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The map label for this gene is ndk

Identifier: 15678286

GI number: 15678286

Start: 198997

End: 199452

Strand: Direct

Name: ndk

Synonym: MTH258

Alternate gene names: 15678286

Gene position: 198997-199452 (Clockwise)

Preceding gene: 15678285

Following gene: 15678287

Centisome position: 11.36

GC content: 46.49

Gene sequence:

>456_bases
ATGATGGAAAAAAGCTTTGTAATGTTAAAACCTGACGCAGTAAAAAGGCGCCTCGCAGGAAGGATAATAGCCAGGTTCGA
GGACAGGGGACTCAAGATAGTCGCCTTTAAGATGCTGCAGATCCCGGAAGACCTTGCAATGGAGCACTACCAGGAACACA
GGGAAAAGCCCTTCTTCAGGGACCTGGTGGACTACATAACATCAGCACCTGTCATTGCAATGGTCATTGAGGGTAAGGAC
TGCATATCCCTCATAAGGAAGATGGTTGGCGCAACCAACCCTGCAGAGGCAGACCTCGGGACAATCAGGGGAGACTTCGC
CCTTGAAACAGGTAGAAACATAATACACGCTTCAGATTCTCCAGAATCAGCCGAAAGGGAGATTAAACTTTTCTTTGATG
AATCGGAAATTTGCAGTTACGAGATGCCTGATAGAGAAATGATATACGAGGAATAA

Upstream 100 bases:

>100_bases
TCAAAAGGGACGGTACAATCTATTTCTTCTGCAGCAGCAAATGCGAGAAAAACATGATAAAACTGGGAAGGGTTCCAAGA
AAAGTTAAATGGGTCAAAAA

Downstream 100 bases:

>100_bases
ACGCGGAGATTCCAATGAAGATCAGATCACCCATCGTCTCAGTACTCGGACACGTGGATCACGGGAAAACCACACTTCTT
GACCATATAAGGGGCAGCGC

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase [H]

Number of amino acids: Translated: 151; Mature: 151

Protein sequence:

>151_residues
MMEKSFVMLKPDAVKRRLAGRIIARFEDRGLKIVAFKMLQIPEDLAMEHYQEHREKPFFRDLVDYITSAPVIAMVIEGKD
CISLIRKMVGATNPAEADLGTIRGDFALETGRNIIHASDSPESAEREIKLFFDESEICSYEMPDREMIYEE

Sequences:

>Translated_151_residues
MMEKSFVMLKPDAVKRRLAGRIIARFEDRGLKIVAFKMLQIPEDLAMEHYQEHREKPFFRDLVDYITSAPVIAMVIEGKD
CISLIRKMVGATNPAEADLGTIRGDFALETGRNIIHASDSPESAEREIKLFFDESEICSYEMPDREMIYEE
>Mature_151_residues
MMEKSFVMLKPDAVKRRLAGRIIARFEDRGLKIVAFKMLQIPEDLAMEHYQEHREKPFFRDLVDYITSAPVIAMVIEGKD
CISLIRKMVGATNPAEADLGTIRGDFALETGRNIIHASDSPESAEREIKLFFDESEICSYEMPDREMIYEE

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate [H]

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family [H]

Homologues:

Organism=Homo sapiens, GI37693993, Length=148, Percent_Identity=51.3513513513513, Blast_Score=165, Evalue=2e-41,
Organism=Homo sapiens, GI4826862, Length=138, Percent_Identity=52.8985507246377, Blast_Score=161, Evalue=2e-40,
Organism=Homo sapiens, GI38045913, Length=148, Percent_Identity=50, Blast_Score=160, Evalue=3e-40,
Organism=Homo sapiens, GI4557797, Length=148, Percent_Identity=50, Blast_Score=160, Evalue=4e-40,
Organism=Homo sapiens, GI66392203, Length=149, Percent_Identity=46.9798657718121, Blast_Score=154, Evalue=3e-38,
Organism=Homo sapiens, GI66392227, Length=149, Percent_Identity=46.9798657718121, Blast_Score=154, Evalue=3e-38,
Organism=Homo sapiens, GI66392205, Length=149, Percent_Identity=46.9798657718121, Blast_Score=154, Evalue=3e-38,
Organism=Homo sapiens, GI4505409, Length=149, Percent_Identity=46.9798657718121, Blast_Score=154, Evalue=3e-38,
Organism=Homo sapiens, GI66392192, Length=149, Percent_Identity=46.9798657718121, Blast_Score=154, Evalue=3e-38,
Organism=Homo sapiens, GI37574614, Length=140, Percent_Identity=35, Blast_Score=89, Evalue=1e-18,
Organism=Homo sapiens, GI7019465, Length=140, Percent_Identity=35, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI5031951, Length=146, Percent_Identity=34.2465753424658, Blast_Score=71, Evalue=3e-13,
Organism=Escherichia coli, GI1788866, Length=137, Percent_Identity=46.7153284671533, Blast_Score=135, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17506807, Length=149, Percent_Identity=48.3221476510067, Blast_Score=153, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI71995094, Length=132, Percent_Identity=34.8484848484849, Blast_Score=72, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6322783, Length=148, Percent_Identity=45.945945945946, Blast_Score=152, Evalue=2e-38,
Organism=Drosophila melanogaster, GI45549037, Length=148, Percent_Identity=48.6486486486487, Blast_Score=163, Evalue=4e-41,
Organism=Drosophila melanogaster, GI18860097, Length=136, Percent_Identity=30.1470588235294, Blast_Score=73, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001564
- InterPro:   IPR023005 [H]

Pfam domain/function: PF00334 NDK [H]

EC number: =2.7.4.6 [H]

Molecular weight: Translated: 17376; Mature: 17376

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS00469 NDP_KINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
6.0 %Met     (Translated Protein)
7.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
6.0 %Met     (Mature Protein)
7.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMEKSFVMLKPDAVKRRLAGRIIARFEDRGLKIVAFKMLQIPEDLAMEHYQEHREKPFFR
CCCCCEEEECCHHHHHHHHHHHHHHHHCCCEEEEEHHHHHCCHHHHHHHHHHHHCCCHHH
DLVDYITSAPVIAMVIEGKDCISLIRKMVGATNPAEADLGTIRGDFALETGRNIIHASDS
HHHHHHCCCCEEEEEECCHHHHHHHHHHHCCCCCCCCCHHHHCCCEEECCCCEEEECCCC
PESAEREIKLFFDESEICSYEMPDREMIYEE
CCCCCCEEEEEECCCCCCCCCCCCHHCCCCC
>Mature Secondary Structure
MMEKSFVMLKPDAVKRRLAGRIIARFEDRGLKIVAFKMLQIPEDLAMEHYQEHREKPFFR
CCCCCEEEECCHHHHHHHHHHHHHHHHCCCEEEEEHHHHHCCHHHHHHHHHHHHCCCHHH
DLVDYITSAPVIAMVIEGKDCISLIRKMVGATNPAEADLGTIRGDFALETGRNIIHASDS
HHHHHHCCCCEEEEEECCHHHHHHHHHHHCCCCCCCCCHHHHCCCEEECCCCEEEECCCC
PESAEREIKLFFDESEICSYEMPDREMIYEE
CCCCCCEEEEEECCCCCCCCCCCCHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]