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Identifier: 15678320

GI number: 15678320

Start: 227212

End: 228906

Strand: Direct

Name: Not Available

Synonym: MTH292

Alternate gene names: 15678320

Gene position: 227212-228906 (Clockwise)

Preceding gene: 15678317

Following gene: 15678321

Centisome position: 12.97

GC content: 51.68

Gene sequence:

>1695_bases
GTGATTGAAATGGGCTCTGCAGCTTTATTAAGACCAGAATCCCTCGATGAAAAGATAACACTTTCAATGAGCATTTCTGT
ACTCACAATATCCGTCATGGCACTGATTCTATGGTTAACCGGGGCACTCCAGACACCCAAGGTTGGACCCTTCCTTGATA
AGGACCCGACCATATTCATGAGCTTCATTCTCCTGGCCGCCGCCATACTCGCCCTGAAGGCTTCTAGGAAAGTAACATCC
CTCGTTCTATCACTGATGGTCCTGGCCATCCAGTTCTCTGGAGGTAGCCAGCCCCTCCACCCTCAGGCATGGACAGTAAC
ATCCATGATAATCATATCATACTCCACTGCAGTGATCCTTTTTTCAATTGAAAGATACTCGGCTGCCCAGATAATCAGTT
ACACTGCGGGTACAGTGGCATATGCACTGTTCCTATCAGAGATTACAGGGATTACGGAAACAGAGCCGCATTTCAGGGCA
TGCATAACCTCTGCTGCAATGATGGTGTTCCTGGCCATAGGTCTCCTCAGCACCCACCCATCCCATGGTGTTGTGGAGCC
ACTCTATTCAGGGAGGATCGGGGGCTACACCGGGAGGATGCTGATACCCATCGTGATAGGGTCCCTGACCCTCACGTCAT
TCATAGTAATCAGCGGCAGCAGCCACATACCATTCTCTGCCGATGTCTTCCTGGCCACCCTGAACCTGGCACTTTTAATT
GTAATAATAACATTCACAGCCTACAAACTCAACGTGGTGGATTATGAGAGAATAAAAAATCAGAGGAAAAGCCAGAGGAT
GTGGAGGTTCTTCAGGAATGTTGTGGATAACCTTGAGGAGGCGGTGGCGGTCCTGGACCGTAACGGGGAAGTCCTGCACA
GCAACACCGCGATGAAGAACCTGGAACTGGACCTCAGGAGACTGTGGAGGGAAAACCTGGAGGGTAAGGATCTTCCACAG
CCCATAGGAACCATCAGGTCAGGTGGGAGGTACTTCACGGGATGGGCCATACCCCTGGATGATGGTGGGATCATATCCCT
GATGGATATAAGCGGGCTTGTGGAGGTACAGGAGGACCTGCGGTCATCCCTCAGGGAGAAGGAGGCGCTGCTGAGGGAAC
TTCAGCACAGGGTCAGGAACAACCTTCAGATAATCACAAGCCTCATAAACATCCAGCTTCAGGATGCAGATGGCCCGGTA
AAGGAGGCGCTCCTGGCTACCCAGACCAGGGTGAGGGCCATGACCATAATACAGGAGTCACTCTACAGCACTGATGGCTA
CAGCAGTGTACACATCGAATCATGCATCTCCCGGATGACAGAGCACCTCAAATCCCTGCTGGGTGCACATGGTGTGGGAT
TCAATATCAGGGCTGACCTCAGACTCAACCTTGAAACAGCAATGCCCCTCTGCCTCATGGTGAATGAGCTTGTGACAAAT
GCCATAAAACATGCATTCCCTGAGGGGAAGGGAGAGGTCCACATTGAGATAGATGAGGGGGAATCGGGGTACCACATGCG
CTTTGCAGATGATGGCATTGGGTTCAGTGGGGAGGGGGAAGGCACCGGCCTGAAACTTGTAAGGATCCTTGTGGAGCAGC
TTGAGGGTGACCTGAAGATACTTGTAGATGAGGAGAAAGGGGGGACAGAGATACTGGTGCCCTTCAGGGAACTCCAGTAC
AGGGAGAGGACCTAG

Upstream 100 bases:

>100_bases
AGGCCTTAAAATGGTTATTATCCTGTCAGTTCCCCCAGATATTCCATTTAAAGATTTTTTCGAAAAAATATTTATTATAT
CATGTTTATAGATCAGAAAG

Downstream 100 bases:

>100_bases
CAGTTAAACCATGGAGGTGAATGGAATACGGTGGCTGGCATCTGACATGTACTGTCACTGTATCTGAGGGGGGAAACATT
TGATAGGAATGAACTCCATA

Product: sensory transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 564; Mature: 564

Protein sequence:

>564_residues
MIEMGSAALLRPESLDEKITLSMSISVLTISVMALILWLTGALQTPKVGPFLDKDPTIFMSFILLAAAILALKASRKVTS
LVLSLMVLAIQFSGGSQPLHPQAWTVTSMIIISYSTAVILFSIERYSAAQIISYTAGTVAYALFLSEITGITETEPHFRA
CITSAAMMVFLAIGLLSTHPSHGVVEPLYSGRIGGYTGRMLIPIVIGSLTLTSFIVISGSSHIPFSADVFLATLNLALLI
VIITFTAYKLNVVDYERIKNQRKSQRMWRFFRNVVDNLEEAVAVLDRNGEVLHSNTAMKNLELDLRRLWRENLEGKDLPQ
PIGTIRSGGRYFTGWAIPLDDGGIISLMDISGLVEVQEDLRSSLREKEALLRELQHRVRNNLQIITSLINIQLQDADGPV
KEALLATQTRVRAMTIIQESLYSTDGYSSVHIESCISRMTEHLKSLLGAHGVGFNIRADLRLNLETAMPLCLMVNELVTN
AIKHAFPEGKGEVHIEIDEGESGYHMRFADDGIGFSGEGEGTGLKLVRILVEQLEGDLKILVDEEKGGTEILVPFRELQY
RERT

Sequences:

>Translated_564_residues
MIEMGSAALLRPESLDEKITLSMSISVLTISVMALILWLTGALQTPKVGPFLDKDPTIFMSFILLAAAILALKASRKVTS
LVLSLMVLAIQFSGGSQPLHPQAWTVTSMIIISYSTAVILFSIERYSAAQIISYTAGTVAYALFLSEITGITETEPHFRA
CITSAAMMVFLAIGLLSTHPSHGVVEPLYSGRIGGYTGRMLIPIVIGSLTLTSFIVISGSSHIPFSADVFLATLNLALLI
VIITFTAYKLNVVDYERIKNQRKSQRMWRFFRNVVDNLEEAVAVLDRNGEVLHSNTAMKNLELDLRRLWRENLEGKDLPQ
PIGTIRSGGRYFTGWAIPLDDGGIISLMDISGLVEVQEDLRSSLREKEALLRELQHRVRNNLQIITSLINIQLQDADGPV
KEALLATQTRVRAMTIIQESLYSTDGYSSVHIESCISRMTEHLKSLLGAHGVGFNIRADLRLNLETAMPLCLMVNELVTN
AIKHAFPEGKGEVHIEIDEGESGYHMRFADDGIGFSGEGEGTGLKLVRILVEQLEGDLKILVDEEKGGTEILVPFRELQY
RERT
>Mature_564_residues
MIEMGSAALLRPESLDEKITLSMSISVLTISVMALILWLTGALQTPKVGPFLDKDPTIFMSFILLAAAILALKASRKVTS
LVLSLMVLAIQFSGGSQPLHPQAWTVTSMIIISYSTAVILFSIERYSAAQIISYTAGTVAYALFLSEITGITETEPHFRA
CITSAAMMVFLAIGLLSTHPSHGVVEPLYSGRIGGYTGRMLIPIVIGSLTLTSFIVISGSSHIPFSADVFLATLNLALLI
VIITFTAYKLNVVDYERIKNQRKSQRMWRFFRNVVDNLEEAVAVLDRNGEVLHSNTAMKNLELDLRRLWRENLEGKDLPQ
PIGTIRSGGRYFTGWAIPLDDGGIISLMDISGLVEVQEDLRSSLREKEALLRELQHRVRNNLQIITSLINIQLQDADGPV
KEALLATQTRVRAMTIIQESLYSTDGYSSVHIESCISRMTEHLKSLLGAHGVGFNIRADLRLNLETAMPLCLMVNELVTN
AIKHAFPEGKGEVHIEIDEGESGYHMRFADDGIGFSGEGEGTGLKLVRILVEQLEGDLKILVDEEKGGTEILVPFRELQY
RERT

Specific function: Member of the two-component regulatory system pdtaR/pdtaS. Autophosphorylates, probably on a histidine residue, and transfers its phosphate group to pdtaR [H]

COG id: COG3920

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR022066
- InterPro:   IPR011495
- InterPro:   IPR005467 [H]

Pfam domain/function: PF12282 H_kinase_N; PF02518 HATPase_c; PF07568 HisKA_2 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 62259; Mature: 62259

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEMGSAALLRPESLDEKITLSMSISVLTISVMALILWLTGALQTPKVGPFLDKDPTIFM
CCCCCCCCEECCCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
SFILLAAAILALKASRKVTSLVLSLMVLAIQFSGGSQPLHPQAWTVTSMIIISYSTAVIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHHCCEEEE
FSIERYSAAQIISYTAGTVAYALFLSEITGITETEPHFRACITSAAMMVFLAIGLLSTHP
EEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
SHGVVEPLYSGRIGGYTGRMLIPIVIGSLTLTSFIVISGSSHIPFSADVFLATLNLALLI
CCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHHH
VIITFTAYKLNVVDYERIKNQRKSQRMWRFFRNVVDNLEEAVAVLDRNGEVLHSNTAMKN
HHHHHHHHEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHH
LELDLRRLWRENLEGKDLPQPIGTIRSGGRYFTGWAIPLDDGGIISLMDISGLVEVQEDL
HHHHHHHHHHHCCCCCCCCCHHHHHHCCCEEEEEEEEEECCCCEEEEECHHHHHHHHHHH
RSSLREKEALLRELQHRVRNNLQIITSLINIQLQDADGPVKEALLATQTRVRAMTIIQES
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
LYSTDGYSSVHIESCISRMTEHLKSLLGAHGVGFNIRADLRLNLETAMPLCLMVNELVTN
HHCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEHHHHHHHHHHHHHHHHH
AIKHAFPEGKGEVHIEIDEGESGYHMRFADDGIGFSGEGEGTGLKLVRILVEQLEGDLKI
HHHHHCCCCCCEEEEEEECCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCEEE
LVDEEKGGTEILVPFRELQYRERT
EEECCCCCCEEEEEHHHHHCCCCC
>Mature Secondary Structure
MIEMGSAALLRPESLDEKITLSMSISVLTISVMALILWLTGALQTPKVGPFLDKDPTIFM
CCCCCCCCEECCCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
SFILLAAAILALKASRKVTSLVLSLMVLAIQFSGGSQPLHPQAWTVTSMIIISYSTAVIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHHCCEEEE
FSIERYSAAQIISYTAGTVAYALFLSEITGITETEPHFRACITSAAMMVFLAIGLLSTHP
EEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
SHGVVEPLYSGRIGGYTGRMLIPIVIGSLTLTSFIVISGSSHIPFSADVFLATLNLALLI
CCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHHH
VIITFTAYKLNVVDYERIKNQRKSQRMWRFFRNVVDNLEEAVAVLDRNGEVLHSNTAMKN
HHHHHHHHEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHH
LELDLRRLWRENLEGKDLPQPIGTIRSGGRYFTGWAIPLDDGGIISLMDISGLVEVQEDL
HHHHHHHHHHHCCCCCCCCCHHHHHHCCCEEEEEEEEEECCCCEEEEECHHHHHHHHHHH
RSSLREKEALLRELQHRVRNNLQIITSLINIQLQDADGPVKEALLATQTRVRAMTIIQES
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
LYSTDGYSSVHIESCISRMTEHLKSLLGAHGVGFNIRADLRLNLETAMPLCLMVNELVTN
HHCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEHHHHHHHHHHHHHHHHH
AIKHAFPEGKGEVHIEIDEGESGYHMRFADDGIGFSGEGEGTGLKLVRILVEQLEGDLKI
HHHHHCCCCCCEEEEEEECCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCEEE
LVDEEKGGTEILVPFRELQYRERT
EEECCCCCCEEEEEHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]