGTCACGCTTTGGCTCTGAAATCTTCTACCTTGA
TGATATACTGATCTAG

Upstream 100 bases:

>100_bases
TATTATTACTTTTAATACAGTCAGGTACATATTAGTAATACTCATCTTTTTTTAGAAATTATTAAATAATGATTAGACCA
ACCACTGAACCGGTGATAGC

Downstream 100 bases:

>100_bases
GACTTTGGGAGTTTATGAAAAAACATGACACGCATGGAGGTGTGATTGTTGTTTAGATTCAGAGATTTCACAACAGCTGA
TCTGGCCTTCACGGGCCTCA

Product: magnesium chelatase subunit ChlI

Products: ADP; phosphate; Mg-protoporphyrin IX; H+

Alternate protein names: NA

Number of amino acids: Translated: 591; Mature: 591

Protein sequence:

>591_residues
MDNHYFPFTAIVGQELLKKALILNAINPSIGGVLIRGDKGTGKSTAVRSLRDVLPDRKMVEGCRFGCDPDGAEICMECRR
KLEEQGSLPSRQVRMEVVDLPVSATEDMVVGSLDIKRALRDGIKALEPGILARANGNILYIDEVNLLDDYIVNVLLDAAA
MGVNIIEREGISIQHPSRFILAGTMNPEEGDLRPQILDRFGLSVDVEAIKDPDERIEVIKRAMKFQEDPESFHSRFRRKQ
EELREKIIRARSLLEMVELDDETLGLIVEIAAALGIRTHRADIITARTARALAAFNGRRRVTGDDVMEAALLAMKHRLRQ
LPFQRQQELSQEIIEDIMNGEFEDDSEIDRERRLRRDLKIPDLKGSLQGQSSSTVTGRRGKYVRARENPEPSSVAVDATL
RKAASAGTGTIEPEHLMEKVRIGKSRALYIIVLDTSSSMRLERKIKFAKTVSWLLLRDSYEKRNRIALIAFRGYEANLVV
EPTSNLETVEEALEGLRSGGRTPLTPALRLAAEVASSSSDEACTAVVISDGRCNVFINSNLEEDMNMLETELRNLNLLFV
NAEPEKRSLGILEDMASRFGSEIFYLDDILI

Sequences:

>Translated_591_residues
MDNHYFPFTAIVGQELLKKALILNAINPSIGGVLIRGDKGTGKSTAVRSLRDVLPDRKMVEGCRFGCDPDGAEICMECRR
KLEEQGSLPSRQVRMEVVDLPVSATEDMVVGSLDIKRALRDGIKALEPGILARANGNILYIDEVNLLDDYIVNVLLDAAA
MGVNIIEREGISIQHPSRFILAGTMNPEEGDLRPQILDRFGLSVDVEAIKDPDERIEVIKRAMKFQEDPESFHSRFRRKQ
EELREKIIRARSLLEMVELDDETLGLIVEIAAALGIRTHRADIITARTARALAAFNGRRRVTGDDVMEAALLAMKHRLRQ
LPFQRQQELSQEIIEDIMNGEFEDDSEIDRERRLRRDLKIPDLKGSLQGQSSSTVTGRRGKYVRARENPEPSSVAVDATL
RKAASAGTGTIEPEHLMEKVRIGKSRALYIIVLDTSSSMRLERKIKFAKTVSWLLLRDSYEKRNRIALIAFRGYEANLVV
EPTSNLETVEEALEGLRSGGRTPLTPALRLAAEVASSSSDEACTAVVISDGRCNVFINSNLEEDMNMLETELRNLNLLFV
NAEPEKRSLGILEDMASRFGSEIFYLDDILI
>Mature_591_residues
MDNHYFPFTAIVGQELLKKALILNAINPSIGGVLIRGDKGTGKSTAVRSLRDVLPDRKMVEGCRFGCDPDGAEICMECRR
KLEEQGSLPSRQVRMEVVDLPVSATEDMVVGSLDIKRALRDGIKALEPGILARANGNILYIDEVNLLDDYIVNVLLDAAA
MGVNIIEREGISIQHPSRFILAGTMNPEEGDLRPQILDRFGLSVDVEAIKDPDERIEVIKRAMKFQEDPESFHSRFRRKQ
EELREKIIRARSLLEMVELDDETLGLIVEIAAALGIRTHRADIITARTARALAAFNGRRRVTGDDVMEAALLAMKHRLRQ
LPFQRQQELSQEIIEDIMNGEFEDDSEIDRERRLRRDLKIPDLKGSLQGQSSSTVTGRRGKYVRARENPEPSSVAVDATL
RKAASAGTGTIEPEHLMEKVRIGKSRALYIIVLDTSSSMRLERKIKFAKTVSWLLLRDSYEKRNRIALIAFRGYEANLVV
EPTSNLETVEEALEGLRSGGRTPLTPALRLAAEVASSSSDEACTAVVISDGRCNVFINSNLEEDMNMLETELRNLNLLFV
NAEPEKRSLGILEDMASRFGSEIFYLDDILI

Specific function: Unknown

COG id: COG1239

COG function: function code H; Mg-chelatase subunit ChlI

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Mg-chelatase subunits D/I family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000523 [H]

Pfam domain/function: PF01078 Mg_chelatase [H]

EC number: 6.6.1.1

Molecular weight: Translated: 66125; Mature: 66125

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS50234 VWFA ; PS00589 PTS_HPR_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNHYFPFTAIVGQELLKKALILNAINPSIGGVLIRGDKGTGKSTAVRSLRDVLPDRKMV
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCHHHH
EGCRFGCDPDGAEICMECRRKLEEQGSLPSRQVRMEVVDLPVSATEDMVVGSLDIKRALR
HHCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHEEEEEEECCCCCCCCCEECHHHHHHHHH
DGIKALEPGILARANGNILYIDEVNLLDDYIVNVLLDAAAMGVNIIEREGISIQHPSRFI
HHHHHHCCCEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHCCHHHHCCCCCEECCCEEE
LAGTMNPEEGDLRPQILDRFGLSVDVEAIKDPDERIEVIKRAMKFQEDPESFHSRFRRKQ
EEECCCCCCCCCCHHHHHHHCCCEEEHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
EELREKIIRARSLLEMVELDDETLGLIVEIAAALGIRTHRADIITARTARALAAFNGRRR
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCC
VTGDDVMEAALLAMKHRLRQLPFQRQQELSQEIIEDIMNGEFEDDSEIDRERRLRRDLKI
CCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCC
PDLKGSLQGQSSSTVTGRRGKYVRARENPEPSSVAVDATLRKAASAGTGTIEPEHLMEKV
CCCCCCCCCCCCCCEECCCCCEEECCCCCCCCCEEHHHHHHHHHCCCCCCCCHHHHHHHH
RIGKSRALYIIVLDTSSSMRLERKIKFAKTVSWLLLRDSYEKRNRIALIAFRGYEANLVV
HCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCHHCCCCEEEEEEECCCCEEEE
EPTSNLETVEEALEGLRSGGRTPLTPALRLAAEVASSSSDEACTAVVISDGRCNVFINSN
CCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEEECCEEEEEECCC
LEEDMNMLETELRNLNLLFVNAEPEKRSLGILEDMASRFGSEIFYLDDILI
CHHHHHHHHHHHCCCEEEEEECCCCCHHCHHHHHHHHHHCCCEEECCCCCC
>Mature Secondary Structure
MDNHYFPFTAIVGQELLKKALILNAINPSIGGVLIRGDKGTGKSTAVRSLRDVLPDRKMV
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCHHHH
EGCRFGCDPDGAEICMECRRKLEEQGSLPSRQVRMEVVDLPVSATEDMVVGSLDIKRALR
HHCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHEEEEEEECCCCCCCCCEECHHHHHHHHH
DGIKALEPGILARANGNILYIDEVNLLDDYIVNVLLDAAAMGVNIIEREGISIQHPSRFI
HHHHHHCCCEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHCCHHHHCCCCCEECCCEEE
LAGTMNPEEGDLRPQILDRFGLSVDVEAIKDPDERIEVIKRAMKFQEDPESFHSRFRRKQ
EEECCCCCCCCCCHHHHHHHCCCEEEHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
EELREKIIRARSLLEMVELDDETLGLIVEIAAALGIRTHRADIITARTARALAAFNGRRR
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCC
VTGDDVMEAALLAMKHRLRQLPFQRQQELSQEIIEDIMNGEFEDDSEIDRERRLRRDLKI
CCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCC
PDLKGSLQGQSSSTVTGRRGKYVRARENPEPSSVAVDATLRKAASAGTGTIEPEHLMEKV
CCCCCCCCCCCCCCEECCCCCEEECCCCCCCCCEEHHHHHHHHHCCCCCCCCHHHHHHHH
RIGKSRALYIIVLDTSSSMRLERKIKFAKTVSWLLLRDSYEKRNRIALIAFRGYEANLVV
HCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCHHCCCCEEEEEEECCCCEEEE
EPTSNLETVEEALEGLRSGGRTPLTPALRLAAEVASSSSDEACTAVVISDGRCNVFINSN
CCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEEECCEEEEEECCC
LEEDMNMLETELRNLNLLFVNAEPEKRSLGILEDMASRFGSEIFYLDDILI
CHHHHHHHHHHHCCCEEEEEECCCCCHHCHHHHHHHHHHCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; protoporphyrin IX; Mg2+; H2O

Specific reaction: ATP + protoporphyrin IX + Mg2+ + H2O = ADP + phosphate + Mg-protoporphyrin IX + 2 H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]