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The map label for this gene is arcB

Identifier: 15674018

GI number: 15674018

Start: 2113059

End: 2114123

Strand: Reverse

Name: arcB

Synonym: L0109

Alternate gene names: 15674018

Gene position: 2114123-2113059 (Counterclockwise)

Preceding gene: 15674019

Following gene: 15674017

Centisome position: 89.37

GC content: 37.18

Gene sequence:

>1065_bases
ATGACATCACCACTTATTACAAAAGCAGAAGTAAACTCAGTATTCCAAGGTCGCAGCTTACTTGCTGAAAAAGATTTCAC
ACCAGCTGAAATTAACTACCTTGTTGATTTTGGTCTTCATTTGAAAGCATTGAAACAACAAAACATTCCTCACCACTACC
TTGAAGGTAAAAATATTGCCTTGCTCTTTGCAAAAACTTCAACTCGTACACGTGCTGCCTTTACAACTGCTGCAATTGAC
CTTGGTGCTCATCCAGAATACCTTGGAGCTAACGATATTCAATTGGGAATTAAAGAATCAACAGAAGATACAGCTCGCGT
GCTTGGTTCAATGTTTGATGCTATCGAACGTCGTGGATTTTCTCAAAAAGAAGTTGAAGATTTGGCAAAATACTCTGGTG
TTCCAGTTTGGAATGGTTTGACAGATGATTGGCATCCAACACAAATGATTGCAGACTTTATGACTGTTAAAGAAAACTTT
GGACATCTTAAAGGTTTGACATTAGTCTACGTAGGTGATGGTCGTAACAACATGGCAAACTCACTTATCGTAACTGGTTC
TATGCTTGGTGTGAATGTTCATATTGTTGCTCCAGATTCACTTCATCCTACTAAAGAAGTTATGGATATTGCAAATAAAT
TTGCTGAAAAATCAGGTGCTAAACCTCTTGCAACTTCAAATATTGAAGAAGGTGTTAAAGGCGCAAACATTATTTACTCA
GACGTTTGGGTATCAATGGGAGAATCTAACTGGGAAGAACGTGTTAAACTTTTGACTCCATACCGTATCACAATGGATAT
GCTTAAAATGACTGGAAATGCTGACAATGGTCAATTGATCTTTATGCACTGCTTACCAGCATTCCATGATACTGAAACTG
AATATGGTAAAGAAATCAAAGAAAAATATGGTTTGACAGAAATGGAAGTGACTGACGAAGTATTCCGTTCTAAATATGCT
CGCCAATTTGAAGAAGCAGAAAATCGTATGCACTCTATCAAAGCAATCATGGCTGCAACTTTGGGTAATTTATTTATCCC
AGCAGTTCCTGAAGATTTTAAATAA

Upstream 100 bases:

>100_bases
TGATAATTAAATTATTTAGGAAAGAGTGAATCACTAGCTTATTAATGTAATTTAAAAAATTCATTAAATATAATAAAAAT
AGAAAAAGGAAGAAAAAATA

Downstream 100 bases:

>100_bases
TTAAAATAGATAATTTGTCAGTTTACTGACAGAGCTGTCAGTAAACTGATAGATTTTGATTTAAGTCGTTGAAAGCAGTC
TAAGATAAAATTAGACTGTT

Product: ornithine carbamoyltransferase

Products: NA

Alternate protein names: OTCase

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MTSPLITKAEVNSVFQGRSLLAEKDFTPAEINYLVDFGLHLKALKQQNIPHHYLEGKNIALLFAKTSTRTRAAFTTAAID
LGAHPEYLGANDIQLGIKESTEDTARVLGSMFDAIERRGFSQKEVEDLAKYSGVPVWNGLTDDWHPTQMIADFMTVKENF
GHLKGLTLVYVGDGRNNMANSLIVTGSMLGVNVHIVAPDSLHPTKEVMDIANKFAEKSGAKPLATSNIEEGVKGANIIYS
DVWVSMGESNWEERVKLLTPYRITMDMLKMTGNADNGQLIFMHCLPAFHDTETEYGKEIKEKYGLTEMEVTDEVFRSKYA
RQFEEAENRMHSIKAIMAATLGNLFIPAVPEDFK

Sequences:

>Translated_354_residues
MTSPLITKAEVNSVFQGRSLLAEKDFTPAEINYLVDFGLHLKALKQQNIPHHYLEGKNIALLFAKTSTRTRAAFTTAAID
LGAHPEYLGANDIQLGIKESTEDTARVLGSMFDAIERRGFSQKEVEDLAKYSGVPVWNGLTDDWHPTQMIADFMTVKENF
GHLKGLTLVYVGDGRNNMANSLIVTGSMLGVNVHIVAPDSLHPTKEVMDIANKFAEKSGAKPLATSNIEEGVKGANIIYS
DVWVSMGESNWEERVKLLTPYRITMDMLKMTGNADNGQLIFMHCLPAFHDTETEYGKEIKEKYGLTEMEVTDEVFRSKYA
RQFEEAENRMHSIKAIMAATLGNLFIPAVPEDFK
>Mature_353_residues
TSPLITKAEVNSVFQGRSLLAEKDFTPAEINYLVDFGLHLKALKQQNIPHHYLEGKNIALLFAKTSTRTRAAFTTAAIDL
GAHPEYLGANDIQLGIKESTEDTARVLGSMFDAIERRGFSQKEVEDLAKYSGVPVWNGLTDDWHPTQMIADFMTVKENFG
HLKGLTLVYVGDGRNNMANSLIVTGSMLGVNVHIVAPDSLHPTKEVMDIANKFAEKSGAKPLATSNIEEGVKGANIIYSD
VWVSMGESNWEERVKLLTPYRITMDMLKMTGNADNGQLIFMHCLPAFHDTETEYGKEIKEKYGLTEMEVTDEVFRSKYAR
QFEEAENRMHSIKAIMAATLGNLFIPAVPEDFK

Specific function: Arginine biosynthesis; sixth step. [C]

COG id: COG0078

COG function: function code E; Ornithine carbamoyltransferase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family

Homologues:

Organism=Homo sapiens, GI38788445, Length=340, Percent_Identity=36.4705882352941, Blast_Score=218, Evalue=5e-57,
Organism=Homo sapiens, GI18105007, Length=350, Percent_Identity=25.1428571428571, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI1790703, Length=337, Percent_Identity=48.0712166172107, Blast_Score=318, Evalue=3e-88,
Organism=Escherichia coli, GI1786469, Length=326, Percent_Identity=49.3865030674847, Blast_Score=317, Evalue=1e-87,
Organism=Escherichia coli, GI48994908, Length=381, Percent_Identity=26.509186351706, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI2367364, Length=239, Percent_Identity=31.3807531380753, Blast_Score=72, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI193204318, Length=251, Percent_Identity=27.8884462151394, Blast_Score=76, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6322373, Length=331, Percent_Identity=32.6283987915408, Blast_Score=169, Evalue=7e-43,
Organism=Saccharomyces cerevisiae, GI6322331, Length=195, Percent_Identity=30.2564102564103, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24642586, Length=334, Percent_Identity=26.6467065868263, Blast_Score=92, Evalue=5e-19,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2066 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): OTCC_LACLA (P0C2U0)

Other databases:

- EMBL:   AE005176
- PIR:   D86879
- RefSeq:   NP_268193.1
- ProteinModelPortal:   P0C2U0
- SMR:   P0C2U0
- GeneID:   1115712
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L0109
- NMPDR:   fig|272623.1.peg.2090
- HOGENOM:   HBG579429
- OMA:   NHETVES
- ProtClustDB:   PRK02102
- BRENDA:   2.1.3.3
- HAMAP:   MF_01109
- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002292
- PRINTS:   PR00100
- PRINTS:   PR00102
- TIGRFAMs:   TIGR00658

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N; SSF53671 Asp/Orn_carbamoyltranf

EC number: =2.1.3.3

Molecular weight: Translated: 39456; Mature: 39325

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS00097 CARBAMOYLTRANSFERASE

Important sites: BINDING 118-118 BINDING 145-145

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSPLITKAEVNSVFQGRSLLAEKDFTPAEINYLVDFGLHLKALKQQNIPHHYLEGKNIA
CCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHCCCCHHHCCCCCEE
LLFAKTSTRTRAAFTTAAIDLGAHPEYLGANDIQLGIKESTEDTARVLGSMFDAIERRGF
EEEEECCCCHHHHHHHHEEECCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCC
SQKEVEDLAKYSGVPVWNGLTDDWHPTQMIADFMTVKENFGHLKGLTLVYVGDGRNNMAN
CHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCC
SLIVTGSMLGVNVHIVAPDSLHPTKEVMDIANKFAEKSGAKPLATSNIEEGVKGANIIYS
EEEEEEEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCEEEE
DVWVSMGESNWEERVKLLTPYRITMDMLKMTGNADNGQLIFMHCLPAFHDTETEYGKEIK
HHHHHCCCCCHHHHHHHCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCHHHHHHHHH
EKYGLTEMEVTDEVFRSKYARQFEEAENRMHSIKAIMAATLGNLFIPAVPEDFK
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TSPLITKAEVNSVFQGRSLLAEKDFTPAEINYLVDFGLHLKALKQQNIPHHYLEGKNIA
CCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHCCCCHHHCCCCCEE
LLFAKTSTRTRAAFTTAAIDLGAHPEYLGANDIQLGIKESTEDTARVLGSMFDAIERRGF
EEEEECCCCHHHHHHHHEEECCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCC
SQKEVEDLAKYSGVPVWNGLTDDWHPTQMIADFMTVKENFGHLKGLTLVYVGDGRNNMAN
CHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCC
SLIVTGSMLGVNVHIVAPDSLHPTKEVMDIANKFAEKSGAKPLATSNIEEGVKGANIIYS
EEEEEEEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCEEEE
DVWVSMGESNWEERVKLLTPYRITMDMLKMTGNADNGQLIFMHCLPAFHDTETEYGKEIK
HHHHHCCCCCHHHHHHHCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCHHHHHHHHH
EKYGLTEMEVTDEVFRSKYARQFEEAENRMHSIKAIMAATLGNLFIPAVPEDFK
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471