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Identifier: 15678223

GI number: 15678223

Start: 139294

End: 140670

Strand: Direct

Name: Not Available

Synonym: MTH195

Alternate gene names: 15678223

Gene position: 139294-140670 (Clockwise)

Preceding gene: 15678222

Following gene: 15678226

Centisome position: 7.95

GC content: 52.8

Gene sequence:

>1377_bases
TTGAATGAGTACAATGACAGGTCACTGCGTTTGTATGTGCTTATAGCGGCAACACTTTCATCATTTCTCACCCCCTTCAT
GGGTTCATCAATCAATGTGGCGCTTCCTGTTATAGCGCTGCAGTTTAAAATCGATGCAATACTCCAGACATGGATACCCA
CGGCCTTTCTCCTGGCAGCCGCCATATTTGCGGTCCCCTTCGGGAGGCTGTCTGAGATATACGGGATGAAGAGGGTCTTC
GTCTATGGTAACATAATCTTCACTGTTTCAGCGATTCTCTCGGCCTTCTCACCCTCAGCCATGGCACTGATAGTGTTCAG
GGCCATCCAGGGCGTCGGGTCGGCCATGATATTCGTGACGGGCCTTGCCATACTCACAAGGGTCTTCCCGCCCTATGAGC
GGGGTAAGGCCATAGGGATAAACACGGCCGCAGTCTACATTGGCCTCTCAATGGGACCGGTCCTCGGGGGATTCCTCACA
AGGTTCCTGGGATGGCAGAGCATATTCCTCTCTACGGTACCCCTGACAGTCATCGTCCTCGCGGTTAGTCTCCTTAGAAT
TGATGGTGAATGGGCAGATGCTGCCGGCGAAACCTTCGATATCCCCGGATCCATATCCTACTGTATCTTCCTGTTTCTAC
TCATGTATGGATTCTCAGCTCTCCCTGATACCATGGGGGCCCTCATGATCCTCCTGAGCATAGGGGCCTTCGCTGTTTTC
CTCAGAATGGAGCTGTCATCAACCAGCCCTGTCTTCAATGTGAGGCTCTTCAGGAACCTTACCTTCAGCTTCTCAAGCCT
TGCAGCCCTCATAAATTACAGTGCAACCTTTGCAGTATCACTCCTCCTCAGCTACCACCTCCAGTATATCAAGGGCCTTG
ACCCTGGCTCAAGCGGCCTCATACTGGTGACACAGCCCATCGTCATGGCCCTGGTGGCGCCAGTGGCGGGCAGGGCATCT
GACAGGTTCAACCCCCAGACACTTGCAGGTATCGGCATGGCTGTGACCTCCCTGGCGCTCCTAAGCCTCAGCATACTCGA
TAGAACCACCCCTGTGCCAATGATAATCGTATCACTCTTCGTGCTGGGACTGGGCTTCGGTTTCTTCTCATCACCCAACA
CCAATGCCATAATGGGTTCCGTTGAGAGGAAGGACTATGGTATTGCATCGGCAACCGTCAGCTCCATGAGGCTCATAGGC
CAGGCCTTCAGCATAGGGATAGTGACGCTTATCTTCGCATTCCTCATAGGGAGGGTTCCAATCTCTCCTGCAAACTATGA
CCTCCTCATAGAGAGCACAAGGATATGCTTCCTGATATTCGGCGTGCTATGCTTTGTGGGGGTCTTCGCTGCAACTGCCC
GCAGAAACGATGGTTAA

Upstream 100 bases:

>100_bases
TTCATTTTTCTGTTTTTAAATTTTTTCATTTCATTCGCTCTGAAAATTATTTAAATGGCCCACCCTATAGTAATAACCAG
TTTTTTCTGGAGGGAAAAAT

Downstream 100 bases:

>100_bases
ATGGATCCTTATCTACTTAAATCATTTTCTTTTGCAGTTAGGTGCTGTAATAGGGATGCCGGGTCTGGTCCTCTAAAGAA
CATTCACTCAGGGCTAAACT

Product: efflux pump antibiotic resistance protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MNEYNDRSLRLYVLIAATLSSFLTPFMGSSINVALPVIALQFKIDAILQTWIPTAFLLAAAIFAVPFGRLSEIYGMKRVF
VYGNIIFTVSAILSAFSPSAMALIVFRAIQGVGSAMIFVTGLAILTRVFPPYERGKAIGINTAAVYIGLSMGPVLGGFLT
RFLGWQSIFLSTVPLTVIVLAVSLLRIDGEWADAAGETFDIPGSISYCIFLFLLMYGFSALPDTMGALMILLSIGAFAVF
LRMELSSTSPVFNVRLFRNLTFSFSSLAALINYSATFAVSLLLSYHLQYIKGLDPGSSGLILVTQPIVMALVAPVAGRAS
DRFNPQTLAGIGMAVTSLALLSLSILDRTTPVPMIIVSLFVLGLGFGFFSSPNTNAIMGSVERKDYGIASATVSSMRLIG
QAFSIGIVTLIFAFLIGRVPISPANYDLLIESTRICFLIFGVLCFVGVFAATARRNDG

Sequences:

>Translated_458_residues
MNEYNDRSLRLYVLIAATLSSFLTPFMGSSINVALPVIALQFKIDAILQTWIPTAFLLAAAIFAVPFGRLSEIYGMKRVF
VYGNIIFTVSAILSAFSPSAMALIVFRAIQGVGSAMIFVTGLAILTRVFPPYERGKAIGINTAAVYIGLSMGPVLGGFLT
RFLGWQSIFLSTVPLTVIVLAVSLLRIDGEWADAAGETFDIPGSISYCIFLFLLMYGFSALPDTMGALMILLSIGAFAVF
LRMELSSTSPVFNVRLFRNLTFSFSSLAALINYSATFAVSLLLSYHLQYIKGLDPGSSGLILVTQPIVMALVAPVAGRAS
DRFNPQTLAGIGMAVTSLALLSLSILDRTTPVPMIIVSLFVLGLGFGFFSSPNTNAIMGSVERKDYGIASATVSSMRLIG
QAFSIGIVTLIFAFLIGRVPISPANYDLLIESTRICFLIFGVLCFVGVFAATARRNDG
>Mature_458_residues
MNEYNDRSLRLYVLIAATLSSFLTPFMGSSINVALPVIALQFKIDAILQTWIPTAFLLAAAIFAVPFGRLSEIYGMKRVF
VYGNIIFTVSAILSAFSPSAMALIVFRAIQGVGSAMIFVTGLAILTRVFPPYERGKAIGINTAAVYIGLSMGPVLGGFLT
RFLGWQSIFLSTVPLTVIVLAVSLLRIDGEWADAAGETFDIPGSISYCIFLFLLMYGFSALPDTMGALMILLSIGAFAVF
LRMELSSTSPVFNVRLFRNLTFSFSSLAALINYSATFAVSLLLSYHLQYIKGLDPGSSGLILVTQPIVMALVAPVAGRAS
DRFNPQTLAGIGMAVTSLALLSLSILDRTTPVPMIIVSLFVLGLGFGFFSSPNTNAIMGSVERKDYGIASATVSSMRLIG
QAFSIGIVTLIFAFLIGRVPISPANYDLLIESTRICFLIFGVLCFVGVFAATARRNDG

Specific function: Unknown

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Escherichia coli, GI87081983, Length=391, Percent_Identity=27.8772378516624, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI1788710, Length=326, Percent_Identity=25.7668711656442, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1789042, Length=328, Percent_Identity=25, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1790195, Length=384, Percent_Identity=25.78125, Blast_Score=89, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6323735, Length=327, Percent_Identity=24.1590214067278, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 49135; Mature: 49135

Theoretical pI: Translated: 9.42; Mature: 9.42

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEYNDRSLRLYVLIAATLSSFLTPFMGSSINVALPVIALQFKIDAILQTWIPTAFLLAA
CCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHH
AIFAVPFGRLSEIYGMKRVFVYGNIIFTVSAILSAFSPSAMALIVFRAIQGVGSAMIFVT
HHHHHCHHHHHHHHCCHHHEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHH
GLAILTRVFPPYERGKAIGINTAAVYIGLSMGPVLGGFLTRFLGWQSIFLSTVPLTVIVL
HHHHHHHHCCCHHCCCEEEEEHHHHEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVSLLRIDGEWADAAGETFDIPGSISYCIFLFLLMYGFSALPDTMGALMILLSIGAFAVF
HHHHHHCCCCHHCCCCCCCCCCCCHHHHHHHHHHHHCHHCCHHHHHHHHHHHHHHHHHHH
LRMELSSTSPVFNVRLFRNLTFSFSSLAALINYSATFAVSLLLSYHLQYIKGLDPGSSGL
HHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCE
ILVTQPIVMALVAPVAGRASDRFNPQTLAGIGMAVTSLALLSLSILDRTTPVPMIIVSLF
EEEHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
VLGLGFGFFSSPNTNAIMGSVERKDYGIASATVSSMRLIGQAFSIGIVTLIFAFLIGRVP
HHHHCCCCCCCCCCCHHCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
ISPANYDLLIESTRICFLIFGVLCFVGVFAATARRNDG
CCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNEYNDRSLRLYVLIAATLSSFLTPFMGSSINVALPVIALQFKIDAILQTWIPTAFLLAA
CCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHH
AIFAVPFGRLSEIYGMKRVFVYGNIIFTVSAILSAFSPSAMALIVFRAIQGVGSAMIFVT
HHHHHCHHHHHHHHCCHHHEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHH
GLAILTRVFPPYERGKAIGINTAAVYIGLSMGPVLGGFLTRFLGWQSIFLSTVPLTVIVL
HHHHHHHHCCCHHCCCEEEEEHHHHEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVSLLRIDGEWADAAGETFDIPGSISYCIFLFLLMYGFSALPDTMGALMILLSIGAFAVF
HHHHHHCCCCHHCCCCCCCCCCCCHHHHHHHHHHHHCHHCCHHHHHHHHHHHHHHHHHHH
LRMELSSTSPVFNVRLFRNLTFSFSSLAALINYSATFAVSLLLSYHLQYIKGLDPGSSGL
HHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCE
ILVTQPIVMALVAPVAGRASDRFNPQTLAGIGMAVTSLALLSLSILDRTTPVPMIIVSLF
EEEHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
VLGLGFGFFSSPNTNAIMGSVERKDYGIASATVSSMRLIGQAFSIGIVTLIFAFLIGRVP
HHHHCCCCCCCCCCCHHCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
ISPANYDLLIESTRICFLIFGVLCFVGVFAATARRNDG
CCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]