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The map label for this gene is glk

Identifier: 15674005

GI number: 15674005

Start: 2100698

End: 2101669

Strand: Direct

Name: glk

Synonym: L84096

Alternate gene names: 15674005

Gene position: 2100698-2101669 (Clockwise)

Preceding gene: 15674004

Following gene: 15674006

Centisome position: 88.8

GC content: 39.61

Gene sequence:

>972_bases
ATGACTGCAAGTAAAATTATCGGTATCGACCTTGGTGGAACTTCAATTAAATTTGGAATTTTGACACTCGATGGTGAGGT
TCAAGATAAATGGTCTATCCCGACAAATATTTTAGAAGATGGAAAACATATCGTTCCTGATATTATTGAATCAATCAACC
ACCGTTTAAGCCTTTATAACTTGGACAAATCTGAATTTCTTGGAATTGGAATGGGAACACCAGGTTCAGTAAATATTTCT
GAAAGTACCGTAAAAGCTGCTTTTAACTTAAACTGGGCAGATACTCAAGAAGTAGGTAAACCAATCTCTGAAGGTGTTGG
CCTTCCATTCATTTTGGATAACGATGCTAACGTTGCTGCTCTTGGCGAACGTTGGGTAGGGGCAGGTGAAAATAATCCAG
ATGTTGTTTTCATTACTCTTGGAACTGGTGTTGGTGGCGGAATTATCGCTTCAGGTGAGCTCGTTCATGGTGTTGCCGGA
GCTGGTGGCGAAATTGGCCACATTTGTGTTGACCCTTATGGTTTTGAATGTACTTGTGGAAATCGCGGTTGCTTGGAAAC
AGTAACTTCTGCAACAGGTATCGTTCGTTTAGCTCGTAAATTCGCTGAAGAATATGAAGGTGATTCTACTATTAAAGCAG
CTATTGACAATGGTGATGAAGTGACTTCTAAAGACATCTTCTTTGCAGCTCAAGAAGGAGATCACTTCAGCTTATCCGTT
GTTGATAAATTTGCTTATTATCTCGGTTTTGCTTGTGCAAACCTTGGTTCTACTTTGAACCCTGCTTCAATCGTCATCGG
TGGTGGTGTTTCTGCTGCTGGAGAATTCTTACGTGAAAAAGTTGAAAAATATTTCACTAAATATGCCTTTTCAACTGTTC
GTAACTCAAGTAAAATCAAACTTGCTGTCCTTGGAAATGACGCTGGAATTATCGGTGCCGCAAGTCTTGCTCTTAAATTT
AAAGGAGAATAA

Upstream 100 bases:

>100_bases
TGCTCGCTTGATTTTGGCACGTGAAGAGAGAATTGAAAAGAAAAAATCTACGACCAATAAAAAATGATTCTTTTTTTATT
GTCAGATTGGAGAAAAAAAC

Downstream 100 bases:

>100_bases
TTTTGGTTATTATTATCATTGATATCATTCTTATTTTAGTAATTATCGGAATGTTTGTCTATCCTCGTTGGAATCTTCGT
CGTAATGCTAAACTTGTTGA

Product: glucokinase

Products: NA

Alternate protein names: Glucose kinase [H]

Number of amino acids: Translated: 323; Mature: 322

Protein sequence:

>323_residues
MTASKIIGIDLGGTSIKFGILTLDGEVQDKWSIPTNILEDGKHIVPDIIESINHRLSLYNLDKSEFLGIGMGTPGSVNIS
ESTVKAAFNLNWADTQEVGKPISEGVGLPFILDNDANVAALGERWVGAGENNPDVVFITLGTGVGGGIIASGELVHGVAG
AGGEIGHICVDPYGFECTCGNRGCLETVTSATGIVRLARKFAEEYEGDSTIKAAIDNGDEVTSKDIFFAAQEGDHFSLSV
VDKFAYYLGFACANLGSTLNPASIVIGGGVSAAGEFLREKVEKYFTKYAFSTVRNSSKIKLAVLGNDAGIIGAASLALKF
KGE

Sequences:

>Translated_323_residues
MTASKIIGIDLGGTSIKFGILTLDGEVQDKWSIPTNILEDGKHIVPDIIESINHRLSLYNLDKSEFLGIGMGTPGSVNIS
ESTVKAAFNLNWADTQEVGKPISEGVGLPFILDNDANVAALGERWVGAGENNPDVVFITLGTGVGGGIIASGELVHGVAG
AGGEIGHICVDPYGFECTCGNRGCLETVTSATGIVRLARKFAEEYEGDSTIKAAIDNGDEVTSKDIFFAAQEGDHFSLSV
VDKFAYYLGFACANLGSTLNPASIVIGGGVSAAGEFLREKVEKYFTKYAFSTVRNSSKIKLAVLGNDAGIIGAASLALKF
KGE
>Mature_322_residues
TASKIIGIDLGGTSIKFGILTLDGEVQDKWSIPTNILEDGKHIVPDIIESINHRLSLYNLDKSEFLGIGMGTPGSVNISE
STVKAAFNLNWADTQEVGKPISEGVGLPFILDNDANVAALGERWVGAGENNPDVVFITLGTGVGGGIIASGELVHGVAGA
GGEIGHICVDPYGFECTCGNRGCLETVTSATGIVRLARKFAEEYEGDSTIKAAIDNGDEVTSKDIFFAAQEGDHFSLSVV
DKFAYYLGFACANLGSTLNPASIVIGGGVSAAGEFLREKVEKYFTKYAFSTVRNSSKIKLAVLGNDAGIIGAASLALKFK
GE

Specific function: Acts As A Repressor Of The Nagebacd Operon And Acts Both As An Activator And A Repressor For The Transcription Of The Glmsu Operon. [C]

COG id: COG1940

COG function: function code KG; Transcriptional regulator/sugar kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ROK (nagC/xylR) family [H]

Homologues:

Organism=Homo sapiens, GI4885285, Length=274, Percent_Identity=31.021897810219, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI190014632, Length=274, Percent_Identity=31.021897810219, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI298566315, Length=274, Percent_Identity=31.021897810219, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI298566325, Length=274, Percent_Identity=31.021897810219, Blast_Score=108, Evalue=5e-24,
Organism=Escherichia coli, GI1786891, Length=310, Percent_Identity=25.4838709677419, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1787878, Length=280, Percent_Identity=25.3571428571429, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI87081733, Length=320, Percent_Identity=28.75, Blast_Score=94, Evalue=9e-21,
Organism=Escherichia coli, GI1787363, Length=326, Percent_Identity=27.6073619631902, Blast_Score=94, Evalue=9e-21,
Organism=Escherichia coli, GI87082127, Length=227, Percent_Identity=26.8722466960352, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI87082230, Length=282, Percent_Identity=28.3687943262411, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790522, Length=319, Percent_Identity=26.0188087774295, Blast_Score=80, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000600
- InterPro:   IPR004654 [H]

Pfam domain/function: PF00480 ROK [H]

EC number: =2.7.1.2 [H]

Molecular weight: Translated: 33792; Mature: 33661

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: PS01125 ROK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTASKIIGIDLGGTSIKFGILTLDGEVQDKWSIPTNILEDGKHIVPDIIESINHRLSLYN
CCCCEEEEEEECCCEEEEEEEEECCCCCCCCCCCHHHHHCCCCHHHHHHHHHHCEEEEEE
LDKSEFLGIGMGTPGSVNISESTVKAAFNLNWADTQEVGKPISEGVGLPFILDNDANVAA
CCHHHEEEEECCCCCCEEECHHHEEEEEECCCCCHHHHCCHHHHCCCCCEEECCCCCEEE
LGERWVGAGENNPDVVFITLGTGVGGGIIASGELVHGVAGAGGEIGHICVDPYGFECTCG
ECHHHCCCCCCCCCEEEEEECCCCCCCEEECCCEEEEECCCCCCCCEEEECCCCCEEECC
NRGCLETVTSATGIVRLARKFAEEYEGDSTIKAAIDNGDEVTSKDIFFAAQEGDHFSLSV
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEEECCCCEEEEHH
VDKFAYYLGFACANLGSTLNPASIVIGGGVSAAGEFLREKVEKYFTKYAFSTVRNSSKIK
HHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
LAVLGNDAGIIGAASLALKFKGE
EEEEECCCCEEEEEEEEEEECCC
>Mature Secondary Structure 
TASKIIGIDLGGTSIKFGILTLDGEVQDKWSIPTNILEDGKHIVPDIIESINHRLSLYN
CCCEEEEEEECCCEEEEEEEEECCCCCCCCCCCHHHHHCCCCHHHHHHHHHHCEEEEEE
LDKSEFLGIGMGTPGSVNISESTVKAAFNLNWADTQEVGKPISEGVGLPFILDNDANVAA
CCHHHEEEEECCCCCCEEECHHHEEEEEECCCCCHHHHCCHHHHCCCCCEEECCCCCEEE
LGERWVGAGENNPDVVFITLGTGVGGGIIASGELVHGVAGAGGEIGHICVDPYGFECTCG
ECHHHCCCCCCCCCEEEEEECCCCCCCEEECCCEEEEECCCCCCCCEEEECCCCCEEECC
NRGCLETVTSATGIVRLARKFAEEYEGDSTIKAAIDNGDEVTSKDIFFAAQEGDHFSLSV
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEEECCCCEEEEHH
VDKFAYYLGFACANLGSTLNPASIVIGGGVSAAGEFLREKVEKYFTKYAFSTVRNSSKIK
HHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
LAVLGNDAGIIGAASLALKFKGE
EEEEECCCCEEEEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]