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The map label for this gene is pgi

Identifier: 15674150

GI number: 15674150

Start: 2244198

End: 2245544

Strand: Reverse

Name: pgi

Synonym: L0012

Alternate gene names: 15674150

Gene position: 2245544-2244198 (Counterclockwise)

Preceding gene: 15674152

Following gene: 15674147

Centisome position: 94.93

GC content: 39.79

Gene sequence:

>1347_bases
ATGGCTCATATTAAATTTGACTATTCAAAACTCACTCCATTTGTAGCTGAAAATGAATTAGACGAAATCCAATGGCAAAT
CGACGGGGCAGCTAAATTGCTCCACGAAGGAAAAGGTGCTGGGAGCGATTATATCGGATGGCTTGACCTTCCTGAAGATT
ACGACAAAGAAGAATTTGCTCGTATTCAAAAAGCAGCTAAAAAAATTCAATCTGATTCAGAAGTTCTTATTGTTATCGGT
ATCGGTGGTTCATACCTCGGTGCACGTGCAGCAATTGACTTTTTGAGCAACAGCTTTGTTAACTTGCAAACTGCCGAAGA
ACGTAAAGCACCACGTATTCTTTATGCTGGTAACTCAATTTCTTCATCATACTTGGCTGACCTTGTAGATTACGTTGCTG
ACAAAGATTTCTCTGTAAATGTAATCTCTAAATCAGGTACAACAACAGAACCAGCGATTGCTTTCCGTGTCTTCGAAGAA
ATGTTAGTTAAAAAATACGGTCGTGAAGAAGCAAACAAACGTATTTACGCAACAACTGATAAAGAAAAAGGTGCTGTAAA
AGTTAATGCTGACGCAAACAACTGGGAAACTTTCGTTGTTCCAGATTCAGTTGGTGGACGCTTCTCAGTATTGACAGCTG
TTGGACTTTTGCCAATTGCAGCTTCAGGTGCTGATATCACAGCTTTGATGGAAGGTGCTAACGCTGCGCGTAAAGAATAC
ACTTCTACAAATGTTCATGAAAATGATGCTTACGCCTATGCTGCACTTCGCAATATCCTTTACCGTAAAGGTAAATTCTC
AGAAATCTTGATCAATTACGAACCAAGCCTTCAGTATTTCTCAGAATGGTGGAAACAATTGGCTGGTGAATCAGAAGGGA
AAGACCAAAAAGGAATTTACCCAACTTCAGCTAACTTCTCAACAGACCTTCACTCATTAGGACAATGGATTCAAGAAGGA
ACACGTACTGTTTTTGAAACAGCAATCCGTATTGAAAAACCACGTAAAAACATCAACATTCCAGAACTTGACGCTGACCT
TGATGGACTTGGATACTTGCAAGGTAAAGATGTTGATTTCGTTAACAAAAAAGCAGCTGACGGCGTGCTTCTTGCTCACA
CTGACGGAAATGTTCCAAACATGATCGTGACATTGCCTGAACAAGACGAATTCACACTTGGATATGCAATTTACTTCTTT
GAACTTGCTATCGGTGTTTCTGGTTACTTGAACGGAATTAACCCATTCAACCAACCAGGTGTTGAAGCTTACAAGAAAAA
TATGTTCGCTCTTCTTGGTAAACCAGGATTTGAAGAACTCAGCAAAGAATTGAATGACCGCCTTTAA

Upstream 100 bases:

>100_bases
GATAAAATGAACTAGAAAATTCGAAGATAAAACAATGCAAAAGTTGTCGTTCTTCAATAGCTAAATTCTCGTAAAAAGCG
AGAAATTGAAAGGAATTAAA

Downstream 100 bases:

>100_bases
TCTTTGATTAAAAGTGTCATAAAAATCACTGACAAGATTTCTGTCAGTGATTTTTTGTATTCATTTCTTACTGATAAATC
CTGTCAGTAAAATTATTATT

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MAHIKFDYSKLTPFVAENELDEIQWQIDGAAKLLHEGKGAGSDYIGWLDLPEDYDKEEFARIQKAAKKIQSDSEVLIVIG
IGGSYLGARAAIDFLSNSFVNLQTAEERKAPRILYAGNSISSSYLADLVDYVADKDFSVNVISKSGTTTEPAIAFRVFEE
MLVKKYGREEANKRIYATTDKEKGAVKVNADANNWETFVVPDSVGGRFSVLTAVGLLPIAASGADITALMEGANAARKEY
TSTNVHENDAYAYAALRNILYRKGKFSEILINYEPSLQYFSEWWKQLAGESEGKDQKGIYPTSANFSTDLHSLGQWIQEG
TRTVFETAIRIEKPRKNINIPELDADLDGLGYLQGKDVDFVNKKAADGVLLAHTDGNVPNMIVTLPEQDEFTLGYAIYFF
ELAIGVSGYLNGINPFNQPGVEAYKKNMFALLGKPGFEELSKELNDRL

Sequences:

>Translated_448_residues
MAHIKFDYSKLTPFVAENELDEIQWQIDGAAKLLHEGKGAGSDYIGWLDLPEDYDKEEFARIQKAAKKIQSDSEVLIVIG
IGGSYLGARAAIDFLSNSFVNLQTAEERKAPRILYAGNSISSSYLADLVDYVADKDFSVNVISKSGTTTEPAIAFRVFEE
MLVKKYGREEANKRIYATTDKEKGAVKVNADANNWETFVVPDSVGGRFSVLTAVGLLPIAASGADITALMEGANAARKEY
TSTNVHENDAYAYAALRNILYRKGKFSEILINYEPSLQYFSEWWKQLAGESEGKDQKGIYPTSANFSTDLHSLGQWIQEG
TRTVFETAIRIEKPRKNINIPELDADLDGLGYLQGKDVDFVNKKAADGVLLAHTDGNVPNMIVTLPEQDEFTLGYAIYFF
ELAIGVSGYLNGINPFNQPGVEAYKKNMFALLGKPGFEELSKELNDRL
>Mature_447_residues
AHIKFDYSKLTPFVAENELDEIQWQIDGAAKLLHEGKGAGSDYIGWLDLPEDYDKEEFARIQKAAKKIQSDSEVLIVIGI
GGSYLGARAAIDFLSNSFVNLQTAEERKAPRILYAGNSISSSYLADLVDYVADKDFSVNVISKSGTTTEPAIAFRVFEEM
LVKKYGREEANKRIYATTDKEKGAVKVNADANNWETFVVPDSVGGRFSVLTAVGLLPIAASGADITALMEGANAARKEYT
STNVHENDAYAYAALRNILYRKGKFSEILINYEPSLQYFSEWWKQLAGESEGKDQKGIYPTSANFSTDLHSLGQWIQEGT
RTVFETAIRIEKPRKNINIPELDADLDGLGYLQGKDVDFVNKKAADGVLLAHTDGNVPNMIVTLPEQDEFTLGYAIYFFE
LAIGVSGYLNGINPFNQPGVEAYKKNMFALLGKPGFEELSKELNDRL

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family

Homologues:

Organism=Escherichia coli, GI1790457, Length=381, Percent_Identity=25.1968503937008, Blast_Score=65, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6319673, Length=406, Percent_Identity=25.1231527093596, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PI_LACLA (P81181)

Other databases:

- EMBL:   AE005176
- PIR:   H86895
- RefSeq:   NP_268325.1
- ProteinModelPortal:   P81181
- SMR:   P81181
- PhosSite:   P81181
- GeneID:   1115845
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L0012
- NMPDR:   fig|272623.1.peg.2223
- HOGENOM:   HBG615843
- OMA:   MMQGAAD
- ProtClustDB:   PRK14097
- BioCyc:   LLAC272623:L0012-MONOMER
- BioCyc:   MetaCyc:MONOMER-13046
- BRENDA:   5.3.1.9
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00473
- InterPro:   IPR001672
- InterPro:   IPR018189
- PANTHER:   PTHR11469
- PRINTS:   PR00662

Pfam domain/function: PF00342 PGI

EC number: =5.3.1.9

Molecular weight: Translated: 49595; Mature: 49464

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1; PS00174 P_GLUCOSE_ISOMERASE_2; PS51463 P_GLUCOSE_ISOMERASE_3

Important sites: ACT_SITE 290-290 ACT_SITE 311-311 ACT_SITE 425-425

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHIKFDYSKLTPFVAENELDEIQWQIDGAAKLLHEGKGAGSDYIGWLDLPEDYDKEEFA
CCEEEECHHHCCCHHHCCCHHHEEEEECHHHHHHHCCCCCCCCCEEEECCCCCCCHHHHH
RIQKAAKKIQSDSEVLIVIGIGGSYLGARAAIDFLSNSFVNLQTAEERKAPRILYAGNSI
HHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHCCCEEEEEHHHCCCCEEEEECCCC
SSSYLADLVDYVADKDFSVNVISKSGTTTEPAIAFRVFEEMLVKKYGREEANKRIYATTD
CHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCHHHHCCEEEEECC
KEKGAVKVNADANNWETFVVPDSVGGRFSVLTAVGLLPIAASGADITALMEGANAARKEY
CCCCCEEEECCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCHHHHHHCCHHHHHHH
TSTNVHENDAYAYAALRNILYRKGKFSEILINYEPSLQYFSEWWKQLAGESEGKDQKGIY
CCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCC
PTSANFSTDLHSLGQWIQEGTRTVFETAIRIEKPRKNINIPELDADLDGLGYLQGKDVDF
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCH
VNKKAADGVLLAHTDGNVPNMIVTLPEQDEFTLGYAIYFFELAIGVSGYLNGINPFNQPG
HCHHCCCCEEEEECCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCC
VEAYKKNMFALLGKPGFEELSKELNDRL
HHHHHHHHHHHHCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
AHIKFDYSKLTPFVAENELDEIQWQIDGAAKLLHEGKGAGSDYIGWLDLPEDYDKEEFA
CEEEECHHHCCCHHHCCCHHHEEEEECHHHHHHHCCCCCCCCCEEEECCCCCCCHHHHH
RIQKAAKKIQSDSEVLIVIGIGGSYLGARAAIDFLSNSFVNLQTAEERKAPRILYAGNSI
HHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHCCCEEEEEHHHCCCCEEEEECCCC
SSSYLADLVDYVADKDFSVNVISKSGTTTEPAIAFRVFEEMLVKKYGREEANKRIYATTD
CHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCHHHHCCEEEEECC
KEKGAVKVNADANNWETFVVPDSVGGRFSVLTAVGLLPIAASGADITALMEGANAARKEY
CCCCCEEEECCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCHHHHHHCCHHHHHHH
TSTNVHENDAYAYAALRNILYRKGKFSEILINYEPSLQYFSEWWKQLAGESEGKDQKGIY
CCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCC
PTSANFSTDLHSLGQWIQEGTRTVFETAIRIEKPRKNINIPELDADLDGLGYLQGKDVDF
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCH
VNKKAADGVLLAHTDGNVPNMIVTLPEQDEFTLGYAIYFFELAIGVSGYLNGINPFNQPG
HCHHCCCCEEEEECCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCC
VEAYKKNMFALLGKPGFEELSKELNDRL
HHHHHHHHHHHHCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471; 9169021