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Identifier: 15678297

GI number: 15678297

Start: 205542

End: 206948

Strand: Direct

Name: Not Available

Synonym: MTH269

Alternate gene names: 15678297

Gene position: 205542-206948 (Clockwise)

Preceding gene: 15678296

Following gene: 15678298

Centisome position: 11.74

GC content: 53.94

Gene sequence:

>1407_bases
TTGAACCTGAGGGCTGGCAGATTGAATAGCGGGATGGAGGATGAGGCCGCGGAGTTCACATCATCCCTCACATTTGATCA
CCACATATTTGAGGCCGACATTGAGTGTAACATGGCACATACACGCATGCTGGCCCATGAGGGCATAATCCCTGAGGAAG
TGGCCGCTAAAATCATAGATGCCCTTGAAAGCCTCAGGGAGGAGGGTATAGAGGCCCTTGACATGGACCCATCGGTGGAG
GATATCCATATGGCCGTTGAGAACTATGTAACGGCCAGGATCGGAGAGGAAGCAGGGTTCATGCACACAGGCAAATCCAG
GAACGATCAGGTCGCAACCGATCTCAGACTGGCCCTCAGGGAGAGGATAAGGACAATAAGCCGTGAACTCCTTGATTTTA
TTGACAGTATCTCAGACCTTGCCCTCGATCACACCGAAACCGTCATGGTGGGCTACACCCACCTTCAGCATGCCCAGCCA
ACAACCCTAGGCCACCACCTCATGGCCTACGCCAGCTCCCTCAGGAGGGACTATGAGAGGCTCCAGGATACCCTTAAGAG
GGTTGACCAGAACCCCCTGGGATCCGCTGCCATGACAACAACCAGCTTCCCCATAAACAGGGAACTCACGACCCGGCTCC
TCGGGTTCTCAGATTACATGAAAAATTCCATGGACGCCGTCAGTGCAAGGGACTTCATAGCAGAGACGGTATTCGACCTC
TCAATGCTGGCAGTGAACCTCAGCAGGATCTCAGAGGAGATGATACTCTGGAGCACCCACGAGTTTGGTATCGTGGAGAT
ACCTGATGAATTCTCATCAACATCATCCATCATGCCCCAGAAGAAGAACCCTGATGTGGCTGAGATAGCCCGTGCAAAGA
CATCCACCGTCCAGGGAGAACTTGTAACCATCCTTGGAATCATGAAGGCACTCCCCTACACCTACAACAGGGACCTGCAG
GAGGTAACACCCCACCTCTGGAGGGCCGTCGACACGGTACTCTCAATGATCAGGGTTGTCAGGGGAATGCTCCTCGGCAT
CAGGGTTAACAGGAACCGGGCCCTTGAACTTGCAGGTGCCAACTTCGCAACAGCCACAGACCTTGCAGACATCATAGTAC
GTGAGCGGGGGATACCCTTCAGGGTGGCCCACAGGATAGTGGGAAGGCTTGTTACAAGGGCCATTGAGGACGGCCTCGCA
CCCGGTGACGTGGATTCAGTTTACCTTGACGAGGTCAGCCTGGAGGTCACCGGACGGAAACTTGAACTTGACCCTGAACT
TGTTGAGAAGGCCCTTGATCCCCTTGAGAACGTCAGGATGAGGAGGATACCTGGAGGACCCGCCCCTGAGATGGTCAGGG
TTGCGGTTGAGGAGATGAAGTCCTTCATTGAATCTGAGAGGAAATGA

Upstream 100 bases:

>100_bases
TCAGGTGCTCAAACGGTGTCTTCATGGCAGACCATGGGGACAGGTACGCCTGCGGTAAATGCGGATACACCGAATGGAAA
AACAGGGAATAGGTGGAAAC

Downstream 100 bases:

>100_bases
GGAAGTTTCCTGACGGGATTAAATAACTCTTTTTCATGCTCCCCGCACTTTCAGGCAGGTTATTGACCTTTCCTGGAGGT
TCCCGTAAATTTGAAGTTAA

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 468; Mature: 468

Protein sequence:

>468_residues
MNLRAGRLNSGMEDEAAEFTSSLTFDHHIFEADIECNMAHTRMLAHEGIIPEEVAAKIIDALESLREEGIEALDMDPSVE
DIHMAVENYVTARIGEEAGFMHTGKSRNDQVATDLRLALRERIRTISRELLDFIDSISDLALDHTETVMVGYTHLQHAQP
TTLGHHLMAYASSLRRDYERLQDTLKRVDQNPLGSAAMTTTSFPINRELTTRLLGFSDYMKNSMDAVSARDFIAETVFDL
SMLAVNLSRISEEMILWSTHEFGIVEIPDEFSSTSSIMPQKKNPDVAEIARAKTSTVQGELVTILGIMKALPYTYNRDLQ
EVTPHLWRAVDTVLSMIRVVRGMLLGIRVNRNRALELAGANFATATDLADIIVRERGIPFRVAHRIVGRLVTRAIEDGLA
PGDVDSVYLDEVSLEVTGRKLELDPELVEKALDPLENVRMRRIPGGPAPEMVRVAVEEMKSFIESERK

Sequences:

>Translated_468_residues
MNLRAGRLNSGMEDEAAEFTSSLTFDHHIFEADIECNMAHTRMLAHEGIIPEEVAAKIIDALESLREEGIEALDMDPSVE
DIHMAVENYVTARIGEEAGFMHTGKSRNDQVATDLRLALRERIRTISRELLDFIDSISDLALDHTETVMVGYTHLQHAQP
TTLGHHLMAYASSLRRDYERLQDTLKRVDQNPLGSAAMTTTSFPINRELTTRLLGFSDYMKNSMDAVSARDFIAETVFDL
SMLAVNLSRISEEMILWSTHEFGIVEIPDEFSSTSSIMPQKKNPDVAEIARAKTSTVQGELVTILGIMKALPYTYNRDLQ
EVTPHLWRAVDTVLSMIRVVRGMLLGIRVNRNRALELAGANFATATDLADIIVRERGIPFRVAHRIVGRLVTRAIEDGLA
PGDVDSVYLDEVSLEVTGRKLELDPELVEKALDPLENVRMRRIPGGPAPEMVRVAVEEMKSFIESERK
>Mature_468_residues
MNLRAGRLNSGMEDEAAEFTSSLTFDHHIFEADIECNMAHTRMLAHEGIIPEEVAAKIIDALESLREEGIEALDMDPSVE
DIHMAVENYVTARIGEEAGFMHTGKSRNDQVATDLRLALRERIRTISRELLDFIDSISDLALDHTETVMVGYTHLQHAQP
TTLGHHLMAYASSLRRDYERLQDTLKRVDQNPLGSAAMTTTSFPINRELTTRLLGFSDYMKNSMDAVSARDFIAETVFDL
SMLAVNLSRISEEMILWSTHEFGIVEIPDEFSSTSSIMPQKKNPDVAEIARAKTSTVQGELVTILGIMKALPYTYNRDLQ
EVTPHLWRAVDTVLSMIRVVRGMLLGIRVNRNRALELAGANFATATDLADIIVRERGIPFRVAHRIVGRLVTRAIEDGLA
PGDVDSVYLDEVSLEVTGRKLELDPELVEKALDPLENVRMRRIPGGPAPEMVRVAVEEMKSFIESERK

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=467, Percent_Identity=34.2612419700214, Blast_Score=273, Evalue=3e-73,
Organism=Homo sapiens, GI68303542, Length=467, Percent_Identity=34.2612419700214, Blast_Score=273, Evalue=3e-73,
Organism=Homo sapiens, GI68303549, Length=467, Percent_Identity=32.3340471092077, Blast_Score=241, Evalue=8e-64,
Organism=Homo sapiens, GI68303547, Length=467, Percent_Identity=32.1199143468951, Blast_Score=239, Evalue=3e-63,
Organism=Escherichia coli, GI1790398, Length=402, Percent_Identity=40.0497512437811, Blast_Score=293, Evalue=1e-80,
Organism=Saccharomyces cerevisiae, GI6321806, Length=466, Percent_Identity=34.3347639484979, Blast_Score=256, Evalue=5e-69,
Organism=Drosophila melanogaster, GI221473854, Length=399, Percent_Identity=36.0902255639098, Blast_Score=254, Evalue=8e-68,
Organism=Drosophila melanogaster, GI78706858, Length=399, Percent_Identity=36.0902255639098, Blast_Score=254, Evalue=8e-68,
Organism=Drosophila melanogaster, GI24583245, Length=309, Percent_Identity=25.2427184466019, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI78710009, Length=221, Percent_Identity=29.4117647058824, Blast_Score=69, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_METTH (O26369)

Other databases:

- EMBL:   AE000666
- PIR:   H69133
- RefSeq:   NP_275412.1
- ProteinModelPortal:   O26369
- SMR:   O26369
- STRING:   O26369
- GeneID:   1470230
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH269
- NMPDR:   fig|187420.1.peg.267
- eggNOG:   arNOG04975
- HOGENOM:   HBG539632
- OMA:   MAEDLIF
- ProtClustDB:   PRK00855
- BioCyc:   MTHE187420:MTH269-MONOMER
- BRENDA:   4.3.2.1
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 52441; Mature: 52441

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLRAGRLNSGMEDEAAEFTSSLTFDHHIFEADIECNMAHTRMLAHEGIIPEEVAAKIID
CCCCCCCCCCCCCHHHHHHHHHCCCCHHEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHH
ALESLREEGIEALDMDPSVEDIHMAVENYVTARIGEEAGFMHTGKSRNDQVATDLRLALR
HHHHHHHCCCCEECCCCCHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCHHHHHHHHHHH
ERIRTISRELLDFIDSISDLALDHTETVMVGYTHLQHAQPTTLGHHLMAYASSLRRDYER
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
LQDTLKRVDQNPLGSAAMTTTSFPINRELTTRLLGFSDYMKNSMDAVSARDFIAETVFDL
HHHHHHHHCCCCCCCHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SMLAVNLSRISEEMILWSTHEFGIVEIPDEFSSTSSIMPQKKNPDVAEIARAKTSTVQGE
HHHHHHHHHHHHHHHEEECCCCCEEECCHHHCCHHHCCCCCCCCCHHHHHHHHHHHHHHH
LVTILGIMKALPYTYNRDLQEVTPHLWRAVDTVLSMIRVVRGMLLGIRVNRNRALELAGA
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCEEEECCC
NFATATDLADIIVRERGIPFRVAHRIVGRLVTRAIEDGLAPGDVDSVYLDEVSLEVTGRK
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHHEEEEEECCE
LELDPELVEKALDPLENVRMRRIPGGPAPEMVRVAVEEMKSFIESERK
EECCHHHHHHHHCHHHHCHHHCCCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNLRAGRLNSGMEDEAAEFTSSLTFDHHIFEADIECNMAHTRMLAHEGIIPEEVAAKIID
CCCCCCCCCCCCCHHHHHHHHHCCCCHHEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHH
ALESLREEGIEALDMDPSVEDIHMAVENYVTARIGEEAGFMHTGKSRNDQVATDLRLALR
HHHHHHHCCCCEECCCCCHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCHHHHHHHHHHH
ERIRTISRELLDFIDSISDLALDHTETVMVGYTHLQHAQPTTLGHHLMAYASSLRRDYER
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
LQDTLKRVDQNPLGSAAMTTTSFPINRELTTRLLGFSDYMKNSMDAVSARDFIAETVFDL
HHHHHHHHCCCCCCCHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SMLAVNLSRISEEMILWSTHEFGIVEIPDEFSSTSSIMPQKKNPDVAEIARAKTSTVQGE
HHHHHHHHHHHHHHHEEECCCCCEEECCHHHCCHHHCCCCCCCCCHHHHHHHHHHHHHHH
LVTILGIMKALPYTYNRDLQEVTPHLWRAVDTVLSMIRVVRGMLLGIRVNRNRALELAGA
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCEEEECCC
NFATATDLADIIVRERGIPFRVAHRIVGRLVTRAIEDGLAPGDVDSVYLDEVSLEVTGRK
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHHEEEEEECCE
LELDPELVEKALDPLENVRMRRIPGGPAPEMVRVAVEEMKSFIESERK
EECCHHHHHHHHCHHHHCHHHCCCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463