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Identifier: 15678189

GI number: 15678189

Start: 106903

End: 108207

Strand: Direct

Name: Not Available

Synonym: MTH161

Alternate gene names: 15678189

Gene position: 106903-108207 (Clockwise)

Preceding gene: 15678188

Following gene: 15678190

Centisome position: 6.1

GC content: 52.11

Gene sequence:

>1305_bases
ATGATTCTGATGATCTGGAATAGGGAAATGGAATGCATATCAAGGGATGAACTGGAGGAACTGCAGCTCAGGAGACTACA
GGATACCGTGAAGAGGGCCTATGAGAATGTACCCTACTACAGGGAGGCCTTTGAAAGGGTGGAGGTTTACCCCGAGGATA
TAGAGACCCTTGACGATATAGAAAAACTCCCCTACACAACAAAGGACGACCTGAGGAGGGTCTACCCCTTCGGGATGTTC
GCAGTGCCACGCAGGGAGATAGTTGAGGTTCACACATCATCAGGGACAACAGGCAAGCCGGTGGTCTCAGGCTACACCAG
GGAGGACATTGAAATATGGAGTGAGGTCATGGCAAGGGGCCTTACCATGATGGGCCTCACCGAGGATGATGTAATCCAGA
ACACCCACGGCTACGGACTTTTCACAGGGGGCTTCGGTGTCCACTACGGGGCCCAGAAGATCGGGGCCACGGTCATACCC
ATATCAACGGGGCAGACAAGAAGGCAGATAGAGATAATGAAGGACTTCGGAACAACAGTCATGATATTCACACCATCCTA
CGGTCTCTACCTTTCTGAAATAGCACGTGAAGAAGGATTCAACCCTGAAGAGTCCAGGATAAAGGCAATAGGCTTCGGAG
CCGAGATGTGGACCGAGGAGATGAGGGCTGAGATCGAGAGAAGATTCAATGCACCGGCCTTCAACATATACGGCCTGACA
GAGATAATGGGGCCAGGTGTTGCAATGGAGTGCAGTGAGAAGAAGGGACTCCACATTGCAGAGGACCACTTCTACCCTGA
GATAATAGATAAGAACGGTGAGAGGCTCGGCCCAGGGGAAAGGGGTGAACTTGTGATCACAACACTGACGAGGGTGGGGA
TGCCTGTTATAAGGTTCAGGACCAAGGACATAACCTCCATAGACTATGACCCCTGCAACTGCGGCAGGACCCTTGCAAGG
ATCTCAAGGATCACAGGCAGGGTTGACGATATGCTCAAGGTCCGCGGGGTATCAGTGTTCCCATCACAGATAGAGAAGGC
GCTACTCCGCATAGACGGAATAGAACCCCACTACCAGATAATAGTGACAAGGCCCCACCTCATGGATGAACTTGAGGTCA
GGGTTGAAACATCACCGGAACTCTTCTCAGATGATATCCGGAAGATGGTGGAGACCCGGGACCGCATCGAGGAGTTCATA
GAGAATGAGATAGGCCTCAGGGTCAAGGTGACCCTTGTGGAACCCGGAACCATACCCCGGAGTGAGGGCAAGACTGTGAG
GGTGATAGACAGGAGGAACCTCTAG

Upstream 100 bases:

>100_bases
TTAAATCATCATCTTCCATGGAGTTTCTCCTGGTCCAAATACCGGGGTAACATTTATTTTTAAAGCATCATAAATCATTA
AGAGTTACACTGATCCGGGA

Downstream 100 bases:

>100_bases
TTTAAAGGACGAGGCTGTGATAATATGAGGGTTAAGCAGATATCTATATTCCTTGAAAATAAGAAGGGCCGGCTCTGGAA
GGCCCTCAGCACACTTGCAG

Product: coenzyme F390 synthetase III

Products: NA

Alternate protein names: Phenylacetyl-CoA ligase; PA-CoA ligase [H]

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MILMIWNREMECISRDELEELQLRRLQDTVKRAYENVPYYREAFERVEVYPEDIETLDDIEKLPYTTKDDLRRVYPFGMF
AVPRREIVEVHTSSGTTGKPVVSGYTREDIEIWSEVMARGLTMMGLTEDDVIQNTHGYGLFTGGFGVHYGAQKIGATVIP
ISTGQTRRQIEIMKDFGTTVMIFTPSYGLYLSEIAREEGFNPEESRIKAIGFGAEMWTEEMRAEIERRFNAPAFNIYGLT
EIMGPGVAMECSEKKGLHIAEDHFYPEIIDKNGERLGPGERGELVITTLTRVGMPVIRFRTKDITSIDYDPCNCGRTLAR
ISRITGRVDDMLKVRGVSVFPSQIEKALLRIDGIEPHYQIIVTRPHLMDELEVRVETSPELFSDDIRKMVETRDRIEEFI
ENEIGLRVKVTLVEPGTIPRSEGKTVRVIDRRNL

Sequences:

>Translated_434_residues
MILMIWNREMECISRDELEELQLRRLQDTVKRAYENVPYYREAFERVEVYPEDIETLDDIEKLPYTTKDDLRRVYPFGMF
AVPRREIVEVHTSSGTTGKPVVSGYTREDIEIWSEVMARGLTMMGLTEDDVIQNTHGYGLFTGGFGVHYGAQKIGATVIP
ISTGQTRRQIEIMKDFGTTVMIFTPSYGLYLSEIAREEGFNPEESRIKAIGFGAEMWTEEMRAEIERRFNAPAFNIYGLT
EIMGPGVAMECSEKKGLHIAEDHFYPEIIDKNGERLGPGERGELVITTLTRVGMPVIRFRTKDITSIDYDPCNCGRTLAR
ISRITGRVDDMLKVRGVSVFPSQIEKALLRIDGIEPHYQIIVTRPHLMDELEVRVETSPELFSDDIRKMVETRDRIEEFI
ENEIGLRVKVTLVEPGTIPRSEGKTVRVIDRRNL
>Mature_434_residues
MILMIWNREMECISRDELEELQLRRLQDTVKRAYENVPYYREAFERVEVYPEDIETLDDIEKLPYTTKDDLRRVYPFGMF
AVPRREIVEVHTSSGTTGKPVVSGYTREDIEIWSEVMARGLTMMGLTEDDVIQNTHGYGLFTGGFGVHYGAQKIGATVIP
ISTGQTRRQIEIMKDFGTTVMIFTPSYGLYLSEIAREEGFNPEESRIKAIGFGAEMWTEEMRAEIERRFNAPAFNIYGLT
EIMGPGVAMECSEKKGLHIAEDHFYPEIIDKNGERLGPGERGELVITTLTRVGMPVIRFRTKDITSIDYDPCNCGRTLAR
ISRITGRVDDMLKVRGVSVFPSQIEKALLRIDGIEPHYQIIVTRPHLMDELEVRVETSPELFSDDIRKMVETRDRIEEFI
ENEIGLRVKVTLVEPGTIPRSEGKTVRVIDRRNL

Specific function: Catalyzes the activation of phenylacetic acid to phenylacetyl-CoA [H]

COG id: COG1541

COG function: function code H; Coenzyme F390 synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1787664, Length=437, Percent_Identity=47.3684210526316, Blast_Score=401, Evalue=1e-113,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000873
- InterPro:   IPR011880 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.30 [H]

Molecular weight: Translated: 49792; Mature: 49792

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILMIWNREMECISRDELEELQLRRLQDTVKRAYENVPYYREAFERVEVYPEDIETLDDI
CEEEEECCCHHHHCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHH
EKLPYTTKDDLRRVYPFGMFAVPRREIVEVHTSSGTTGKPVVSGYTREDIEIWSEVMARG
HHCCCCCHHHHHHHCCCCEEECCCHHEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCC
LTMMGLTEDDVIQNTHGYGLFTGGFGVHYGAQKIGATVIPISTGQTRRQIEIMKDFGTTV
CEEECCCHHHHHHCCCCCEEEECCCCHHCCHHHHCCEEEEECCCCCHHHHHHHHHCCCEE
MIFTPSYGLYLSEIAREEGFNPEESRIKAIGFGAEMWTEEMRAEIERRFNAPAFNIYGLT
EEECCCCCHHHHHHHHHCCCCCCHHHEEEEECCHHHHHHHHHHHHHHHCCCCEEEEEEHH
EIMGPGVAMECSEKKGLHIAEDHFYPEIIDKNGERLGPGERGELVITTLTRVGMPVIRFR
HHHCCCCEEECCCCCCCEEECCCCCHHHHCCCCCCCCCCCCCCEEEEEHHHCCCCEEEEE
TKDITSIDYDPCNCGRTLARISRITGRVDDMLKVRGVSVFPSQIEKALLRIDGIEPHYQI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEECHHHHHHHHHHHCCCCCCEEE
IVTRPHLMDELEVRVETSPELFSDDIRKMVETRDRIEEFIENEIGLRVKVTLVEPGTIPR
EEECCCHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCC
SEGKTVRVIDRRNL
CCCCEEEEEECCCC
>Mature Secondary Structure
MILMIWNREMECISRDELEELQLRRLQDTVKRAYENVPYYREAFERVEVYPEDIETLDDI
CEEEEECCCHHHHCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHH
EKLPYTTKDDLRRVYPFGMFAVPRREIVEVHTSSGTTGKPVVSGYTREDIEIWSEVMARG
HHCCCCCHHHHHHHCCCCEEECCCHHEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCC
LTMMGLTEDDVIQNTHGYGLFTGGFGVHYGAQKIGATVIPISTGQTRRQIEIMKDFGTTV
CEEECCCHHHHHHCCCCCEEEECCCCHHCCHHHHCCEEEEECCCCCHHHHHHHHHCCCEE
MIFTPSYGLYLSEIAREEGFNPEESRIKAIGFGAEMWTEEMRAEIERRFNAPAFNIYGLT
EEECCCCCHHHHHHHHHCCCCCCHHHEEEEECCHHHHHHHHHHHHHHHCCCCEEEEEEHH
EIMGPGVAMECSEKKGLHIAEDHFYPEIIDKNGERLGPGERGELVITTLTRVGMPVIRFR
HHHCCCCEEECCCCCCCEEECCCCCHHHHCCCCCCCCCCCCCCEEEEEHHHCCCCEEEEE
TKDITSIDYDPCNCGRTLARISRITGRVDDMLKVRGVSVFPSQIEKALLRIDGIEPHYQI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEECHHHHHHHHHHHCCCCCCEEE
IVTRPHLMDELEVRVETSPELFSDDIRKMVETRDRIEEFIENEIGLRVKVTLVEPGTIPR
EEECCCHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCC
SEGKTVRVIDRRNL
CCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9748275; 9278503; 10766858 [H]