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The map label for this gene is rpl18p

Identifier: 15678053

GI number: 15678053

Start: 10693

End: 11271

Strand: Direct

Name: rpl18p

Synonym: MTH22

Alternate gene names: 15678053

Gene position: 10693-11271 (Clockwise)

Preceding gene: 15678052

Following gene: 15678054

Centisome position: 0.61

GC content: 48.36

Gene sequence:

>579_bases
TTGGCACATGGACCAAGATACAAGCTGGCATTTAGAAGAAGAAGGGAAGGTAAAACTGATTACCGGGCCCGCTACAAAAT
GGTAGAAACAGGTAAATCAAGGCTCGTCGTCAGGATAACGACATATCACGTTATTGCACAGATAATCAACGTGGGCATGA
ACGGAGACGAAACACTTGTCTCAGCCCACTCAAAACAGCTCCAGAAAATGGGATGGCTTGGAGGTACAAGCAACACAGCA
GCAGCCTACCTCACAGGTTACCTGTGCGGTAAAAGGGCTCTGAAGGAGGGTATAGAGGAGGCTGTCCTTGACATAGGACT
GAGACCAGCCATCAGGGGCTCAAAGGTATTCGCTGCACTCAAGGGGGCTGTTGACGCAGGACTCAATGTACCCCACGGTG
AATCAGTGCTGCCCGATGAATCAAGAATCAGGGGAGAACACATAATGGAGTACGCAGAATCCCTTGATGAGGAAGAACTC
CGGAAGAGGTTTTCAAAGTACCTTGAAAGGGGTCTTTCCCCTGTGGATCTGCCGGAACACTTTGATGAAATCAAAAAGAG
AATAGATGAAGAGGTATGA

Upstream 100 bases:

>100_bases
GTAAACTGTACAAGATGGCCAAGGGCGGAGCCTTTAAGAGCAAATCTTACATGAAGACCTATGCCCGGGACCACGACATG
CTCAGGTAGGAGGGATTTGA

Downstream 100 bases:

>100_bases
TTATGAACTTCAACATGGAGGAATGGGAGCCAAGGACCCAGCTGGGACGCCTTGTAAAGGAGGGTGTCATAACAAGCATC
GATGAGATCTTTGAAGAGGG

Product: 50S ribosomal protein L18P

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 192; Mature: 191

Protein sequence:

>192_residues
MAHGPRYKLAFRRRREGKTDYRARYKMVETGKSRLVVRITTYHVIAQIINVGMNGDETLVSAHSKQLQKMGWLGGTSNTA
AAYLTGYLCGKRALKEGIEEAVLDIGLRPAIRGSKVFAALKGAVDAGLNVPHGESVLPDESRIRGEHIMEYAESLDEEEL
RKRFSKYLERGLSPVDLPEHFDEIKKRIDEEV

Sequences:

>Translated_192_residues
MAHGPRYKLAFRRRREGKTDYRARYKMVETGKSRLVVRITTYHVIAQIINVGMNGDETLVSAHSKQLQKMGWLGGTSNTA
AAYLTGYLCGKRALKEGIEEAVLDIGLRPAIRGSKVFAALKGAVDAGLNVPHGESVLPDESRIRGEHIMEYAESLDEEEL
RKRFSKYLERGLSPVDLPEHFDEIKKRIDEEV
>Mature_191_residues
AHGPRYKLAFRRRREGKTDYRARYKMVETGKSRLVVRITTYHVIAQIINVGMNGDETLVSAHSKQLQKMGWLGGTSNTAA
AYLTGYLCGKRALKEGIEEAVLDIGLRPAIRGSKVFAALKGAVDAGLNVPHGESVLPDESRIRGEHIMEYAESLDEEELR
KRFSKYLERGLSPVDLPEHFDEIKKRIDEEV

Specific function: This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance

COG id: COG0256

COG function: function code J; Ribosomal protein L18

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribosomal protein L18P family

Homologues:

Organism=Homo sapiens, GI14591909, Length=239, Percent_Identity=33.4728033472803, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17534333, Length=236, Percent_Identity=36.4406779661017, Blast_Score=126, Evalue=6e-30,
Organism=Saccharomyces cerevisiae, GI6325126, Length=217, Percent_Identity=37.3271889400922, Blast_Score=119, Evalue=2e-28,
Organism=Drosophila melanogaster, GI116007384, Length=233, Percent_Identity=33.4763948497854, Blast_Score=123, Evalue=8e-29,
Organism=Drosophila melanogaster, GI116007382, Length=233, Percent_Identity=33.4763948497854, Blast_Score=123, Evalue=8e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RL18_METTH (O26130)

Other databases:

- EMBL:   AE000666
- PIR:   B69127
- RefSeq:   NP_275167.1
- ProteinModelPortal:   O26130
- SMR:   O26130
- STRING:   O26130
- GeneID:   1469984
- GenomeReviews:   AE000666_GR
- KEGG:   mth:MTH22
- NMPDR:   fig|187420.1.peg.22
- eggNOG:   arNOG08828
- HOGENOM:   HBG391676
- OMA:   SRVYAAL
- PhylomeDB:   O26130
- ProtClustDB:   PRK08569
- BioCyc:   MTHE187420:MTH22-MONOMER
- GO:   GO:0005840
- GO:   GO:0006412
- HAMAP:   MF_01337_A
- InterPro:   IPR005484
- InterPro:   IPR005485
- PANTHER:   PTHR23410
- PRINTS:   PR00058

Pfam domain/function: PF00861 Ribosomal_L18p

EC number: NA

Molecular weight: Translated: 21613; Mature: 21482

Theoretical pI: Translated: 9.48; Mature: 9.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHGPRYKLAFRRRREGKTDYRARYKMVETGKSRLVVRITTYHVIAQIINVGMNGDETLV
CCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHCCCCCCHHHH
SAHSKQLQKMGWLGGTSNTAAAYLTGYLCGKRALKEGIEEAVLDIGLRPAIRGSKVFAAL
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
KGAVDAGLNVPHGESVLPDESRIRGEHIMEYAESLDEEELRKRFSKYLERGLSPVDLPEH
HHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCHHH
FDEIKKRIDEEV
HHHHHHHHCCCC
>Mature Secondary Structure 
AHGPRYKLAFRRRREGKTDYRARYKMVETGKSRLVVRITTYHVIAQIINVGMNGDETLV
CCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHCCCCCCHHHH
SAHSKQLQKMGWLGGTSNTAAAYLTGYLCGKRALKEGIEEAVLDIGLRPAIRGSKVFAAL
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
KGAVDAGLNVPHGESVLPDESRIRGEHIMEYAESLDEEELRKRFSKYLERGLSPVDLPEH
HHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCHHH
FDEIKKRIDEEV
HHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463