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The map label for this gene is gapB

Identifier: 15674228

GI number: 15674228

Start: 2332466

End: 2333476

Strand: Reverse

Name: gapB

Synonym: L0005

Alternate gene names: 15674228

Gene position: 2333476-2332466 (Counterclockwise)

Preceding gene: 15674229

Following gene: 15674227

Centisome position: 98.64

GC content: 40.55

Gene sequence:

>1011_bases
ATGGTAGTTAAAGTTGGTATTAACGGTTTCGGTCGTATCGGTCGTCTTGCTTTCCGTCGTATTCAAAATGTTGAAGGTGT
TGAAGTTGTTGCAATCAACGACTTGACAGATCCAGCAATGCTTGCTCACTTGCTTAAATACGATACAACTCAAGGTCGTT
TTGATGGTAAAGTTGAAGTTAAAGATGGTGGTTTTGAAGTTAACGGTAAATTCGTTAAAGTTACTGCTGAATCTAACCCA
GCTAACATCAACTGGGCTGAAGTTGGTGCAGAAATCGTTCTTGAAGCAACTGGTTTCTTCGCAACTAAAGAAAAAGCTGA
ACAACACTTGCACGCTAACGGTGCTAAAAAAGTTGTTATCACTGCACCTGGTGGATCTGATGTTAAAACAATCGTTTTCA
ACACTAACCACGAAGTACTTGATGGAACTGAAACAGTAATTTCAGCTGGTTCATGTACAACTAACTGTCTTGCTCCAATG
GCTGATACTTTGAACAAACAATTCGGTATCAAAGTTGGTACAATGACTACAGTTCACGGTTACACTGGTGACCAAATGAC
TCTTGATGGCCCACACCGTGGTGGAGACTTCCGTCGCGCACGTGCTGCAGCTGAAAACATCGTACCTAACTCAACAGGTG
CTGCTAAAGCTATCGGTCTTGTATTGCCAGAACTTCAAGGTAAACTTCAAGGACATGCTCAACGTGTACCAGTTCCAACT
GGTTCATTGACTGAACTTGTTACTATCCTTAACAAAGAAGTTACAGTTGACGAAATCAACGCAGCTATGAAAGCTGCTTC
AAATGAATCATTTGGTTACAACGAAGACCAAATCGTTTCATCTGATATCGTTGGTATCTCAAACTCTTCACTCTTTGATG
CTACTCAAACTGAAGTTACTTCAGCTGATGGAGCTCAACTTGTTAAAACTGTATCTTGGTACGATAACGAAATGTCATAC
ACTTCAAACCTTGTTCGTACACTTGCATACTTCGCTAAAATCGCTAAATAA

Upstream 100 bases:

>100_bases
AAAAAGTGTTAAAATAAAAGAGTAAGTTAAATTGTTAACTTAGTCAATTTAAAAGGTAAGCCTTTTATAAAATCTAATCC
CTATAAGGAGGAAACTACTA

Downstream 100 bases:

>100_bases
TTTTCCGATTTTAACGGTATAAAAACCAGTCTTCGGGCTGGTTTTTTTTTGATTTAATAAAGGAGAGAAGATGGAAACAC
CAAAATGTATTCATTGTTCA

Product: glyceraldehyde 3-phosphate dehydrogenase

Products: NA

Alternate protein names: GAPDH [H]

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MVVKVGINGFGRIGRLAFRRIQNVEGVEVVAINDLTDPAMLAHLLKYDTTQGRFDGKVEVKDGGFEVNGKFVKVTAESNP
ANINWAEVGAEIVLEATGFFATKEKAEQHLHANGAKKVVITAPGGSDVKTIVFNTNHEVLDGTETVISAGSCTTNCLAPM
ADTLNKQFGIKVGTMTTVHGYTGDQMTLDGPHRGGDFRRARAAAENIVPNSTGAAKAIGLVLPELQGKLQGHAQRVPVPT
GSLTELVTILNKEVTVDEINAAMKAASNESFGYNEDQIVSSDIVGISNSSLFDATQTEVTSADGAQLVKTVSWYDNEMSY
TSNLVRTLAYFAKIAK

Sequences:

>Translated_336_residues
MVVKVGINGFGRIGRLAFRRIQNVEGVEVVAINDLTDPAMLAHLLKYDTTQGRFDGKVEVKDGGFEVNGKFVKVTAESNP
ANINWAEVGAEIVLEATGFFATKEKAEQHLHANGAKKVVITAPGGSDVKTIVFNTNHEVLDGTETVISAGSCTTNCLAPM
ADTLNKQFGIKVGTMTTVHGYTGDQMTLDGPHRGGDFRRARAAAENIVPNSTGAAKAIGLVLPELQGKLQGHAQRVPVPT
GSLTELVTILNKEVTVDEINAAMKAASNESFGYNEDQIVSSDIVGISNSSLFDATQTEVTSADGAQLVKTVSWYDNEMSY
TSNLVRTLAYFAKIAK
>Mature_336_residues
MVVKVGINGFGRIGRLAFRRIQNVEGVEVVAINDLTDPAMLAHLLKYDTTQGRFDGKVEVKDGGFEVNGKFVKVTAESNP
ANINWAEVGAEIVLEATGFFATKEKAEQHLHANGAKKVVITAPGGSDVKTIVFNTNHEVLDGTETVISAGSCTTNCLAPM
ADTLNKQFGIKVGTMTTVHGYTGDQMTLDGPHRGGDFRRARAAAENIVPNSTGAAKAIGLVLPELQGKLQGHAQRVPVPT
GSLTELVTILNKEVTVDEINAAMKAASNESFGYNEDQIVSSDIVGISNSSLFDATQTEVTSADGAQLVKTVSWYDNEMSY
TSNLVRTLAYFAKIAK

Specific function: Second phase of glycolysis; first step. [C]

COG id: COG0057

COG function: function code G; Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI7669492, Length=335, Percent_Identity=45.3731343283582, Blast_Score=273, Evalue=1e-73,
Organism=Homo sapiens, GI7657116, Length=333, Percent_Identity=43.2432432432432, Blast_Score=261, Evalue=8e-70,
Organism=Escherichia coli, GI1788079, Length=338, Percent_Identity=50.5917159763314, Blast_Score=320, Evalue=1e-88,
Organism=Escherichia coli, GI1789295, Length=343, Percent_Identity=36.4431486880466, Blast_Score=222, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI17534679, Length=340, Percent_Identity=46.7647058823529, Blast_Score=269, Evalue=1e-72,
Organism=Caenorhabditis elegans, GI17534677, Length=340, Percent_Identity=46.4705882352941, Blast_Score=269, Evalue=1e-72,
Organism=Caenorhabditis elegans, GI32566163, Length=340, Percent_Identity=45.5882352941176, Blast_Score=268, Evalue=3e-72,
Organism=Caenorhabditis elegans, GI17568413, Length=340, Percent_Identity=45.5882352941176, Blast_Score=268, Evalue=3e-72,
Organism=Saccharomyces cerevisiae, GI6322468, Length=342, Percent_Identity=47.3684210526316, Blast_Score=279, Evalue=5e-76,
Organism=Saccharomyces cerevisiae, GI6321631, Length=338, Percent_Identity=46.7455621301775, Blast_Score=276, Evalue=4e-75,
Organism=Saccharomyces cerevisiae, GI6322409, Length=338, Percent_Identity=44.0828402366864, Blast_Score=273, Evalue=4e-74,
Organism=Drosophila melanogaster, GI17933600, Length=333, Percent_Identity=45.3453453453453, Blast_Score=273, Evalue=1e-73,
Organism=Drosophila melanogaster, GI18110149, Length=333, Percent_Identity=45.3453453453453, Blast_Score=273, Evalue=1e-73,
Organism=Drosophila melanogaster, GI85725000, Length=333, Percent_Identity=45.6456456456456, Blast_Score=271, Evalue=3e-73,
Organism=Drosophila melanogaster, GI22023983, Length=333, Percent_Identity=45.6456456456456, Blast_Score=271, Evalue=3e-73,
Organism=Drosophila melanogaster, GI19922412, Length=331, Percent_Identity=42.9003021148036, Blast_Score=255, Evalue=3e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020831
- InterPro:   IPR020829
- InterPro:   IPR020828
- InterPro:   IPR006424
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02800 Gp_dh_C; PF00044 Gp_dh_N [H]

EC number: =1.2.1.12 [H]

Molecular weight: Translated: 35820; Mature: 35820

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVKVGINGFGRIGRLAFRRIQNVEGVEVVAINDLTDPAMLAHLLKYDTTQGRFDGKVEV
CEEEEECCCCCHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEE
KDGGFEVNGKFVKVTAESNPANINWAEVGAEIVLEATGFFATKEKAEQHLHANGAKKVVI
ECCCEEECCEEEEEEECCCCCCCCHHHHCCEEEEEECCCCHHHHHHHHHHCCCCCCEEEE
TAPGGSDVKTIVFNTNHEVLDGTETVISAGSCTTNCLAPMADTLNKQFGIKVGTMTTVHG
ECCCCCCEEEEEEECCCCEECCCHHEEECCCCCHHHHHHHHHHHHHHHCEEEEEEEEEEC
YTGDQMTLDGPHRGGDFRRARAAAENIVPNSTGAAKAIGLVLPELQGKLQGHAQRVPVPT
CCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCEECCCCC
GSLTELVTILNKEVTVDEINAAMKAASNESFGYNEDQIVSSDIVGISNSSLFDATQTEVT
CHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCEECCCEEECCCCCCCCCCHHHHC
SADGAQLVKTVSWYDNEMSYTSNLVRTLAYFAKIAK
CCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVVKVGINGFGRIGRLAFRRIQNVEGVEVVAINDLTDPAMLAHLLKYDTTQGRFDGKVEV
CEEEEECCCCCHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEE
KDGGFEVNGKFVKVTAESNPANINWAEVGAEIVLEATGFFATKEKAEQHLHANGAKKVVI
ECCCEEECCEEEEEEECCCCCCCCHHHHCCEEEEEECCCCHHHHHHHHHHCCCCCCEEEE
TAPGGSDVKTIVFNTNHEVLDGTETVISAGSCTTNCLAPMADTLNKQFGIKVGTMTTVHG
ECCCCCCEEEEEEECCCCEECCCHHEEECCCCCHHHHHHHHHHHHHHHCEEEEEEEEEEC
YTGDQMTLDGPHRGGDFRRARAAAENIVPNSTGAAKAIGLVLPELQGKLQGHAQRVPVPT
CCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCEECCCCC
GSLTELVTILNKEVTVDEINAAMKAASNESFGYNEDQIVSSDIVGISNSSLFDATQTEVT
CHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCEECCCEEECCCCCCCCCCHHHHC
SADGAQLVKTVSWYDNEMSYTSNLVRTLAYFAKIAK
CCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7773380; 11337471 [H]